Automated description from the Alliance of Genome Resources (Release 7.4.0)
Predicted to enable 5'-3' DNA helicase activity; damaged DNA binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within several processes, including hemopoiesis; nervous system development; and rRNA metabolic process. Located in nucleus. Is expressed in central nervous system; eye; hair follicle; and liver. Used to study photosensitive trichothiodystrophy and xeroderma pigmentosum group D. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; acquired immunodeficiency syndrome; carcinoma (multiple); hematologic cancer (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit).
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