Gene Ontology Classifications

Symbol
Name
ID

Fkbp1a
FK506 binding protein 1a
MGI:95541

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables FK506 binding activity; identical protein binding activity; and transmembrane transporter binding activity. Involved in heart trabecula formation; regulation of ryanodine-sensitive calcium-release channel activity; and ventricular cardiac muscle tissue morphogenesis. Acts upstream of or within several processes, including T cell proliferation; release of sequestered calcium ion into cytosol; and response to caffeine. Located in sarcoplasmic reticulum membrane. Is active in synapse. Is expressed in several structures, including brain ventricular layer; jaw; orbito-sphenoid; thalamus mantle layer; and ventral grey horn. Used to study Barth syndrome. Orthologous to several human genes including FKBP1A (FKBP prolyl isomerase 1A).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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