Automated description from the Alliance of Genome Resources (Release 7.4.0)
Enables growth hormone receptor activity and peptide hormone binding activity. Involved in growth hormone receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of growth. Acts upstream of with a positive effect on taurine metabolic process. Located in nucleus and plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Used to study Laron syndrome. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor).
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