Gene Ontology Classifications

Symbol
Name
ID

Grik3
glutamate receptor, ionotropic, kainate 3
MGI:95816

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Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables glutamate-gated calcium ion channel activity and ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway; glutamatergic synaptic transmission; and negative regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within regulation of membrane potential. Located in plasma membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including central nervous system; chordamesoderm; future brain; gonad; and retina. Orthologous to human GRIK3 (glutamate ionotropic receptor kainate type subunit 3).

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Aspect

Category

Evidence

Aspect	Category	Classification Term	Context	Proteoform	Evidence	Inferred From	Reference(s)
Data error.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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