Automated description from the Alliance of Genome Resources (Release 7.4.0)
Enables kainate selective glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within excitatory postsynaptic potential; glutamatergic synaptic transmission; and regulation of synaptic vesicle fusion to presynaptic active zone membrane. Located in endoplasmic reticulum and postsynaptic membrane. Part of kainate selective glutamate receptor complex. Is active in hippocampal mossy fiber to CA3 synapse; postsynaptic density membrane; and presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and visual system. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human GRIK5 (glutamate ionotropic receptor kainate type subunit 5).
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