Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Predicted to enable protein-folding chaperone binding activity. Involved in several processes, including glial cell activation; positive regulation of cellular component organization; and regulation of defense response. Acts upstream of or within several processes, including blastocyst hatching; locomotory exploration behavior; and positive regulation of cell population proliferation. Located in several cellular components, including endoplasmic reticulum; lysosome; and trans-Golgi network. Is active in cerebellar climbing fiber to Purkinje cell synapse. Is expressed in several structures, including brain; early conceptus; gonad; placenta; and skin. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor).

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Gene Ontology Evidence Code Abbreviations:

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