Automated description from the Alliance of Genome Resources (Release 7.3.0)
Enables ErbB-2 class receptor binding activity and chemorepellent activity. Involved in several processes, including ERBB signaling pathway; nervous system development; and postsynapse to nucleus signaling pathway. Acts upstream of or within several processes, including nervous system development; positive regulation of intracellular signal transduction; and regulation of protein metabolic process. Located in several cellular components, including axon; neuromuscular junction; and plasma membrane. Is active in several cellular components, including GABA-ergic synapse; mossy fiber rosette; and synaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1).
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