Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables insulin receptor activity. Involved in several processes, including adrenal gland development; insulin receptor signaling pathway; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of with a positive effect on receptor internalization. Acts upstream of or within several processes, including exocrine pancreas development; peptidyl-tyrosine autophosphorylation; and positive regulation of mitotic nuclear division. Located in caveola. Is active in plasma membrane. Is expressed in several structures, including brain; connective tissue; enteric nervous system; female reproductive system; and heart. Used to study diabetic retinopathy and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in Donohue syndrome; glucose metabolism disease (multiple); hepatocellular carcinoma; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor).

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Gene Ontology Evidence Code Abbreviations:

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