Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

A structural constituent of nuclear lamina. Involved in several processes, including establishment or maintenance of microtubule cytoskeleton polarity; negative regulation of cardiac muscle hypertrophy in response to stress; and protein localization to nucleus. Acts upstream of or within several processes, including negative regulation of apoptotic signaling pathway; protein import into nucleus; and ventricular cardiac muscle cell development. Located in lamin filament and nuclear membrane. Is active in nuclear lamina. Is expressed in several structures, including embryo mesenchyme; epithelium; heart; hemolymphoid system; and musculature. Used to study achalasia; dilated cardiomyopathy 1A; neuromuscular disease (multiple); otitis media; and progeria. Human ortholog(s) of this gene implicated in several diseases, including Werner syndrome; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); neuromuscular disease (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C).

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Gene Ontology Evidence Code Abbreviations:

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