Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in several processes, including embryonic nail plate morphogenesis; face morphogenesis; and negative regulation of odontoblast differentiation. Acts upstream of or within several processes, including embryonic limb morphogenesis; regulation of gene expression; and skeletal system development. Located in nucleus. Part of transcription regulator complex. Is active in nuclear periphery. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study orofacial cleft and tooth agenesis. Human ortholog(s) of this gene implicated in cleft lip; cleft palate; orofacial cleft 5; tooth and nail syndrome; and tooth disease (multiple). Orthologous to human MSX1 (msh homeobox 1).

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Gene Ontology Evidence Code Abbreviations:

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