Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and arachidonate binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; negative regulation of microglial cell activation; and regulation of gene expression. Acts upstream of or within with a negative effect on wound healing involved in inflammatory response. Acts upstream of or within several processes, including brown fat cell differentiation; cellular response to lithium ion; and regulation of gene expression. Located in cytosol and nucleus. Part of SUMO ligase complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; musculoskeletal system; and nervous system. Used to study abdominal obesity-metabolic syndrome; congenital generalized lipodystrophy type 2; familial partial lipodystrophy; primary pulmonary hypertension; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma).

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Gene Ontology Evidence Code Abbreviations:

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