Automated description from the Alliance of Genome Resources (Release 7.4.0)
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Contributes to DNA binding activity. Involved in embryonic hemopoiesis; positive regulation of erythrocyte differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; neurogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; hemolymphoid system; and sensory organ. Used to study lymphoid leukemia. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor).
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