Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to radiation; intrinsic apoptotic signaling pathway; and positive regulation of programmed cell death. Acts upstream of or within several processes, including mitochondrion organization; negative regulation of cell population proliferation; and regulation of apoptotic process. Located in several cellular components, including chromosome; germ cell nucleus; and mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study several diseases, including breast cancer (multiple); lung cancer (multiple); non-Hodgkin lymphoma (multiple); pancreatic carcinoma (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).

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Gene Ontology Evidence Code Abbreviations:

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