Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and double-stranded DNA binding activity. Involved in several processes, including kidney development; regulation of DNA-templated transcription; and reproductive structure development. Acts upstream of or within several processes, including male gonad development; negative regulation of mesenchymal cell apoptotic process involved in metanephros development; and vasculogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; body cavity or lining; central nervous system; genitourinary system; and heart. Used to study Denys-Drash syndrome and congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma (multiple); and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).

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Gene Ontology Evidence Code Abbreviations:

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