Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables several functions, including calmodulin binding activity; identical protein binding activity; and ryanodine-sensitive calcium-release channel activity. Involved in several processes, including cellular response to caffeine; cellular response to epinephrine stimulus; and regulation of heart contraction. Acts upstream of or within several processes, including cardiac muscle hypertrophy; left ventricular cardiac muscle tissue morphogenesis; and positive regulation of heart rate. Located in Z disc; sarcoplasmic reticulum membrane; and smooth endoplasmic reticulum. Part of calcium channel complex. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Used to study catecholaminergic polymorphic ventricular tachycardia 1 and heart disease. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2).

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Gene Ontology Evidence Code Abbreviations:

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