Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.5.0)

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and bHLH transcription factor binding activity. Involved in several processes, including BMP signaling pathway; ligamentous ossification; and regulation of DNA-templated transcription. Acts upstream of with a positive effect on gene expression. Acts upstream of or within several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule biosynthetic process; and skeletal system development. Located in chromatin; cytoplasm; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including genitourinary system; jaw; limb mesenchyme; sensory organ; and skeleton. Used to study cleidocranial dysplasia and congenital hypothyroidism. Human ortholog(s) of this gene implicated in cleidocranial dysplasia; lung non-small cell carcinoma; and metaphyseal dysplasia-maxillary hypoplasia-brachydactyly syndrome. Orthologous to human RUNX2 (RUNX family transcription factor 2).

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Gene Ontology Evidence Code Abbreviations:

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