Gene Expression Literature Summary

• Symbol: Ryk
• Name: receptor-like tyrosine kinase
• ID: MGI:101766

26 matching records from 26 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E4.5	E6.5	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	P
Immunohistochemistry (section)											1				1	1	1				2			1	2	3
In situ RNA (section)	1	1					1		1		4		1		2		4		3		2				4	4
Immunohistochemistry (whole mount)													1													1
In situ RNA (whole mount)			1		1										1
In situ reporter (knock in)													1				4				1				2
Northern blot				1		1		1		1		1		2		1		1								3
Western blot											1		1				2								2	1
RT-PCR									1		2		1			1	2	2		2		1		1	1	5
cDNA clones				1	1										2	1									1
RNase protection									1								1		1		1		1		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ryk  receptor-like tyrosine kinase   (Synonyms: ERK-3, Vik)
Results	Reference
1*	J:316524 Andre P, Wang Q, Wang N, Gao B, Schilit A, Halford MM, Stacker SA, Zhang X, Yang Y, The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2. J Biol Chem. 2012 Dec 28;287(53):44518-25
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2*	J:13545 Biesecker LG, Gottschalk LR, Emerson SG, Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7044-8
6	J:228557 Blakely BD, Bye CR, Fernando CV, Prasad AA, Pasterkamp RJ, Macheda ML, Stacker SA, Parish CL, Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons. Stem Cells Dev. 2013 Aug 1;22(15):2132-44
1	J:256509 Chang WH, Choi SH, Moon BS, Cai M, Lyu J, Bai J, Gao F, Hajjali I, Zhao Z, Campbell DB, Weiner LP, Lu W, Smek1/2 is a nuclear chaperone and cofactor for cleaved Wnt receptor Ryk, regulating cortical neurogenesis. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10717-E10725
3	J:316795 Famili F, Perez LG, Naber BA, Noordermeer JN, Fradkin LG, Staal FJ, The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis. Cell Death Dis. 2016 Nov 24;7(11):e2479
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
2	J:53865 Halford MM, Oates AC, Hibbs ML, Wilks AF, Stacker SA, Genomic structure and expression of the mouse growth factor receptor related to tyrosine kinases (Ryk). J Biol Chem. 1999 Mar 12;274(11):7379-90
2	J:234936 Hollis ER 2nd, Ishiko N, Yu T, Lu CC, Haimovich A, Tolentino K, Richman A, Tury A, Wang SH, Pessian M, Jo E, Kolodkin A, Zou Y, Ryk controls remapping of motor cortex during functional recovery after spinal cord injury. Nat Neurosci. 2016 May;19(5):697-705
2*	J:19807 Hovens CM, Stacker SA, Andres AC, Harpur AG, Ziemiecki A, Wilks AF, RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11818-22
4	J:109038 Keeble TR, Halford MM, Seaman C, Kee N, Macheda M, Anderson RB, Stacker SA, Cooper HM, The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. J Neurosci. 2006 May 24;26(21):5840-8
9	J:282804 Kim HT, Yin W, Nakamichi Y, Panza P, Grohmann B, Buettner C, Guenther S, Ruppert C, Kobayashi Y, Guenther A, Stainier DYR, WNT/RYK signaling restricts goblet cell differentiation during lung development and repair. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25697-25706
9*	J:19199 Larsson-Blomberg L, Dzierzak E, Isolation of tyrosine kinase related genes expressed in the early hematopoietic system. FEBS Lett. 1994 Jul 11;348(2):119-25
5	J:168206 Liu Y, Shi J, Lu CC, Wang ZB, Lyuksyutova AI, Song XJ, Zou Y, Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract. Nat Neurosci. 2005 Sep;8(9):1151-9
1*	J:93897 Lu W, Yamamoto V, Ortega B, Baltimore D, Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell. 2004 Oct 1;119(1):97-108
9	J:142801 Lyu J, Yamamoto V, Lu W, Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev Cell. 2008 Nov;15(5):773-80
2*	J:190423 Macheda ML, Sun WW, Kugathasan K, Hogan BM, Bower NI, Halford MM, Zhang YF, Jacques BE, Lieschke GJ, Dabdoub A, Stacker SA, The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling. J Biol Chem. 2012 Aug 24;287(35):29312-23
5	J:283040 McKenzie MG, Cobbs LV, Dummer PD, Petros TJ, Halford MM, Stacker SA, Zou Y, Fishell GJ, Au E, Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons. Neuron. 2019 Sep 4;103(5):853-864.e4
1	J:22208 Ruiz JC, Conlon FL, Robertson EJ, Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994 Dec;48(3):153-64
14	J:52203 Serfas MS, Tyner AL, Ryk is expressed in a differentiation-specific manner in epithelial tissues and is strongly induced in decidualizing uterine stroma. Oncogene. 1998 Dec 31;17(26):3435-44
1	J:27414 Sommers CL, Huang K, Shores EW, Grinberg A, Charlick DA, Kozak CA, Love PE, Murine txk: a protein tyrosine kinase gene regulated by T cell activation. Oncogene. 1995 Jul 20;11(2):245-51
2*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
8*	J:297051 Wang S, Roy JP, Tomlinson AJ, Wang EB, Tsai YH, Cameron L, Underwood J, Spence JR, Walton KD, Stacker SA, Gumucio DL, Lechler T, RYK-mediated filopodial pathfinding facilitates midgut elongation. Development. 2020 Oct 27;147(20):dev195388
4	J:170544 Zhong J, Kim HT, Lyu J, Yoshikawa K, Nakafuku M, Lu W, The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development. Development. 2011 Feb;138(3):409-19