Gene Expression Literature Summary

• Symbol: Mcl1
• Name: myeloid cell leukemia sequence 1
• ID: MGI:101769

21 matching records from 21 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3	E4	E5	E5.5	E6.5	E8	E8.5	E9.5	E10	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E17.5	E18.5	P
Immunohistochemistry (section)																				1	2
In situ RNA (section)			1	1	1					1						1					1
In situ RNA (whole mount)	1	1						1
Western blot						1		1	2		1	1	2	1							2
RT-PCR						1			1		1	1	1		1		1	1	1		4
cDNA clones							1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mcl1  myeloid cell leukemia sequence 1   (Synonyms: Mcl-1)
Results	Reference
1*	J:68216 Akasaka T, van Lohuizen M, van der Lugt N, Mizutani-Koseki Y, Kanno M, Taniguchi M, Vidal M, Alkema M, Berns A, Koseki H, Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development. 2001 May;128(9):1587-97
2	J:137346 Arbour N, Vanderluit JL, Le Grand JN, Jahani-Asl A, Ruzhynsky VA, Cheung EC, Kelly MA, MacKenzie AE, Park DS, Opferman JT, Slack RS, Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage. J Neurosci. 2008 Jun 11;28(24):6068-78
3	J:301138 Chen SH, Lu CH, Tsai MJ, TCTP is Essential for Cell Proliferation and Survival during CNS Development. Cells. 2020 Jan 6;9(1):133
1*	J:157660 Dowdy CR, Xie R, Frederick D, Hussain S, Zaidi SK, Vradii D, Javed A, Li X, Jones SN, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation. Hum Mol Genet. 2010 Mar 15;19(6):1048-57
1	J:337771 El-Saafin F, Bergamasco MI, Chen Y, May RE, Esakky P, Hediyeh-Zadeh S, Dixon M, Wilcox S, Davis MJ, Strasser A, Smyth GK, Thomas T, Voss AK, Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ. 2022 May;29(5):1013-1027
3*	J:306253 Flemmer RT, Connolly SP, Geizer BA, Opferman JT, Vanderluit JL, The Role of Mcl-1 in Embryonic Neural Precursor Cell Apoptosis. Front Cell Dev Biol. 2021;9:659531
3	J:296752 Fogarty LC, Flemmer RT, Geizer BA, Licursi M, Karunanithy A, Opferman JT, Hirasawa K, Vanderluit JL, Mcl-1 and Bcl-xL are essential for survival of the developing nervous system. Cell Death Differ. 2019 Aug;26(8):1501-1515
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1	J:270807 Grabow S, Kueh AJ, Ke F, Vanyai HK, Sheikh BN, Dengler MA, Chiang W, Eccles S, Smyth IM, Jones LK, de Sauvage FJ, Scott M, Whitehead L, Voss AK, Strasser A, Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities. Cell Rep. 2018 Sep 18;24(12):3285-3295.e4
2	J:344559 Hughes CHK, Smith OE, Meinsohn MC, Brunelle M, Gevry N, Murphy BD, Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2220849120
1	J:199864 Kaneko-Goto T, Sato Y, Katada S, Kinameri E, Yoshihara S, Nishiyori A, Kimura M, Fujita H, Touhara K, Reed RR, Yoshihara Y, Goofy coordinates the acuity of olfactory signaling. J Neurosci. 2013 Aug 7;33(32):12987-96
1*	J:142128 Kerenyi MA, Grebien F, Gehart H, Schifrer M, Artaker M, Kovacic B, Beug H, Moriggl R, Mullner EW, Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. Blood. 2008 Nov 1;112(9):3878-88
1*	J:193822 Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S, Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
1	J:253948 Magarin M, Pohl T, Lill A, Schulz H, Blaschke F, Heuser A, Thierfelder L, Donath S, Drenckhahn JD, Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress. J Mol Cell Cardiol. 2016 Aug;97:1-14
1	J:296081 Nguyen PM, Dagley LF, Preaudet A, Lam N, Giam M, Fung KY, Aizel K, van Duijneveldt G, Tan CW, Hirokawa Y, Yip HYK, Love CG, Poh AR, Cruz A, Burstroem C, Feltham R, Abdirahman SM, Meiselbach K, Low RRJ, Palmieri M, Ernst M, Webb AI, Burgess T, Sieber OM, Bouillet P, Putoczki TL, Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer. Cell Death Differ. 2020 Feb;27(2):742-757
1	J:48814 Okita H, Umezawa A, Suzuki A, Hata J, Up-regulated expression of murine Mcl1/EAT, a bcl-2 related gene, in the early stage of differentiation of murine embryonal carcinoma cells and embryonic stem cells. Biochim Biophys Acta. 1998 Jul 9;1398(3):335-41
1*	J:142508 Ota M, Sasaki H, Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development. 2008 Dec;135(24):4059-69
6*	J:59429 Rinkenberger JL, Horning S, Klocke B, Roth K, Korsmeyer SJ, Mcl-1 deficiency results in peri-implantation embryonic lethality. Genes Dev. 2000 Jan 1;14(1):23-7
1	J:358134 Soma S, Murakami K, Fukuchi Y, Kunimoto H, Nakajima H, O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation. Stem Cells. 2024 Jan 13;42(1):55-63
1*	J:102178 Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ, Wang HG, Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol. 2005 Nov;25(21):9369-82
2	J:278909 Weng SY, Yang CY, Li CC, Sun TP, Tung SY, Yen JJ, Tsai TF, Chen CM, Chen SH, Hsiao M, Huang PH, Yang-Yen HF, Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer. J Hepatol. 2011 Apr;54(4):685-94