Gene Expression Literature Summary

• Symbol: Pou4f3
• Name: POU domain, class 4, transcription factor 3
• ID: MGI:102523

53 matching records from 53 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	E20	P
Immunohistochemistry (section)	1	1	3		4		3		3		8		4		3		5		3	1	8
In situ RNA (section)			1		1		2		2		6		2		2	1	3				8
Immunohistochemistry (whole mount)								1	2	1		1	1		1						2
In situ RNA (whole mount)	1								1		3						1
Northern blot						1
RT-PCR		1	1	2	1	2	3		5	1	2	3	2	1			3	1			7
cDNA clones						1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pou4f3  POU domain, class 4, transcription factor 3   (Synonyms: Brn-3.1, Brn3.1, Brn3c)
Results	Reference
4	J:175804 Brzezinski JA 4th, Kim EJ, Johnson JE, Reh TA, Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina. Development. 2011 Aug;138(16):3519-31
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
3*	J:112338 Deng M, Pan L, Xie X, Gan L, Differential expression of LIM domain-only (LMO) genes in the developing mouse inner ear. Gene Expr Patterns. 2006 Dec;6(8):857-63
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:200106 Duncan JS, Fritzsch B, Continued expression of GATA3 is necessary for cochlear neurosensory development. PLoS One. 2013;8(4):e62046
1	J:33502 Erkman L, McEvilly RJ, Luo L, Ryan AK, Hooshmand F, O'Connell SM, Keithley EM, Rapaport DH, Ryan AF, Rosenfeld MG, Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature. 1996 Jun 13;381(6583):603-6
1*	J:276652 Fang Q, Zhang Y, Da P, Shao B, Pan H, He Z, Cheng C, Li D, Guo J, Wu X, Guan M, Liao M, Zhang Y, Sha S, Zhou Z, Wang J, Wang T, Su K, Chai R, Chen F, Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Sci Rep. 2019 Mar 4;9(1):3357
1	J:32903 Gan L, Xiang M, Zhou L, Wagner DS, Klein WH, Nathans J, POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3920-5
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:311164 Hayashi Y, Chiang H, Tian C, Indzhykulian AA, Edge ASB, Norrie disease protein is essential for cochlear hair cell maturation. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2106369118
6	J:119779 Hertzano R, Dror AA, Montcouquiol M, Ahmed ZM, Ellsworth B, Camper S, Friedman TB, Kelley MW, Avraham KB, Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system. Eur J Neurosci. 2007 Feb;25(4):999-1005
7*	J:92833 Hertzano R, Montcouquiol M, Rashi-Elkeles S, Elkon R, Yucel R, Frankel WN, Rechavi G, Moroy T, Friedman TB, Kelley MW, Avraham KB, Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. Hum Mol Genet. 2004 Sep 15;13(18):2143-53
2*	J:177585 Hesse K, Vaupel K, Kurt S, Buettner R, Kirfel J, Moser M, AP-2delta is a crucial transcriptional regulator of the posterior midbrain. PLoS One. 2011;6(8):e23483
1	J:220948 Jahan I, Pan N, Kersigo J, Fritzsch B, Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea. PLoS One. 2010;5(7):e11661
1	J:98458 Kiernan AE, Pelling AL, Leung KK, Tang AS, Bell DM, Tease C, Lovell-Badge R, Steel KP, Cheah KS, Sox2 is required for sensory organ development in the mammalian inner ear. Nature. 2005 Apr 21;434(7036):1031-5
6	J:191198 Kopecky BJ, Jahan I, Fritzsch B, Correct Timing of Proliferation and Differentiation is Necessary for Normal Inner Ear Development and Auditory Hair Cell Viability. Dev Dyn. 2013 Feb;242(2):132-47
2	J:316103 Li X, Gaillard F, Monckton EA, Glubrecht DD, Persad AR, Moser M, Sauve Y, Godbout R, Loss of AP-2delta reduces retinal ganglion cell numbers and axonal projections to the superior colliculus. Mol Brain. 2016 Jun 4;9(1):62
2	J:241892 Marcucci F, Murcia-Belmonte V, Wang Q, Coca Y, Ferreiro-Galve S, Kuwajima T, Khalid S, Ross ME, Mason C, Herrera E, The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells. Cell Rep. 2016 Dec 20;17(12):3153-3164
1	J:344891 Maunsell HR, Ellis K, Kelley MW, Driver EC, Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti. J Neurosci. 2023 Jul 19;43(29):5305-5318
1	J:264387 Maurer KA, Kowalchuk A, Shoja-Taheri F, Brown NL, Integral bHLH factor regulation of cell cycle exit and RGC differentiation. Dev Dyn. 2018 May 17;
3	J:37118 McEvilly RJ, Erkman L, Luo L, Sawchenko PE, Ryan AF, Rosenfeld MG, Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons. Nature. 1996 Dec 12;384(6609):574-7
4*	J:267832 McInturff S, Burns JC, Kelley MW, Characterization of spatial and temporal development of Type I and Type II hair cells in the mouse utricle using new cell-type-specific markers. Biol Open. 2018 Nov 19;7(11):bio038083
1	J:308270 Moon KH, Ma JH, Min H, Koo H, Kim H, Ko HW, Bok J, Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models. Elife. 2020 Dec 31;9:e56551
1*	J:96463 Moraes F, Novoa A, Jerome-Majewska LA, Papaioannou VE, Mallo M, Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development. Mech Dev. 2005 Feb;122(2):199-212
1*	J:47261 Morsli H, Choo D, Ryan A, Johnson R, Wu DK, Development of the mouse inner ear and origin of its sensory organs. J Neurosci. 1998 May 1;18(9):3327-35
1	J:53713 Morsli H, Tuorto F, Choo D, Postiglione MP, Simeone A, Wu DK, Otx1 and Otx2 activities are required for the normal development of the mouse inner ear. Development. 1999 Jun;126(11):2335-43
1*	J:304855 Oliver KM, Florez-Paz DM, Badea TC, Mentis GZ, Menon V, de Nooij JC, Molecular correlates of muscle spindle and Golgi tendon organ afferents. Nat Commun. 2021 Mar 1;12(1):1451
1	J:335097 Qin T, Ho CC, Wang B, Hui CC, Sham MH, Sufu- and Spop-mediated regulation of Gli2 is essential for the control of mammalian cochlear hair cell differentiation. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2206571119
4	J:245876 Rohacek AM, Bebee TW, Tilton RK, Radens CM, McDermott-Roe C, Peart N, Kaur M, Zaykaner M, Cieply B, Musunuru K, Barash Y, Germiller JA, Krantz ID, Carstens RP, Epstein DJ, ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Dev Cell. 2017 Nov 06;43(3):318-331.e5
2	J:235958 Rousso DL, Qiao M, Kagan RD, Yamagata M, Palmiter RD, Sanes JR, Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression. Cell Rep. 2016 May 31;15(9):1930-44
1	J:96345 Sage C, Huang M, Karimi K, Gutierrez G, Vollrath MA, Zhang DS, Garcia-Anoveros J, Hinds PW, Corwin JT, Corey DP, Chen ZY, Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. Science. 2005 Feb 18;307(5712):1114-8
2*	J:268084 Saha A, Tiwari S, Dharmarajan S, Otteson DC, Belecky-Adams TL, Class I histone deacetylases in retinal progenitors and differentiating ganglion cells. Gene Expr Patterns. 2018 Dec;30:37-48
1	J:57002 Salminen M, Meyer BI, Bober E, Gruss P, Netrin 1 is required for semicircular canal formation in the mouse inner ear. Development. 2000 Jan;127(1):13-22
2*	J:221671 Scheffer DI, Shen J, Corey DP, Chen ZY, Gene Expression by Mouse Inner Ear Hair Cells during Development. J Neurosci. 2015 Apr 22;35(16):6366-80
8*	J:16381 Theil T, McLean-Hunter S, Zornig M, Moroy T, Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Nucleic Acids Res. 1993 Dec 25;21(25):5921-9
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2	J:345248 Tran HN, Nguyen QH, Jeong Y, Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron fate and regulates differentiation of the dorsal midbrain into the inferior and superior colliculi. Front Cell Dev Biol. 2024;12:1336308
2	J:75445 Wagner KD, Wagner N, Vidal VP, Schley G, Wilhelm D, Schedl A, Englert C, Scholz H, The Wilms' tumor gene Wt1 is required for normal development of the retina. EMBO J. 2002 Mar 15;21(6):1398-405
1*	J:80025 Wallis D, Hamblen M, Zhou Y, Venken KJ, Schumacher A, Grimes HL, Zoghbi HY, Orkin SH, Bellen HJ, The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development. 2003 Jan;130(1):221-32
1*	J:282256 Wan Y, Liu X, Zheng D, Wang Y, Chen H, Zhao X, Liang G, Yu D, Gan L, Systematic identification of intergenic long-noncoding RNAs in mouse retinas using full-length isoform sequencing. BMC Genomics. 2019 Jul 8;20(1):559
2	J:73779 Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH, Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development. 2002 Jan;129(2):467-77
1	J:345358 Wang X, Llamas J, Trecek T, Shi T, Tao L, Makmura W, Crump JG, Segil N, Gnedeva K, SoxC transcription factors shape the epigenetic landscape to establish competence for sensory differentiation in the mammalian organ of Corti. Proc Natl Acad Sci U S A. 2023 Aug 22;120(34):e2301301120
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
1*	J:307862 Wilkerson BA, Zebroski HL, Finkbeiner CR, Chitsazan AD, Beach KE, Sen N, Zhang RC, Bermingham-McDonogh O, Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris. Elife. 2021 May 18;10:e60108
8*	J:107704 Xiang M, Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors. Dev Biol. 1998 May 15;197(2):155-69
4	J:42478 Xiang M, Gan L, Li D, Chen ZY, Zhou L, O'Malley BW Jr, Klein W , Nathans J, Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9445-50
1*	J:35877 Xiang M, Gan L, Zhou L, Klein WH, Nathans J, Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11950-5
8*	J:43752 Xiang M, Gao WQ, Hasson T, Shin JJ, Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells. Development. 1998 Oct;125(20):3935-46
1	J:308134 Yu HV, Tao L, Llamas J, Wang X, Nguyen JD, Trecek T, Segil N, POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2105137118
1	J:273440 Zak M, van Oort T, Hendriksen FG, Garcia MI, Vassart G, Grolman W, LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea. Front Cell Neurosci. 2016;10:186
2	J:108702 Zhang CL, Zou Y, Yu RT, Gage FH, Evans RM, Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. Genes Dev. 2006 May 15;20(10):1308-20
5	J:183949 Zou M, Li S, Klein WH, Xiang M, Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Dev Biol. 2012 Apr 15;364(2):114-27