Gene Expression Literature Summary

• Symbol: Umod
• Name: uromodulin
• ID: MGI:102674

65 matching records from 65 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E12.5	E13	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E20	P
Immunohistochemistry (section)	1	1	1	2		1	2	3		11	1	38
In situ RNA (section)				6						1		7
RT-PCR				2	1			2	1	1		6

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Umod  uromodulin   (Synonyms: Tamm-Horsfall glycoprotein, THP, Urehd1, urehr4, uromucoid)
Results	Reference
1	J:262507 Barker N, Rookmaaker MB, Kujala P, Ng A, Leushacke M, Snippert H, van de Wetering M, Tan S, Van Es JH, Huch M, Poulsom R, Verhaar MC, Peters PJ, Clevers H, Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development. Cell Rep. 2012 Sep 27;2(3):540-52
1	J:243561 Basta JM, Robbins L, Denner DR, Kolar GR, Rauchman M, A Sall1-NuRD interaction regulates multipotent nephron progenitors and is required for loop of Henle formation. Development. 2017 Sep 01;144(17):3080-3094
1*	J:109247 Bates CM, Kegg H, Grady S, Expression of somatostatin in the adult and developing mouse kidney. Kidney Int. 2004 Nov;66(5):1785-93
1*	J:142800 Brunskill EW, Aronow BJ, Georgas K, Rumballe B, Valerius MT, Aronow J, Kaimal V, Jegga AG, Yu J, Grimmond S, McMahon AP, Patterson LT, Little MH, Potter SS, Atlas of gene expression in the developing kidney at microanatomic resolution. (Erratum: Dev Cell 2009; 16:482). Dev Cell. 2008 Nov;15(5):781-91
1	J:239251 Brzoska HL, d'Esposito AM, Kolatsi-Joannou M, Patel V, Igarashi P, Lei Y, Finnell RH, Lythgoe MF, Woolf AS, Papakrivopoulou E, Long DA, Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning. Kidney Int. 2016 Dec;90(6):1274-1284
1	J:320189 Buchholz B, Schley G, Faria D, Kroening S, Willam C, Schreiber R, Klanke B, Burzlaff N, Jantsch J, Kunzelmann K, Eckardt KU, Hypoxia-inducible factor-1alpha causes renal cyst expansion through calcium-activated chloride secretion. J Am Soc Nephrol. 2014 Mar;25(3):465-74
1	J:138769 Caubit X, Lye CM, Martin E, Core N, Long DA, Vola C, Jenkins D, Garratt AN, Skaer H, Woolf AS, Fasano L, Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development. 2008 Oct;135(19):3301-10
1	J:112200 Chen J, Boyle S, Zhao M, Su W, Takahashi K, Davis L, Decaestecker M, Takahashi T, Breyer MD, Hao CM, Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes. J Am Soc Nephrol. 2006 May;17(5):1283-91
1*	J:215391 Chen Y, Chiang HC, Litchfield P, Pena M, Juang C, Riley DJ, Expression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney disease. J Biomed Sci. 2014 Jul 17;21(1):63
2	J:229250 Cui J, Li X, Duan Z, Xue W, Wang Z, Lu S, Lin R, Liu M, Zhu G, Huang JD, Analysis of Kif5b expression during mouse kidney development. PLoS One. 2015;10(4):e0126002
1	J:296650 England AR, Chaney CP, Das A, Patel M, Malewska A, Armendariz D, Hon GC, Strand DW, Drake KA, Carroll TJ, Identification and characterization of cellular heterogeneity within the developing renal interstitium. Development. 2020 Aug 14;147(15):dev190108
1	J:355097 Gao C, Chen L, Chen E, Tsilosani A, Xia Y, Zhang W, Generation of Distal Renal Segments Involves a Unique Population of Aqp2 + Progenitor Cells. J Am Soc Nephrol. 2021 Dec 1;32(12):3035-3049
1	J:125113 Garcia-Gonzalez MA, Menezes LF, Piontek KB, Kaimori J, Huso DL, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG, Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet. 2007 Aug 15;16(16):1940-50
1	J:165114 Garcia-Gonzalez MA, Outeda P, Zhou Q, Zhou F, Menezes LF, Qian F, Huso DL, Germino GG, Piontek KB, Watnick T, Pkd1 and Pkd2 are required for normal placental development. PLoS One. 2010;5(9)
3*	J:138858 Georgas K, Rumballe B, Wilkinson L, Chiu HS, Lesieur E, Gilbert T, Little MH, Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney. Histochem Cell Biol. 2008 Nov;130(5):927-42
3	J:243840 Gerl K, Steppan D, Fuchs M, Wagner C, Willam C, Kurtz A, Kurt B, Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development. Am J Pathol. 2017 Jul;187(7):1496-1511
1	J:101176 Grieshammer U, Cebrian C, Ilagan R, Meyers E, Herzlinger D, Martin GR, FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development. 2005 Sep;132(17):3847-57
2*	J:333283 Guan N, Kobayashi H, Ishii K, Davidoff O, Sha F, Ikizler TA, Hao CM, Chandel NS, Haase VH, Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency. Kidney Int. 2022 Jul;102(1):108-120
4*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:79509 Hashemolhosseini S, Hadjihannas M, Stolt C, Haas C, Amann K, Wegner M, Restricted expression of mouse GCMa/Gcm1 in kidney and thymus. Mech Dev. 2002 Oct;118(1-2):175
2*	J:119488 Hossain Z, Ali SM, Ko HL, Xu J, Ng CP, Guo K, Qi Z, Ponniah S, Hong W, Hunziker W, Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1631-6
1	J:291050 Ide S, Finer G, Maezawa Y, Onay T, Souma T, Scott R, Ide K, Akimoto Y, Li C, Ye M, Zhao X, Baba Y, Minamizuka T, Jin J, Takemoto M, Yokote K, Quaggin SE, Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development. J Am Soc Nephrol. 2018 Dec;29(12):2795-2808
1*	J:28941 Igarashi P, Vanden Heuvel GB, Payne JA, Forbush B 3rd, Cloning, embryonic expression, and alternative splicing of a murine kidney-specific Na-K-Cl cotransporter. Am J Physiol. 1995 Sep;269(3 Pt 2):F405-18
1	J:210997 Ihermann-Hella A, Lume M, Miinalainen IJ, Pirttiniemi A, Gui Y, Peranen J, Charron J, Saarma M, Costantini F, Kuure S, Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion. PLoS Genet. 2014 Mar;10(3):e1004193
1	J:68843 Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Matsuo S, Kusugami K, Saito H, Muramatsu T, Syndecan-4 deficiency increases susceptibility to kappa-carrageenan-induced renal damage. Lab Invest. 2001 Apr;81(4):509-16
1	J:98344 Jadeja S, Smyth I, Pitera JE, Taylor MS, van Haelst M, Bentley E, McGregor L, Hopkins J, Chalepakis G, Philip N, Perez Aytes A, Watt FM, Darling SM, Jackson I, Woolf AS, Scambler PJ, Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. Nat Genet. 2005 May;37(5):520-5
1	J:294193 Jones LK, Lam R, McKee KK, Aleksandrova M, Dowling J, Alexander SI, Mallawaarachchi A, Cottle DL, Short KM, Pais L, Miner JH, Mallett AJ, Simons C, McCarthy H, Yurchenco PD, Smyth IM, A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder. Development. 2020 Jun 22;147(21):dev189183
1	J:154841 Jouret F, Igarashi T, Gofflot F, Wilson PD, Karet FE, Thakker RV, Devuyst O, Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5. Kidney Int. 2004 Jan;65(1):198-208
1	J:267799 Kanda S, Tanigawa S, Ohmori T, Taguchi A, Kudo K, Suzuki Y, Sato Y, Hino S, Sander M, Perantoni AO, Sugano S, Nakao M, Nishinakamura R, Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor. J Am Soc Nephrol. 2014 Nov;25(11):2584-95
1	J:290104 Kenig-Kozlovsky Y, Scott RP, Onay T, Carota IA, Thomson BR, Gil HJ, Ramirez V, Yamaguchi S, Tanna CE, Heinen S, Wu C, Stan RV, Klein JD, Sands JM, Oliver G, Quaggin SE, Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels. J Am Soc Nephrol. 2018 Apr;29(4):1097-1107
1	J:235417 Kim YM, Kim WY, Nam SA, Choi AR, Kim H, Kim YK, Kim HS, Kim J, Role of Prox1 in the Transforming Ascending Thin Limb of Henle's Loop during Mouse Kidney Development. PLoS One. 2015;10(5):e0127429
1*	J:290840 Klein G, Langegger M, Goridis C, Ekblom P, Neural cell adhesion molecules during embryonic induction and development of the kidney. Development. 1988 Apr;102(4):749-61
2	J:320427 Kobayashi H, Liu J, Urrutia AA, Burmakin M, Ishii K, Rajan M, Davidoff O, Saifudeen Z, Haase VH, Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development. Kidney Int. 2017 Dec;92(6):1370-1383
1	J:321428 Kruber P, Angay O, Winkler A, Bosl MR, Kneitz S, Heinze KG, Gessler M, Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation. Int J Cancer. 2019 Mar 15;144(6):1391-1400
1	J:333146 Kumar S, Fan X, Rasouly HM, Sharma R, Salant DJ, Lu W, ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis. JCI Insight. 2023 Jan 10;8(1)
2	J:74182 Legallicier B, Trugnan G, Murphy G, Lelongt B, Ronco P, Expression of the type IV collagenase system during mouse kidney development and tubule segmentation. J Am Soc Nephrol. 2001 Nov;12(11):2358-69
1*	J:214703 Lian P, Li A, Li Y, Liu H, Liang D, Hu B, Lin D, Jiang T, Moeckel G, Qin D, Wu G, Loss of polycystin-1 inhibits Bicc1 expression during mouse development. PLoS One. 2014;9(3):e88816
2	J:337772 Liang X, Aranyi T, Zhou J, Guan Y, Hu H, Liu H, Susztak K, Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment. J Am Soc Nephrol. 2023 Apr 1;34(4):572-589
1*	J:273779 Lindstrom NO, McMahon JA, Guo J, Tran T, Guo Q, Rutledge E, Parvez RK, Saribekyan G, Schuler RE, Liao C, Kim AD, Abdelhalim A, Ruffins SW, Thornton ME, Baskin L, Grubbs B, Kesselman C, McMahon AP, Conserved and Divergent Features of Human and Mouse Kidney Organogenesis. J Am Soc Nephrol. 2018 Mar;29(3):785-805
1	J:220445 Liu Z, Brunskill E, Boyle S, Chen S, Turkoz M, Guo Y, Grant R, Kopan R, Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity. Development. 2015 Mar 15;142(6):1193-202
1	J:118250 Mahoney ZX, Sammut B, Xavier RJ, Cunningham J, Go G, Brim KL, Stappenbeck TS, Miner JH, Swat W, Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19872-7
1	J:239657 Mao Y, Francis-West P, Irvine KD, Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching. Development. 2015 Aug 01;142(15):2574-85
2*	J:302552 Naganuma H, Miike K, Ohmori T, Tanigawa S, Ichikawa T, Yamane M, Eto M, Niwa H, Kobayashi A, Nishinakamura R, Molecular detection of maturation stages in the developing kidney. Dev Biol. 2021 Feb;470:62-73
1*	J:241850 Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A, Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3
3	J:309403 Nakagawa N, Xin C, Roach AM, Naiman N, Shankland SJ, Ligresti G, Ren S, Szak S, Gomez IG, Duffield JS, Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis. Kidney Int. 2015 Jun;87(6):1125-40
1	J:124940 Nechiporuk T, Fernandez TE, Vasioukhin V, Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in dlg5(-/-) mice. Dev Cell. 2007 Sep;13(3):338-50
1	J:309384 Neirijnck Y, Reginensi A, Renkema KY, Massa F, Kozlov VM, Dhib H, Bongers EMHF, Feitz WF, van Eerde AM, Lefebvre V, Knoers NVAM, Tabatabaei M, Schulz H, McNeill H, Schaefer F, Wegner M, Sock E, Schedl A, Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT). Kidney Int. 2018 May;93(5):1142-1153
2	J:306107 Niborski LL, Paces-Fessy M, Ricci P, Bourgeois A, Magalhaes P, Kuzma-Kuzniarska M, Lesaulnier C, Reczko M, Declercq E, Zurbig P, Doucet A, Umbhauer M, Cereghini S, Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model. Dis Model Mech. 2021 May 1;14(5):dmm047498
1	J:244798 Recuenco MC, Ohmori T, Tanigawa S, Taguchi A, Fujimura S, Conti MA, Wei Q, Kiyonari H, Abe T, Adelstein RS, Nishinakamura R, Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons. J Am Soc Nephrol. 2015 May;26(5):1081-91
2	J:138247 Saburi S, Hester I, Fischer E, Pontoglio M, Eremina V, Gessler M, Quaggin SE, Harrison R, Mount R, McNeill H, Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet. 2008 Aug;40(8):1010-5
1*	J:1730 Sainio K, Gilbert SF, Lehtonen E, Nishi M, Kumar NM, Gilula NB, Saxen L, Differential expression of gap junction mRNAs and proteins in the developing murine kidney and in experimentally induced nephric mesenchymes. Development. 1992 Jul;115(3):827-37
1	J:205755 Sakaguchi M, Sharmin S, Taguchi A, Ohmori T, Fujimura S, Abe T, Kiyonari H, Komatsu Y, Mishina Y, Asashima M, Araki E, Nishinakamura R, The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth. Nat Commun. 2013;4:1398
1	J:247344 Takahashi K, Kim R, Lauhan C, Park Y, Nguyen NG, Vestweber D, Dominguez MG, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gale NW, Takahashi T, Expression of receptor-type protein tyrosine phosphatase in developing and adult renal vasculature. PLoS One. 2017;12(5):e0177192
1*	J:86844 Takahashi T, Takahashi K, Gerety S, Wang H, Anderson DJ, Daniel TO, Temporally compartmentalized expression of ephrin-B2 during renal glomerular development. J Am Soc Nephrol. 2001 Dec;12(12):2673-82
1	J:152884 Tanaka M, Endo S, Okuda T, Economides AN, Valenzuela DM, Murphy AJ, Robertson E, Sakurai T, Fukatsu A, Yancopoulos GD, Kita T, Yanagita M, Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. Kidney Int. 2008 Jan;73(2):181-91
2	J:171050 Thiagarajan RD, Georgas KM, Rumballe BA, Lesieur E, Chiu HS, Taylor D, Tang DT, Grimmond SM, Little MH, Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286
3*	J:140468 Walter B, Schlechter T, Hergt M, Berger I, Hofmann I, Differential expression pattern of protein ARVCF in nephron segments of human and mouse kidney. Histochem Cell Biol. 2008 Nov;130(5):943-56
1	J:340740 Xu J, Zhou X, Zhang T, Zhang B, Xu PX, Smarca4 deficiency induces Pttg1 oncogene upregulation and hyperproliferation of tubular and interstitial cells during kidney development. Front Cell Dev Biol. 2023;11:1233317
2	J:119674 Yamaguchi Y, Yonemura S, Takada S, Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse. Development. 2006 Dec;133(23):4737-48
1	J:350264 Yano-Sakamoto K, Kitai Y, Toriu N, Yamamoto S, Mizuta K, Saitou M, Tsukiyama T, Taniuchi I, Osato M, Yanagita M, Expression pattern of Runt-related transcription factor (RUNX) family members and the role of RUNX1 during kidney development. Biochem Biophys Res Commun. 2024 Aug 30;722:150155
1*	J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
1	J:170839 Ye X, Wang Y, Rattner A, Nathans J, Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney. Development. 2011 Mar;138(6):1161-72
1	J:142685 Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, McMahon AP, A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development. 2009 Jan;136(1):161-71
1	J:127628 Yu S, Hackmann K, Gao J, He X, Piontek K, Garcia Gonzalez MA, Menezes LF, Xu H, Germino GG, Zuo J, Qian F, Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18688-93
2*	J:57001 Yuan HT, Suri C, Yancopoulos GD, Woolf AS, Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation. J Am Soc Nephrol. 1999 Aug;10(8):1722-36