Gene Expression Literature Summary

• Symbol: Foxn1
• Name: forkhead box N1
• ID: MGI:102949

74 matching records from 74 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8	E9	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	P
Immunohistochemistry (section)					2	8	3	6	2	7		3	1	3		5		2		2	10
In situ RNA (section)				1	1	23	3	10	1	7		5		8	1	4				1	6
In situ RNA (whole mount)				1		6		1
In situ reporter (knock in)				3		4		2		1				1		1					2
Northern blot																					2
Western blot								1				1									1
RT-PCR	1	1	1	1	1	2	1	4	1	4	1	3	1	2	1	2	1	1	1	1	11
cDNA clones																					1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Foxn1  forkhead box N1   (Synonyms: D11Bhm185e, Hfh11, whn)
Results	Reference
5	J:237523 Bain VE, Gordon J, O'Neil JD, Ramos I, Richie ER, Manley NR, Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate. Development. 2016 Nov 01;143(21):4027-4037
5	J:247180 Barsanti M, Lim JM, Hun ML, Lister N, Wong K, Hammett MV, Lepletier A, Boyd RL, Giudice A, Chidgey AP, A novel Foxn1eGFP/+ mouse model identifies Bmp4-induced maintenance of Foxn1 expression and thymic epithelial progenitor populations. Eur J Immunol. 2017 Feb;47(2):291-304
3	J:119113 Bleul CC, Boehm T, BMP signaling is required for normal thymus development. J Immunol. 2005 Oct 15;175(8):5213-21
2	J:304609 Caprio C, Lania G, Bilio M, Ferrentino R, Chen L, Baldini A, EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm. Dis Model Mech. 2021 Feb 19;:dmm.046789
1	J:161296 Chen L, Zhao P, Wells L, Amemiya CT, Condie BG, Manley NR, Mouse and zebrafish Hoxa3 orthologues have nonequivalent in vivo protein function. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10555-60
6	J:309371 Chilukuri RV, Patel VK, Martinez M, Guyden JC, Samms MD, The Antigenic Determinant That Defines Thymic Nurse Cells Is Expressed by Thymic Epithelial Progenitor Cells. Front Cell Dev Biol. 2014 Apr 28;2(13)
10	J:217502 Chojnowski JL, Masuda K, Trau HA, Thomas K, Capecchi M, Manley NR, Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse. Development. 2014 Oct;141(19):3697-708
1	J:164351 Corbeaux T, Hess I, Swann JB, Kanzler B, Haas-Assenbaum A, Boehm T, Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16613-8
3*	J:58554 Dear TN, Boehm T, Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development. Mech Dev. 1999 Dec;89(1-2):201-9
1	J:153593 Dooley J, Erickson M, Farr AG, Lessons from thymic epithelial heterogeneity: FoxN1 and tissue-restricted gene expression by extrathymic, endodermally derived epithelium. J Immunol. 2009 Oct 15;183(8):5042-9
1*	J:278363 Du Q, Hoover AR, Dozmorov I, Raj P, Khan S, Molina E, Chang TC, de la Morena MT, Cleaver OB, Mendell JT, van Oers NSC, MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019 May 20;49(4):618-631.e5
4	J:338937 Farley AM, Chengrui A, Palmer S, Liu D, Kousa AI, Rouse P, Major V, Sweetman J, Morys J, Corsinotti A, Nichols J, Ure J, McLay R, Boulter L, Chapman SJ, Tomlinson SR, Blackburn CC, Thymic epithelial cell fate and potency in early organogenesis assessed by single cell transcriptional and functional analysis. Front Immunol. 2023;14:1202163
2*	J:239434 Fleger-Weckmann A, Ustun Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R, Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis. Matrix Biol. 2016 Dec;56:42-56
1	J:162413 Foster KE, Gordon J, Cardenas K, Veiga-Fernandes H, Makinen T, Grigorieva E, Wilkinson DG, Blackburn CC, Richie E, Manley NR, Adams RH, Kioussis D, Coles MC, EphB-ephrin-B2 interactions are required for thymus migration during organogenesis. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13414-9
4	J:318898 Fujimori S, Ohigashi I, Abe H, Matsushita Y, Katagiri T, Taketo MM, Takahama Y, Takada S, Fine-tuning of beta-catenin in mouse thymic epithelial cells is required for postnatal T-cell development. Elife. 2022 Jan 19;11:e69088
4	J:322001 Gao H, Cao M, Deng K, Yang Y, Song J, Ni M, Xie C, Fan W, Ou C, Huang D, Lin L, Liu L, Li Y, Sun H, Cheng X, Wu J, Xia C, Deng X, Mou L, Chen P, The Lineage Differentiation and Dynamic Heterogeneity of Thymic Epithelial Cells During Thymus Organogenesis. Front Immunol. 2022;13:805451
3	J:187709 Gardiner JR, Jackson AL, Gordon J, Lickert H, Manley NR, Basson MA, Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis. Development. 2012 Sep;139(18):3456-66
3*	J:69783 Gordon J, Bennett AR, Blackburn CC, Manley NR, Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch. Mech Dev. 2001 May;103(1-2):141-3
1	J:176247 Gordon J, Manley NR, Mechanisms of thymus organogenesis and morphogenesis. Development. 2011 Sep;138(18):3865-78
2*	J:157956 Gordon J, Patel SR, Mishina Y, Manley NR, Evidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis. Dev Biol. 2010 Mar 1;339(1):141-54
5	J:125817 Gordon J, Xiao S, Hughes B rd, Su DM, Navarre SP, Condie BG, Manley NR, Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus. BMC Dev Biol. 2007;7:69
2	J:352089 Grammer C, Komorowska JA, Swann JB, Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development. iScience. 2024 Jul 19;27(7):110258
2*	J:145693 Griffith AV, Cardenas K, Carter C, Gordon J, Iberg A, Engleka K, Epstein JA, Manley NR, Richie ER, Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos. Dev Biol. 2009 Mar 1;327(1):216-27
1	J:279006 Hasten E, Morrow BE, Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndrome. PLoS Genet. 2019 Aug;15(8):e1008301
3*	J:76015 Hetzer-Egger C, Schorpp M, Haas-Assenbaum A, Balling R, Peters H, Boehm T, Thymopoiesis requires Pax9 function in thymic epithelial cells. Eur J Immunol. 2002 Apr;32(4):1175-81
7*	J:149208 Itoi M, Tsukamoto N, Amagai T, Expression of Dll4 and CCL25 in Foxn1-negative epithelial cells in the post-natal thymus. Int Immunol. 2007 Feb;19(2):127-32
1	J:124645 Itoi M, Tsukamoto N, Yoshida H, Amagai T, Mesenchymal cells are required for functional development of thymic epithelial cells. Int Immunol. 2007 Aug;19(8):953-64
1*	J:150086 Kiso M, Tanaka S, Saba R, Matsuda S, Shimizu A, Ohyama M, Okano HJ, Shiroishi T, Okano H, Saga Y, The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9292-7
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
3*	J:239298 Kur-Piotrowska A, Kopcewicz M, Kozak LP, Sachadyn P, Grabowska A, Gawronska-Kozak B, Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing. BMC Genomics. 2017 Jan 09;18(1):56
3*	J:278361 Larsen BM, Cowan JE, Wang Y, Tanaka Y, Zhao Y, Voisin B, Constantinides MG, Nagao K, Belkaid Y, Awasthi P, Takahama Y, Bhandoola A, Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells. J Immunol. 2019 Aug 1;203(3):686-695
2	J:54224 Lee D, Prowse DM, Brissette JL, Association between mouse nude gene expression and the initiation of epithelial terminal differentiation. Dev Biol. 1999 Apr 15;208(2):362-74
1	J:228844 Leilei Y, Bing L, Yang L, Shaoxia W, Yuan X, Dongping W, Huahu Y, Shichen S, Guangzhou Z, Ruiyun P, Lin Z, Wenlong L, iRhom2 mutation leads to aberrant hair follicle differentiation in mice. PLoS One. 2014;9(12):e115114
4	J:290414 Li J, Gordon J, Chen ELY, Xiao S, Wu L, Zuniga-Pflucker JC, Manley NR, NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development. Development. 2020 Jun 22;147(12):dev178988
2*	J:301543 Li J, Lee YK, Fu W, Whalen AM, Estable MC, Raftery LA, White K, Weiner L, Brissette JL, Modeling by disruption and a selected-for partner for the nude locus. EMBO Rep. 2020 Dec 28;:e49804
5	J:291487 Liu D, Kousa AI, O'Neill KE, Rouse P, Popis M, Farley AM, Tomlinson SR, Ulyanchenko S, Guillemot F, Seymour PA, Jorgensen MC, Serup P, Koch U, Radtke F, Blackburn CC, Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development. Development. 2020 Jun 22;147(12):dev178582
1*	J:167511 Liu Z, Farley A, Chen L, Kirby BJ, Kovacs CS, Blackburn CC, Manley NR, Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions. PLoS Genet. 2010;6(12):e1001251
4*	J:121311 Liu Z, Yu S, Manley NR, Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia. Dev Biol. 2007 May 1;305(1):333-46
1	J:320197 Magaletta ME, Lobo M, Kernfeld EM, Aliee H, Huey JD, Parsons TJ, Theis FJ, Maehr R, Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development. Nat Commun. 2022 Jan 24;13(1):457
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2*	J:95019 Manley NR, Selleri L, Brendolan A, Gordon J, Cleary ML, Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs. Dev Biol. 2004 Dec 15;276(2):301-12
1*	J:154534 Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU, Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806
6*	J:58632 Meier N, Dear TN, Boehm T, Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation. Mech Dev. 1999 Dec;89(1-2):215-21
1	J:161749 Mill P, Lee AW, Fukata Y, Tsutsumi R, Fukata M, Keighren M, Porter RM, McKie L, Smyth I, Jackson IJ, Palmitoylation regulates epidermal homeostasis and hair follicle differentiation. PLoS Genet. 2009 Nov;5(11):e1000748
2*	J:104611 Moore-Scott BA, Manley NR, Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs. Dev Biol. 2005 Feb 15;278(2):323-35
1	J:327225 Nagakubo D, Hirakawa M, Iwanami N, Boehm T, Limits to in vivo fate changes of epithelia in thymus and parathyroid by ectopic expression of transcription factors Gcm2 and Foxn1. Sci Rep. 2022 Aug 8;12(1):13554
1*	J:274110 Nakayama Y, Masuda Y, Ohta H, Tanaka T, Washida M, Nabeshima YI, Miyake A, Itoh N, Konishi M, Fgf21 regulates T-cell development in the neonatal and juvenile thymus. Sci Rep. 2017 Mar 23;7(1):330
14*	J:21194 Nehls M, Pfeifer D, Schorpp M, Hedrich H, Boehm T, New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature. 1994 Nov 3;372(6501):103-7
3*	J:177992 Nowell CS, Bredenkamp N, Tetelin S, Jin X, Tischner C, Vaidya H, Sheridan JM, Stenhouse FH, Heussen R, Smith AJ, Blackburn CC, Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet. 2011 Nov;7(11):e1002348
2	J:330284 Nusser A, Sagar, Swann JB, Krauth B, Diekhoff D, Calderon L, Happe C, Grun D, Boehm T, Developmental dynamics of two bipotent thymic epithelial progenitor types. Nature. 2022 Jun;606(7912):165-171
1	J:167713 Okubo T, Kawamura A, Takahashi J, Yagi H, Morishima M, Matsuoka R, Takada S, Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice. Development. 2011 Jan;138(2):339-48
1	J:142136 Owens P, Bazzi H, Engelking E, Han G, Christiano AM, Wang XJ, Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity. Dev Biol. 2008 Oct 1;322(1):156-66
1*	J:112219 Patel SR, Gordon J, Mahbub F, Blackburn CC, Manley NR, Bmp4 and Noggin expression during early thymus and parathyroid organogenesis. Gene Expr Patterns. 2006 Dec;6(8):794-9
1	J:331697 Ramachandran J, Zhou W, Bardenhagen AE, Nasr T, Yates ER, Zorn AM, Ji H, Vokes SA, Hedgehog regulation of epithelial cell state and morphogenesis in the larynx. Elife. 2022 Nov 18;11
1	J:154590 Randall V, McCue K, Roberts C, Kyriakopoulou V, Beddow S, Barrett AN, Vitelli F, Prescott K, Shaw-Smith C, Devriendt K, Bosman E, Steffes G, Steel KP, Simrick S, Basson MA, Illingworth E, Scambler PJ, Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J Clin Invest. 2009 Nov;119(11):3301-10
4	J:214094 Reeh KA, Cardenas KT, Bain VE, Liu Z, Laurent M, Manley NR, Richie ER, Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis. Development. 2014 Aug;141(15):2950-8
1	J:316450 Rode I, Martins VC, Kublbeck G, Maltry N, Tessmer C, Rodewald HR, Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus. J Immunol. 2015 Dec 15;195(12):5678-87
1*	J:157679 Saade M, Irla M, Yammine M, Boulanger N, Victorero G, Vincentelli R, Penninger JM, Hollander GA, Chauvet S, Nguyen C, Spatial (Tbata) expression in mature medullary thymic epithelial cells. Eur J Immunol. 2010 Feb;40(2):530-8
1	J:257520 Sardella C, Winkler C, Quignodon L, Hardman JA, Toffoli B, Giordano Attianese GMP, Hundt JE, Michalik L, Vinson CR, Paus R, Desvergne B, Gilardi F, Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion. J Invest Dermatol. 2018 Mar;138(3):500-510
1*	J:71183 Su D, Ellis S, Napier A, Lee K, Manley NR, Hoxa3 and pax1 regulate epithelial cell death and proliferation during thymus and parathyroid organogenesis. Dev Biol. 2001 Aug 15;236(2):316-29
2*	J:147173 Sultana DA, Tomita S, Hamada M, Iwanaga Y, Kitahama Y, Khang NV, Hirai S, Ohigashi I, Nitta S, Amagai T, Takahashi S, Takahama Y, Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development. Blood. 2009 Mar 26;113(13):2976-87
2	J:255792 Swann JB, Krauth B, Happe C, Boehm T, Cooperative interaction of BMP signalling and Foxn1 gene dosage determines the size of the functionally active thymic epithelial compartment. Sci Rep. 2017 Aug 17;7(1):8492
1	J:108342 Terszowski G, Muller SM, Bleul CC, Blum C, Schirmbeck R, Reimann J, Pasquier LD, Amagai T, Boehm T, Rodewald HR, Evidence for a functional second thymus in mice. Science. 2006 Apr 14;312(5771):284-7
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
3*	J:180986 Wei Q, Condie BG, A focused in situ hybridization screen identifies candidate transcriptional regulators of thymic epithelial cell development and function. PLoS One. 2011;6(11):e26795
3	J:342003 Xiao S, Zhang W, Li J, Manley NR, Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells. Front Immunol. 2023;14:1261081
1	J:79848 Xu PX, Zheng W, Laclef C, Maire P, Maas RL, Peters H, Xu X, Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development. 2002 Jul;129(13):3033-44
1	J:273271 Yamada T, Tatsumi N, Anraku A, Suzuki H, Kamejima S, Uchiyama T, Ohkido I, Yokoo T, Okabe M, Gcm2 regulates the maintenance of parathyroid cells in adult mice. PLoS One. 2019;14(1):e0210662
2	J:38514 Ye H, Kelly TF, Samadani U, Lim L, Rubio S, Overdier DG, Roebuck KA , Costa RH, Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. Mol Cell Biol. 1997 Mar;17(3):1626-41
1	J:95866 Zamisch M, Moore-Scott B, Su DM, Lucas PJ, Manley N, Richie ER, Ontogeny and regulation of IL-7-expressing thymic epithelial cells. J Immunol. 2005 Jan 1;174(1):60-7
1	J:136961 Zhang Y, Andl T, Yang SH, Teta M, Liu F, Seykora JT, Tobias JW, Piccolo S, Schmidt-Ullrich R, Nagy A, Taketo MM, Dlugosz AA, Millar SE, Activation of {beta}-catenin signaling programs embryonic epidermis to hair follicle fate. Development. 2008 Jun;135(12):2161-72
1	J:108725 Zou D, Silvius D, Davenport J, Grifone R, Maire P, Xu PX, Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. Dev Biol. 2006 May 15;293(2):499-512
7*	J:63747 Zuklys S, Balciunaite G, Agarwal A, Fasler-Kan E, Palmer E, Hollander GA, Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). J Immunol. 2000 Aug 15;165(4):1976-83
5	J:146244 Zuklys S, Gill J, Keller MP, Hauri-Hohl M, Zhanybekova S, Balciunaite G, Na KJ, Jeker LT, Hafen K, Tsukamoto N, Amagai T, Taketo MM, Krenger W, Hollander GA, Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function. J Immunol. 2009 Mar 1;182(5):2997-3007