Gene Expression Literature Summary

• Symbol: E2f4
• Name: E2F transcription factor 4
• ID: MGI:103012

30 matching records from 30 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E2.5	E3	E3.5	E4.5	E9.5	E10	E10.5	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)												1				1						1			2
In situ RNA (section)										4		2	3	3		4						3	2	1	2
In situ RNA (whole mount)									1	1	1					1
In situ reporter (knock in)													1												1
Northern blot														1											2
Western blot							1		1	1		2	3	2		1	1	3			1	2			4
RT-PCR	1	1	1	1	1	1		1	2	2		2	6	4	1	2		1	1	1	1	1		1	10
cDNA clones																	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

E2f4  E2F transcription factor 4   (Synonyms: 2010111M04Rik)
Results	Reference
3*	J:314268 Akagawa R, Nabeshima YI, Kawauchi T, Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons. Front Cell Dev Biol. 2021;9:753175
2*	J:21634 Beijersbergen RL, Kerkhoven RM, Zhu L, Carlee L, Voorhoeve PM, Bernards R, E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev. 1994 Nov 15;8(22):2680-90
1*	J:171293 Campbell GR, Baudhuin A, Vranizan K, Ngai J, Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Mol Cell Neurosci. 2011 Feb;46(2):548-61
3	J:276975 Cuitino MC, Pecot T, Sun D, Kladney R, Okano-Uchida T, Shinde N, Saeed R, Perez-Castro AJ, Webb A, Liu T, Bae SI, Clijsters L, Selner N, Coppola V, Timmers C, Ostrowski MC, Pagano M, Leone G, Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation. Cell Rep. 2019 Jun 18;27(12):3547-3560.e5
8*	J:40858 Dagnino L, Fry CJ, Bartley SM, Farnham P, Gallie BL, Phillips RA, Expression patterns of the E2F family of transcription factors during murine epithelial development. Cell Growth Differ. 1997 May;8(5):553-63
6*	J:42771 Dagnino L, Fry CJ, Bartley SM, Farnham P, Gallie BL, Phillips RA, Expression patterns of the E2F family of transcription factors during mouse nervous system development. Mech Dev. 1997 Aug;66(1-2):13-25
3*	J:121517 Danielian PS, Bender Kim CF, Caron AM, Vasile E, Bronson RT, Lees JA, E2f4 is required for normal development of the airway epithelium. Dev Biol. 2007 May 15;305(2):564-76
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
5	J:129010 Dirlam A, Spike BT, Macleod KF, Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. Mol Cell Biol. 2007 Dec;27(24):8713-28
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1	J:353480 Huang S, Reed C, Ilsley M, Magor G, Tallack M, Landsberg M, Mitchell H, Gillinder K, Perkins A, Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis. Nat Commun. 2024 Aug 15;15(1):7019
1	J:186500 Kaneko H, Kobayashi E, Yamamoto M, Shimizu R, N- and C-terminal transactivation domains of GATA1 protein coordinate hematopoietic program. J Biol Chem. 2012 Jun 15;287(25):21439-49
1*	J:95686 Keegan CE, Hutz JE, Else T, Adamska M, Shah SP, Kent AE, Howes JM, Beamer WG, Hammer GD, Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Hum Mol Genet. 2005 Jan 1;14(1):113-23
2*	J:79647 Kelley-Loughnane N, Sabla GE, Ley-Ebert C, Aronow BJ, Bezerra JA, Independent and overlapping transcriptional activation during liver development and regeneration in mice. Hepatology. 2002 Mar;35(3):525-34
6	J:191198 Kopecky BJ, Jahan I, Fritzsch B, Correct Timing of Proliferation and Differentiation is Necessary for Normal Inner Ear Development and Auditory Hair Cell Viability. Dev Dyn. 2013 Feb;242(2):132-47
1	J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
9*	J:63376 Kusek JC, Greene RM, Nugent P, Pisano MM, Expression of the E2F family of transcription factors during murine development. Int J Dev Biol. 2000 Apr;44(3):267-77
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:311151 Nakano T, Aochi H, Hirasaki M, Takenaka Y, Fujita K, Tamura M, Soma H, Kamezawa H, Koizumi T, Shibuya H, Inomata R, Okuda A, Murakoshi T, Shimada A, Inoue I, Effects of Ppargamma1 deletion on late-stage murine embryogenesis and cells that undergo endocycle. Dev Biol. 2021 Oct;478:222-235
2*	J:153105 Tallack MR, Keys JR, Humbert PO, Perkins AC, EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2. J Biol Chem. 2009 Jul 31;284(31):20966-74
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
17*	J:176112 van Amerongen MJ, Diehl F, Novoyatleva T, Patra C, Engel FB, E2F4 is required for cardiomyocyte proliferation. Cardiovasc Res. 2010 Apr 1;86(1):92-102
1	J:310313 Vinjamur DS, Wade KJ, Mohamad SF, Haar JL, Sawyer ST, Lloyd JA, Kruppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation. Haematologica. 2014 Oct;99(10):1565-73
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
6*	J:213978 Vuong L, Brobst DE, Saadi A, Ivanovic I, Al-Ubaidi MR, Pattern of expression of p53, its family members, and regulators during early ocular development and in the post-mitotic retina. Invest Ophthalmol Vis Sci. 2012 Jul;53(8):4821-31
2	J:117307 Wenzel PL, Wu L, de Bruin A, Chong JL, Chen WY, Dureska G, Sites E, Pan T, Sharma A, Huang K, Ridgway R, Mosaliganti K, Sharp R, Machiraju R, Saltz J, Yamamoto H, Cross JC, Robinson ML, Leone G, Rb is critical in a mammalian tissue stem cell population. Genes Dev. 2007 Jan 1;21(1):85-97
1*	J:187480 Westendorp B, Major JL, Nader M, Salih M, Leenen FH, Tuana BS, The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy. FASEB J. 2012 Jun;26(6):2569-79
2*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:159853 Zhang J, Li H, Yabut O, Fitzpatrick H, D'Arcangelo G, Herrup K, Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. J Neurosci. 2010 Apr 14;30(15):5219-28