Gene Expression Literature Summary

• Symbol: Cacna1c
• Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
• ID: MGI:103013

45 matching records from 45 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E8	E8.5	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	P
Immunohistochemistry (section)		1	1	1	2	1	4		4		1	1	3			1	4		2	1	2		5
In situ RNA (section)												1	1							1
Immunohistochemistry (whole mount)	1
In situ RNA (whole mount)															1
In situ reporter (knock in)				1			1				1		1				1						2
Northern blot												1				1		1				1	1
Western blot					1		1		2			1	1						1	3	2		4
RT-PCR	1	1	2	3	2	1		1	4	1		2	2		3	3			1	2	6		19
cDNA clones																1							1
RNase protection												1		1				1				1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cacna1c  calcium channel, voltage-dependent, L type, alpha 1C subunit   (Synonyms: (alpha)1 subunit, Cav1.2, Cchl1a1, D930026N18Rik, L-type Cav1.2)
Results	Reference
7*	J:90043 Acosta L, Haase H, Morano I, Moorman AF, Franco D, Regional expression of L-type calcium channel subunits during cardiac development. Dev Dyn. 2004 May;230(1):131-6
3*	J:280678 Atsuta Y, Tomizawa RR, Levin M, Tabin CJ, L-type voltage-gated Ca(2+) channel CaV1.2 regulates chondrogenesis during limb development. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21592-21601
3	J:242531 Bedogni F, Cobolli Gigli C, Pozzi D, Rossi RL, Scaramuzza L, Rossetti G, Pagani M, Kilstrup-Nielsen C, Matteoli M, Landsberger N, Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms. Cereb Cortex. 2016 Jun;26(6):2517-2529
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:119559 Bouwman J, Spijker S, Schut D, Wachtler B, Ylstra B, Smit AB, Verhage M, Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse. J Neurochem. 2006 Oct;99(1):84-96
11*	J:31819 Chaudhari N, Beam KG, mRNA for cardiac calcium channel is expressed during development of skeletal muscle. Dev Biol. 1993 Feb;155(2):507-15
4*	J:355328 Chevalier NR, Zig L, Gomis A, Amedzrovi Agbesi RJ, El Merhie A, Pontoizeau L, Le Parco I, Rouach N, Arnoux I, de Santa Barbara P, Faure S, Calcium wave dynamics in the embryonic mouse gut mesenchyme: impact on smooth muscle differentiation. Commun Biol. 2024 Oct 7;7(1):1277
1*	J:86174 Cohen-Barak O, Yi Z, Hagiwara N, Monzen K, Komuro I, Brilliant MH, Sox6 regulation of cardiac myocyte development. Nucleic Acids Res. 2003 Oct 15;31(20):5941-8
2*	J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
2	J:200733 Ding J, Domes K, Hofmann F, Wegener JW, Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes. Pflugers Arch. 2013 Jul;465(7):955-64
2*	J:176723 Domes K, Ding J, Lemke T, Blaich A, Wegener JW, Brandmayr J, Moosmang S, Hofmann F, Truncation of murine cav1.2 at asp-1904 results in heart failure after birth. J Biol Chem. 2011 Sep 30;286(39):33863-71
1*	J:206966 Etemad S, Obermair GJ, Bindreither D, Benedetti A, Stanika R, Di Biase V, Burtscher V, Koschak A, Kofler R, Geley S, Wille A, Lusser A, Flockerzi V, Flucher BE, Differential neuronal targeting of a new and two known calcium channel beta4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014 Jan 22;34(4):1446-61
1*	J:37583 Fassler R, Rohwedel J, Maltsev V, Bloch W, Lentini S, Guan K, Gullberg D, Hescheler J, Addicks K, Wobus AM, Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin. J Cell Sci. 1996 Dec;109(Pt 13):2989-99
2	J:294971 Fecher-Trost C, Lux F, Busch KM, Raza A, Winter M, Hielscher F, Belkacemi T, van der Eerden B, Boehm U, Freichel M, Weissgerber P, Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development. J Bone Miner Res. 2019 Apr;34(4):699-710
2	J:231297 Furtado MB, Wilmanns JC, Chandran A, Tonta M, Biben C, Eichenlaub M, Coleman HA, Berger S, Bouveret R, Singh R, Harvey RP, Ramialison M, Pearson JT, Parkington HC, Rosenthal NA, Costa MW, A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels. Differentiation. 2016 Jan-Mar;91(1-3):29-41
1*	J:345775 Gomez-Ospina N, Panagiotakos G, Portmann T, Pasca SP, Rabah D, Budzillo A, Kinet JP, Dolmetsch RE, A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT. PLoS One. 2013;8(4):e60526
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2*	J:119550 Harrell MD, Harbi S, Hoffman JF, Zavadil J, Coetzee WA, Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Physiol Genomics. 2007 Feb 12;28(3):273-83
2	J:349860 Hashimoto K, Ohira M, Kodama A, Kimoto M, Inoue M, Tone S, Usui Y, Hanashima A, Goto T, Ogura Y, Ujihara Y, Mohri S, Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics. Sci Rep. 2024 Jun 14;14(1):13727
1	J:232973 Hirst CS, Foong JP, Stamp LA, Fegan E, Dent S, Cooper EC, Lomax AE, Anderson CR, Bornstein JC, Young HM, McKeown SJ, Ion channel expression in the developing enteric nervous system. PLoS One. 2015;10(3):e0123436
2	J:203847 Hoggatt AM, Kim JR, Ustiyan V, Ren X, Kalin TV, Kalinichenko VV, Herring BP, The transcription factor Foxf1 binds to serum response factor and myocardin to regulate gene transcription in visceral smooth muscle cells. J Biol Chem. 2013 Oct 4;288(40):28477-87
1	J:263568 Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH, LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Cardiovasc Res. 2015 Oct 1;108(1):197-208
1	J:302968 Koopman CD, De Angelis J, Iyer SP, Verkerk AO, Da Silva J, Berecki G, Jeanes A, Baillie GJ, Paterson S, Uribe V, Ehrlich OV, Robinson SD, Garric L, Petrou S, Simons C, Vetter I, Hogan BM, de Boer TP, Bakkers J, Smith KA, The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2018220118
2	J:228865 Law C, Schaan Profes M, Levesque M, Kaltschmidt JA, Verhage M, Kania A, Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1. J Neurosci. 2016 Jan 13;36(2):561-76
1	J:320532 Lee SM, Yeh PWL, Yeh HH, L-Type Calcium Channels Contribute to Ethanol-Induced Aberrant Tangential Migration of Primordial Cortical GABAergic Interneurons in the Embryonic Medial Prefrontal Cortex. eNeuro. 2022 Jan-Feb;9(1):ENEURO.0359-21.2021
4	J:341710 Li H, Korcari A, Ciufo D, Mendias CL, Rodeo SA, Buckley MR, Loiselle AE, Pitt GS, Cao C, Increased Ca(2+) signaling through Ca(V) 1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties. FASEB J. 2023 Jul;37(7):e23007
1	J:208830 Lin SS, Tzeng BH, Lee KR, Smith RJ, Campbell KP, Chen CC, Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage. Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1990-8
7*	J:156342 Link S, Meissner M, Held B, Beck A, Weissgerber P, Freichel M, Flockerzi V, Diversity and developmental expression of L-type calcium channel beta2 proteins and their influence on calcium current in murine heart. J Biol Chem. 2009 Oct 30;284(44):30129-37
3*	J:84059 Lu DP, Li Y, Bathgate R, Day M, O'Neill C, Ligand-activated signal transduction in the 2-cell embryo. Biol Reprod. 2003 Jul;69(1):106-16
4*	J:171157 Marshall MR, Clark JP 3rd, Westenbroek R, Yu FH, Scheuer T, Catterall WA, Functional Roles of a C-terminal Signaling Complex of CaV1 Channels and A-kinase Anchoring Protein 15 in Brain Neurons. J Biol Chem. 2011 Apr 8;286(14):12627-39
2	J:273025 Moreau JLM, Kesteven S, Martin EMMA, Lau KS, Yam MX, O'Reilly VC, Del Monte-Nieto G, Baldini A, Feneley MP, Moon AM, Harvey RP, Sparrow DB, Chapman G, Dunwoodie SL, Gene-environment interaction impacts on heart development and embryo survival. Development. 2019 Feb 20;146(4):dev172957
1	J:186596 Nakamura TY, Jeromin A, Mikoshiba K, Wakabayashi S, Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals. Circ Res. 2011 Aug 19;109(5):512-23
12	J:299727 Panagiotakos G, Haveles C, Arjun A, Petrova R, Rana A, Portmann T, Pasca SP, Palmer TD, Dolmetsch RE, Aberrant calcium channel splicing drives defects in cortical differentiation in Timothy syndrome. Elife. 2019 Dec 23;8:e51037
1*	J:83693 Porter GA Jr, Makuck RF, Rivkees SA, Intracellular calcium plays an essential role in cardiac development. Dev Dyn. 2003 Jun;227(2):280-90
1	J:298043 Prokic I, Cowling BS, Kutchukian C, Kretz C, Tasfaout H, Gache V, Hergueux J, Wendling O, Ferry A, Toussaint A, Gavriilidis C, Nattarayan V, Koch C, Laine J, Combe R, Tiret L, Jacquemond V, Pilot-Storck F, Laporte J, Differential physiological role of BIN1 isoforms in skeletal muscle development, function and regeneration. Dis Model Mech. 2020 Sep 29;:dmm044354
2*	J:197612 Ramachandran KV, Hennessey JA, Barnett AS, Yin X, Stadt HA, Foster E, Shah RA, Yazawa M, Dolmetsch RE, Kirby ML, Pitt GS, Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. J Clin Invest. 2013 Apr 1;123(4):1638-46
2*	J:161494 Schlick B, Flucher BE, Obermair GJ, Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons. Neuroscience. 2010 May 19;167(3):786-98
1*	J:276621 Semmler J, Kormann J, Srinivasan SP, Koster A, Salzer D, Reppel M, Hescheler J, Plomann M, Nguemo F, Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart. Pharmacol Res. 2018 Feb;128:200-210
4*	J:100234 Shao Y, Alicknavitch M, Farach-Carson MC, Expression of voltage sensitive calcium channel (VSCC) L-type Cav1.2 (alpha1C) and T-type Cav3.2 (alpha1H) subunits during mouse bone development. Dev Dyn. 2005 Sep;234(1):54-62
4	J:336298 Taliani V, Buonaiuto G, Desideri F, Setti A, Santini T, Galfre S, Schirone L, Mariani D, Frati G, Valenti V, Sciarretta S, Perlas E, Nicoletti C, Musaro A, Ballarino M, The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart. Elife. 2023 Mar 6;12
1	J:316473 Tampakakis E, Gangrade H, Glavaris S, Htet M, Murphy S, Lin BL, Liu T, Saberi A, Miyamoto M, Kowalski W, Mukouyama YS, Lee G, Minichiello L, Kwon C, Heart neurons use clock genes to control myocyte proliferation. Sci Adv. 2021 Dec 3;7(49):eabh4181
5	J:152610 Tang ZZ, Zheng S, Nikolic J, Black DL, Developmental control of CaV1.2 L-type calcium channel splicing by Fox proteins. Mol Cell Biol. 2009 Sep;29(17):4757-65
3	J:101090 Toba Y, Pakiam JG, Wray S, Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse. Eur J Neurosci. 2005 Jul;22(1):79-92
9	J:238633 Tyser RC, Miranda AM, Chen CM, Davidson SM, Srinivas S, Riley PR, Calcium handling precedes cardiac differentiation to initiate the first heartbeat. Elife. 2016 Oct 11;5:e17113
4*	J:86180 Xu M, Welling A, Paparisto S, Hofmann F, Klugbauer N, Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice. J Biol Chem. 2003 Oct 17;278(42):40837-41