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Gene Expression Literature Summary
Symbol
Name
ID
Pdpn
podoplanin
MGI:103098

274 matching records from 274 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E7 E7.5 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E19.5 E20 E P
Immunohistochemistry (section) 5 1 10 2 16 3 20 1 20 2 25 2 14 1 22 28 4 89 3 1 3 79
In situ RNA (section) 2 1 2 5 2 1 1 2
Immunohistochemistry (whole mount) 1 4 1 4 2 4 1 3 3 1 11
In situ RNA (whole mount) 1 1
In situ reporter (knock in) 2
Western blot 1 2 1 3 1 2
RT-PCR 1 1 4 1 3 1 2 3 1 4 3 29 1 18
cDNA clones 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Pdpn  podoplanin   (Synonyms: Gp38, OTS-8, PA2.26, RANDAM-2, T1a, T1alpha)
Results  Reference
1J:187154 Arora R, Metzger RJ, Papaioannou VE, Multiple roles and interactions of tbx4 and tbx5 in development of the respiratory system. PLoS Genet. 2012 Aug;8(8):e1002866
1J:170930 Asahina K, Zhou B, Pu WT, Tsukamoto H, Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar;53(3):983-95
1J:290418 Ashokkumar D, Zhang Q, Much C, Bledau AS, Naumann R, Alexopoulou D, Dahl A, Goveas N, Fu J, Anastassiadis K, Stewart AF, Kranz A, MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation. Development. 2020 Jun 17;147(12):dev186999
1*J:130165 Baguma-Nibasheka M, Kablar B, Pulmonary hypoplasia in the connective tissue growth factor (Ctgf) null mouse. Dev Dyn. 2008 Feb;237(2):485-93
1J:152968 Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D, Makinen T, Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell. 2009 Aug;17(2):175-86
2J:180971 Becker PM, Tran TS, Delannoy MJ, He C, Shannon JM, McGrath-Morrow S, Semaphorin 3A contributes to distal pulmonary epithelial cell differentiation and lung morphogenesis. PLoS One. 2011;6(11):e27449
1*J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1J:131960 Bell SM, Schreiner CM, Wert SE, Mucenski ML, Scott WJ, Whitsett JA, R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development. 2008 Mar;135(6):1049-58
5J:159868 Benezech C, White A, Mader E, Serre K, Parnell S, Pfeffer K, Ware CF, Anderson G, Caamano JH, Ontogeny of stromal organizer cells during lymph node development. J Immunol. 2010 Apr 15;184(8):4521-30
1J:162815 Bertozzi CC, Schmaier AA, Mericko P, Hess PR, Zou Z, Chen M, Chen CY, Xu B, Lu MM, Zhou D, Sebzda E, Santore MT, Merianos DJ, Stadtfeld M, Flake AW, Graf T, Skoda R, Maltzman JS, Koretzky GA, Kahn ML, Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010 Jul 29;116(4):661-70
2J:180979 Besnard V, Wert SE, Ikegami M, Xu Y, Heffner C, Murray SA, Donahue LR, Whitsett JA, Maternal synchronization of gestational length and lung maturation. PLoS One. 2011;6(11):e26682
6J:276488 Bilodeau M, Shojaie S, Ackerley C, Post M, Rossant J, Identification of a proximal progenitor population from murine fetal lungs with clonogenic and multilineage differentiation potential. Stem Cell Reports. 2014 Oct 14;3(4):634-49
1J:327898 Bobe S, Beckmann D, Klump DM, Dierkes C, Kirschnick N, Redder E, Bauer N, Schafers M, Erapaneedi R, Risse B, van de Pavert SA, Kiefer F, Volumetric imaging reveals VEGF-C-dependent formation of hepatic lymph vessels in mice. Front Cell Dev Biol. 2022;10:949896
2J:237426 Boucherat O, Landry-Truchon K, Aoidi R, Houde N, Nadeau V, Charron J, Jeannotte L, Lung development requires an active ERK/MAPK pathway in the lung mesenchyme. Dev Dyn. 2017 Jan;246(1):72-82
2J:239777 Boucherat O, Landry-Truchon K, Berube-Simard FA, Houde N, Beuret L, Lezmi G, Foulkes WD, Delacourt C, Charron J, Jeannotte L, Epithelial inactivation of Yy1 abrogates lung branching morphogenesis. Development. 2015 Sep 01;142(17):2981-95
2J:202792 Boucherat O, Montaron S, Berube-Simard FA, Aubin J, Philippidou P, Wellik DM, Dasen JS, Jeannotte L, Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15;304(12):L817-30
1J:214083 Boucherat O, Nadeau V, Berube-Simard FA, Charron J, Jeannotte L, Crucial requirement of ERK/MAPK signaling in respiratory tract development. Development. 2014 Aug;141(16):3197-211
2*J:206581 Bowles J, Secker G, Nguyen C, Kazenwadel J, Truong V, Frampton E, Curtis C, Skoczylas R, Davidson TL, Miura N, Hong YK, Koopman P, Harvey NL, Francois M, Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Dev Biol. 2014 Feb 1;386(1):25-33
1J:229471 Branchfield K, Nantie L, Verheyden JM, Sui P, Wienhold MD, Sun X, Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science. 2016 Feb 12;351(6274):707-10
2J:258787 Bresson L, Faraldo MM, Di-Cicco A, Quintanilla M, Glukhova MA, Deugnier MA, Podoplanin regulates mammary stem cell function and tumorigenesis by potentiating Wnt/beta-catenin signaling. Development. 2018 Feb 21;145(4):dev160382
1J:301331 Bridges JP, Sudha P, Lipps D, Wagner A, Guo M, Du Y, Brown K, Filuta A, Kitzmiller J, Stockman C, Chen X, Weirauch MT, Jobe AH, Whitsett JA, Xu Y, Glucocorticoid regulates mesenchymal cell differentiation required for perinatal lung morphogenesis and function. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L239-L255
1J:331471 Brownfield DG, de Arce AD, Ghelfi E, Gillich A, Desai TJ, Krasnow MA, Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling. Nat Commun. 2022 Nov 21;13(1):7137
2J:336100 Brutsch SM, Madzharova E, Pantasis S, Wustemann T, Gurri S, Steenbock H, Gazdhar A, Kuhn G, Angel P, Bellusci S, Brinckmann J, Auf dem Keller U, Werner S, Bordoli MR, Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome. Cell Mol Life Sci. 2023 Mar 15;80(4):89
1*J:200762 Buttler K, Becker J, Pukrop T, Wilting J, Maldevelopment of dermal lymphatics in Wnt5a-knockout-mice. Dev Biol. 2013 Sep 15;381(2):365-76
3J:316183 Cai Y, Yoneda M, Tomita T, Kurotani R, Okamoto M, Kido T, Abe H, Mitzner W, Guha A, Kimura S, Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice. BMC Pulm Med. 2015 Jul 16;15:72
1J:196959 Castagnaro L, Lenti E, Maruzzelli S, Spinardi L, Migliori E, Farinello D, Sitia G, Harrelson Z, Evans SM, Guidotti LG, Harvey RP, Brendolan A, Nkx2-5(+)islet1(+) mesenchymal precursors generate distinct spleen stromal cell subsets and participate in restoring stromal network integrity. Immunity. 2013 Apr 18;38(4):782-91
1J:138769 Caubit X, Lye CM, Martin E, Core N, Long DA, Vola C, Jenkins D, Garratt AN, Skaer H, Woolf AS, Fasano L, Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development. 2008 Oct;135(19):3301-10
1J:241728 Chao CM, Yahya F, Moiseenko A, Tiozzo C, Shrestha A, Ahmadvand N, El Agha E, Quantius J, Dilai S, Kheirollahi V, Jones M, Wilhem J, Carraro G, Ehrhardt H, Zimmer KP, Barreto G, Ahlbrecht K, Morty RE, Herold S, Abellar RG, Seeger W, Schermuly R, Zhang JS, Minoo P, Bellusci S, Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia. J Pathol. 2017 Jan;241(1):91-103
1J:228786 Charrier LE, Loie E, Laprise P, Mouse Crumbs3 sustains epithelial tissue morphogenesis in vivo. Sci Rep. 2015;5:17699
1J:190484 Chen CY, Bertozzi C, Zou Z, Yuan L, Lee JS, Lu M, Stachelek SJ, Srinivasan S, Guo L, Vicente A, Mericko P, Levy RJ, Makinen T, Oliver G, Kahn ML, Blood flow reprograms lymphatic vessels to blood vessels. J Clin Invest. 2012 Jun 1;122(6):2006-17
2J:339854 Chen SY, Liu FC, The Fgf9-Nolz1-Wnt2 axis regulates morphogenesis of the lung. Development. 2023 Aug 15;150(16):dev201827
2J:286704 Cheng HW, Onder L, Novkovic M, Soneson C, Lutge M, Pikor N, Scandella E, Robinson MD, Miyazaki JI, Tersteegen A, Sorg U, Pfeffer K, Rulicke T, Hehlgans T, Ludewig B, Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp. Nat Commun. 2019 Apr 15;10(1):1739
1J:302676 Cheong H, Wu J, Gonzales LK, Guttentag SH, Thompson CB, Lindsten T, Analysis of a lung defect in autophagy-deficient mouse strains. Autophagy. 2014 Jan;10(1):45-56
2J:197340 Chung C, Kim T, Kim M, Kim M, Song H, Kim TS, Seo E, Lee SH, Kim H, Kim SK, Yoo G, Lee DH, Hwang DS, Kinashi T, Kim JM, Lim DS, Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7732-7
1J:214964 Clark JK, O'keefe A, Mastracci TL, Sussel L, Matise MP, Kucenas S, Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development. Dev Dyn. 2014 Sep;243(9):1116-29
1J:228894 Coles GL, Baglia LA, Ackerman KG, KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms. PLoS Genet. 2015 Oct;11(10):e1005525
2*J:226614 Costello I, Nowotschin S, Sun X, Mould AW, Hadjantonakis AK, Bikoff EK, Robertson EJ, Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015 Oct 15;29(20):2108-22
1J:276950 Coulombe P, Paliouras GN, Clayton A, Hussainkhel A, Fuller M, Jovanovic V, Dauphinee S, Umlandt P, Xiang P, Kyle AH, Minchinton AI, Humphries RK, Hoodless PA, Parker JDK, Wright JL, Karsan A, Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling. Cell Rep. 2019 May 7;27(6):1769-1780.e4
1J:237076 Crosswhite PL, Podsiadlowska JJ, Curtis CD, Gao S, Xia L, Srinivasan RS, Griffin CT, CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity. J Clin Invest. 2016 Jun 01;126(6):2254-66
1J:154975 D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V, Martinez D, Aubyn D, Grose R, Thomas GJ, Spencer-Dene B, Zicha D, Davies D, Tybulewicz V, Hodivala-Dilke KM, Regulation of lymphatic-blood vessel separation by endothelial Rac1. Development. 2009 Dec;136(23):4043-53
4J:93150 Dagenais SL, Hartsough RL, Erickson RP, Witte MH, Butler MG, Glover TW, Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome. Gene Expr Patterns. 2004 Oct;4(6):611-9
3J:325442 Dai H, Zhu M, Li W, Si G, Xing Y, Activation of PI3K/p110alpha in the Lung Mesenchyme Affects Branching Morphogenesis and Club Cell Differentiation. Front Cell Dev Biol. 2022;10:880206
3*J:291486 Daniel E, Barlow HR, Sutton GI, Gu X, Htike Y, Cowdin MA, Cleaver O, Cyp26b1 is an essential regulator of distal airway epithelial differentiation during lung development. Development. 2020 Feb 20;147(4):dev181560
1*J:121517 Danielian PS, Bender Kim CF, Caron AM, Vasile E, Bronson RT, Lees JA, E2f4 is required for normal development of the airway epithelium. Dev Biol. 2007 May 15;305(2):564-76
2J:137723 Dellinger M, Hunter R, Bernas M, Gale N, Yancopoulos G, Erickson R, Witte M, Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice. Dev Biol. 2008 Jul 15;319(2):309-20
2J:207561 Dellinger MT, Meadows SM, Wynne K, Cleaver O, Brekken RA, Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. PLoS One. 2013;8(9):e74686
3J:207468 Desai TJ, Brownfield DG, Krasnow MA, Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature. 2014 Mar 13;507(7491):190-4
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2J:146956 Douglas YL, Mahtab EA, Jongbloed MR, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Deruiter MC, Gittenberger-de Groot AC, Pulmonary vein, dorsal atrial wall and atrial septum abnormalities in podoplanin knockout mice with disturbed posterior heart field contribution. Pediatr Res. 2009 Jan;65(1):27-32
5J:207219 Driskell RR, Lichtenberger BM, Hoste E, Kretzschmar K, Simons BD, Charalambous M, Ferron SR, Herault Y, Pavlovic G, Ferguson-Smith AC, Watt FM, Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature. 2013 Dec 12;504(7479):277-81
1J:208714 Duong T, Koltowska K, Pichol-Thievend C, Le Guen L, Fontaine F, Smith KA, Truong V, Skoczylas R, Stacker SA, Achen MG, Koopman P, Hogan BM, Francois M, VEGFD regulates blood vascular development by modulating SOX18 activity. Blood. 2014 Feb 13;123(7):1102-12
1J:106392 Eblaghie MC, Reedy M, Oliver T, Mishina Y, Hogan BL, Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. Dev Biol. 2006 Mar 1;291(1):67-82
1J:181715 Finney BA, Schweighoffer E, Navarro-Nunez L, Benezech C, Barone F, Hughes CE, Langan SA, Lowe KL, Pollitt AY, Mourao-Sa D, Sheardown S, Nash GB, Smithers N, Reis e Sousa C, Tybulewicz VL, Watson SP, CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood. 2012 Feb 16;119(7):1747-56
1J:211183 Flaht-Zabost A, Gula G, Ciszek B, Czarnowska E, Jankowska-Steifer E, Madej M, Niderla-Bielinska J, Radomska-Lesniewska D, Ratajska A, Cardiac mouse lymphatics: developmental and anatomical update. Anat Rec (Hoboken). 2014 Jun;297(6):1115-30
2J:250104 Flodby P, Li C, Liu Y, Wang H, Marconett CN, Laird-Offringa IA, Minoo P, Lee AS, Zhou B, The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. Am J Respir Cell Mol Biol. 2016 Jul;55(1):135-49
1J:142875 Follit JA, San Agustin JT, Xu F, Jonassen JA, Samtani R, Lo CW, Pazour GJ, The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex. PLoS Genet. 2008 Dec;4(12):e1000315
3J:143564 Francois M, Caprini A, Hosking B, Orsenigo F, Wilhelm D, Browne C, Paavonen K, Karnezis T, Shayan R, Downes M, Davidson T, Tutt D, Cheah KS, Stacker SA, Muscat GE, Achen MG, Dejana E, Koopman P, Sox18 induces development of the lymphatic vasculature in mice. Nature. 2008 Dec 4;456(7222):643-7
1*J:183953 Francois M, Short K, Secker GA, Combes A, Schwarz Q, Davidson TL, Smyth I, Hong YK, Harvey NL, Koopman P, Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice. Dev Biol. 2012 Apr 15;364(2):89-98
1J:144581 Fu J, Gerhardt H, McDaniel JM, Xia B, Liu X, Ivanciu L, Ny A, Hermans K, Silasi-Mansat R, McGee S, Nye E, Ju T, Ramirez MI, Carmeliet P, Cummings RD, Lupu F, Xia L, Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest. 2008 Nov;118(11):3725-37
2J:247780 Fujimoto J, Nunomura-Nakamura S, Liu Y, Lang W, McDowell T, Jakubek Y, Ezzeddine D, Kapere Ochieng J, Petersen J, Davies G, Fukuoka J, Wistuba II, Ehli E, Fowler J, Scheet P, Kadara H, Development of Kras mutant lung adenocarcinoma in mice with knockout of the airway lineage-specific gene Gprc5a. Int J Cancer. 2017 Oct 15;141(8):1589-1599
1J:220467 Galvis LA, Holik AZ, Short KM, Pasquet J, Lun AT, Blewitt ME, Smyth IM, Ritchie ME, Asselin-Labat ML, Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung. Development. 2015 Apr 15;142(8):1458-69
2J:228882 Geng X, Cha B, Mahamud MR, Lim KC, Silasi-Mansat R, Uddin MK, Miura N, Xia L, Simon AM, Engel JD, Chen H, Lupu F, Srinivasan RS, Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development. Dev Biol. 2016 Jan 1;409(1):218-33
2J:171347 Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima M, Furuichi T, Ikegawa S, Gao X, Chen YG, Jiang D, Ning W, Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7058-63
2J:209770 Geng Y, Li L, Dong Y, Liu X, Li XH, Ning W, Impaired elastin deposition in Fstl1-/- lung allograft under the renal capsule. PLoS One. 2013;8(11):e81368
5*J:122248 Gittenberger-de Groot AC, Mahtab EA, Hahurij ND, Wisse LJ, Deruiter MC, Wijffels MC, Poelmann RE, Nkx2.5-negative myocardium of the posterior heart field and its correlation with podoplanin expression in cells from the developing cardiac pacemaking and conduction system. Anat Rec (Hoboken). 2007 Jan;290(1):115-22
1J:224813 Gohlke JM, Armant O, Parham FM, Smith MV, Zimmer C, Castro DS, Nguyen L, Parker JS, Gradwohl G, Portier CJ, Guillemot F, Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biol. 2008;6:15
1J:136180 Gontan C, de Munck A, Vermeij M, Grosveld F, Tibboel D, Rottier R, Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol. 2008 May 1;317(1):296-309
4*J:137168 Gordon EJ, Gale NW, Harvey NL, Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels. Dev Dyn. 2008 Jul;237(7):1901-9
2*J:248980 Guo H, Kazadaeva Y, Ortega FE, Manjunath N, Desai TJ, Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung. Dev Biol. 2017 Oct 1;430(1):214-223
1J:270164 Guo M, Du Y, Gokey JJ, Ray S, Bell SM, Adam M, Sudha P, Perl AK, Deshmukh H, Potter SS, Whitsett JA, Xu Y, Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nat Commun. 2019 Jan 3;10(1):37
1J:302122 Guo SS, Seiwert A, Szeto IYY, Fassler R, Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins. Exp Cell Res. 2021 Jan 1;398(1):112391
1J:266939 Habermehl D, Parkitna JR, Kaden S, Brugger B, Wieland F, Grone HJ, Schutz G, Glucocorticoid activity during lung maturation is essential in mesenchymal and less in alveolar epithelial cells. Mol Endocrinol. 2011 Aug;25(8):1280-8
4J:194396 Hagerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams RH, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F, A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J. 2013 Feb 12;32(5):629-44
1J:197815 Hashimoto S, Chen H, Que J, Brockway BL, Drake JA, Snyder JC, Randell SH, Stripp BR, beta-Catenin-SOX2 signaling regulates the fate of developing airway epithelium. J Cell Sci. 2012 Feb 15;125(Pt 4):932-42
1J:310843 He H, Chen J, Zhao J, Zhang P, Qiao Y, Wan H, Wang J, Mei M, Bao S, Li Q, PRMT7 targets of Foxm1 controls alveolar myofibroblast proliferation and differentiation during alveologenesis. Cell Death Dis. 2021 Sep 8;12(9):841
1J:243870 He H, Huang M, Sun S, Wu Y, Lin X, Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development. PLoS Genet. 2017 Aug;13(8):e1006992
1J:258489 Herman AM, Rhyner AM, Devine WP, Marrelli SP, Bruneau BG, Wythe JD, A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse. Biol Open. 2018 Feb 8;:bio026799
1J:308528 Hernandez Vasquez MN, Ulvmar MH, Gonzalez-Loyola A, Kritikos I, Sun Y, He L, Halin C, Petrova TV, Makinen T, Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels. EMBO J. 2021 Jun 15;40(12):e107192
1J:240020 Herriges JC, Verheyden JM, Zhang Z, Sui P, Zhang Y, Anderson MJ, Swing DA, Zhang Y, Lewandoski M, Sun X, FGF-Regulated ETV Transcription Factors Control FGF-SHH Feedback Loop in Lung Branching. Dev Cell. 2015 Nov 09;35(3):322-32
2*J:243650 Herriges MJ, Tischfield DJ, Cui Z, Morley MP, Han Y, Babu A, Li S, Lu M, Cendan I, Garcia BA, Anderson SA, Morrisey EE, The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain lung development and homeostasis. Genes Dev. 2017 May 01;31(9):889-903
1J:207924 Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, Herzog B, Lu M, Nieswandt B, Oliver G, Makinen T, Xia L, Kahn ML, Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. J Clin Invest. 2014 Jan 2;124(1):273-84
2*J:135686 Hirashima M, Sano K, Morisada T, Murakami K, Rossant J, Suda T, Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos. Dev Biol. 2008 Apr 1;316(1):149-59
8J:307823 Hoover C, Kondo Y, Shao B, McDaniel MJ, Lee R, McGee S, Whiteheart S, Bergmeier W, McEver RP, Xia L, Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin. Blood. 2021 May 20;137(20):2756-2769
1J:198291 Huang Y, Kapere Ochieng J, Kempen MB, Munck AB, Swagemakers S, van Ijcken W, Grosveld F, Tibboel D, Rottier RJ, Hypoxia inducible factor 3alpha plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development. PLoS One. 2013;8(2):e57695
7J:199909 Im SK, Jeong H, Jeong HW, Kim KT, Hwang D, Ikegami M, Kong YY, Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice. PLoS One. 2013;8(3):e58511
1J:135241 Izvolsky KI, Lu J, Martin G, Albrecht KH, Cardoso WV, Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis. 2008 Jan;46(1):8-18
2*J:293098 Jafree DJ, Moulding D, Kolatsi-Joannou M, Perretta Tejedor N, Price KL, Milmoe NJ, Walsh CL, Correra RM, Winyard PJ, Harris PC, Ruhrberg C, Walker-Samuel S, Riley PR, Woolf AS, Scambler PJ, Long DA, Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease. Elife. 2019 Dec 6;8:e48183
2J:213127 Jakus Z, Gleghorn JP, Enis DR, Sen A, Chia S, Liu X, Rawnsley DR, Yang Y, Hess PR, Zou Z, Yang J, Guttentag SH, Nelson CM, Kahn ML, Lymphatic function is required prenatally for lung inflation at birth. J Exp Med. 2014 May 5;211(5):815-26
3J:329963 Janardhan HP, Dresser K, Hutchinson L, Trivedi CM, Pathological MAPK activation-mediated lymphatic basement membrane disruption causes lymphangiectasia that is treatable with ravoxertinib. JCI Insight. 2022 Sep 8;7(17):e153033
4J:252596 Janardhan HP, Milstone ZJ, Shin M, Lawson ND, Keaney JF Jr, Trivedi CM, Hdac3 regulates lymphovenous and lymphatic valve formation. J Clin Invest. 2017 Nov 1;127(11):4193-4206
3*J:102103 Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T, A neurogenomics approach to gene expression analysis in the developing brain. Brain Res Mol Brain Res. 2004 Dec 20;132(2):116-27
1J:199291 Jiang M, Ku WY, Fu J, Offermanns S, Hsu W, Que J, Gpr177 regulates pulmonary vasculature development. Development. 2013 Sep;140(17):3589-94
2J:265611 Jin J, Li Y, Ren J, Man Lam S, Zhang Y, Hou Y, Zhang X, Xu R, Shui G, Ma RZ, Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. Am J Respir Cell Mol Biol. 2016 Mar;54(3):410-23
1*J:304253 Jones MR, Dilai S, Lingampally A, Chao CM, Danopoulos S, Carraro G, Mukhametshina R, Wilhelm J, Baumgart-Vogt E, Al Alam D, Chen C, Minoo P, Zhang JS, Bellusci S, A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Front Genet. 2018;9:746
2J:190719 Joza S, Wang J, Fox E, Hillman V, Ackerley C, Post M, Loss of semaphorin-neuropilin-1 signaling causes dysmorphic vascularization reminiscent of alveolar capillary dysplasia. Am J Pathol. 2012 Dec;181(6):2003-17
6J:320186 Kalisch-Smith JI, Morris EC, Strevens MAA, Redpath AN, Klaourakis K, Szumska D, Outhwaite JE, Sun X, Vieira JM, Smart N, De Val S, Riley PR, Sparrow DB, Analysis of Placental Arteriovenous Formation Reveals New Insights Into Embryos With Congenital Heart Defects. Front Genet. 2021;12:806136
1*J:244466 Karpanen T, Padberg Y, van de Pavert SA, Dierkes C, Morooka N, Peterson-Maduro J, van de Hoek G, Adrian M, Mochizuki N, Sekiguchi K, Kiefer F, Schulte D, Schulte-Merker S, An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation. Circ Res. 2017 Apr 14;120(8):1263-1275
2*J:161985 Karunamuni G, Yang K, Doughman YQ, Wikenheiser J, Bader D, Barnett J, Austin A, Parsons-Wingerter P, Watanabe M, Expression of lymphatic markers during avian and mouse cardiogenesis. Anat Rec (Hoboken). 2010 Feb;293(2):259-70
1J:225799 Kazenwadel J, Betterman KL, Chong CE, Stokes PH, Lee YK, Secker GA, Agalarov Y, Demir CS, Lawrence DM, Sutton DL, Tabruyn SP, Miura N, Salminen M, Petrova TV, Matthews JM, Hahn CN, Scott HS, Harvey NL, GATA2 is required for lymphatic vessel valve development and maintenance. J Clin Invest. 2015 Aug 3;125(8):2979-94
1J:239820 Kechele DO, Blue RE, Zwarycz B, Espenschied ST, Mah AT, Siegel MB, Perou CM, Ding S, Magness ST, Lund PK, Caron KM, Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation. J Clin Invest. 2017 Feb 01;127(2):593-607
1*J:181072 Kellermayer Z, Labadi A, Czompoly T, Arnold HH, Balogh P, Absence of Nkx2-3 homeodomain transcription factor induces the formation of LYVE-1-positive endothelial cysts without lymphatic commitment in the spleen. J Histochem Cytochem. 2011 Jul;59(7):690-700
1J:290104 Kenig-Kozlovsky Y, Scott RP, Onay T, Carota IA, Thomson BR, Gil HJ, Ramirez V, Yamaguchi S, Tanna CE, Heinen S, Wu C, Stan RV, Klein JD, Sands JM, Oliver G, Quaggin SE, Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels. J Am Soc Nephrol. 2018 Apr;29(4):1097-1107
1*J:266596 Kersbergen A, Best SA, Dworkin S, Ah-Cann C, de Vries ME, Asselin-Labat ML, Ritchie ME, Jane SM, Sutherland KD, Lung morphogenesis is orchestrated through Grainyhead-like 2 (Grhl2) transcriptional programs. Dev Biol. 2018 Nov 1;443(1):1-9
1J:292005 Kim E, Jiang M, Huang H, Zhang Y, Tjota N, Gao X, Robert J, Gilmore N, Gan L, Que J, Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation. Dev Cell. 2019 Dec 16;51(6):675-683.e4
1J:163853 Kim H, Nguyen VP, Petrova TV, Cruz M, Alitalo K, Dumont DJ, Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature. BMC Dev Biol. 2010;10:72
3J:268349 Kim HT, Yin W, Jin YJ, Panza P, Gunawan F, Grohmann B, Buettner C, Sokol AM, Preussner J, Guenther S, Kostin S, Ruppert C, Bhagwat AM, Ma X, Graumann J, Looso M, Guenther A, Adelstein RS, Offermanns S, Stainier DYR, Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease. Nat Commun. 2018 Nov 2;9(1):4600
2J:282804 Kim HT, Yin W, Nakamichi Y, Panza P, Grohmann B, Buettner C, Guenther S, Ruppert C, Kobayashi Y, Guenther A, Stainier DYR, WNT/RYK signaling restricts goblet cell differentiation during lung development and repair. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25697-25706
1J:284576 Kim JE, Fei L, Yin WC, Coquenlorge S, Rao-Bhatia A, Zhang X, Shi SSW, Lee JH, Hahn NA, Rizvi W, Kim KH, Sung HK, Hui CC, Guo G, Kim TH, Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches. Nat Commun. 2020 Jan 17;11(1):334
1*J:122404 Kim KE, Sung HK, Koh GY, Lymphatic development in mouse small intestine. Dev Dyn. 2007 Jul;236(7):2020-5
3J:308935 Kinoshita A, Ohyama K, Tanimura S, Matsuda K, Kishino T, Negishi Y, Asahina N, Shiraishi H, Hosoki K, Tomiwa K, Ishihara N, Mishima H, Mori R, Nakashima M, Saitoh S, Yoshiura KI, Itpr1 regulates the formation of anterior eye segment tissues derived from neural crest cells. Development. 2021 Aug 15;148(16):dev188755
3J:214795 Klein KR, Karpinich NO, Espenschied ST, Willcockson HH, Dunworth WP, Hoopes SL, Kushner EJ, Bautch VL, Caron KM, Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development. Dev Cell. 2014 Sep 8;30(5):528-40
1*J:153218 Klinger S, Turgeon B, Levesque K, Wood GA, Aagaard-Tillery KM, Meloche S, Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16710-5
1J:222246 Klotz L, Norman S, Vieira JM, Masters M, Rohling M, Dube KN, Bollini S, Matsuzaki F, Carr CA, Riley PR, Cardiac lymphatics are heterogeneous in origin and respond to injury. Nature. 2015 Jun 4;522(7554):62-7
1*J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1*J:99326 Kuhnert F, Campagnolo L, Xiong JW, Lemons D, Fitch MJ, Zou Z, Kiosses WB, Gardner H, Stuhlmann H, Dosage-dependent requirement for mouse Vezf1 in vascular system development. Dev Biol. 2005 Jul 1;283(1):140-156
3*J:149253 Kulkarni RM, Greenberg JM, Akeson AL, NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009 May-Jun;126(5-6):350-65
1J:245768 Landry-Truchon K, Houde N, Boucherat O, Joncas FH, Dasen JS, Philippidou P, Mansfield JH, Jeannotte L, HOXA5 plays tissue-specific roles in the developing respiratory system. Development. 2017 Oct 01;144(19):3547-3561
1J:318015 Lange AW, Sridharan A, Xu Y, Stripp BR, Perl AK, Whitsett JA, Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung. J Mol Cell Biol. 2015 Feb;7(1):35-47
4J:237343 Laresgoiti U, Nikolic MZ, Rao C, Brady JL, Richardson RV, Batchen EJ, Chapman KE, Rawlins EL, Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate. Development. 2016 Oct 15;143(20):3686-3699
1J:162807 Larrieu-Lahargue F, Welm AL, Thomas KR, Li DY, Netrin-4 induces lymphangiogenesis in vivo. Blood. 2010 Jul 1;115(26):5418-26
2*J:123725 Lax S, Hou TZ, Jenkinson E, Salmon M, MacFadyen JR, Isacke CM, Anderson G, Cunningham AF, Buckley CD, CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair. FEBS Lett. 2007 Jul 24;581(18):3550-6
1J:297998 Lee DD, Hochstetler A, Sah E, Xu H, Lowe CW, Santiaguel S, Thornton JL, Pajakowski A, Schwarz MA, Influence of aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1 on epithelial differentiation and organization during lung development. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L369-L379
1J:306217 Lee H, Ko HW, Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development. BMB Rep. 2020 Jul;53(7):367-372
1J:216439 Lee KM, Danuser R, Stein JV, Graham D, Nibbs RJ, Graham GJ, The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO J. 2014 Nov 3;33(21):2564-80
2J:324834 Lenti E, Genovese L, Bianchessi S, Maurizio A, Sain SB, di Lillo A, Mattavelli G, Harel I, Bernassola F, Hehlgans T, Pfeffer K, Crosti M, Abrignani S, Evans SM, Sitia G, Guimaraes-Camboa N, Russo V, van de Pavert SA, Garcia-Manteiga JM, Brendolan A, Fate mapping and scRNA sequencing reveal origin and diversity of lymph node stromal precursors. Immunity. 2022 Apr 12;55(4):606-622.e6
1J:200617 Li A, Hardy R, Stoner S, Tuckermann J, Seibel M, Zhou H, Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure. PLoS One. 2013;8(5):e63578
2J:250062 Li A, Ma S, Smith SM, Lee MK, Fischer A, Borok Z, Bellusci S, Li C, Minoo P, Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate. BMC Biol. 2016 Mar 16;14:19
3J:302372 Li C, Smith SM, Peinado N, Gao F, Li W, Lee MK, Zhou B, Bellusci S, Pryhuber GS, Ho HH, Borok Z, Minoo P, WNT5a-ROR Signaling Is Essential for Alveologenesis. Cells. 2020 Feb 7;9(2):384
1J:308018 Li E, Ustiyan V, Wen B, Kalin GT, Whitsett JA, Kalin TV, Kalinichenko VV, Blastocyst complementation reveals that NKX2-1 establishes the proximal-peripheral boundary of the airway epithelium. Dev Dyn. 2021 Jul;250(7):1001-1020
1J:335070 Li MH, Kuetemeyer JM, Yallowitz AR, Wellik DM, Characterization of a novel Hoxa5eGFP mouse line. Dev Dyn. 2023 Apr;252(4):536-546
1*J:327630 Li R, Cai Y, Lin H, Dong L, Tang M, Lang Y, Qi Y, Peng Y, Zhou B, Yang G, Teng Y, Yang X, Generation of an Ihh-mKate2-Dre knock-in mouse line. Genesis. 2022 Jul;60(6-7):e23488
1*J:320419 Li R, Zhang Y, Garg A, Sui P, Sun X, E3 ubiquitin ligase FBXW7 balances airway cell fates. Dev Biol. 2022 Mar;483:89-97
1J:249155 Li X, Fang Y, Li X, Liang J, Jiang D, Geng Y, Ning W, Apical Secretion of FSTL1 in the Respiratory Epithelium for Normal Lung Development. PLoS One. 2016;11(6):e0158385
2J:194339 Li Y, Wang J, Asahina K, Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2324-9
1J:223043 Liebl J, Zhang S, Moser M, Agalarov Y, Demir CS, Hager B, Bibb JA, Adams RH, Kiefer F, Miura N, Petrova TV, Vollmar AM, Zahler S, Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2. Nat Commun. 2015;6:7274
1J:214993 Lin C, Chen MH, Yao E, Song H, Gacayan R, Hui CC, Chuang PT, Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development. Dev Biol. 2014 Aug 15;392(2):324-33
4*J:224948 Lin C, Yao E, Chuang PT, A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth. Dev Biol. 2015 Jul 1;403(1):101-13
1J:244106 Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson-Peer K, Chuang PT, YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. Elife. 2017 Mar 21;6:e21130
1J:314657 Lin S, Zhang Q, Cao Z, Lu Y, Zhang H, Yan K, Liu Y, McKee MD, Qin C, Chen Z, Feng JQ, Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype. J Biol Chem. 2014 Aug 1;289(31):21533-43
1J:244674 Liu X, Pasula S, Song H, Tessneer KL, Dong Y, Hahn S, Yago T, Brophy ML, Chang B, Cai X, Wu H, McManus J, Ichise H, Georgescu C, Wren JD, Griffin C, Xia L, Srinivasan RS, Chen H, Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function. Sci Signal. 2014 Oct 14;7(347):ra97
1J:181392 Londhe VA, Maisonet TM, Lopez B, Jeng JM, Xiao J, Li C, Minoo P, Conditional deletion of epithelial IKKbeta impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis. Respir Res. 2011;12:134
1*J:130988 Londhe VA, Nguyen HT, Jeng JM, Li X, Li C, Tiozzo C, Zhu N, Minoo P, NF-kB induces lung maturation during mouse lung morphogenesis. Dev Dyn. 2008 Feb;237(2):328-38
1*J:287785 Longmire TA, Ikonomou L, Hawkins F, Christodoulou C, Cao Y, Jean JC, Kwok LW, Mou H, Rajagopal J, Shen SS, Dowton AA, Serra M, Weiss DJ, Green MD, Snoeck HW, Ramirez MI, Kotton DN, Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell. 2012 Apr 6;10(4):398-411
1J:241923 Lopez IP, Pineiro-Hermida S, Pais RS, Torrens R, Hoeflich A, Pichel JG, Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation. PLoS One. 2016;11(11):e0166388
2J:315454 Loscertales M, Nicolaou F, Jeanne M, Longoni M, Gould DB, Sun Y, Maalouf FI, Nagy N, Donahoe PK, Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation. BMC Biol. 2016 Jul 13;14:59
1*J:122356 Lovgren AK, Kovarova M, Koller BH, cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis. Mol Cell Biol. 2007 Jun;27(12):4416-30
2*J:224632 Lowe KL, Finney BA, Deppermann C, Hagerling R, Gazit SL, Frampton J, Buckley C, Camerer E, Nieswandt B, Kiefer F, Watson SP, Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development. Blood. 2015 Jun 11;125(24):3769-77
1J:202226 Lu K, Reddy R, Berika M, Warburton D, El-Hashash AH, Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling. Dev Biol. 2013 Oct 1;382(1):110-23
4J:195172 Ludtke TH, Farin HF, Rudat C, Schuster-Gossler K, Petry M, Barnett P, Christoffels VM, Kispert A, Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b. PLoS Genet. 2013 Jan;9(1):e1003189
1*J:193822 Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S, Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
1J:185190 Lutter S, Xie S, Tatin F, Makinen T, Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation. J Cell Biol. 2012 Jun 11;197(6):837-49
1J:316476 Ma W, Gil HJ, Liu X, Diebold LP, Morgan MA, Oxendine-Burns MJ, Gao P, Chandel NS, Oliver G, Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell fate specification and maintenance. Sci Adv. 2021 Apr;7(18)
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
3J:284120 Mahamud MR, Geng X, Ho YC, Cha B, Kim Y, Ma J, Chen L, Myers G, Camper S, Mustacich D, Witte M, Choi D, Hong YK, Chen H, Varshney G, Engel JD, Wang S, Kim TH, Lim KC, Srinivasan RS, GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126. Development. 2019 Nov 5;146(21):dev184218
1*J:142644 Mahtab EA, Vicente-Steijn R, Hahurij ND, Jongbloed MR, Wisse LJ, Deruiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC, Podoplanin deficient mice show a rhoa-related hypoplasia of the sinus venosus myocardium including the sinoatrial node. Dev Dyn. 2008 Dec 18;238(1):183-193
6*J:132132 Mahtab EA, Wijffels MC, Van Den Akker NM, Hahurij ND, Lie-Venema H, Wisse LJ, Deruiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC, Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development. Dev Dyn. 2008 Mar;237(3):847-57
1J:204322 Majima T, Takeuchi K, Sano K, Hirashima M, Zankov DP, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ogita H, An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo. PLoS One. 2013;8(6):e68134
1J:95885 Makinen T, Adams RH, Bailey J, Lu Q, Ziemiecki A, Alitalo K, Klein R, Wilkinson GA, PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev. 2005 Feb 1;19(3):397-410
1J:261809 Mayer C, Hafemeister C, Bandler RC, Machold R, Batista Brito R, Jaglin X, Allaway K, Butler A, Fishell G, Satija R, Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462
1*J:252121 McCoy AM, Herington JL, Stouch AN, Mukherjee AB, Lakhdari O, Blackwell TS, Prince LS, IKKbeta Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis. Am J Pathol. 2017 Dec;187(12):2635-2644
1*J:213577 McGinley AL, Li Y, Deliu Z, Wang QT, Additional sex combs-like family genes are required for normal cardiovascular development. Genesis. 2014 Jul;52(7):671-86
2J:158087 McPherson JP, Sarras H, Lemmers B, Tamblyn L, Migon E, Matysiak-Zablocki E, Hakem A, Azami SA, Cardoso R, Fish J, Sanchez O, Post M, Hakem R, Essential role for Bclaf1 in lung development and immune system function. Cell Death Differ. 2009 Feb;16(2):331-9
1J:155272 Mellgren AM, Smith CL, Olsen GS, Eskiocak B, Zhou B, Kazi MN, Ruiz FR, Pu WT, Tallquist MD, Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res. 2008 Dec 5;103(12):1393-401
4*J:119680 Millien G, Spira A, Hinds A, Wang J, Williams MC, Ramirez MI, Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development. BMC Dev Biol. 2006;6:35
2J:267889 Moon S, Im SK, Kim N, Youn H, Park UH, Kim JY, Kim AR, An SJ, Kim JH, Sun W, Hwang JT, Kim EJ, Um SJ, Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis. Cell Death Dis. 2018 Nov 2;9(11):1118
1*J:110719 Moreno-Barriuso N, Lopez-Malpartida AV, de Pablo F, Pichel JG, Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev Dyn. 2006 Aug;235(8):2040-50
1J:107439 Morisada T, Oike Y, Yamada Y, Urano T, Akao M, Kubota Y, Maekawa H, Kimura Y, Ohmura M, Miyamoto T, Nozawa S, Koh GY, Alitalo K, Suda T, Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood. 2005 Jun 15;105(12):4649-56
4J:262023 Morooka N, Futaki S, Sato-Nishiuchi R, Nishino M, Totani Y, Shimono C, Nakano I, Nakajima H, Mochizuki N, Sekiguchi K, Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling. Circ Res. 2017 Apr 14;120(8):1276-1288
1J:231667 Munger SJ, Geng X, Srinivasan RS, Witte MH, Paul DL, Simon AM, Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice. Dev Biol. 2016 Apr 15;412(2):173-90
1J:282576 Nakajima K, Ono M, Radovic U, Dizdarevic S, Tomizawa SI, Kuroha K, Nagamatsu G, Hoshi I, Matsunaga R, Shirakawa T, Kurosawa T, Miyazaki Y, Seki M, Suzuki Y, Koseki H, Nakamura M, Suda T, Ohbo K, Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice. Dis Model Mech. 2019 Nov 12;12(11):dmm040139
3J:272609 Nantie LB, Young RE, Paltzer WG, Zhang Y, Johnson RL, Verheyden JM, Sun X, Lats1/2 inactivation reveals Hippo function in alveolar type I cell differentiation during lung transition to air breathing. Development. 2018 Nov 9;145(21):dev163105
5*J:196288 Nechiporuk T, Klezovitch O, Nguyen L, Vasioukhin V, Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis. Dev Biol. 2013 May 15;377(2):375-84
1J:276879 Noe N, Shim A, Millette K, Luo Y, Azhar M, Shi W, Warburton D, Turcatel G, Mesenchyme-specific deletion of Tgf-beta1 in the embryonic lung disrupts branching morphogenesis and induces lung hypoplasia. Lab Invest. 2019 Apr 25;
1J:243620 Nonomura K, Woo SH, Chang RB, Gillich A, Qiu Z, Francisco AG, Ranade SS, Liberles SD, Patapoutian A, Piezo2 senses airway stretch and mediates lung inflation-induced apnoea. Nature. 2017 Jan 12;541(7636):176-181
2J:275825 Norman TA Jr, Gower AC, Chen F, Fine A, Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation. PLoS One. 2019;14(5):e0216795
1J:161950 O'Brien KB, Alberich-Jorda M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S, CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development. 2010 Jul;137(13):2147-56
4J:263065 Ogawa T, Li Y, Lua I, Hartner A, Asahina K, Isolation of a unique hepatic stellate cell population expressing integrin alpha8 from embryonic mouse livers. Dev Dyn. 2018 Jun;247(6):867-881
1J:97215 Okubo T, Knoepfler PS, Eisenman RN, Hogan BL, Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation. Development. 2005 Mar;132(6):1363-74
1J:259045 Onder L, Morbe U, Pikor N, Novkovic M, Cheng HW, Hehlgans T, Pfeffer K, Becher B, Waisman A, Rulicke T, Gommerman J, Mueller CG, Sawa S, Scandella E, Ludewig B, Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis. Immunity. 2017 Jul 18;47(1):80-92.e4
2J:104891 Osafune K, Takasato M, Kispert A, Asashima M, Nishinakamura R, Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. Development. 2006 Jan;133(1):151-61
2J:248982 Pan H, Zhang H, Abraham P, Komatsu Y, Lyons K, Kaartinen V, Mishina Y, BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development. Dev Biol. 2017 Sep 1;429(1):260-270
2J:220787 Pan Y, Yago T, Fu J, Herzog B, McDaniel JM, Mehta-D'Souza P, Cai X, Ruan C, McEver RP, West C, Dai K, Chen H, Xia L, Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets. Blood. 2014 Dec 4;124(24):3656-65
1J:282057 Pawlak JB, Balint L, Lim L, Ma W, Davis RB, Benyo Z, Soares MJ, Oliver G, Kahn ML, Jakus Z, Caron KM, Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling. J Clin Invest. 2019 Nov 1;129(11):4912-4921
1J:225736 Payne S, Burney MJ, McCue K, Popal N, Davidson SM, Anderson RH, Scambler PJ, A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development. Dev Biol. 2015 Sep 1;405(1):82-95
2J:178114 Pei L, Leblanc M, Barish G, Atkins A, Nofsinger R, Whyte J, Gold D, He M, Kawamura K, Li HR, Downes M, Yu RT, Powell HC, Lingrel JB, Evans RM, Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. Nat Med. 2011;17(11):1466-72
1*J:137010 Petrou P, Pavlakis E, Dalezios Y, Galanopoulos VK, Chalepakis G, Basement membrane distortions impair lung lobation and capillary organization in the mouse model for fraser syndrome. J Biol Chem. 2005 Mar 18;280(11):10350-6
2J:92818 Petrova TV, Karpanen T, Norrmen C, Mellor R, Tamakoshi T, Finegold D, Ferrell R, Kerjaschki D, Mortimer P, Yla-Herttuala S, Miura N, Alitalo K, Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. Nat Med. 2004 Sep;10(9):974-981
1J:264119 Pichol-Thievend C, Betterman KL, Liu X, Ma W, Skoczylas R, Lesieur E, Bos FL, Schulte D, Schulte-Merker S, Hogan BM, Oliver G, Harvey NL, Francois M, A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development. Development. 2018 May 17;145(10):dev160184
1J:187967 Plosa EJ, Gooding KA, Zent R, Prince LS, Nonmuscle myosin II regulation of lung epithelial morphology. Dev Dyn. 2012 Nov;241(11):1770-81
1J:217594 Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince LS, Blackwell TS, Zent R, Epithelial beta1 integrin is required for lung branching morphogenesis and alveolarization. Development. 2014 Dec;141(24):4751-62
2J:175564 Porter JL, Bukey BR, Geyer AJ, Willnauer CP, Reynolds PR, Immunohistochemical detection and regulation of alpha5 nicotinic acetylcholine receptor (nAChR) subunits by FoxA2 during mouse lung organogenesis. Respir Res. 2011;12:82
2J:296328 Pradhan A, Dunn A, Ustiyan V, Bolte C, Wang G, Whitsett JA, Zhang Y, Porollo A, Hu YC, Xiao R, Szafranski P, Shi D, Stankiewicz P, Kalin TV, Kalinichenko VV, The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia. Am J Respir Crit Care Med. 2019 Oct 15;200(8):1045-1056
2J:305472 Prados A, Onder L, Cheng HW, Morbe U, Lutge M, Gil-Cruz C, Perez-Shibayama C, Koliaraki V, Ludewig B, Kollias G, Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity. Nat Immunol. 2021 Apr;22(4):510-519
1J:154450 Rawlins EL, Clark CP, Xue Y, Hogan BL, The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells. Development. 2009 Nov;136(22):3741-5
2*J:313517 Robbins ME, Cho HY, Hansen JM, Luchsinger JR, Locy ML, Velten M, Kleeberger SR, Rogers LK, Tipple TE, Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice. Redox Biol. 2021 Jan;38:101797
1J:226305 Romand R, Ripp R, Poidevin L, Boeglin M, Geffers L, Dolle P, Poch O, Integrated annotation and analysis of in situ hybridization images using the ImAnno system: application to the ear and sensory organs of the fetal mouse. PLoS One. 2015;10(2):e0118024
1J:296443 Rondon-Galeano M, Skoczylas R, Bower NI, Simons C, Gordon E, Francois M, Koltowska K, Hogan BM, MAFB modulates the maturation of lymphatic vascular networks in mice. Dev Dyn. 2020 Oct;249(10):1201-1216
1J:198319 Sayin VI, Nilton A, Ibrahim MX, Agren P, Larsson E, Petit MM, Hulten LM, Stahlman M, Johansson BR, Bergo MO, Lindahl P, Zfp148 deficiency causes lung maturation defects and lethality in newborn mice that are rescued by deletion of p53 or antioxidant treatment. PLoS One. 2013;8(2):e55720
4J:94978 Schacht V, Ramirez MI, Hong YK, Hirakawa S, Feng D, Harvey N, Williams M, Dvorak AM, Dvorak HF, Oliver G, Detmar M, T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 2003 Jul 15;22(14):3546-56
1J:173650 Sgantzis N, Yiakouvaki A, Remboutsika E, Kontoyiannis DL, HuR controls lung branching morphogenesis and mesenchymal FGF networks. Dev Biol. 2011 Jun 15;354(2):267-79
2J:255690 Shen H, Cavallero S, Estrada KD, Sandovici I, Kumar SR, Makita T, Lien CL, Constancia M, Sucov HM, Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion. Cardiovasc Res. 2015 Mar 1;105(3):271-8
4J:338969 Shi CY, Elcavage LE, Chivukula RR, Stefano J, Kleaveland B, Bartel DP, ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development. Genome Res. 2023 Aug 2;
1J:195140 Shi W, Bain AL, Schwer B, Al-Ejeh F, Smith C, Wong L, Chai H, Miranda MS, Ho U, Kawaguchi M, Miura Y, Finnie JW, Wall M, Heierhorst J, Wicking C, Spring KJ, Alt FW, Khanna KK, Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet. 2013 Feb;9(2):e1003298
3J:290284 Shrestha A, Carraro G, Nottet N, Vazquez-Armendariz AI, Herold S, Cordero J, Singh I, Wilhelm J, Barreto G, Morty R, El Agha E, Mari B, Chen C, Zhang JS, Chao CM, Bellusci S, A critical role for miR-142 in alveolar epithelial lineage formation in mouse lung development. Cell Mol Life Sci. 2019 Jul;76(14):2817-2832
2J:121421 Shu W, Lu MM, Zhang Y, Tucker PW, Zhou D, Morrisey EE, Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development. 2007 May;134(10):1991-2000
1J:331695 Siret C, van Lessen M, Bavais J, Jeong HW, Reddy Samawar SK, Kapupara K, Wang S, Simic M, de Fabritus L, Tchoghandjian A, Fallet M, Huang H, Sarrazin S, Sieweke MH, Stumm R, Sorokin L, Adams RH, Schulte-Merker S, Kiefer F, van de Pavert SA, Deciphering the heterogeneity of the Lyve1(+) perivascular macrophages in the mouse brain. Nat Commun. 2022 Nov 30;13(1):7366
1J:185693 Smith CL, Baek ST, Sung CY, Tallquist MD, Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling. Circ Res. 2011 Jun 10;108(12):e15-26
4J:217677 Snitow ME, Li S, Morley MP, Rathi K, Lu MM, Kadzik RS, Stewart KM, Morrisey EE, Ezh2 represses the basal cell lineage during lung endoderm development. Development. 2015 Jan 1;142(1):108-17
1J:159823 Sohaskey ML, Jiang Y, Zhao JJ, Mohr A, Roemer F, Harland RM, Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. J Cell Biol. 2010 May 3;189(3):511-25
3*J:217439 Srinivasan RS, Escobedo N, Yang Y, Interiano A, Dillard ME, Finkelstein D, Mukatira S, Gil HJ, Nurmi H, Alitalo K, Oliver G, The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors. Genes Dev. 2014 Oct 1;28(19):2175-87
4J:177488 Srinivasan RS, Oliver G, Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves. Genes Dev. 2011 Oct 15;25(20):2187-97
2J:228184 Stanczuk L, Martinez-Corral I, Ulvmar MH, Zhang Y, Lavina B, Fruttiger M, Adams RH, Saur D, Betsholtz C, Ortega S, Alitalo K, Graupera M, Makinen T, cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels. Cell Rep. 2015 Mar 10;
2J:278572 Stone OA, Stainier DYR, Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium. Dev Cell. 2019 Jul 22;50(2):247-255.e3
2J:239521 Stzepourginski I, Nigro G, Jacob JM, Dulauroy S, Sansonetti PJ, Eberl G, Peduto L, CD34+ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E506-E513
1J:235118 Sun C, Yu D, Ye W, Liu C, Gu S, Sinsheimer NR, Song Z, Li X, Chen C, Song Y, Wang S, Schrader L, Chen Y, The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesis. J Biol Chem. 2015 Jan 23;290(4):2007-23
2J:240685 Takara K, Maruo N, Oka K, Kaji C, Hatakeyama Y, Sawa N, Kato Y, Yamashita J, Kojima H, Sawa Y, Morphological study of tooth development in podoplanin-deficient mice. PLoS One. 2017;12(2):e0171912
1*J:265020 Tang X, Snowball JM, Xu Y, Na CL, Weaver TE, Clair G, Kyle JE, Zink EM, Ansong C, Wei W, Huang M, Lin X, Whitsett JA, EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. J Clin Invest. 2017 Dec 1;127(12):4314-4325
1J:122355 Taniguchi K, Kohno R, Ayada T, Kato R, Ichiyama K, Morisada T, Oike Y, Yonemitsu Y, Maehara Y, Yoshimura A, Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling. Mol Cell Biol. 2007 Jun;27(12):4541-50
1J:338930 Tarnick J, Elhendawi M, Holland I, Chang Z, Davies JA, Innervation of the developing kidney in vivo and in vitro. Biol Open. 2023 Aug 15;12(8)
5*J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1J:272733 Thomson BR, Souma T, Tompson SW, Onay T, Kizhatil K, Siggs OM, Feng L, Whisenhunt KN, Yanovitch TL, Kalaydjieva L, Azmanov DN, Finzi S, Tanna CE, Hewitt AW, Mackey DA, Bradfield YS, Souzeau E, Javadiyan S, Wiggs JL, Pasutto F, Liu X, John SW, Craig JE, Jin J, Young TL, Quaggin SE, Angiopoietin-1 is required for Schlemm's canal development in mice and humans. J Clin Invest. 2017 Dec 1;127(12):4421-4436
2J:232285 Tibboel J, Groenman FA, Selvaratnam J, Wang J, Tseu I, Huang Z, Caniggia I, Luo D, van Tuyl M, Ackerley C, de Jongste JC, Tibboel D, Post M, Hypoxia-inducible factor-1 stimulates postnatal lung development but does not prevent O2-induced alveolar injury. Am J Respir Cell Mol Biol. 2015 Apr;52(4):448-58
1J:192736 Tiozzo C, Carraro G, Al Alam D, Baptista S, Danopoulos S, Li A, Lavarreda-Pearce M, Li C, De Langhe S, Chan B, Borok Z, Bellusci S, Minoo P, Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest. 2012 Nov 1;122(11):3862-72
1J:167962 Tiozzo C, De Langhe S, Yu M, Londhe VA, Carraro G, Li M, Li C, Xing Y, Anderson S, Borok Z, Bellusci S, Minoo P, Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury. Am J Respir Crit Care Med. 2009 Oct 15;180(8):701-12
2J:320430 Toda Nakamura M, Zhang H, Guo D, Ueharu H, Pan H, Scott G, Harris M, Ray M, Feng JQ, Harris SE, Bonewald LF, Mishina Y, Podoplanin is dispensable for mineralized tissue formation and maintenance in the Swiss outbred mouse background. Genesis. 2021 Oct;59(10):e23450
1J:309653 Tong Y, Park SH, Wu D, Xu W, Guillot SJ, Jin L, Li X, Wang Y, Lin CS, Fu Z, An essential role of intestinal cell kinase in lung development is linked to the perinatal lethality of human ECO syndrome. FEBS Lett. 2017 May;591(9):1247-1257
1J:328045 Trinh LT, Osipovich AB, Sampson L, Wong J, Wright CVE, Magnuson MA, Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development. iScience. 2022 Sep 16;25(9):104905
1J:162840 Trompouki E, Tsagaratou A, Kosmidis SK, Dolle P, Qian J, Kontoyiannis DL, Cardoso WV, Mosialos G, Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation. Neoplasia. 2009 May;11(5):469-76
1J:234401 Tsao PN, Matsuoka C, Wei SC, Sato A, Sato S, Hasegawa K, Chen HK, Ling TY, Mori M, Cardoso WV, Morimoto M, Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8242-7
1J:150051 Tsao PN, Vasconcelos M, Izvolsky KI, Qian J, Lu J, Cardoso WV, Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development. 2009 Jul;136(13):2297-307
2J:175774 Tsao PN, Wei SC, Wu MF, Huang MT, Lin HY, Lee MC, Lin KM, Wang IJ, Kaartinen V, Yang LT, Cardoso WV, Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development. Development. 2011 Aug;138(16):3533-43
5J:266086 Tsukiji N, Inoue O, Morimoto M, Tatsumi N, Nagatomo H, Ueta K, Shirai T, Sasaki T, Otake S, Tamura S, Tachibana T, Okabe M, Hirashima M, Ozaki Y, Suzuki-Inoue K, Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction. Blood. 2018 Sep 13;132(11):1167-1179
1J:225175 Turcatel G, Rubin N, Menke DB, Martin G, Shi W, Warburton D, Lung mesenchymal expression of Sox9 plays a critical role in tracheal development. BMC Biol. 2013;11:117
3J:160267 Uhrin P, Zaujec J, Breuss JM, Olcaydu D, Chrenek P, Stockinger H, Fuertbauer E, Moser M, Haiko P, Fassler R, Alitalo K, Binder BR, Kerjaschki D, Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood. 2010 May 13;115(19):3997-4005
2J:277451 Valente M, Resende TP, Nascimento DS, Burlen-Defranoux O, Soares-da-Silva F, Dupont B, Cumano A, Pinto-do-O P, Mouse HSA+ immature cardiomyocytes persist in the adult heart and expand after ischemic injury. PLoS Biol. 2019 Jun;17(6):e3000335
6J:336858 Vallecillo-Garcia P, Orgeur M, Comai G, Poehle-Kronnawitter S, Fischer C, Gloger M, Dumas CE, Giesecke-Thiel C, Sauer S, Tajbakhsh S, Hopken UE, Stricker S, A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation. Immunity. 2023 Jun 13;56(6):1204-1219.e8
1J:208884 van de Pavert SA, Ferreira M, Domingues RG, Ribeiro H, Molenaar R, Moreira-Santos L, Almeida FF, Ibiza S, Barbosa I, Goverse G, Labao-Almeida C, Godinho-Silva C, Konijn T, Schooneman D, O'Toole T, Mizee MR, Habani Y, Haak E, Santori FR, Littman DR, Schulte-Merker S, Dzierzak E, Simas JP, Mebius RE, Veiga-Fernandes H, Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature. 2014 Apr 3;508(7494):123-7
2J:157747 van de Pavert SA, Olivier BJ, Goverse G, Vondenhoff MF, Greuter M, Beke P, Kusser K, Hopken UE, Lipp M, Niederreither K, Blomhoff R, Sitnik K, Agace WW, Randall TD, de Jonge WJ, Mebius RE, Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. Nat Immunol. 2009 Nov;10(11):1193-9
1J:290308 van Soldt BJ, Qian J, Li J, Tang N, Lu J, Cardoso WV, Yap and its subcellular localization have distinct compartment-specific roles in the developing lung. Development. 2019 May 1;146(9):dev175810
1J:96850 van Tuyl M, Groenman F, Kuliszewski M, Ridsdale R, Wang J, Tibboel D, Post M, Overexpression of lunatic fringe does not affect epithelial cell differentiation in the developing mouse lung. Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L672-82
4*J:284147 Velecela V, Torres-Cano A, Garcia-Melero A, Ramiro-Pareta M, Muller-Sanchez C, Segarra-Mondejar M, Chau YY, Campos-Bonilla B, Reina M, Soriano FX, Hastie ND, Martinez FO, Martinez-Estrada OM, Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of Bmp4. Development. 2019 Oct 17;146(20):dev178723
1J:204465 Volckaert T, Campbell A, Dill E, Li C, Minoo P, De Langhe S, Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors. Development. 2013 Sep;140(18):3731-42
4J:142686 Vondenhoff MF, van de Pavert SA, Dillard ME, Greuter M, Goverse G, Oliver G, Mebius RE, Lymph sacs are not required for the initiation of lymph node formation. Development. 2009 Jan;136(1):29-34
2J:332515 Wan L, Hu X, Xia T, Li F, Chi Q, Ma H, Yan S, Li W, Huang W, Disruption of Cdyl gene impairs mouse lung epithelium differentiation and maturation. Gene. 2023 Feb 15;853:147088
2J:233746 Wang X, Wang Y, Snitow ME, Stewart KM, Li S, Lu M, Morrisey EE, Expression of histone deacetylase 3 instructs alveolar type I cell differentiation by regulating a Wnt signaling niche in the lung. Dev Biol. 2016 Jun 15;414(2):161-9
1J:237534 Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M, Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development. Development. 2016 Dec 01;143(23):4441-4451
1J:195044 Wang Y, Tian Y, Morley MP, Lu MM, Demayo FJ, Olson EN, Morrisey EE, Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway. Dev Cell. 2013 Feb 25;24(4):345-58
1J:119654 Weatherbee SD, Anderson KV, Niswander LA, LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development. 2006 Dec;133(24):4993-5000
4*J:123756 Wiener RS, Cao YX, Hinds A, Ramirez MI, Williams MC, Angiotensin converting enzyme 2 is primarily epithelial and is developmentally regulated in the mouse lung. J Cell Biochem. 2007 Aug 1;101(5):1278-91
1J:139011 Wilkinson GA, Schittny JC, Reinhardt DP, Klein R, Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity. Dev Dyn. 2008 Aug;237(8):2220-34
2J:162625 Wu M, Smith CL, Hall JA, Lee I, Luby-Phelps K, Tallquist MD, Epicardial spindle orientation controls cell entry into the myocardium. Dev Cell. 2010 Jul 20;19(1):114-25
1J:327590 Xia S, Menden HL, Townley N, Mabry SM, Johnston J, Nyp MF, Heruth DP, Korfhagen T, Sampath V, Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung. JCI Insight. 2021 Apr 8;6(7)
1*J:136063 Xu B, Qu X, Gu S, Doughman YQ, Watanabe M, Dunwoodie SL, Yang YC, Cited2 is required for fetal lung maturation. Dev Biol. 2008 May 1;317(1):95-105
1J:155893 Xu K, Nieuwenhuis E, Cohen BL, Wang W, Canty AJ, Danska JS, Coultas L, Rossant J, Wu MY, Piscione TD, Nagy A, Gossler A, Hicks GG, Hui CC, Henkelman RM, Yu LX, Sled JG, Gridley T, Egan SE, Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L45-56
2*J:325049 Xu W, Nelson-Maney NP, Balint L, Kwon HB, Davis RB, Dy DCM, Dunleavey JM, St Croix B, Caron KM, Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development. Int J Mol Sci. 2022 May 20;23(10)
2J:285142 Xu W, Wittchen ES, Hoopes SL, Stefanini L, Burridge K, Caron KM, Small GTPase Rap1A/B Is Required for Lymphatic Development and Adrenomedullin-Induced Stabilization of Lymphatic Endothelial Junctions. Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2410-2422
1J:156869 Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivee B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A, Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. J Cell Biol. 2010 Jan 11;188(1):115-30
1J:124125 Yamamoto H, Yun EJ, Gerber HP, Ferrara N, Whitsett JA, Vu TH, Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol. 2007 Aug 1;308(1):44-53
1J:325725 Yang G, Lu S, Jiang J, Weng J, Zeng X, Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway. Int J Mol Sci. 2022 May 27;23(11)
4J:191306 Yang Y, Garcia-Verdugo JM, Soriano-Navarro M, Srinivasan RS, Scallan JP, Singh MK, Epstein JA, Oliver G, Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos. Blood. 2012 Sep 13;120(11):2340-8
1J:184806 Yao LC, Baluk P, Srinivasan RS, Oliver G, McDonald DM, Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation. Am J Pathol. 2012 Jun;180(6):2561-75
1J:321577 Yin W, Liontos A, Koepke J, Ghoul M, Mazzocchi L, Liu X, Lu C, Wu H, Fysikopoulos A, Sountoulidis A, Seeger W, Ruppert C, Gunther A, Stainier DYR, Samakovlis C, An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea. Development. 2022 Feb 1;149(3):dev199804
2J:312414 Yogosawa S, Ohkido M, Horii T, Okazaki Y, Nakayama J, Yoshida S, Toyokuni S, Hatada I, Morimoto M, Yoshida K, Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient. Commun Biol. 2021 Oct 20;4(1):1204
3J:196001 Yu H, He K, Li L, Sun L, Tang F, Li R, Ning W, Jin Y, Deletion of STK40 protein in mice causes respiratory failure and death at birth. J Biol Chem. 2013 Feb 22;288(8):5342-52
1J:93296 Yu H, Wessels A, Chen J, Phelps AL, Oatis J, Tint GS, Patel SB, Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome. BMC Dev Biol. 2004 Mar 2;4(1):1
1J:79393 Yuan L, Moyon D, Pardanaud L, Breant C, Karkkainen MJ, Alitalo K, Eichmann A, Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development. 2002 Oct;129(20):4797-806
1J:239184 Zhang J, Liu Z, Zhang T, Lin Z, Li Z, Zhang A, Sun X, Gao J, Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice. Sci Rep. 2016 Sep 20;6:33856
3J:332095 Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Chuang PT, mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity. Nat Commun. 2022 Nov 25;13(1):7252
1J:159121 Zhang M, Liu X, Zhang Y, Zhao J, Loss of betaarrestin1 and betaarrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice. Dev Biol. 2010 Mar 15;339(2):407-17
1*J:314587 Zhang S, Dai H, Li W, Wang R, Wu H, Shen M, Hu Y, Xie L, Xing Y, TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway. Cell Death Dis. 2021 Nov 16;12(12):1086
1J:257930 Zhang Y, Daubel N, Stritt S, Makinen T, Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels. Development. 2018 Feb 8;145(3):dev156745
1J:138407 Zhang Y, Goss AM, Cohen ED, Kadzik R, Lepore JJ, Muthukumaraswamy K, Yang J, DeMayo FJ, Whitsett JA, Parmacek MS, Morrisey EE, A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet. 2008 Jul;40(7):862-70
1J:324215 Zhang Y, Yokoyama S, Herriges JC, Zhang Z, Young RE, Verheyden JM, Sun X, E3 ubiquitin ligase RFWD2 controls lung branching through protein-level regulation of ETV transcription factors. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7557-62
1J:196696 Zou Z, Enis DR, Bui H, Khandros E, Kumar V, Jakus Z, Thom C, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML, The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood. 2013 Apr 18;121(16):3228-36

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