Gene Expression Literature Summary

• Symbol: Meox1
• Name: mesenchyme homeobox 1
• ID: MGI:103220

166 matching records from 166 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E6	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E18.5	E	P
Immunohistochemistry (section)					1		2	1			2		1
In situ RNA (section)				1	3	1	12	2	8		4	1	1		4	2	4		3		1	1	2	4
Immunohistochemistry (whole mount)				1		1	5	1	2	1
In situ RNA (whole mount)					3	9	50	10	43	4	26	3	7	1					2				7	1
Northern blot		1	1		1		1	1	1												1			1
RT-PCR	1			1	1		2		4				2		3	1	1	1	1	1	1	1		2
cDNA clones							1																1	2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Meox1  mesenchyme homeobox 1   (Synonyms: D330041M02Rik, Mox-1, Mox1)
Results	Reference
1	J:239303 Amin S, Neijts R, Simmini S, van Rooijen C, Tan SC, Kester L, van Oudenaarden A, Creyghton MP, Deschamps J, Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche. Cell Rep. 2016 Dec 20;17(12):3165-3177
1	J:313582 Anderson MJ, Magidson V, Kageyama R, Lewandoski M, Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function. Elife. 2020 Nov 19;9:e55608
1*	J:30828 Ang SL, Jin O, Rhinn M, Daigle N, Stevenson L, Rossant J, A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development. 1996 Jan;122(1):243-52
1*	J:19895 Ang SL, Rossant J, HNF-3 beta is essential for node and notochord formation in mouse development. Cell. 1994 Aug 26;78(4):561-74
1	J:290418 Ashokkumar D, Zhang Q, Much C, Bledau AS, Naumann R, Alexopoulou D, Dahl A, Goveas N, Fu J, Anastassiadis K, Stewart AF, Kranz A, MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation. Development. 2020 Jun 17;147(12):dev186999
1	J:251816 Bazzi H, Soroka E, Alcorn HL, Anderson KV, STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10928-E10936
1*	J:63761 Beckers J, Schlautmann N, Gossler A, The mouse rib-vertebrae mutation disrupts anterior-posterior somite patterning and genetically interacts with a delta1 null allele. Mech Dev. 2000 Jul;95(1-2):35-46
1*	J:83956 Bladt F, Aippersbach E, Gelkop S, Strasser GA, Nash P, Tafuri A, Gertler FB, Pawson T, The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol. 2003 Jul;23(13):4586-97
1	J:183946 Bloomekatz J, Grego-Bessa J, Migeotte I, Anderson KV, Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo. Dev Biol. 2012 Apr 15;364(2):192-201
3	J:330573 Bonet F, Anez SB, Inacio JM, Futschik ME, Belo JA, CCBE1 Is Essential for Epicardial Function during Myocardium Development. Int J Mol Sci. 2022 Oct 20;23(20)
1	J:52317 Borello U, Coletta M, Tajbakhsh S, Leyns L, De Robertis EM, Buckingham M, Cossu G, Transplacental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos. Development. 1999 Oct;126(19):4247-55
2*	J:226497 Brewer JR, Molotkov A, Mazot P, Hoch RV, Soriano P, Fgfr1 regulates development through the combinatorial use of signaling proteins. Genes Dev. 2015 Sep 1;29(17):1863-74
1	J:90513 Bussen M, Petry M, Schuster-Gossler K, Leitges M, Gossler A, Kispert A, The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev. 2004 May 15;18(10):1209-21
15*	J:3682 Candia AF, Hu J, Crosby J, Lalley PA, Noden D, Nadeau JH, Wright CV, Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development. 1992 Dec;116(4):1123-36
5*	J:38427 Candia AF, Wright CV, Differential localization of Mox-1 and Mox-2 proteins indicates distinct roles during development. Int J Dev Biol. 1996 Dec;40(6):1179-84
1*	J:259848 Chal J, Al Tanoury Z, Oginuma M, Moncuquet P, Gobert B, Miyanari A, Tassy O, Guevara G, Hubaud A, Bera A, Sumara O, Garnier JM, Kennedy L, Knockaert M, Gayraud-Morel B, Tajbakhsh S, Pourquie O, Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro. Development. 2018 Mar 19;145(6):dev157339
1*	J:80954 Chapman DL, Papaioannou VE, Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature. 1998 Feb 12;391(6668):695-7
2	J:139339 Chawengsaksophak K, de Graaff W, Rossant J, Deschamps J, Beck F, Cdx2 is essential for axial elongation in mouse development. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7641-5
1	J:81582 Chen W, Liang Y, Deng W, Shimizu K, Ashique AM, Li E, Li YP, The zinc-finger protein CNBP is required for forebrain formation in the mouse. Development. 2003 Apr;130(7):1367-79
2	J:21129 Chen WS, Manova K, Weinstein DC, Duncan SA, Plump AS, Prezioso VR, Bachvarova RF, Darnell JE Jr, Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 1994 Oct 15;8(20):2466-77
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
3	J:348800 Clark JF, Soriano P, Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development. Genes Dev. 2024 Jun 4;
1*	J:19211 Conlon FL, Lyons KM, Takaesu N, Barth KS, Kispert A, Herrmann B, Robertson EJ, A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development. 1994 Jul;120(7):1919-28
6*	J:23131 Conlon FL, Wright CV, Robertson EJ, Effects of the TWis mutation on notochord formation and mesodermal patterning. Mech Dev. 1995 Feb;49(3):201-9
1*	J:25248 Conlon RA, Reaume AG, Rossant J, Notch1 is required for the coordinate segmentation of somites. Development. 1995 May;121(5):1533-45
2*	J:185600 Cota CD, Garcia-Garcia MJ, The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis. Dev Dyn. 2012 Aug;241(8):1249-59
1	J:186907 D'Andrea D, Liguori GL, Le Good JA, Lonardo E, Andersson O, Constam DB, Persico MG, Minchiotti G, Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction. J Cell Biol. 2008 Feb 11;180(3):597-605
1	J:239417 Dai HQ, Wang BA, Yang L, Chen JJ, Zhu GC, Sun ML, Ge H, Wang R, Chapman DL, Tang F, Sun X, Xu GL, TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature. 2016 Oct 27;538(7626):528-532
2	J:143845 Davy A, Soriano P, Ephrin-B2 forward signaling regulates somite patterning and neural crest cell development. Dev Biol. 2007 Apr 1;304(1):182-93
1	J:221164 Di Giovanni V, Walker KA, Bushnell D, Schaefer C, Sims-Lucas S, Puri P, Bates CM, Fibroblast growth factor receptor-Frs2alpha signaling is critical for nephron progenitors. Dev Biol. 2015 Apr 1;400(1):82-93
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2	J:50343 Ding J, Yang L, Yan YT, Chen A, Desai N, Wynshaw-Boris A, Shen MM, Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo [see comments]. Nature. 1998 Oct 15;395(6703):702-7
1	J:89189 Dunn NR, Vincent SD, Oxburgh L, Robertson EJ, Bikoff EK, Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo. Development. 2004 Apr;131(8):1717-28
1*	J:129202 Dunty WC Jr, Biris KK, Chalamalasetty RB, Taketo MM, Lewandoski M, Yamaguchi TP, Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation. Development. 2008 Jan;135(1):85-94
1	J:142039 Egea J, Erlacher C, Montanez E, Burtscher I, Yamagishi S, Hess M, Hampel F, Sanchez R, Rodriguez-Manzaneque MT, Bosl MR, Fassler R, Lickert H, Klein R, Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Genes Dev. 2008 Dec 1;22(23):3349-3362
1	J:355651 El Azhar Y, Schulthess P, van Oostrom MJ, Weterings SDC, Meijer WHM, Tsuchida-Straeten N, Thomas WM, Bauer M, Sonnen KF, Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking. Development. 2024 Sep 15;151(18):dev202936
1	J:58961 Esterbauer H, Oberkofler H, Krempler F, Patsch W, Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics. 1999 Nov 15;62(1):98-102
1	J:332217 Feng J, Han X, Yuan Y, Cho CK, Janeckova E, Guo T, Pareek S, Rahman MS, Zheng B, Bi J, Jing J, Zhang M, Xu J, Ho TV, Chai Y, TGF-beta signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development. Elife. 2022 Dec 21;11
2*	J:41809 Filosa S, RiveraPerez JA, Gomez AP, Gansmuller A, Sasaki H, Behringer RR, Ang SL, goosecoid and HNF-3 beta genetically interact to regulate neural tube patterning during mouse embryogenesis. Development. 1997 JUL;124(14):2843-2854
2*	J:134429 Flagg AE, Earley JU, Svensson EC, FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Dev Biol. 2007 Apr 1;304(1):308-16
2*	J:45340 Friedrich GA, Hildebrand JD, Soriano P, The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse. Dev Biol. 1997 Dec 15;192(2):364-74
1*	J:29978 Furuta Y, Ilic D, Kanazawa S, Takeda N, Yamamoto T, Aizawa S, Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene. 1995 Nov 16;11(10):1989-95
1	J:159978 Gao Z, Kim GH, Mackinnon AC, Flagg AE, Bassett B, Earley JU, Svensson EC, Ets1 is required for proper migration and differentiation of the cardiac neural crest. Development. 2010 May;137(9):1543-51
1	J:98216 Garcia-Garcia MJ, Eggenschwiler JT, Caspary T, Alcorn HL, Wyler MR, Huangfu D, Rakeman AS, Lee JD, Feinberg EH, Timmer JR, Anderson KV, Inaugural Article: Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5913-9
3	J:139139 Garcia-Garcia MJ, Shibata M, Anderson KV, Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development. 2008 Sep;135(18):3053-62
1	J:139149 Gaunt SJ, Drage D, Trubshaw RC, Increased Cdx protein dose effects upon axial patterning in transgenic lines of mice. Development. 2008 Aug;135(15):2511-20
1	J:36210 Georges-Labouesse EN, George EL, Rayburn H, Hynes RO, Mesodermal development in mouse embryos mutant for fibronectin. Dev Dyn. 1996 Oct;207(2):145-56
6	J:107403 Glaser S, Schaft J, Lubitz S, Vintersten K, van der Hoeven F, Tufteland KR, Aasland R, Anastassiadis K, Ang SL, Stewart AF, Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development. Development. 2006 Apr;133(8):1423-32
1*	J:44237 Goh KL, Yang JT, Hynes RO, Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos. Development. 1997 Nov;124(21):4309-19
1	J:179218 Grainger S, Lam J, Savory JG, Mears AJ, Rijli FM, Lohnes D, Cdx regulates Dll1 in multiple lineages. Dev Biol. 2012 Jan 1;361(1):1-11
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
2	J:31335 Greco TL, Takada S, Newhouse MM, McMahon JA, McMahon AP, Camper SA, Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev. 1996 Feb 1;10(3):313-24
1*	J:47700 Greene ND, Gerrelli D, Van Straaten HW, Copp AJ, Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects. Mech Dev. 1998 Apr;73(1):59-72
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1*	J:96452 Gurniak CB, Perlas E, Witke W, The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev Biol. 2005 Feb 1;278(1):231-41
1	J:77443 Hart AH, Hartley L, Sourris K, Stadler ES, Li R, Stanley EG, Tam PP, Elefanty AG, Robb L, Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. Development. 2002 Aug;129(15):3597-608
1	J:279070 Hernandez-Martinez R, Ramkumar N, Anderson KV, p120-catenin regulates WNT signaling and EMT in the mouse embryo. Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16872-16881
1*	J:58691 Hildebrand JD, Soriano P, Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice. Cell. 1999 Nov 24;99(5):485-97
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
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1*	J:122556 Inoue T, Ota M, Mikoshiba K, Aruga J, Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo. Dev Biol. 2007 Jun 15;306(2):669-84
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1	J:104870 Jin O, Harpal K, Ang SL, Rossant J, Otx2 and HNF3beta genetically interact in anterior patterning. Int J Dev Biol. 2001;45(1):357-65
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1*	J:102739 Jukkola T, Trokovic R, Maj P, Lamberg A, Mankoo B, Pachnis V, Savilahti H, Partanen J, Meox1Cre: a mouse line expressing Cre recombinase in somitic mesoderm. Genesis. 2005 Nov;43(3):148-53
1*	J:48268 Kasarskis A, Manova K, Anderson KV, A phenotype-based screen for embryonic lethal mutations in the mouse. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7485-90
5	J:170613 Kirilenko P, He G, Mankoo BS, Mallo M, Jones R, Bobola N, Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2. Mol Cell Biol. 2011 Mar;31(6):1301-8
2	J:62984 Kitajima S, Takagi A, Inoue T, Saga Y, MesP1 and MesP2 are essential for the development of cardiac mesoderm. Development. 2000 Aug;127(15):3215-26
1*	J:222399 Kitazawa T, Fujisawa K, Narboux-Neme N, Arima Y, Kawamura Y, Inoue T, Wada Y, Kohro T, Aburatani H, Kodama T, Kim KS, Sato T, Uchijima Y, Maeda K, Miyagawa-Tomita S, Minoux M, Rijli FM, Levi G, Kurihara Y, Kurihara H, Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process. Dev Biol. 2015 Jun 15;402(2):162-74
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2*	J:329046 Li B, Brusman L, Dahlka J, Niswander LA, TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration. Development. 2022 Sep 1;149(17):dev200442
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1	J:320197 Magaletta ME, Lobo M, Kernfeld EM, Aliee H, Huey JD, Parsons TJ, Theis FJ, Maehr R, Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development. Nat Commun. 2022 Jan 24;13(1):457
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1	J:173526 Migeotte I, Grego-Bessa J, Anderson KV, Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo. Development. 2011 Jul;138(14):3011-20
1	J:70273 Mitchell KJ, Pinson KI, Kelly OG, Brennan J, Zupicich J, Scherz P, Leighton PA, Goodrich LV, Lu X, Avery BJ, Tate P, Dill K, Pangilinan E, Wakenight P, Tessier-Lavigne M, Skarnes WC, Functional analysis of secreted and transmembrane proteins critical to mouse development. Nat Genet. 2001 Jul;28(3):241-9
2	J:119568 Miura S, Davis S, Klingensmith J, Mishina Y, BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development. 2006 Oct;133(19):3767-75
1	J:177114 Miura S, Mishina Y, Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of smads and TAK1 in early mouse embryo. Dev Dyn. 2011 Nov;240(11):2474-81
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3*	J:64982 Nacke S, Schafer R, M, De Angelis H, Mundlos S, Mouse mutant 'rib-vertebrae' (rv): A defect in somite polarity. Dev Dyn. 2000 Oct;219(2):192-200
2	J:170831 Naiche LA, Holder N, Lewandoski M, FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4018-23
1	J:110233 Nakajima Y, Morimoto M, Takahashi Y, Koseki H, Saga Y, Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2. Development. 2006 Jul;133(13):2517-25
1	J:54067 Niederreither K, Subbarayan V, Dolle P, Chambon P, Embryonic retinoic acid synthesis is essential for early mouse post-implantation development [see comments]. Nat Genet. 1999 Apr;21(4):444-8
2*	J:185807 Nowotschin S, Ferrer-Vaquer A, Concepcion D, Papaioannou VE, Hadjantonakis AK, Interaction of Wnt3a, Msgn1 and Tbx6 in neural versus paraxial mesoderm lineage commitment and paraxial mesoderm differentiation in the mouse embryo. Dev Biol. 2012 Jul 1;367(1):1-14
1*	J:29277 Oka C, Nakano T, Wakeham A, de la Pompa JL, Mori C, Sakai T, Okazaki S, Kawaichi M, Shiota K, Mak TW, Honjo T, Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development. 1995 Oct;121(10):3291-301
1	J:299536 Omelchenko T, Hall A, Anderson KV, beta-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo. Nat Commun. 2020 Nov 27;11(1):6066
1	J:237500 Osipovich AB, Gangula R, Vianna PG, Magnuson MA, Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation. Development. 2016 Dec 15;143(24):4595-4607
1*	J:90276 Ota MS, Loebel DA, O'Rourke MP, Wong N, Tsoi B, Tam PP, Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells. Dev Dyn. 2004 Jun;230(2):216-28
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