Gene Expression Literature Summary
|
Symbol Name ID |
Hand2
heart and neural crest derivatives expressed 2 MGI:103580 |
| Age | E5.5 | E6.5 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E | P |
| Immunohistochemistry (section) | 1 | 1 | 1 | 1 | 1 | 5 | 1 | 4 | 3 | 1 | 3 | 2 | 1 | 1 | 2 | 5 | ||||||||||||
| In situ RNA (section) | 1 | 1 | 5 | 3 | 22 | 3 | 36 | 2 | 14 | 1 | 16 | 2 | 8 | 2 | 11 | 1 | 2 | 2 | 11 | 1 | 1 | 2 | 1 | 8 | 7 | |||
| In situ RNA (whole mount) | 6 | 2 | 7 | 11 | 63 | 20 | 103 | 10 | 39 | 2 | 12 | 1 | 1 | 1 | 3 | 1 | 1 | 14 | 1 | |||||||||
| In situ reporter (knock in) | 2 | 1 | 3 | 1 | 1 | |||||||||||||||||||||||
| Northern blot | 1 | 1 | 1 | 1 | 1 | |||||||||||||||||||||||
| Western blot | 2 | 5 | 1 | 1 | 4 | |||||||||||||||||||||||
| RT-PCR | 1 | 7 | 5 | 26 | 3 | 24 | 2 | 7 | 1 | 9 | 10 | 2 | 4 | 1 | 1 | 6 | 1 | 2 | 1 | 6 | 1 | 21 | ||||||
| cDNA clones | 1 | 1 | 1 | 1 |
| Hand2 heart and neural crest derivatives expressed 2 (Synonyms: bHLHa26, dHAND, Ehand2, Hed, Thing2) | |
| Results | Reference |
| 1 | J:310312 Abe M, Cox TC, Firulli AB, Kanai SM, Dahlka J, Lim KC, Engel JD, Clouthier DE, GATA3 is essential for separating patterning domains during facial morphogenesis. Development. 2021 Sep 1;148(17):dev199534 |
| 5* | J:162064 Abe M, Michikami I, Fukushi T, Abe A, Maeda Y, Ooshima T, Wakisaka S, Hand2 regulates chondrogenesis in vitro and in vivo. Bone. 2010 May;46(5):1359-68 |
| 5* | J:81037 Abe M, Tamamura Y, Yamagishi H, Maeda T, Kato J, Tabata MJ, Srivastava D, Wakisaka S, Kurisu K, Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis. Cell Tissue Res. 2002 Nov;310(2):201-12 |
| 2 | J:78687 Abu-Issa R, Smyth G, Smoak I, Yamamura K, Meyers EN, Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse. Development. 2002 Oct;129(19):4613-25 |
| 1 | J:81154 Agarwal P, Wylie JN, Galceran J, Arkhitko O, Li C, Deng C, Grosschedl R, Bruneau BG, Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo. Development. 2003 Feb;130(3):623-33 |
| 2 | J:163487 Aggarwal VS, Carpenter C, Freyer L, Liao J, Petti M, Morrow BE, Mesodermal Tbx1 is required for patterning the proximal mandible in mice. Dev Biol. 2010 Aug 15;344(2):669-81 |
| 1* | J:236309 Aires R, Jurberg AD, Leal F, Novoa A, Cohn MJ, Mallo M, Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity. Dev Cell. 2016 Aug 8;38(3):262-74 |
| 1 | J:207610 Akiyama R, Kawakami H, Taketo MM, Evans SM, Wada N, Petryk A, Kawakami Y, Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the beta-catenin pathway. Dev Biol. 2014 Mar 1;387(1):37-48 |
| 2 | J:220960 Akiyama R, Kawakami H, Wong J, Oishi I, Nishinakamura R, Kawakami Y, Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5075-80 |
| 8* | J:241318 Anderson KM, Anderson DM, McAnally JR, Shelton JM, Bassel-Duby R, Olson EN, Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development. Nature. 2016 Nov 17;539(7629):433-436 |
| 1 | J:303634 Arai Y, Ito M, Tanaka K, Ozawa J, Motojima Y, Matsuoka K, Igarashi K, Namba F, Increased expression of heme oxygenase-1 suppresses airway branching morphogenesis in fetal mouse lungs exposed to inflammation. Pediatr Res. 2020 Feb;87(3):494-500 |
| 1* | J:181888 Ashe A, Butterfield NC, Town L, Courtney AD, Cooper AN, Ferguson C, Barry R, Olsson F, Liem KF Jr, Parton RG, Wainwright BJ, Anderson KV, Whitelaw E, Wicking C, Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Hum Mol Genet. 2012 Apr 15;21(8):1808-23 |
| 3* | J:135300 Babbs C, Furniss D, Morriss-Kay GM, Wilkie AO, Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog. Mech Dev. 2008 May-Jun;125(5-6):517-26 |
| 2 | J:152830 Balic A, Adams D, Mina M, Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process. Dev Dyn. 2009 Sep 23;238(10):2599-2613 |
| 1 | J:175541 Bangs F, Antonio N, Thongnuek P, Welten M, Davey MG, Briscoe J, Tickle C, Generation of mice with functional inactivation of talpid3, a gene first identified in chicken. Development. 2011 Aug;138(15):3261-72 |
| 2 | J:128020 Barbosa AC, Funato N, Chapman S, McKee MD, Richardson JA, Olson EN, Yanagisawa H, Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol. 2007 Oct 1;310(1):154-68 |
| 1* | J:245730 Bardot P, Vincent SD, Fournier M, Hubaud A, Joint M, Tora L, Pourquie O, The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Development. 2017 Oct 15;144(20):3808-3818 |
| 2* | J:165398 Barnes RM, Firulli BA, Conway SJ, Vincentz JW, Firulli AB, Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives. Dev Dyn. 2010 Nov;239(11):3086-97 |
| 3 | J:171088 Barnes RM, Firulli BA, Vandusen NJ, Morikawa Y, Conway SJ, Cserjesi P, Vincentz JW, Firulli AB, Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development. Circ Res. 2011 Apr 15;108(8):940-9 |
| 4 | J:173619 Barron F, Woods C, Kuhn K, Bishop J, Howard MJ, Clouthier DE, Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis. Development. 2011 Jun;138(11):2249-59 |
| 1* | J:83881 Bell SM, Schreiner CM, Hess KA, Anderson KP, Scott WJ, Asymmetric limb malformations in a new transgene insertional mutant, footless. Mech Dev. 2003 May;120(5):597-605 |
| 2 | J:171190 Bensoussan-Trigano V, Lallemand Y, Saint Cloment C, Robert B, Msx1 and Msx2 in limb mesenchyme modulate digit number and identity. Dev Dyn. 2011 May;240(5):1190-202 |
| 1 | J:327336 Bertol JW, Johnston S, Ahmed R, Xie VK, Hubka KM, Cruz L, Nitschke L, Stetsiv M, Goering JP, Nistor P, Lowell S, Hoskens H, Claes P, Weinberg SM, Saadi I, Farach-Carson MC, Fakhouri WD, TWIST1 interacts with beta/delta-catenins during neural tube development and regulates fate transition in cranial neural crest cells. Development. 2022 Aug 1;149(15):dev200068 |
| 1* | J:80696 Beverdam A, Merlo GR, Paleari L, Mantero S, Genova F, Barbieri O, Janvier P, Levi G, Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: Mirror of the past?. Genesis. 2002 Dec;34(4):221-7 |
| 1 | J:303643 Bi X, Wang K, Yang L, Pan H, Jiang H, Wei Q, Fang M, Yu H, Zhu C, Cai Y, He Y, Gan X, Zeng H, Yu D, Zhu Y, Jiang H, Qiu Q, Yang H, Zhang YE, Wang W, Zhu M, He S, Zhang G, Tracing the genetic footprints of vertebrate landing in non-teleost ray-finned fishes. Cell. 2021 Mar 4;184(5):1377-1391.e14 |
| 7 | J:41048 Biben C, Harvey RP, Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. Genes Dev. 1997 Jun 1;11(11):1357-69 |
| 2* | J:168038 Bimonte S, De Angelis A, Quagliata L, Giusti F, Tammaro R, Dallai R, Ascenzi MG, Diez-Roux G, Franco B, Ofd1 is required in limb bud patterning and endochondral bone development. Dev Biol. 2011 Jan 15;349(2):179-91 |
| 2 | J:278550 Boing M, Brand-Saberi B, Napirei M, Murine transcription factor Math6 is a regulator of placenta development. Sci Rep. 2018 Oct 9;8(1):14997 |
| 1 | J:181229 Bonilla-Claudio M, Wang J, Bai Y, Klysik E, Selever J, Martin JF, Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development. Development. 2012 Feb;139(4):709-19 |
| 2 | J:230425 Bouilloux F, Thireau J, Venteo S, Farah C, Karam S, Dauvilliers Y, Valmier J, Copeland NG, Jenkins NA, Richard S, Marmigere F, Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. Elife. 2016;5:e11627 |
| 1 | J:188038 Bowers M, Eng L, Lao Z, Turnbull RK, Bao X, Riedel E, Mackem S, Joyner AL, Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3. Dev Biol. 2012 Oct 1;370(1):110-24 |
| 4 | J:201804 Breckenridge RA, Piotrowska I, Ng KE, Ragan TJ, West JA, Kotecha S, Towers N, Bennett M, Kienesberger PC, Smolenski RT, Siddall HK, Offer JL, Mocanu MM, Yelon DM, Dyck JR, Griffin JL, Abramov AY, Gould AP, Mohun TJ, Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism. PLoS Biol. 2013 Sep;11(9):e1001666 |
| 2* | J:69468 Briegel KJ, Joyner AL, Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development. Dev Biol. 2001 May 15;233(2):291-304 |
| 1* | J:116770 Britanova O, Depew MJ, Schwark M, Thomas BL, Miletich I, Sharpe P, Tarabykin V, Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development. Am J Hum Genet. 2006 Oct;79(4):668-78 |
| 2 | J:67359 Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG, Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Mol Cell Biol. 2001 Mar;21(5):1730-6 |
| 1 | J:71845 Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG, A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell. 2001 Sep 21;106(6):709-21 |
| 1 | J:149223 Buchmann-Moller S, Miescher I, John N, Krishnan J, Deng CX, Sommer L, Multiple lineage-specific roles of Smad4 during neural crest development. Dev Biol. 2009 Jun 15;330(2):329-38 |
| 3 | J:153595 Butterfield NC, Metzis V, McGlinn E, Bruce SJ, Wainwright BJ, Wicking C, Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. Development. 2009 Oct;136(20):3515-24 |
| 1 | J:98516 Cai CL, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Li X, Rosenfeld MG, Chen J, Evans S, T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development. 2005 May;132(10):2475-87 |
| 1* | J:199480 Cao T, Wang C, Yang M, Wu C, Wang B, Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants. Dev Biol. 2013 Jul 15;379(2):221-8 |
| 3 | J:109528 Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L, Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development. 2006 Jun;133(11):2263-73 |
| 1 | J:239780 Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G, The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors. Cell Stem Cell. 2015 Sep 03;17(3):287-99 |
| 2 | J:332132 Cattaneo P, Hayes MGB, Baumgarten N, Hecker D, Peruzzo S, Aslan GS, Kunderfranco P, Larcher V, Zhang L, Contu R, Fonseca G, Spinozzi S, Chen J, Condorelli G, Dimmeler S, Schulz MH, Heinz S, Guimaraes-Camboa N, Evans SM, DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal. Nat Commun. 2022 Dec 2;13(1):7444 |
| 9* | J:62028 Charite J, McFadden DG, Olson EN, The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. Development. 2000 Jun;127(11):2461-70 |
| 1* | J:48572 Charng MJ, Frenkel PA, Lin Q, Yamada M, Schwartz RJ, Olson EN , Overbeek P , Schneider MD, A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice. Dev Biol. 1998 Jul 1;199(1):72-9 |
| 1 | J:197773 Chen D, Li S, Singh R, Spinette S, Sedlmeier R, Epstein HF, Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development. J Cell Sci. 2012 Aug 15;125(Pt 16):3893-903 |
| 1 | J:89476 Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, Chen Z, Yang Z, Schneider MD, Chien KR, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou W, BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004 May;131(9):2219-31 |
| 1 | J:139946 Chen YH, Ishii M, Sucov HM, Maxson RE Jr, Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol. 2008;8:75 |
| 2 | J:124119 Chen YH, Ishii M, Sun J, Sucov HM, Maxson RE Jr, Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Dev Biol. 2007 Aug 15;308(2):421-37 |
| 2* | J:59338 Clouthier DE, Williams SC, Yanagisawa H, Wieduwilt M, Richardson JA, Yanagisawa M, Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice. Dev Biol. 2000 Jan 1;217(1):10-24 |
| 1 | J:184511 Cohen ED, Miller MF, Wang Z, Moon RT, Morrisey EE, Wnt5a and Wnt11 are essential for second heart field progenitor development. Development. 2012 Jun;139(11):1931-40 |
| 1 | J:161416 Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG, Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol. 2010 Jun 15;342(2):169-79 |
| 1 | J:196365 Compagnucci C, Debiais-Thibaud M, Coolen M, Fish J, Griffin JN, Bertocchini F, Minoux M, Rijli FM, Borday-Birraux V, Casane D, Mazan S, Depew MJ, Pattern and polarity in the development and evolution of the gnathostome jaw: Both conservation and heterotopy in the branchial arches of the shark, Scyliorhinus canicula. Dev Biol. 2013 May 15;377(2):428-48 |
| 3 | J:166770 Coppola E, d'Autreaux F, Rijli FM, Brunet JF, Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation. Development. 2010 Dec;137(24):4211-20 |
| 1 | J:77392 Crispino JD, Lodish MB, Thurberg BL, Litovsky SH, Collins T, Molkentin JD, Orkin SH, Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev. 2001 Apr 1;15(7):839-44 |
| 5* | J:28009 Cross JC, Flannery ML, Blanar MA, Steingrimsson E, Jenkins NA, Copeland NG, Rutter WJ, Werb Z, Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development. 1995 Aug;121(8):2513-23 |
| 1 | J:167534 Cui C, Chatterjee B, Francis D, Yu Q, SanAgustin JT, Francis R, Tansey T, Henry C, Wang B, Lemley B, Pazour GJ, Lo CW, Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome. Dis Model Mech. 2011 Jan;4(1):43-56 |
| 11 | J:135127 D'Autreaux F, Morikawa Y, Cserjesi P, Gershon MD, Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia. Development. 2007 Jun;134(12):2237-49 |
| 1* | J:82458 Davenport TG, Jerome-Majewska LA, Papaioannou VE, Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome. Development. 2003 May;130(10):2263-73 |
| 1 | J:297083 De Zoysa P, Liu J, Toubat O, Choi J, Moon A, Gill PS, Duarte A, Sucov HM, Kumar SR, Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression. Development. 2020 Sep 11;147(17):dev185249 |
| 1* | J:264204 Deimling SJ, Lau K, Hui CC, Hopyan S, Genetic interaction between Gli3 and Ezh2 during limb pattern formation. Mech Dev. 2018 Jun;151:30-36 |
| 1 | J:176023 del Barco Barrantes I, Coya JM, Maina F, Arthur JS, Nebreda AR, Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12764-9 |
| 6 | J:262042 Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B, Harvey RP, Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature. 2018 May;557(7705):439-445 |
| 2* | J:114714 DeLaurier A, Schweitzer R, Logan M, Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb. Dev Biol. 2006 Nov 1;299(1):22-34 |
| 1 | J:301894 Delgado I, Lopez-Delgado AC, Rosello-Diez A, Giovinazzo G, Cadenas V, Fernandez-de-Manuel L, Sanchez-Cabo F, Anderson MJ, Lewandoski M, Torres M, Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb. Sci Adv. 2020 Jun;6(23):eaaz0742 |
| 1 | J:79553 Depew MJ, Lufkin T, Rubenstein JL, Specification of jaw subdivisions by Dlx genes. Science. 2002 Oct 11;298(5592):381-5 |
| 1 | J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41 |
| 1 | J:104550 Dettlaff-Swiercz DA, Wettschureck N, Moers A, Huber K, Offermanns S, Characteristic defects in neural crest cell-specific Galphaq/Galpha11- and Galpha12/Galpha13-deficient mice. Dev Biol. 2005 Jun 1;282(1):174-82 |
| 1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
| 6 | J:208305 Dirkx E, Gladka MM, Philippen LE, Armand AS, Kinet V, Leptidis S, El Azzouzi H, Salic K, Bourajjaj M, da Silva GJ, Olieslagers S, van der Nagel R, de Weger R, Bitsch N, Kisters N, Seyen S, Morikawa Y, Chanoine C, Heymans S, Volders PG, Thum T, Dimmeler S, Cserjesi P, Eschenhagen T, da Costa Martins PA, De Windt LJ, Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. Nat Cell Biol. 2013 Nov;15(11):1282-93 |
| 4* | J:188116 Dobreva MP, Lhoest L, Pereira PN, Umans L, Chuva de Sousa Lopes SM, Zwijsen A, Periostin as a biomarker of the amniotic membrane. Stem Cells Int. 2012;2012:987185 |
| 2* | J:296137 Elliott KH, Chen X, Salomone J, Chaturvedi P, Schultz PA, Balchand SK, Servetas JD, Zuniga A, Zeller R, Gebelein B, Weirauch MT, Peterson KA, Brugmann SA, Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks. Elife. 2020 Oct 2;9:e56450 |
| 3 | J:232111 Emechebe U, Kumar P P, Rozenberg JM, Moore B, Firment A, Mirshahi T, Moon AM, T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number. Elife. 2016;5:e07897 |
| 1 | J:294823 Fabik J, Kovacova K, Kozmik Z, Machon O, Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway. Biol Open. 2020 Jul 2;9(6):bio052043 |
| 1 | J:330128 Fabik J, Psutkova V, Machon O, Meis2 controls skeletal formation in the hyoid region. Front Cell Dev Biol. 2022;10:951063 |
| 1 | J:267941 Fakhouri WD, Metwalli K, Naji A, Bakhiet S, Quispe-Salcedo A, Nitschke L, Kousa YA, Schutte BC, Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development. Sci Rep. 2017 Aug 2;7(1):7129 |
| 1 | J:245948 Fell SM, Li S, Wallis K, Kock A, Surova O, Rraklli V, Hofig CS, Li W, Mittag J, Henriksson MA, Kenchappa RS, Holmberg J, Kogner P, Schlisio S, Neuroblast differentiation during development and in neuroblastoma requires KIF1Bbeta-mediated transport of TRKA. Genes Dev. 2017 May 15;31(10):1036-1053 |
| 3* | J:345311 Ferguson CA, Firulli BA, Zoia M, Osterwalder M, Firulli AB, Identification and characterization of Hand2 upstream genomic enhancers active in developing stomach and limbs. Dev Dyn. 2024 Feb;253(2):215-232 |
| 6 | J:61522 Fernandez-Teran M, Piedra ME, Kathiriya IS, Srivastava D, Rodriguez-Rey JC, Ros MA, Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the sonic hedgehog pathway. Development. 2000 May;127(10):2133-42 |
| 1 | J:85089 Firulli AB, A HANDful of questions: the molecular biology of the heart and neural crest derivatives (HAND)-subclass of basic helix-loop-helix transcription factors. Gene. 2003 Jul 17;312:27-40 |
| 1 | J:46384 Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN, Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet. 1998 Mar;18(3):266-70 |
| 1* | J:306226 Firulli BA, George RM, Harkin J, Toolan KP, Gao H, Liu Y, Zhang W, Field LJ, Liu Y, Shou W, Payne RM, Rubart-von der Lohe M, Firulli AB, HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure. Cardiovasc Res. 2020 Mar 1;116(3):605-618 |
| 4 | J:105168 Firulli BA, Krawchuk D, Centonze VE, Vargesson N, Virshup DM, Conway SJ, Cserjesi P, Laufer E, Firulli AB, Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet. 2005 Apr;37(4):373-81 |
| 3 | J:164028 Firulli BA, McConville DP, Byers JS 3rd, Vincentz JW, Barnes RM, Firulli AB, Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability. Dev Dyn. 2010 Oct;239(10):2748-60 |
| 3 | J:144188 Funato N, Chapman SL, McKee MD, Funato H, Morris JA, Shelton JM, Richardson JA, Yanagisawa H, Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2. Development. 2009 Feb;136(4):615-25 |
| 3 | J:259576 Funato N, Kokubo H, Nakamura M, Yanagisawa H, Saga Y, Specification of jaw identity by the Hand2 transcription factor. Sci Rep. 2016 Jun 22;6:28405 |
| 1 | J:167570 Funato Y, Terabayashi T, Sakamoto R, Okuzaki D, Ichise H, Nojima H, Yoshida N, Miki H, Nucleoredoxin sustains Wnt/beta-catenin signaling by retaining a pool of inactive dishevelled protein. Curr Biol. 2010 Nov 9;20(21):1945-52 |
| 1 | J:249416 Furtado MB, Costa MW, Pranoto EA, Salimova E, Pinto AR, Lam NT, Park A, Snider P, Chandran A, Harvey RP, Boyd R, Conway SJ, Pearson J, Kaye DM, Rosenthal NA, Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair. Circ Res. 2014 Apr 25;114(9):1422-34 |
| 1 | J:288683 Gacem N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J, Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N, ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. Nat Commun. 2020 Jan 10;11(1):198 |
| 4 | J:159210 Galli A, Robay D, Osterwalder M, Bao X, Benazet JD, Tariq M, Paro R, Mackem S, Zeller R, Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet. 2010;6(4):e1000901 |
| 2 | J:331853 Gao R, Liang X, Cheedipudi S, Cordero J, Jisng X, Zhang Q, Caputo L, Gunther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G, Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate. Cell Res. 2019 Jun;29(6):486-501 |
| 1* | J:70279 Garg V, Yamagishi C, Hu T, Kathiriya IS, Yamagishi H, Srivastava D, Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. Dev Biol. 2001 Jul 1;235(1):62-73 |
| 1 | J:227703 Garside VC, Cullum R, Alder O, Lu DY, Vander Werff R, Bilenky M, Zhao Y, Jones SJ, Marra MA, Underhill TM, Hoodless PA, SOX9 modulates the expression of key transcription factors required for heart valve development. Development. 2015 Dec 15;142(24):4340-50 |
| 1* | J:284183 George MR, Duan Q, Nagle A, Kathiriya IS, Huang Y, Rao K, Haldar SM, Bruneau BG, Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs. Development. 2019 Dec 9;146(23):dev185314 |
| 3* | J:333400 George RM, Firulli BA, Podicheti R, Rusch DB, Mannion BJ, Pennacchio LA, Osterwalder M, Firulli AB, Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis. Development. 2023 Feb 15;150(3):dev201341 |
| 1 | J:197579 Goetz SC, Liem KF Jr, Anderson KV, The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. Cell. 2012 Nov 9;151(4):847-58 |
| 4 | J:76212 Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D, Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet. 2002 May;31(1):25-32 |
| 2* | J:79899 Grotewold L, Ruther U, The Fused toes (Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly. Dev Biol. 2002 Nov 1;251(1):129-41 |
| 2* | J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004; |
| 1 | J:175761 Gyurjan I, Sonderegger B, Naef F, Duboule D, Analysis of the dynamics of limb transcriptomes during mouse development. BMC Dev Biol. 2011;11:47 |
| 1 | J:315113 Hafner R, Bohnenpoll T, Rudat C, Schultheiss TM, Kispert A, Fgfr2 is required for the expansion of the early adrenocortical primordium. Mol Cell Endocrinol. 2015 Sep 15;413:168-77 |
| 1 | J:123620 Hakim ZS, DiMichele LA, Doherty JT, Homeister JW, Beggs HE, Reichardt LF, Schwartz RJ, Brackhan J, Smithies O, Mack CP, Taylor JM, Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment. Mol Cell Biol. 2007 Aug;27(15):5352-64 |
| 1 | J:346579 Han B, Wang Y, Yue S, Zhang YH, Kuang L, Gao BB, Wang Y, Zhang Z, Pu X, Wang XF, Hui CC, Yu TT, Liu C, Cheng SY, Increasing Sufu gene dosage reveals its unorthodox role in promoting polydactyly and medulloblastoma tumorigenesis. JCI Insight. 2024 Feb 15;9(6) |
| 2 | J:299735 Han L, Chaturvedi P, Kishimoto K, Koike H, Nasr T, Iwasawa K, Giesbrecht K, Witcher PC, Eicher A, Haines L, Lee Y, Shannon JM, Morimoto M, Wells JM, Takebe T, Zorn AM, Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis. Nat Commun. 2020 Aug 27;11(1):4158 |
| 8* | J:278239 Han X, Zhang J, Liu Y, Fan X, Ai S, Luo Y, Li X, Jin H, Luo S, Zheng H, Yue Y, Chang Z, Yang Z, Tang F, He A, Shen X, The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2. Development. 2019 Jul 4;146(13):dev176198 |
| 1 | J:233374 Hayashi S, Akiyama R, Wong J, Tahara N, Kawakami H, Kawakami Y, Gata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb Development. PLoS Genet. 2016 Jun;12(6):e1006138 |
| 1 | J:214763 He F, Hu X, Xiong W, Li L, Lin L, Shen B, Yang L, Gu S, Zhang Y, Chen Y, Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect. Dev Biol. 2014 Jul 15;391(2):170-81 |
| 1 | J:170963 Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, Martin JF, Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science. 2011 Apr 22;332(6028):458-61 |
| 5 | J:137726 Hendershot TJ, Liu H, Clouthier DE, Shepherd IT, Coppola E, Studer M, Firulli AB, Pittman DL, Howard MJ, Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons. Dev Biol. 2008 Jul 15;319(2):179-91 |
| 1 | J:138032 Hendershot TJ, Liu H, Sarkar AA, Giovannucci DR, Clouthier DE, Abe M, Howard MJ, Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system. Dev Dyn. 2007 Jan;236(1):93-105 |
| 3 | J:207974 Hill CR, Yuasa M, Schoenecker J, Goudy SL, Jagged1 is essential for osteoblast development during maxillary ossification. Bone. 2014 May;62:10-21 |
| 1* | J:149502 Hill P, Gotz K, Ruther U, A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud. Dev Biol. 2009 Apr 15;328(2):506-16 |
| 1 | J:125087 Hill P, Wang B, Ruther U, The molecular basis of Pallister Hall associated polydactyly. Hum Mol Genet. 2007 Sep 1;16(17):2089-96 |
| 1 | J:332402 Hockman D, Adameyko I, Kaucka M, Barraud P, Otani T, Hunt A, Hartwig AC, Sock E, Waithe D, Franck MCM, Ernfors P, Ehinger S, Howard MJ, Brown N, Reese J, Baker CVH, Striking parallels between carotid body glomus cell and adrenal chromaffin cell development. Dev Biol. 2018 Dec 1;444 Suppl 1(Suppl 1):S308-S324 |
| 1 | J:93588 Hu T, Yamagishi H, Maeda J, McAnally J, Yamagishi C, Srivastava D, Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development. 2004 Nov;131(21):5491-502 |
| 8* | J:92209 Huang F, Wagner M, Siddiqui MA, Ablation of the CLP-1 gene leads to down-regulation of the HAND1 gene and abnormality of the left ventricle of the heart and fetal death. Mech Dev. 2004 Jun;121(6):559-72 |
| 2 | J:199638 Huang T, Hu J, Wang B, Nie Y, Geng J, Cheng L, Tlx3 controls cholinergic transmitter and Peptide phenotypes in a subset of prenatal sympathetic neurons. J Neurosci. 2013 Jun 26;33(26):10667-75 |
| 3 | J:79390 Huber K, Bruhl B, Guillemot F, Olson EN, Ernsberger U, Unsicker K, Development of chromaffin cells depends on MASH1 function. Development. 2002 Oct;129(20):4729-38 |
| 1* | J:96531 Huber K, Karch N, Ernsberger U, Goridis C, Unsicker K, The role of Phox2B in chromaffin cell development. Dev Biol. 2005 Mar 15;279(2):501-8 |
| 2 | J:199593 Huber K, Narasimhan P, Shtukmaster S, Pfeifer D, Evans SM, Sun Y, The LIM-Homeodomain transcription factor Islet-1 is required for the development of sympathetic neurons and adrenal chromaffin cells. Dev Biol. 2013 Aug 15;380(2):286-98 |
| 2* | J:186564 Ikle JM, Artinger KB, Clouthier DE, Identification and characterization of the zebrafish pharyngeal arch-specific enhancer for the basic helix-loop-helix transcription factor Hand2. Dev Biol. 2012 Aug 1;368(1):118-26 |
| 1 | J:239155 Ikle JM, Tavares AL, King M, Ding H, Colombo S, Firulli BA, Firulli AB, Targoff KL, Yelon D, Clouthier DE, Nkx2.5 regulates endothelin converting enzyme-1 during pharyngeal arch patterning. Genesis. 2017 Mar;55(3) |
| 1 | J:267541 Inman KE, Caiaffa CD, Melton KR, Sandell LL, Achilleos A, Kume T, Trainor PA, Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion. Dev Dyn. 2018 Dec;247(12):1286-1296 |
| 1 | J:223126 Inman KE, Purcell P, Kume T, Trainor PA, Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of syngnathia. PLoS Genet. 2013;9(12):e1003949 |
| 2 | J:184018 Itou J, Kawakami H, Quach T, Osterwalder M, Evans SM, Zeller R, Kawakami Y, Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos. Development. 2012 May;139(9):1620-9 |
| 2* | J:82652 Ivey K, Tyson B, Ukidwe P, McFadden DG, Levi G, Olson EN, Srivastava D, Wilkie TM, Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme. Dev Biol. 2003 Mar 15;255(2):230-7 |
| 2 | J:232412 Jeon S, Seong RH, Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway. PLoS Genet. 2016 Mar;12(3):e1005915 |
| 1 | J:139700 Jeong J, Li X, McEvilly RJ, Rosenfeld MG, Lufkin T, Rubenstein JL, Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development. 2008 Sep;135(17):2905-16 |
| 1 | J:89445 Jeong J, Mao J, Tenzen T, Kottmann AH, McMahon AP, Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 2004 Apr 15;18(8):937-51 |
| 4 | J:312493 Jhanwar S, Malkmus J, Stolte J, Romashkina O, Zuniga A, Zeller R, Conserved and species-specific chromatin remodeling and regulatory dynamics during mouse and chicken limb bud development. Nat Commun. 2021 Sep 28;12(1):5685 |
| 1 | J:245767 Jia S, Zhou J, Fanelli C, Wee Y, Bonds J, Schneider P, Mues G, D'Souza RN, Small-molecule Wnt agonists correct cleft palates in Pax9 mutant mice in utero. Development. 2017 Oct 15;144(20):3819-3828 |
| 2 | J:171482 Jin YR, Turcotte TJ, Crocker AL, Han XH, Yoon JK, The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction. Dev Biol. 2011 Apr 1;352(1):1-13 |
| 1 | J:216160 Jurberg AD, Aires R, Novoa A, Rowland JE, Mallo M, Compartment-dependent activities of Wnt3a/beta-catenin signaling during vertebrate axial extension. Dev Biol. 2014 Oct 15;394(2):253-63 |
| 1 | J:198634 Jurberg AD, Aires R, Varela-Lasheras I, Novoa A, Mallo M, Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos. Dev Cell. 2013 Jun 10;25(5):451-62 |
| 1 | J:308791 Kameneva P, Artemov AV, Kastriti ME, Faure L, Olsen TK, Otte J, Erickson A, Semsch B, Andersson ER, Ratz M, Frisen J, Tischler AS, de Krijger RR, Bouderlique T, Akkuratova N, Vorontsova M, Gusev O, Fried K, Sundstrom E, Mei S, Kogner P, Baryawno N, Kharchenko PV, Adameyko I, Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin. Nat Genet. 2021 May;53(5):694-706 |
| 1 | J:162938 Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J, Yeh ET, SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell. 2010 Apr 23;38(2):191-201 |
| 1* | J:79831 Kawakami T, Kawcak T, Li YJ, Zhang W, Hu Y, Chuang PT, Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development. 2002 Dec;129(24):5753-65 |
| 3 | J:186421 Klaus A, Muller M, Schulz H, Saga Y, Martin JF, Birchmeier W, Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10921-6 |
| 2 | J:127596 Klaus A, Saga Y, Taketo MM, Tzahor E, Birchmeier W, Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18531-6 |
| 3 | J:99350 Kmita M, Tarchini B, Zakany J, Logan M, Tabin CJ, Duboule D, Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function. Nature. 2005 Jun 23;435(7045):1113-6 |
| 1 | J:96337 Kokubo H, Miyagawa-Tomita S, Nakazawa M, Saga Y, Johnson RL, Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. Dev Biol. 2005 Feb 15;278(2):301-9 |
| 1 | J:326952 Koyano-Nakagawa N, Gong W, Das S, Theisen JWM, Swanholm TB, Van Ly D, Dsouza N, Singh BN, Kawakami H, Young S, Chen KQ, Kawakami Y, Garry DJ, Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud. Nat Commun. 2022 Jul 21;13(1):4221 |
| 1 | J:205405 Kozhemyakina E, Ionescu A, Lassar AB, GATA6 is a crucial regulator of Shh in the limb bud. PLoS Genet. 2014 Jan;10(1):e1004072 |
| 1 | J:50877 Kraut N, Snider L, Chen CM, Tapscott SJ, Groudine M, Requirement of the mouse I-mfa gene for placental development and skeletal patterning. EMBO J. 1998 Nov 2;17(21):6276-88 |
| 4 | J:165721 Krawchuk D, Weiner SJ, Chen YT, Lu BC, Costantini F, Behringer RR, Laufer E, Twist1 activity thresholds define multiple functions in limb development. Dev Biol. 2010 Nov 1;347(1):133-46 |
| 1* | J:87042 Krebs O, Schreiner CM, Scott WJ Jr, Bell SM, Robbins DJ, Goetz JA, Alt H, Hawes N, Wolf E, Favor J, Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud. Development. 2003 Dec;130(24):6037-47 |
| 1* | J:101265 Kuijper S, Feitsma H, Sheth R, Korving J, Reijnen M, Meijlink F, Function and regulation of Alx4 in limb development: complex genetic interactions with Gli3 and Shh. Dev Biol. 2005 Sep 15;285(2):533-44 |
| 1 | J:327332 Kurz J, Weiss AC, Ludtke TH, Deuper L, Trowe MO, Thiesler H, Hildebrandt H, Heineke J, Duncan SA, Kispert A, GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter. Development. 2022 Aug 1;149(15):dev200522 |
| 1* | J:321979 Kurz J, Weiss AC, Thiesler H, Qasrawi F, Deuper L, Kaur J, Rudat C, Ludtke TH, Wojahn I, Hildebrandt H, Trowe MO, Kispert A, Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter. Development. 2022 Feb 15;149(4):dev199735 |
| 1 | J:144711 Kuss P, Villavicencio-Lorini P, Witte F, Klose J, Albrecht AN, Seemann P, Hecht J, Mundlos S, Mutant Hoxd13 induces extra digits in a mouse model of synpolydactyly directly and by decreasing retinoic acid synthesis. J Clin Invest. 2009 Jan;119(1):146-56 |
| 1 | J:164056 Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D, Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10894-9 |
| 1* | J:178176 Laforest B, Nemer M, GATA5 interacts with GATA4 and GATA6 in outflow tract development. Dev Biol. 2011 Oct 15;358(2):368-78 |
| 2 | J:255884 Laurent F, Girdziusaite A, Gamart J, Barozzi I, Osterwalder M, Akiyama JA, Lincoln J, Lopez-Rios J, Visel A, Zuniga A, Zeller R, HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development. Cell Rep. 2017 May 23;19(8):1602-1613 |
| 1 | J:155850 Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS, Choi K, ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2008 May 8;2(5):497-507 |
| 1 | J:316188 Lee MJ, Kim DE, Zakrzewska A, Yoo YD, Kim SH, Kim ST, Seo JW, Lee YS, Dorn GW 2nd, Oh U, Kim BY, Kwon YT, Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes. J Biol Chem. 2012 Jul 6;287(28):24043-52 |
| 2 | J:63359 Lee Y, Song AJ, Baker R, Micales B, Conway SJ, Lyons GE, Jumonji, a nuclear protein that is necessary for normal heart development [see comments]. Circ Res. 2000 May 12;86(9):932-8 |
| 5 | J:178308 Lei J, Howard MJ, Targeted deletion of Hand2 in enteric neural precursor cells affects its functions in neurogenesis, neurotransmitter specification and gangliogenesis, causing functional aganglionosis. Development. 2011 Nov;138(21):4789-800 |
| 1 | J:254756 Lei R, Zhang K, Wei Y, Chen M, Weinstein LS, Hong Y, Zhu M, Li H, Li H, G-Protein alpha-Subunit Gsalpha Is Required for Craniofacial Morphogenesis. PLoS One. 2016;11(2):e0147535 |
| 1* | J:317083 Letelier J, Naranjo S, Sospedra-Arrufat I, Martinez-Morales JR, Lopez-Rios J, Shubin N, Gomez-Skarmeta JL, The Shh/Gli3 gene regulatory network precedes the origin of paired fins and reveals the deep homology between distal fins and digits. Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2100575118 |
| 1 | J:321017 Leung C, Engineer A, Kim MY, Lu X, Feng Q, Myocardium-Specific Deletion of Rac1 Causes Ventricular Noncompaction and Outflow Tract Defects. J Cardiovasc Dev Dis. 2021 Mar 15;8(3) |
| 1 | J:315097 Leung C, Lu X, Liu M, Feng Q, Rac1 signaling is critical to cardiomyocyte polarity and embryonic heart development. J Am Heart Assoc. 2014 Oct 14;3(5):e001271 |
| 3* | J:226028 Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H, Vokes SA, Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103 |
| 1* | J:293790 Lewis EMA, Sankar S, Tong C, Patterson ES, Waller LE, Gontarz P, Zhang B, Ornitz DM, Kroll KL, Geminin is required for Hox gene regulation to pattern the developing limb. Dev Biol. 2020 Aug 1;464(1):11-23 |
| 2 | J:69771 Lewis PM, Dunn MP, McMahon JA, Logan M, Martin JF, St-Jacques B, McMahon AP, Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell. 2001 Jun 1;105(5):599-612 |
| 2 | J:321504 Lex RK, Zhou W, Ji Z, Falkenstein KN, Schuler KE, Windsor KE, Kim JD, Ji H, Vokes SA, GLI transcriptional repression is inert prior to Hedgehog pathway activation. Nat Commun. 2022 Feb 10;13(1):808 |
| 1* | J:213418 Li D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui CC, Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Dev Cell. 2014 Apr 28;29(2):233-40 |
| 2 | J:243780 Li F, Fu G, Liu Y, Miao X, Li Y, Yang X, Zhang X, Yu D, Gan L, Qiu M, Chen Y, Zhang Z, Zhang Z, ISLET1-Dependent beta-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw. Mol Cell Biol. 2017 Apr 15;37(8) |
| 2 | J:235489 Li J, Wang Q, Cui Y, Yang X, Li Y, Zhang X, Qiu M, Zhang Z, Zhang Z, Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/Gremlin. PLoS One. 2015;10(5):e0128006 |
| 1 | J:338821 Li R, Wang T, Marquardt RM, Lydon JP, Wu SP, DeMayo FJ, TRIM28 modulates nuclear receptor signaling to regulate uterine function. Nat Commun. 2023 Aug 1;14(1):4605 |
| 2 | J:92817 Li S, Zhou D, Lu MM, Morrisey EE, Advanced cardiac morphogenesis does not require heart tube fusion. Science. 2004 Sep 10;305(5690):1619-22 |
| 1 | J:94180 Lickert H, Takeuchi JK, Von Both I, Walls JR, McAuliffe F, Adamson SL, Henkelman RM, Wrana JL, Rossant J, Bruneau BG, Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature. 2004 Nov 4;432(7013):107-12 |
| 4* | J:40724 Lin Q, Schwarz J, Bucana C, Olson EN, Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science. 1997 May 30;276(5317):1404-7 |
| 1 | J:78941 Litingtung Y, Dahn RD, Li Y, Fallon JF, Chiang C, Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature. 2002 Aug 29;418(6901):979-83 |
| 1 | J:98800 Liu A, Wang B, Niswander LA, Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development. 2005 Jul;132(13):3103-11 |
| 2 | J:322043 Liu M, Deng W, Tang L, Liu M, Bao H, Guo C, Zhang C, Lu J, Wang H, Lu Z, Kong S, Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling. Nat Commun. 2022 Feb 22;13(1):1006 |
| 2 | J:146638 Liu N, Barbosa AC, Chapman SL, Bezprozvannaya S, Qi X, Richardson JA, Yanagisawa H, Olson EN, DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis. Development. 2009 Mar;136(6):933-42 |
| 1 | J:89237 Liu W, Selever J, Wang D, Lu MF, Moses KA, Schwartz RJ, Martin JF, Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4489-94 |
| 1* | J:180785 Loebel DA, Hor AC, Bildsoe H, Jones V, Chen YT, Behringer RR, Tam PP, Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton. Dev Biol. 2012 Feb 15;362(2):132-40 |
| 1 | J:213641 Lopez-Rios J, Duchesne A, Speziale D, Andrey G, Peterson KA, Germann P, Unal E, Liu J, Floriot S, Barbey S, Gallard Y, Muller-Gerbl M, Courtney AD, Klopp C, Rodriguez S, Ivanek R, Beisel C, Wicking C, Iber D, Robert B, McMahon AP, Duboule D, Zeller R, Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs. Nature. 2014 Jul 3;511(7507):46-51 |
| 1 | J:184012 Lopez-Rios J, Speziale D, Robay D, Scotti M, Osterwalder M, Nusspaumer G, Galli A, Hollander GA, Kmita M, Zeller R, GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis. Dev Cell. 2012 Apr 17;22(4):837-48 |
| 4 | J:337813 Losa M, Barozzi I, Osterwalder M, Hermosilla-Aguayo V, Morabito A, Chacon BH, Zarrineh P, Girdziusaite A, Benazet JD, Zhu J, Mackem S, Capellini TD, Dickel D, Bobola N, Zuniga A, Visel A, Zeller R, Selleri L, A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2. Nat Commun. 2023 Jul 6;14(1):3993 |
| 1 | J:346456 Lozovska A, Korovesi AG, Dias A, Lopes A, Fowler DA, Martins GG, Novoa A, Mallo M, Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape. Nat Commun. 2024 Mar 20;15(1):2509 |
| 1 | J:238888 Luo W, Zhao X, Jin H, Tao L, Zhu J, Wang H, Hemmings BA, Yang Z, Akt1 signaling coordinates BMP signaling and beta-catenin activity to regulate second heart field progenitor development. Development. 2015 Feb 15;142(4):732-42 |
| 1* | J:146220 Maclean G, Dolle P, Petkovich M, Genetic disruption of CYP26B1 severely affects development of neural crest derived head structures, but does not compromise hindbrain patterning. Dev Dyn. 2009 Mar;238(3):732-45 |
| 1 | J:228335 Makino S, Zhulyn O, Mo R, Puviindran V, Zhang X, Murata T, Fukumura R, Ishitsuka Y, Kotaki H, Matsumaru D, Ishii S, Hui CC, Gondo Y, T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor. PLoS One. 2015;10(3):e0119455 |
| 1 | J:327414 Manivannan S, Mansfield C, Zhang X, Kodigepalli KM, Majumdar U, Garg V, Basu M, Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia. Commun Biol. 2022 Aug 15;5(1):820 |
| 2* | J:149478 Mao J, McGlinn E, Huang P, Tabin CJ, McMahon AP, Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell. 2009 Apr;16(4):600-6 |
| 2* | J:80020 Marcil A, Dumontier E, Chamberland M, Camper SA, Drouin J, Pitx1 and Pitx2 are required for development of hindlimb buds. Development. 2003 Jan;130(1):45-55 |
| 1 | J:111148 Marguerie A, Bajolle F, Zaffran S, Brown NA, Dickson C, Buckingham ME, Kelly RG, Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice. Cardiovasc Res. 2006 Jul 1;71(1):50-60 |
| 1 | J:139169 Menke DB, Guenther C, Kingsley DM, Dual hindlimb control elements in the Tbx4 gene and region-specific control of bone size in vertebrate limbs. Development. 2008 Aug;135(15):2543-53 |
| 2 | J:91163 Mic FA, Sirbu IO, Duester G, Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation. J Biol Chem. 2004 Jun 18;279(25):26698-706 |
| 1 | J:220659 Miller KA, Ah-Cann CJ, Welfare MF, Tan TY, Pope K, Caruana G, Freckmann ML, Savarirayan R, Bertram JF, Dobbie MS, Bateman JF, Farlie PG, Cauli: a mouse strain with an Ift140 mutation that results in a skeletal ciliopathy modelling Jeune syndrome. PLoS Genet. 2013 Aug;9(8):e1003746 |
| 1 | J:251775 Miller KA, Tan TY, Welfare MF, White SM, Stark Z, Savarirayan R, Burgess T, Heggie AA, Caruana G, Bertram JF, Bateman JF, Farlie PG, A mouse splice-site mutant and individuals with atypical chromosome 22q11.2 deletions demonstrate the crucial role for crkl in craniofacial and pharyngeal development. Mol Syndromol. 2014 Dec;5(6):276-86 |
| 1 | J:185124 Misra C, Sachan N, McNally CR, Koenig SN, Nichols HA, Guggilam A, Lucchesi PA, Pu WT, Srivastava D, Garg V, Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet. 2012 May;8(5):e1002690 |
| 1 | J:40145 Molkentin JD, Lin Q, Duncan SA, Olson EN, Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 1997 APR 15;11(8):1061-1072 |
| 2 | J:89474 Morikawa Y, Cserjesi P, Extra-embryonic vasculature development is regulated by the transcription factor HAND1. Development. 2004 May;131(9):2195-204 |
| 3 | J:122604 Morikawa Y, D'Autreaux F, Gershon MD, Cserjesi P, Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Dev Biol. 2007 Jul 1;307(1):114-26 |
| 4 | J:119859 Morikawa Y, Dai YS, Hao J, Bonin C, Hwang S, Cserjesi P, The basic helix-loop-helix factor Hand 2 regulates autonomic nervous system development. Dev Dyn. 2005 Nov;234(3):613-21 |
| 1 | J:153961 Morikawa Y, Zehir A, Maska E, Deng C, Schneider MD, Mishina Y, Cserjesi P, BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development. 2009 Nov;136(21):3575-84 |
| 2 | J:92533 Murakami M, Kataoka K, Tominaga J, Nakagawa O, Kurihara H, Differential cooperation between dHAND and three different E-proteins. Biochem Biophys Res Commun. 2004 Oct 8;323(1):168-174 |
| 1 | J:228776 Muto A, Ikeda S, Lopez-Burks ME, Kikuchi Y, Calof AL, Lander AD, Schilling TF, Nipbl and mediator cooperatively regulate gene expression to control limb development. PLoS Genet. 2014 Sep;10(9):e1004671 |
| 1* | J:83256 Naiche LA, Papaioannou VE, Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois. Development. 2003 Jun;130(12):2681-93 |
| 1 | J:172819 Nakazawa M, Uchida K, Aramaki M, Kodo K, Yamagishi C, Takahashi T, Mikoshiba K, Yamagishi H, Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field. J Mol Cell Cardiol. 2011 Jul;51(1):58-66 |
| 4 | J:83133 Nemer G, Nemer M, Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6. Dev Biol. 2003 Feb 1;254(1):131-48 |
| 1* | J:265627 Nie J, Jiang M, Zhang X, Tang H, Jin H, Huang X, Yuan B, Zhang C, Lai JC, Nagamine Y, Pan D, Wang W, Yang Z, Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development. Cell Rep. 2015 Oct 27;13(4):723-732 |
| 1* | J:67816 Niederreither K, Vermot J, Messaddeq N, Schuhbaur B, Chambon P, Dolle P, Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. Development. 2001 Apr;128(7):1019-31 |
| 1 | J:77442 Niederreither K, Vermot J, Schuhbaur B, Chambon P, Dolle P, Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse. Development. 2002 Aug;129(15):3563-74 |
| 1 | J:147574 Norman RX, Ko HW, Huang V, Eun CM, Abler LL, Zhang Z, Sun X, Eggenschwiler JT, Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet. 2009 May 15;18(10):1740-54 |
| 1 | J:146634 Ohazama A, Haycraft CJ, Seppala M, Blackburn J, Ghafoor S, Cobourne M, Martinelli DC, Fan CM, Peterkova R, Lesot H, Yoder BK, Sharpe PT, Primary cilia regulate Shh activity in the control of molar tooth number. Development. 2009 Mar;136(6):897-903 |
| 2 | J:167713 Okubo T, Kawamura A, Takahashi J, Yagi H, Morishima M, Matsuoka R, Takada S, Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice. Development. 2011 Jan;138(2):339-48 |
| 4* | J:303813 Onimaru K, Tatsumi K, Tanegashima C, Kadota M, Nishimura O, Kuraku S, Developmental hourglass and heterochronic shifts in fin and limb development. Elife. 2021 Feb 9;10:e62865 |
| 5 | J:263215 Osterwalder M, Speziale D, Shoukry M, Mohan R, Ivanek R, Kohler M, Beisel C, Wen X, Scales SJ, Christoffels VM, Visel A, Lopez-Rios J, Zeller R, HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme. Dev Cell. 2014 Nov 10;31(3):345-357 |
| 1 | J:135130 Ota S, Zhou ZQ, Keene DR, Knoepfler P, Hurlin PJ, Activities of N-Myc in the developing limb link control of skeletal size with digit separation. Development. 2007 Apr;134(8):1583-92 |
| 1* | J:167169 Park CY, Pierce SA, von Drehle M, Ivey KN, Morgan JA, Blau HM, Srivastava D, skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration. Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20750-5 |
| 3* | J:110707 Pattyn A, Guillemot F, Brunet JF, Delays in neuronal differentiation in Mash1/Ascl1 mutants. Dev Biol. 2006 Jul 1;295(1):67-75 |
| 1 | J:316050 Paul MH, Harvey RP, Wegner M, Sock E, Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types. Cell Mol Life Sci. 2014 Aug;71(15):2931-45 |
| 1 | J:134635 Peng X, Wu X, Druso JE, Wei H, Park AY, Kraus MS, Alcaraz A, Chen J, Chien S, Cerione RA, Guan JL, Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6638-43 |
| 4* | J:347747 Plummer NW, Smith KG, Jensen P, A knock-in allele of Hand2 expressing Dre recombinase. Genesis. 2024;62(3):e23601 |
| 3 | J:157923 Potzner MR, Tsarovina K, Binder E, Penzo-Mendez A, Lefebvre V, Rohrer H, Wegner M, Sock E, Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system. Development. 2010 Mar;137(5):775-84 |
| 1 | J:311888 Prados B, Gomez-Apinaniz P, Papoutsi T, Luxan G, Zaffran S, Perez-Pomares JM, de la Pompa JL, Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity. Cell Death Dis. 2018 Mar 14;9(3):399 |
| 3 | J:345597 Quilez S, Dumontier E, Baim C, Kam J, Cloutier JF, Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects. Front Cell Dev Biol. 2024;12:1256465 |
| 1 | J:242229 Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z, Wang C, Wang H, Nuclear Shp2 directs normal embryo implantation via facilitating the ERalpha tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017 May 02;114(18):4816-4821 |
| 1 | J:118803 Ribes V, Otto DM, Dickmann L, Schmidt K, Schuhbaur B, Henderson C, Blomhoff R, Wolf CR, Tickle C, Dolle P, Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis. Dev Biol. 2007 Mar 1;303(1):66-81 |
| 1 | J:46383 Riley P, Anson-Cartwright L, Cross JC, The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Nat Genet. 1998 Mar;18(3):271-5 |
| 1 | J:116090 Risebro CA, Smart N, Dupays L, Breckenridge R, Mohun TJ, Riley PR, Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart. Development. 2006 Nov;133(22):4595-606 |
| 5* | J:284123 Ritter N, Ali T, Kopitchinski N, Schuster P, Beisaw A, Hendrix DA, Schulz MH, Muller-McNicoll M, Dimmeler S, Grote P, The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development. Dev Cell. 2019 Sep 9;50(5):644-657.e8 |
| 2 | J:149166 Ruest LB, Clouthier DE, Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism. Dev Biol. 2009 Apr 1;328(1):94-108 |
| 7* | J:83364 Ruest LB, Dager M, Yanagisawa H, Charite J, Hammer RE, Olson EN, Yanagisawa M, Clouthier DE, Dhand-cre transgenic mice reveal specific potential functions of dHAND during craniofacial development. Dev Biol. 2003 May 15;257(2):263-77 |
| 1 | J:97500 Ruest LB, Kedzierski R, Yanagisawa M, Clouthier DE, Deletion of the endothelin-A receptor gene within the developing mandible. Cell Tissue Res. 2005 Mar;319(3):447-53 |
| 2* | J:93183 Ruest LB, Xiang X, Lim KC, Levi G, Clouthier DE, Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity. Development. 2004 Sep;131(18):4413-23 |
| 3* | J:55840 Saga Y, Miyagawa-Tomita S, Takagi A, Kitajima S, Miyazaki Ji, Inoue T, MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube. Development. 1999 Aug;126(15):3437-47 |
| 1* | J:96968 Sagai T, Hosoya M, Mizushina Y, Tamura M, Shiroishi T, Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb. Development. 2005 Feb;132(4):797-803 |
| 1 | J:87798 Sagai T, Masuya H, Tamura M, Shimizu K, Yada Y, Wakana S, Gondo Y, Noda T, Shiroishi T, Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog ( Shh). Mamm Genome. 2004 Jan;15(1):23-34 |
| 4 | J:236978 Santos R, Kawauchi S, Jacobs RE, Lopez-Burks ME, Choi H, Wikenheiser J, Hallgrimsson B, Jamniczky HA, Fraser SE, Lander AD, Calof AL, Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. PLoS Biol. 2016 Sep;14(9):e2000197 |
| 1 | J:131382 Sato T, Kawamura Y, Asai R, Amano T, Uchijima Y, Dettlaff-Swiercz DA, Offermanns S, Kurihara Y, Kurihara H, Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development. 2008 Feb;135(4):755-65 |
| 1 | J:224515 Sato T, Kurihara Y, Asai R, Kawamura Y, Tonami K, Uchijima Y, Heude E, Ekker M, Levi G, Kurihara H, An endothelin-1 switch specifies maxillomandibular identity. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18806-11 |
| 1 | J:156467 Saxena A, Tabin CJ, miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):87-91 |
| 3 | J:173638 Schmidt M, Huber L, Majdazari A, Schutz G, Williams T, Rohrer H, The transcription factors AP-2beta and AP-2alpha are required for survival of sympathetic progenitors and differentiated sympathetic neurons. Dev Biol. 2011 Jul 1;355(1):89-100 |
| 1* | J:71996 Selleri L, Depew MJ, Jacobs Y, Chanda SK, Tsang KY, Cheah KS, Rubenstein JL, O'Gorman S, Cleary ML, Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development. 2001 Sep;128(18):3543-57 |
| 3 | J:128015 Sheth R, Bastida MF, Ros M, Hoxd and Gli3 interactions modulate digit number in the amniote limb. Dev Biol. 2007 Oct 15;310(2):430-41 |
| 4* | J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754 |
| 1 | J:78065 Shirai M, Osugi T, Koga H, Kaji Y, Takimoto E, Komuro I, Hara J, Miwa T, Yamauchi-Takihara K, Takihara Y, The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis. J Clin Invest. 2002 Jul;110(2):177-84 |
| 1 | J:98806 Singh MK, Christoffels VM, Dias JM, Trowe MO, Petry M, Schuster-Gossler K, Burger A, Ericson J, Kispert A, Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2. Development. 2005 Jun;132(12):2697-707 |
| 1* | J:80044 Sohn SJ, Sarvis BK, Cado D, Winoto A, ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression. J Biol Chem. 2002 Nov 8;277(45):43344-51 |
| 4 | J:239945 Souilhol C, Perea-Gomez A, Camus A, Beck-Cormier S, Vandormael-Pournin S, Escande M, Collignon J, Cohen-Tannoudji M, NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo. Development. 2015 Nov 01;142(21):3649-60 |
| 2 | J:350460 Soussi G, Girdziusaite A, Jhanwar S, Palacio V, Notaro M, Sheth R, Zeller R, Zuniga A, TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development. Development. 2024 Jun 1;151(11) |
| 9* | J:35033 Srivastava D, Cserjesi P, Olson EN, A subclass of bHLH proteins required for cardiac morphogenesis. Science. 1995 Dec 22;270(5244):1995-9 |
| 2* | J:40768 Srivastava D, Thomas T, Lin Q, Kirby ML, Brown D, Olson EN, Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet. 1997 Jun;16(2):154-60 |
| 1* | J:338018 Stathopoulou A, Wang P, Thellier C, Kelly RG, Zheng D, Scambler PJ, CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression. Cardiovasc Res. 2023 Apr 13; |
| 2 | J:221159 Stubbusch J, Narasimhan P, Hennchen M, Huber K, Unsicker K, Ernsberger U, Rohrer H, Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015 Apr 15;400(2):210-23 |
| 2 | J:181632 Sun Y, Teng I, Huo R, Rosenfeld MG, Olson LE, Li X, Li X, Asymmetric requirement of surface epithelial beta-catenin during the upper and lower jaw development. Dev Dyn. 2012 Apr;241(4):663-74 |
| 1 | J:63121 Svensson EC, Huggins GS, Lin H, Clendenin C, Jiang F, Tufts R, Dardik FB, Leiden JM, A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2. Nat Genet. 2000 Jul;25(3):353-6 |
| 1 | J:207496 Symmons O, Uslu VV, Tsujimura T, Ruf S, Nassari S, Schwarzer W, Ettwiller L, Spitz F, Functional and topological characteristics of mammalian regulatory domains. Genome Res. 2014 Mar;24(3):390-400 |
| 1 | J:101739 Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG, Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development. 2005 May;132(10):2463-74 |
| 2* | J:87041 Takeuchi JK, Ohgi M, Koshiba-Takeuchi K, Shiratori H, Sakaki I, Ogura K, Saijoh Y, Ogura T, Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis. Development. 2003 Dec;130(24):5953-64 |
| 1* | J:198239 Tamura M, Hosoya M, Fujita M, Iida T, Amano T, Maeno A, Kataoka T, Otsuka T, Tanaka S, Tomizawa S, Shiroishi T, Overdosage of Hand2 causes limb and heart defects in the human chromosomal disorder partial trisomy distal 4q. Hum Mol Genet. 2013 Jun 15;22(12):2471-81 |
| 1* | J:52597 Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S, The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development. 1999 Mar;126(6):1269-80 |
| 3 | J:324161 Tang S, Cope DI, Vasquez YM, Monsivais D, BMP/SMAD1/5 Signaling in the Endometrial Epithelium Is Essential for Receptivity and Early Pregnancy. Endocrinology. 2022 May 1;163(5) |
| 1* | J:190564 Tavares AL, Garcia EL, Kuhn K, Woods CM, Williams T, Clouthier DE, Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch. Dev Biol. 2012 Nov 1;371(1):47-56 |
| 2 | J:241567 Tavares ALP, Cox TC, Maxson RM, Ford HL, Clouthier DE, Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development. Development. 2017 Jun 01;144(11):2021-2031 |
| 2 | J:77675 te Welscher P, Fernandez-Teran M, Ros MA, Zeller R, Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling. Genes Dev. 2002 Feb 15;16(4):421-6 |
| 1 | J:79710 te Welscher P, Zuniga A, Kuijper S, Drenth T, Goedemans HJ, Meijlink F, Zeller R, Progression of vertebrate limb development through SHH-mediated counteraction of GLI3. Science. 2002 Oct 25;298(5594):827-30 |
| 1* | J:155273 Teng GQ, Zhao X, Lees-Miller JP, Quinn FR, Li P, Rancourt DE, London B, Cross JC, Duff HJ, Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality. Circ Res. 2008 Dec 5;103(12):1483-91 |
| 1 | J:147648 Tessari A, Pietrobon M, Notte A, Cifelli G, Gage PJ, Schneider MD, Lembo G, Campione M, Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs. Circ Res. 2008 Apr 11;102(7):813-22 |
| 1* | J:62879 Tevosian SG, Deconinck AE, Tanaka M, Schinke M, Litovsky SH, Izumo S, Fujiwara Y, Orkin SH, FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. Cell. 2000 Jun 23;101(7):729-39 |
| 3* | J:49658 Thomas T, Kurihara H, Yamagishi H, Kurihara Y, Yazaki Y, Olson EN , Srivastava D, A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development. 1998 Aug;125(16):3005-14 |
| 1* | J:47294 Thomas T, Yamagishi H, Overbeek PA, Olson EN, Srivastava D, The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness. Dev Biol. 1998 Apr 15;196(2):228-36 |
| 1* | J:306252 Tissieres V, Geier F, Kessler B, Wolf E, Zeller R, Lopez-Rios J, Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emergence of Artiodactyl Traits. Cell Rep. 2020 Apr 7;31(1):107490 |
| 1 | J:91082 Togi K, Kawamoto T, Yamauchi R, Yoshida Y, Kita T, Tanaka M, Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart. Mol Cell Biol. 2004 Jun;24(11):4627-35 |
| 3 | J:107480 Togi K, Yoshida Y, Matsumae H, Nakashima Y, Kita T, Tanaka M, Essential role of Hand2 in interventricular septum formation and trabeculation during cardiac development. Biochem Biophys Res Commun. 2006 Apr 28;343(1):144-51 |
| 3 | J:111607 Tribioli C, Lufkin T, Bapx1 homeobox gene gain-of-function mice show preaxial polydactyly and activated Shh signaling in the developing limb. Dev Dyn. 2006 Jun 21;235(9):2483-2492 |
| 1* | J:79512 Tribioli C, Robledo R, Lufkin T, The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis. Mech Dev. 2002 Oct;118(1-2):161 |
| 1 | J:98339 Tsarovina K, Pattyn A, Stubbusch J, Muller F, van der Wees J, Schneider C, Brunet JF, Rohrer H, Essential role of Gata transcription factors in sympathetic neuron development. Development. 2004 Oct;131(19):4775-86 |
| 3 | J:163233 Tsarovina K, Reiff T, Stubbusch J, Kurek D, Grosveld FG, Parlato R, Schutz G, Rohrer H, The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons. J Neurosci. 2010 Aug 11;30(32):10833-43 |
| 1 | J:169213 Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D, Hand2 function in second heart field progenitors is essential for cardiogenesis. Dev Biol. 2011 Mar 1;351(1):62-69 |
| 1 | J:258557 Tu Z, Wang Q, Cui T, Wang J, Ran H, Bao H, Lu J, Wang B, Lydon JP, DeMayo F, Zhang S, Kong S, Wu X, Wang H, Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ. 2016 Jan;23(1):169-81 |
| 1 | J:165022 Uchida K, Aramaki M, Nakazawa M, Yamagishi C, Makino S, Fukuda K, Nakamura T, Takahashi T, Mikoshiba K, Yamagishi H, Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis. PLoS One. 2010;5(9) |
| 2 | J:132526 Unezaki S, Horai R, Sudo K, Iwakura Y, Ito S, Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice. Genes Cells. 2007 Jun;12(6):773-85 |
| 1 | J:222450 Uribe V, Badia-Careaga C, Casanova JC, Dominguez JN, de la Pompa JL, Sanz-Ezquerro JJ, Arid3b is essential for second heart field cell deployment and heart patterning. Development. 2014 Nov;141(21):4168-81 |
| 1 | J:175465 Urness LD, Bleyl SB, Wright TJ, Moon AM, Mansour SL, Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development. Dev Biol. 2011 Aug 15;356(2):383-97 |
| 5 | J:311813 VanDusen NJ, Casanovas J, Vincentz JW, Firulli BA, Osterwalder M, Lopez-Rios J, Zeller R, Zhou B, Grego-Bessa J, De La Pompa JL, Shou W, Firulli AB, Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium. Cell Rep. 2014 Dec 24;9(6):2071-83 |
| 5 | J:208894 VanDusen NJ, Vincentz JW, Firulli BA, Howard MJ, Rubart M, Firulli AB, Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death. Dev Biol. 2014 Apr 15;388(2):149-58 |
| 1* | J:293200 Vanyai HK, Garnham A, May RE, McRae HM, Collin C, Wilcox S, Smyth GK, Thomas T, Voss AK, MOZ directs the distal-less homeobox gene expression program during craniofacial development. Development. 2019 Jul 24;146(14):dev175042 |
| 3 | J:163514 Vieux-Rochas M, Mantero S, Heude E, Barbieri O, Astigiano S, Couly G, Kurihara H, Levi G, Merlo GR, Spatio-temporal dynamics of gene expression of the Edn1-Dlx5/6 pathway during development of the lower jaw. Genesis. 2010 Jun;48(6):262-373 |
| 2 | J:138404 Vincentz JW, Barnes RM, Rodgers R, Firulli BA, Conway SJ, Firulli AB, An absence of Twist1 results in aberrant cardiac neural crest morphogenesis. Dev Biol. 2008 Aug 1;320(1):131-9 |
| 1 | J:319653 Vincentz JW, Casasnovas JJ, Barnes RM, Que J, Clouthier DE, Wang J, Firulli AB, Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7563-8 |
| 3* | J:195264 Vincentz JW, Firulli BA, Lin A, Spicer DB, Howard MJ, Firulli AB, Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest. PLoS Genet. 2013 Mar;9(3):e1003405 |
| 2* | J:308710 Vincentz JW, Firulli BA, Toolan KP, Osterwalder M, Pennacchio LA, Firulli AB, HAND transcription factors cooperatively specify the aorta and pulmonary trunk. Dev Biol. 2021 Aug;476:1-10 |
| 1 | J:244253 Vincentz JW, Toolan KP, Zhang W, Firulli AB, Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function. PLoS Genet. 2017 Jul;13(7):e1006922 |
| 1* | J:143454 Vokes SA, Ji H, Wong WH, McMahon AP, A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev. 2008 Oct 1;22(19):2651-63 |
| 1 | J:93034 von Both I, Silvestri C, Erdemir T, Lickert H, Walls JR, Henkelman RM, Rossant J, Harvey RP, Attisano L, Wrana JL, Foxh1 is essential for development of the anterior heart field. Dev Cell. 2004 Sep;7(3):331-45 |
| 1* | J:118340 Wang C, Pan Y, Wang B, A hypermorphic mouse Gli3 allele results in a polydactylous limb phenotype. Dev Dyn. 2007 Mar;236(3):769-76 |
| 1* | J:121609 Wang C, Ruther U, Wang B, The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev Biol. 2007 May 15;305(2):460-9 |
| 1 | J:169047 Wang J, Greene SB, Bonilla-Claudio M, Tao Y, Zhang J, Bai Y, Huang Z, Black BL, Wang F, Martin JF, Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell. 2010 Dec 14;19(6):903-12 |
| 2 | J:330212 Wang S, Tanaka Y, Xu Y, Takeda S, Hirokawa N, KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice. Dev Cell. 2022 Oct 10;57(19):2273-2289.e11 |
| 3 | J:270088 Wang Y, Lu P, Wu B, Morrow BE, Zhou B, NOTCH maintains developmental cardiac gene network through WNT5A. J Mol Cell Cardiol. 2018 Dec;125:98-105 |
| 1* | J:75953 Wei L, Imanaka-Yoshida K, Wang L, Zhan S, Schneider MD, DeMayo FJ, Schwartz RJ, Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Development. 2002 Apr;129(7):1705-14 |
| 1 | J:214811 Weiss AC, Airik R, Bohnenpoll T, Greulich F, Foik A, Trowe MO, Rudat C, Costantini F, Adams RH, Kispert A, Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme. Development. 2014 Sep;141(17):3420-30 |
| 1* | J:279388 Weiss AC, Bohnenpoll T, Kurz J, Blank P, Airik R, Ludtke TH, Kleppa MJ, Deuper L, Kaiser M, Mamo TM, Costa R, von Hahn T, Trowe MO, Kispert A, Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme. J Pathol. 2019 Aug;248(4):452-463 |
| 2* | J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130 |
| 1 | J:130853 Wildner H, Gierl MS, Strehle M, Pla P, Birchmeier C, Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage. Development. 2008 Feb;135(3):473-81 |
| 2 | J:316777 Wilkinson AL, Menelaou K, Rakoczy J, Tan XS, Watson ED, Disruption of Folate Metabolism Causes Poor Alignment and Spacing of Mouse Conceptuses for Multiple Generations. Front Cell Dev Biol. 2021;9:723978 |
| 1 | J:242833 Wu C, Li J, Peterson A, Tao K, Wang B, Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse. Hum Mol Genet. 2017 Jul 01;26(13):2386-2397 |
| 1 | J:175770 Wyngaarden LA, Delgado-Olguin P, Su IH, Bruneau BG, Hopyan S, Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb. Development. 2011 Sep;138(17):3759-67 |
| 1 | J:202466 Wystub K, Besser J, Bachmann A, Boettger T, Braun T, miR-1/133a clusters cooperatively specify the cardiomyogenic lineage by adjustment of myocardin levels during embryonic heart development. PLoS Genet. 2013 Sep;9(9):e1003793 |
| 8 | J:278242 Xia M, Luo W, Jin H, Yang Z, HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis. Development. 2019 Jul 4;146(13):dev177477 |
| 5* | J:149232 Xiong W, He F, Morikawa Y, Yu X, Zhang Z, Lan Y, Jiang R, Cserjesi P, Chen Y, Hand2 is required in the epithelium for palatogenesis in mice. Dev Biol. 2009 Jun 1;330(1):131-41 |
| 1 | J:217617 Xiong Y, Yang P, Proia RL, Hla T, Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. J Clin Invest. 2014 Nov;124(11):4823-8 |
| 2 | J:203059 Xu B, Hrycaj SM, McIntyre DC, Baker NC, Takeuchi JK, Jeannotte L, Gaber ZB, Novitch BG, Wellik DM, Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19438-43 |
| 2 | J:170090 Xu B, Wellik DM, Axial Hox9 activity establishes the posterior field in the developing forelimb. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4888-91 |
| 1* | J:51595 Xu C, Liguori G, Persico MG, Adamson ED, Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. Development. 1999 Feb;126(3):483-94 |
| 1 | J:296001 Xu H, Xiang M, Qin Y, Cheng H, Chen D, Fu Q, Zhang KK, Xie L, Tbx5 inhibits hedgehog signaling in determination of digit identity. Hum Mol Genet. 2020 Jun 3;29(9):1405-1416 |
| 1 | J:309090 Xu J, Liu H, Lan Y, Adam M, Clouthier DE, Potter S, Jiang R, Hedgehog signaling patterns the oral-aboral axis of the mandibular arch. Elife. 2019 Jan 14;8:e40315 |
| 1* | J:305946 Xu M, Yao J, Shi Y, Yi H, Zhao W, Lin X, Yang Z, The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Development. 2021 Apr 15;148(8):dev199026 |
| 1 | J:81331 Yada Y, Makino S, Chigusa-Ishiwa S, Shiroishi T, The mouse polydactylous mutation, luxate (lx), causes anterior shift of the anteroposterior border in the developing hindlimb bud. Int J Dev Biol. 2002;46(7):975-82 |
| 2 | J:106091 Yamagishi C, Yamagishi H, Maeda J, Tsuchihashi T, Ivey K, Hu T, Srivastava D, Sonic hedgehog is essential for first pharyngeal arch development. Pediatr Res. 2006 Mar;59(3):349-54 |
| 7 | J:60342 Yamagishi H, Olson EN, Srivastava D, The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. J Clin Invest. 2000 Feb;105(3):261-70 |
| 1 | J:306640 Yamak A, Hu D, Mittal N, Buikema JW, Ditta S, Lutz PG, Moog-Lutz C, Ellinor PT, Domian IJ, Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle. iScience. 2020 Mar 27;23(3):100959 |
| 3 | J:298597 Yan S, Thienthanasit R, Chen D, Engelen E, Bruhl J, Crossman DK, Kesterson R, Wang Q, Bouazoune K, Jiao K, CHD7 regulates cardiovascular development through ATP-dependent and -independent activities. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28847-28858 |
| 2 | J:81764 Yanagisawa H, Clouthier DE, Richardson JA, Charite J, Olson EN, Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development. Development. 2003 Mar;130(6):1069-78 |
| 1 | J:107396 Yang L, Cai CL, Lin L, Qyang Y, Chung C, Monteiro RM, Mummery CL, Fishman GI, Cogen A, Evans S, Isl1Cre reveals a common Bmp pathway in heart and limb development. Development. 2006 Apr;133(8):1575-85 |
| 1 | J:89029 Yashiro K, Zhao X, Uehara M, Yamashita K, Nishijima M, Nishino J, Saijoh Y, Sakai Y, Hamada H, Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb. Dev Cell. 2004 Mar;6(3):411-22 |
| 2 | J:250659 Ye B, Hou N, Xiao L, Xu Y, Boyer J, Xu H, Li F, APC controls asymmetric Wnt/beta-catenin signaling and cardiomyocyte proliferation gradient in the heart. J Mol Cell Cardiol. 2015 Dec;89(Pt B):287-96 |
| 2 | J:312465 Yin Y, Haller ME, Chadchan SB, Kommagani R, Ma L, Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization. JCI Insight. 2021 Sep 8;6(17) |
| 3* | J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48 |
| 1 | J:62914 Yoon JK, Moon RT, Wold B, The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypes. Dev Biol. 2000 Jun 15;222(2):376-91 |
| 1 | J:244345 Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T, Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice. J Clin Invest. 2017 Jun 01;127(6):2235-2248 |
| 1 | J:91567 Zakany J, Kmita M, Duboule D, A dual role for Hox genes in limb anterior-posterior asymmetry. Science. 2004 Jun 11;304(5677):1669-72 |
| 2* | J:59238 Zammit PS, Kelly RG, Franco D, Brown N, Moorman AF, Buckingham ME, Suppression of atrial myosin gene expression occurs independently in the left and right ventricles of the developing mouse heart. Dev Dyn. 2000 Jan;217(1):75-85 |
| 2 | J:99203 Zeisberg EM, Ma Q, Juraszek AL, Moses K, Schwartz RJ, Izumo S, Pu WT, Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest. 2005 Jun 1;115(6):1522-1531 |
| 1* | J:308982 Zhang H, Xie J, So KKH, Tong KK, Sae-Pang JJ, Wang L, Tsang SL, Chan WY, Wong EYM, Sham MH, Hoxb3 Regulates Jag1 Expression in Pharyngeal Epithelium and Affects Interaction With Neural Crest Cells. Front Physiol. 2020;11:612230 |
| 1* | J:229467 Zhang KK, Xiang M, Zhou L, Liu J, Curry N, Heine Suner D, Garcia-Pavia P, Zhang X, Wang Q, Xie L, Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation. Hum Mol Genet. 2016 Mar 15;25(6):1140-51 |
| 2 | J:183887 Zhang Y, Blackwell EL, McKnight MT, Knutsen GR, Vu WT, Ruest LB, Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2. Dev Dyn. 2012 May;241(5):924-40 |
| 3 | J:170604 Zhang Z, O'Rourke JR, McManus MT, Lewandoski M, Harfe BD, Sun X, The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol. 2011 Mar 15;351(2):254-65 |
| 2 | J:149477 Zhang Z, Verheyden JM, Hassell JA, Sun X, FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell. 2009 Apr;16(4):607-13 |
| 1 | J:97579 Zhao R, Watt AJ, Li J, Luebke-Wheeler J, Morrisey EE, Duncan SA, GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol. 2005 Apr;25(7):2622-31 |
| 1 | J:150673 Zhao X, Sirbu IO, Mic FA, Molotkova N, Molotkov A, Kumar S, Duester G, Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning. Curr Biol. 2009 Jun 23;19(12):1050-7 |
| 3 | J:211548 Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D, Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007 Apr 20;129(2):303-17 |
| 1 | J:310871 Zheng M, Erhardt S, Ai D, Wang J, Bmp Signaling Regulates Hand1 in a Dose-Dependent Manner during Heart Development. Int J Mol Sci. 2021 Sep 11;22(18) |
| 4 | J:219584 Zhulyn O, Hui CC, Sufu and Kif7 in limb patterning and development. Dev Dyn. 2015 Mar;244(3):468-78 |
| 2 | J:213417 Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC, A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers. Dev Cell. 2014 Apr 28;29(2):241-9 |
| 2* | J:218166 Zhulyn O, Nieuwenhuis E, Liu YC, Angers S, Hui CC, Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development. Dev Biol. 2015 Jan 15;397(2):191-202 |
| 1* | J:41878 Zoltewicz JS, Plummer NW, Lin MI, Peterson AS, oto is a homeotic locus with a role in anteroposterior development that is partially redundant with Lim1. Development. 1999 Nov;126(22):5085-95 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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