Gene Expression Literature Summary

• Symbol: Rapgef1
• Name: Rap guanine nucleotide exchange factor (GEF) 1
• ID: MGI:104580

13 matching records from 13 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E18	P
Immunohistochemistry (section)			1			1				1			1		1
In situ RNA (section)				2	3						2
In situ RNA (whole mount)											1
In situ reporter (knock in)	1			2	3		1		1						1
Northern blot		1													1
Western blot								1				2		1	2
RT-PCR		1						2							3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Rapgef1  Rap guanine nucleotide exchange factor (GEF) 1   (Synonyms: 4932418O06Rik, C3G, Grf2)
Results	Reference
1*	J:90089 Ballif BA, Arnaud L, Arthur WT, Guris D, Imamoto A, Cooper JA, Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Curr Biol. 2004 Apr 6;14(7):606-10
1*	J:224930 Cheerathodi M, Vincent JJ, Ballif BA, Quantitative comparison of CrkL-SH3 binding proteins from embryonic murine brain and liver: Implications for developmental signaling and the quantification of protein species variants in bottom-up proteomics. J Proteomics. 2015 Jul 1;125:104-11
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:331698 Ishii K, Kohno T, Sakai K, Hattori M, Reelin regulates the migration of late-born hippocampal CA1 neurons via cofilin phosphorylation. Mol Cell Neurosci. 2022 Nov 23;124:103794
2*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1*	J:226036 Maddala R, Nagendran T, Lang RA, Morozov A, Rao PV, Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. Dev Biol. 2015 Oct 1;406(1):74-91
4	J:248896 Shah B, Lutter D, Bochenek ML, Kato K, Tsytsyura Y, Glyvuk N, Sakakibara A, Klingauf J, Adams RH, Puschel AW, C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development. PLoS One. 2016;11(4):e0154174
6	J:300153 Sriram D, Chintala R, Parthasaradhi BVV, Nayak SC, Mariappan I, Radha V, Expression of a novel brain specific isoform of C3G is regulated during development. Sci Rep. 2020 Nov 2;10(1):18838
2	J:354442 Verma A, Goel A, Koner N, Gunasekaran G, Radha V, Development and tissue specific expression of RAPGEF1 (C3G) transcripts having exons encoding disordered segments with predicted regulatory function. Mol Biol Rep. 2024 Aug 14;51(1):907
2*	J:137018 Voss AK, Britto JM, Dixon MP, Sheikh BN, Collin C, Tan SS, Thomas T, C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment. Development. 2008 Jun;135(12):2139-49
7*	J:80219 Voss AK, Gruss P, Thomas T, The guanine nucleotide exchange factor C3G is necessary for the formation of focal adhesions and vascular maturation. Development. 2003 Jan;130(2):355-67
5	J:119299 Voss AK, Krebs DL, Thomas T, C3G regulates the size of the cerebral cortex neural precursor population. EMBO J. 2006 Aug 9;25(15):3652-63
3	J:187338 Yip YP, Thomas T, Voss AK, Yip JW, Migration of sympathetic preganglionic neurons in the spinal cord of a C3G-deficient mouse suggests that C3G acts in the reelin signaling pathway. J Comp Neurol. 2012 Oct 1;520(14):3194-202