Gene Expression Literature Summary

• Symbol: Utrn
• Name: utrophin
• ID: MGI:104631

28 matching records from 28 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E8.5	E9	E9.5	E10.5	E11	E11.5	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E18	E18.5	E	P
Immunohistochemistry (section)											1			1		2	4		7
In situ RNA (section)		2	1	3	2		2	3		3		2					2	1	2
Immunohistochemistry (whole mount)																			1
In situ RNA (whole mount)				1
In situ reporter (knock in)							1		1					1					1
Northern blot																		1	1
Western blot								1			1	1		1		1			2
RT-PCR	1			1		1	1		1		2		1	1	1			2	6
cDNA clones				1															1
RNase protection																			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Utrn  utrophin   (Synonyms: Dmdl, DRP, G-utrophin)
Results	Reference
1	J:74542 Arikawa-Hirasawa E, Rossi SG, Rotundo RL, Yamada Y, Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice. Nat Neurosci. 2002 Feb;5(2):119-23
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
12*	J:25060 Blake DJ, Schofield JN, Zuellig RA, Gorecki DC, Phelps SR, Barnard EA, Edwards YH, Davies KE, G-utrophin, the autosomal homologue of dystrophin Dp116, is expressed in sensory ganglia and brain. Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3697-701
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2	J:42116 Dixon AK, Tait TM, Campbell EA, Bobrow M, Roberts RG, Freeman TC, Expression of the dystrophin-related protein 2 (Drp2) transcript in the mouse. J Mol Biol. 1997 Jul 25;270(4):551-8
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1	J:33098 Gautam M, Noakes PG, Moscoso L, Rupp F, Scheller RH, Merlie JP, Sanes JR, Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
8	J:334506 Gleneadie HJ, Fernandez-Ruiz B, Sardini A, Van de Pette M, Dimond A, Prinjha RK, McGinty J, French PMW, Bagci H, Merkenschlager M, Fisher AG, Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition. Commun Biol. 2023 Mar 25;6(1):318
1	J:80082 Herbst R, Avetisova E, Burden SJ, Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor. Development. 2002 Dec;129(23):5449-60
1	J:104252 Jaworski A, Burden SJ, Neuromuscular synapse formation in mice lacking motor neuron- and skeletal muscle-derived Neuregulin-1. J Neurosci. 2006 Jan 11;26(2):655-61
5	J:81455 Jimenez-Mallebrera C, Davies K, Putt W, Edwards YH, A study of short utrophin isoforms in mice deficient for full-length utrophin. Mamm Genome. 2003 Jan;14(1):47-60
6	J:17830 Kamakura K, Tadano Y, Kawai M, Ishiura S, Nakamura R, Miyamoto K, Nagata N, Sugita H, Dystrophin-related protein is found in the central nervous system of mice at various developmental stages, especially at the postsynaptic membrane. J Neurosci Res. 1994 Apr 15;37(6):728-34
1*	J:150047 Lei K, Zhang X, Ding X, Guo X, Chen M, Zhu B, Xu T, Zhuang Y, Xu R, Han M, SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10207-12
1	J:82801 Leu M, Bellmunt E, Schwander M, Farinas I, Brenner HR, Muller U, Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development. Development. 2003 Jun;130(11):2291-301
2	J:65651 Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG, Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Mech Dev. 2000 Nov;98(1-2):77-94
1	J:168140 Nguyen AT, Xiao B, Neppl RL, Kallin EM, Li J, Chen T, Wang DZ, Xiao X, Zhang Y, DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev. 2011 Feb 1;25(3):263-74
1	J:184033 Pawlisz AS, Feng Y, Three-dimensional regulation of radial glial functions by Lis1-Nde1 and dystrophin glycoprotein complexes. PLoS Biol. 2011 Oct;9(10):e1001172
6	J:265670 Perkins KJ, Davies KE, Alternative utrophin mRNAs contribute to phenotypic differences between dystrophin-deficient mice and Duchenne muscular dystrophy. FEBS Lett. 2018 Jun;592(11):1856-1869
8	J:16666 Schofield J, Houzelstein D, Davies K, Buckingham M, Edwards YH, Expression of the dystrophin-related protein (utrophin) gene during mouse embryogenesis. Dev Dyn. 1993 Dec;198(4):254-64
1*	J:19768 Schofield JN, Blake DJ, Simmons C, Morris GE, Tinsley JM, Davies KE, Edwards YH, Apo-dystrophin-1 and apo-dystrophin-2, products of the Duchenne muscular dystrophy locus: expression during mouse embryogenesis and in cultured cell lines. Hum Mol Genet. 1994 Aug;3(8):1309-16
3*	J:29265 Schofield JN, Gorecki DC, Blake DJ, Davies K, Edwards YH, Dystroglycan mRNA expression during normal and mdx mouse embryogenesis: a comparison with utrophin and the apo-dystrophins. Dev Dyn. 1995 Oct;204(2):178-85
1	J:146417 Schwander M, Shirasaki R, Pfaff SL, Muller U, Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation. J Neurosci. 2004 Sep 15;24(37):8181-91
1*	J:70507 Smith CL, Mittaud P, Prescott ED, Fuhrer C, Burden SJ, Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors. J Neurosci. 2001 May 1;21(9):3151-60
1	J:138609 Takatoh J, Kudoh H, Kondo S, Hanaoka K, Loss of short dystrophin isoform Dp71 in olfactory ensheathing cells causes vomeronasal nerve defasciculation in mouse olfactory system. Exp Neurol. 2008 Sep;213(1):36-47
1	J:84331 Wang ZZ, Washabaugh CH, Yao Y, Wang JM, Zhang L, Ontell MP, Watkins SC, Rudnicki MA, Ontell M, Aberrant development of motor axons and neuromuscular synapses in MyoD-null mice. J Neurosci. 2003 Jun 15;23(12):5161-9
1	J:119654 Weatherbee SD, Anderson KV, Niswander LA, LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development. 2006 Dec;133(24):4993-5000
1	J:35446 Williamson CM, Schofield J, Dutton ER, Seymour A, Beechey CV , Edwards YH , Peters J, Glomerular-specific imprinting of the mouse gsalpha gene: how does this relate to hormone resistance in albright hereditary osteodystrophy?. Genomics. 1996 1;36(2):280-7
2	J:56354 Wilson J, Putt W, Jimenez C, Edwards YH, Up71 and up140, two novel transcripts of utrophin that are homologues of short forms of dystrophin. Hum Mol Genet. 1999 Jul;8(7):1271-8