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Gene Expression Literature Summary
Symbol
Name
ID 		Tfap2a
transcription factor AP-2, alpha
MGI:104671

312 matching records from 312 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1 E1.5 E2 E2.5 E3 E3.5 E4.5 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18.5 E19.5 E P
Immunohistochemistry (section) 1 3 4 9 53 1 38 1 23 1 8 2 12 1 10 2 11 9 1 5 10 6 50
In situ RNA (section) 1 2 5 2 9 3 10 3 7 3 12 2 8 3 7 2 8 1 1 2 3 5 4 10
Immunohistochemistry (whole mount) 1 2 1 6 2 3
In situ RNA (whole mount) 4 13 10 31 2 18 2 4 1 3 1 1 2 1 5 1
In situ reporter (knock in) 1 2 1 1 1 1 1 1 2
Northern blot 1 1 2 1 1 1 1 1
Western blot 2 1 1 1 1 4
RT-PCR 1 1 2 1 2 2 1 6 9 7 8 1 3 1 6 3 2 5 4 1 8 4 2 1 20
cDNA clones 1 1 2
RNase protection 2 2 2 2 2 2 1 3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Tfap2a  transcription factor AP-2, alpha   (Synonyms: Ap2, Ap-2 (a), AP-2 alpha, AP2alpha, Ap2tf, Tcfap2a)
Results  Reference
2J:310312 Abe M, Cox TC, Firulli AB, Kanai SM, Dahlka J, Lim KC, Engel JD, Clouthier DE, GATA3 is essential for separating patterning domains during facial morphogenesis. Development. 2021 Sep 1;148(17):dev199534
2J:78687 Abu-Issa R, Smyth G, Smoak I, Yamamura K, Meyers EN, Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse. Development. 2002 Oct;129(19):4613-25
1J:163487 Aggarwal VS, Carpenter C, Freyer L, Liao J, Petti M, Morrow BE, Mesodermal Tbx1 is required for patterning the proximal mandible in mice. Dev Biol. 2010 Aug 15;344(2):669-81
1J:245045 Aghajanian H, Cho YK, Rizer NW, Wang Q, Li L, Degenhardt K, Jain R, Pdgfralpha functions in endothelial-derived cells to regulate neural crest cells and the development of the great arteries. Dis Model Mech. 2017 Sep 01;10(9):1101-1108
1J:90701 Ahituv N, Erven A, Fuchs H, Guy K, Ashery-Padan R, Williams T, de Angelis MH, Avraham KB, Steel KP, An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice. Mamm Genome. 2004 Jun;15(6):424-32
2*J:205268 Ahmad N, Aslam M, Muenster D, Horsch M, Khan MA, Carlsson P, Beckers J, Graw J, Pitx3 directly regulates Foxe3 during early lens development. Int J Dev Biol. 2013;57(9-10):741-51
1J:143626 Ai D, Fu X, Wang J, Lu MF, Chen L, Baldini A, Klein WH, Martin JF, Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9319-24
1J:119307 Ai D, Liu W, Ma L, Dong F, Lu MF, Wang D, Verzi MP, Cai C, Gage PJ, Evans S, Black BL, Brown NA, Martin JF, Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium. Dev Biol. 2006 Aug 15;296(2):437-49
2J:273391 Aldunate EZ, Di Foggia V, Di Marco F, Hervas LA, Ribeiro JC, Holder DL, Patel A, Jannini TB, Thompson DA, Martinez-Barbera JP, Pearson RA, Ali RR, Sowden JC, Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision. Sci Rep. 2019 Feb 19;9(1):2314
1J:346780 Amato E Jr, Taroc EZM, Forni PE, Illuminating the terminal nerve: Uncovering the link between GnRH-1 neuron and olfactory development. J Comp Neurol. 2024 Mar;532(3):e25599
1*J:237938 Amin MB, Miura N, Uddin MK, Islam MJ, Yoshida N, Iseki S, Kume T, Trainor PA, Saitsu H, Aoto K, Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis. Congenit Anom (Kyoto). 2017 Jan;57(1):24-31
3*J:111609 Anderson RM, Stottmann RW, Choi M, Klingensmith J, Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. Dev Dyn. 2006 Aug 7;235(9):2507-2520
5*J:294897 Ankamreddy H, Koo H, Lee YJ, Bok J, CXCL12 is required for stirrup-shaped stapes formation during mammalian middle ear development. Dev Dyn. 2020 Sep;249(9):1117-1126
3J:272589 Ankamreddy H, Min H, Kim JY, Yang X, Cho ES, Kim UK, Bok J, Region-specific endodermal signals direct neural crest cells to form the three middle ear ossicles. Development. 2019 Jan 22;146(2):dev167965
2J:222437 Aoto K, Sandell LL, Butler Tjaden NE, Yuen KC, Watt KE, Black BL, Durnin M, Trainor PA, Mef2c-F10N enhancer driven beta-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells. Dev Biol. 2015 Jun 1;402(1):3-16
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1J:288982 Assenza MR, Barbagallo F, Barrios F, Cornacchione M, Campolo F, Vivarelli E, Gianfrilli D, Auletta L, Soricelli A, Isidori AM, Lenzi A, Pellegrini M, Naro F, Critical role of phosphodiesterase 2A in mouse congenital heart defects. Cardiovasc Res. 2018 May 1;114(6):830-845
2*J:231312 Baardman ME, Zwier MV, Wisse LJ, Gittenberger-de Groot AC, Kerstjens-Frederikse WS, Hofstra RM, Jurdzinski A, Hierck BP, Jongbloed MR, Berger RM, Plosch T, DeRuiter MC, Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development. Dis Model Mech. 2016 Apr 1;9(4):413-25
2J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
5*J:181601 Bassett EA, Korol A, Deschamps PA, Buettner R, Wallace VA, Williams T, West-Mays JA, Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina. Dev Dyn. 2012 Apr;241(4):814-29
7J:129080 Bassett EA, Pontoriero GF, Feng W, Marquardt T, Fini ME, Williams T, West-Mays JA, Conditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup development. Mol Cell Biol. 2007 Nov;27(21):7497-510
5J:158712 Bassett EA, Williams T, Zacharias AL, Gage PJ, Fuhrmann S, West-Mays JA, AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis. Hum Mol Genet. 2010 May 1;19(9):1791-804
1*J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
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1J:112229 Bosman EA, Lawson KA, Debruyn J, Beek L, Francis A, Schoonjans L, Huylebroeck D, Zwijsen A, Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels. Development. 2006 Sep;133(17):3399-409
3J:88826 Brewer S, Feng W, Huang J, Sullivan S, Williams T, Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol. 2004 Mar 1;267(1):135-52
4J:88783 Brewer S, Williams T, Loss of AP-2alpha impacts multiple aspects of ventral body wall development and closure. Dev Biol. 2004 Mar 15;267(2):399-417
1J:278101 Brightman DS, Grant RL, Ruzycki PA, Suzuki R, Hennig AK, Chen S, MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity. Sci Rep. 2018 Aug 9;8(1):11902
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1J:204690 Brzezinski JA 4th, Uoon Park K, Reh TA, Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence. Dev Biol. 2013 Dec 15;384(2):194-204
2J:100584 Byrd NA, Meyers EN, Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo. Dev Biol. 2005 Aug 1;284(1):233-45
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1J:154553 Chanas SA, Collinson JM, Ramaesh T, Dora N, Kleinjan DA, Hill RE, West JD, Effects of elevated Pax6 expression and genetic background on mouse eye development. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4045-59
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4*J:31151 Chazaud C, Oulad-Abdelghani M, Bouillet P, Decimo D, Chambon P, Dolle P, AP-2.2, a novel gene related to AP-2, is expressed in the forebrain, limbs and face during mouse embryogenesis. Mech Dev. 1996 Jan;54(1):83-94
1J:227058 Chen D, Wang X, Liang D, Gordon J, Mittal A, Manley N, Degenhardt K, Astrof S, Fibronectin signals through integrin alpha5beta1 to regulate cardiovascular development in a cell type-specific manner. Dev Biol. 2015 Nov 15;407(2):195-210
1*J:154546 Chen L, Sham CW, Chan AM, Francisco LM, Wu Y, Mareninov S, Sharpe AH, Freeman GJ, Yang XJ, Braun J, Gordon LK, Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4941-8
1J:260351 Chen Q, Huang L, Pan D, Zhu LJ, Wang YX, Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis. Cell Rep. 2018 Mar 13;22(11):2860-2872
1J:139006 Chen Y, Doughman YQ, Gu S, Jarrell A, Aota S, Cvekl A, Watanabe M, Dunwoodie SL, Johnson RS, van Heyningen V, Kleinjan DA, Beebe DC, Yang YC, Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development. 2008 Sep;135(17):2939-48
1J:179212 Chen Y, Moon AM, Gaufo GO, Influence of mesodermal Fgf8 on the differentiation of neural crest-derived postganglionic neurons. Dev Biol. 2012 Jan 1;361(1):125-36
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1J:298672 Christ A, Marczenke M, Willnow TE, LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation. Hum Mol Genet. 2020 Nov 25;29(19):3183-3196
3*J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
2*J:59338 Clouthier DE, Williams SC, Yanagisawa H, Wieduwilt M, Richardson JA, Yanagisawa M, Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice. Dev Biol. 2000 Jan 1;217(1):10-24
3J:102820 Conway SJ, Bundy J, Chen J, Dickman E, Rogers R, Will BM, Decreased neural crest stem cell expansion is responsible for the conotruncal heart defects within the splotch (Sp(2H))/Pax3 mouse mutant. Cardiovasc Res. 2000 Aug;47(2):314-28
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1J:269851 Dainichi T, Hayden MS, Park SG, Oh H, Seeley JJ, Grinberg-Bleyer Y, Beck KM, Miyachi Y, Kabashima K, Hashimoto T, Ghosh S, PDK1 Is a Regulator of Epidermal Differentiation that Activates and Organizes Asymmetric Cell Division. Cell Rep. 2016 May 24;15(8):1615-23
1J:180843 Davis N, Mor E, Ashery-Padan R, Roles for Dicer1 in the patterning and differentiation of the optic cup neuroepithelium. Development. 2011 Jan;138(1):127-38
1J:308916 De Zoysa P, Toubat O, Harvey D, Choi J, Kumar SR, Murine Model of Cardiac Defects Observed in Adams-Oliver Syndrome Driven by Delta-Like Ligand-4 Haploinsufficiency. Stem Cells Dev. 2021 Jun 15;30(12):611-621
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1J:283825 Drayson LE, Triplett JW, A Chrnb3-Cre BAC transgenic mouse line for manipulation of gene expression in retinal ganglion cells. Genesis. 2019 Sep;57(9):e23305
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1J:272386 Fan X, Wang D, Burgmaier JE, Teng Y, Romano RA, Sinha S, Yi R, Single Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the Skin. Dev Cell. 2018 Oct 8;47(1):21-37.e5
2J:221018 Farhy C, Elgart M, Shapira Z, Oron-Karni V, Yaron O, Menuchin Y, Rechavi G, Ashery-Padan R, Pax6 is required for normal cell-cycle exit and the differentiation kinetics of retinal progenitor cells. PLoS One. 2013;8(9):e76489
3*J:128903 Feng W, Huang J, Zhang J, Williams T, Identification and analysis of a conserved Tcfap2a intronic enhancer element required for expression in facial and limb bud mesenchyme. Mol Cell Biol. 2008 Jan;28(1):315-25
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3*J:86250 Feng W, Williams T, Cloning and characterization of the mouse AP-2epsilon gene: a novel family member expressed in the developing olfactory bulb. Mol Cell Neurosci. 2003 Oct;24(2):460-75
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2J:171903 Forni PE, Taylor-Burds C, Melvin VS, Williams T, Wray S, Neural Crest and Ectodermal Cells Intermix in the Nasal Placode to Give Rise to GnRH-1 Neurons, Sensory Neurons, and Olfactory Ensheathing Cells. J Neurosci. 2011 May 4;31(18):6915-27
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1J:217408 Green RM, Feng W, Phang T, Fish JL, Li H, Spritz RA, Marcucio RS, Hooper J, Jamniczky H, Hallgrimsson B, Williams T, Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage. Dis Model Mech. 2015 Jan;8(1):31-43
1J:212854 Gregoire S, Karra R, Passer D, Deutsch MA, Krane M, Feistritzer R, Sturzu A, Domian I, Saga Y, Wu SM, Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation. Circ Res. 2013 Mar 15;112(6):900-10
1J:146472 Grenier J, Teillet MA, Grifone R, Kelly RG, Duprez D, Relationship between neural crest cells and cranial mesoderm during head muscle development. PLoS One. 2009;4(2):e4381
1J:254641 Groman-Lupa S, Adewumi J, Park KU, Brzezinski Iv JA, The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina. Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5421-5433
2J:327183 Gu R, Zhang S, Saha SK, Ji Y, Reynolds K, McMahon M, Sun B, Islam M, Trainor PA, Chen Y, Xu Y, Chai Y, Burkart-Waco D, Zhou CJ, Single-cell transcriptomic signatures and gene regulatory networks modulated by Wls in mammalian midline facial formation and clefts. Development. 2022 Jul 15;149(14):dev200533
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2J:172023 Guo C, Sun Y, Zhou B, Adam RM, Li X, Pu WT, Morrow BE, Moon A, Li X, A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011 Apr 1;121(4):1585-95
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