Gene Expression Literature Summary

• Symbol: Gpx4
• Name: glutathione peroxidase 4
• ID: MGI:104767

19 matching records from 19 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7	E7.5	E8	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)	1	1	1		2	1																		4
In situ RNA (section)			1		1	1		1		1		1	1		1	1	1			1	1			1
In situ RNA (whole mount)	1		2	1	2	2	1	1		1			2										1
In situ reporter (knock in)																								1
Northern blot																								2
Western blot																							1	4
RT-PCR	3		3	1	2	2	1	2	1	2	1	4	2	1	2	3	1	2	3	1	2	1		10
cDNA clones																								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gpx4  glutathione peroxidase 4   (Synonyms: 1700027O09Rik, mtPHGPx, PHGPx, phospholipid hydroperoxide glutathione peroxidase, snGPx, sperm nuclei glutathione peroxidase)
Results	Reference
1	J:344220 Bai X, Wang B, Cui Y, Tian S, Zhang Y, You L, Chang YZ, Gao G, Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice. J Neuroinflammation. 2024 Jan 9;21(1):15
3*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
21*	J:114857 Borchert A, Wang CC, Ufer C, Schiebel H, Savaskan NE, Kuhn H, The role of phospholipid hydroperoxide glutathione peroxidase isoforms in murine embryogenesis. J Biol Chem. 2006 Jul 14;281(28):19655-64
6*	J:264805 Brutsch SH, Wang CC, Li L, Stender H, Neziroglu N, Richter C, Kuhn H, Borchert A, Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice. Antioxid Redox Signal. 2015 Feb 1;22(4):281-93
1	J:274697 Celaya AM, Sanchez-Perez I, Bermudez-Munoz JM, Rodriguez-de la Rosa L, Pintado-Berninches L, Perona R, Murillo-Cuesta S, Varela-Nieto I, Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss. Elife. 2019 Apr 2;8:e39159
7*	J:83472 Imai H, Hirao F, Sakamoto T, Sekine K, Mizukura Y, Saito M, Kitamoto T, Hayasaka M, Hanaoka K, Nakagawa Y, Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene. Biochem Biophys Res Commun. 2003 May 30;305(2):278-86
3*	J:97632 Kelly VP, Suzuki T, Nakajima O, Arai T, Tamai Y, Takahashi S, Nishimura S, Yamamoto M, The Distal Sequence Element of the Selenocysteine tRNA Gene Is a Tissue-Dependent Enhancer Essential for Mouse Embryogenesis. Mol Cell Biol. 2005 May;25(9):3658-69
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:106626 Sanchez-Carbente MR, Castro-Obregon S, Covarrubias L, Narvaez V, Motoneuronal death during spinal cord development is mediated by oxidative stress. Cell Death Differ. 2005 Mar;12(3):279-91
2	J:108566 Schnabel D, Salas-Vidal E, Narvaez V, Sanchez-Carbente Mdel R, Hernandez-Garcia D, Cuervo R, Covarrubias L, Expression and regulation of antioxidant enzymes in the developing limb support a function of ROS in interdigital cell death. Dev Biol. 2006 Mar 15;291(2):291-9
5	J:186906 Schneider M, Forster H, Boersma A, Seiler A, Wehnes H, Sinowatz F, Neumuller C, Deutsch MJ, Walch A, Hrabe de Angelis M, Wurst W, Ursini F, Roveri A, Maleszewski M, Maiorino M, Conrad M, Mitochondrial glutathione peroxidase 4 disruption causes male infertility. FASEB J. 2009 Sep;23(9):3233-42
21*	J:109565 Schneider M, Vogt Weisenhorn DM, Seiler A, Bornkamm GW, Brielmeier M, Conrad M, Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase. Gene Expr Patterns. 2006 Jun;6(5):489-94
1*	J:139668 Seiler A, Schneider M, Forster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Radmark O, Wurst W, Bornkamm GW, Schweizer U, Conrad M, Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 2008 Sep;8(3):237-48
5*	J:186220 Tondreau MY, Boucher E, Simard M, Tremblay Y, Bilodeau JF, Sex-specific perinatal expression of glutathione peroxidases during mouse lung development. Mol Cell Endocrinol. 2012 May 15;355(1):87-95
14*	J:137422 Ufer C, Wang CC, Fahling M, Schiebel H, Thiele BJ, Billett EE, Kuhn H, Borchert A, Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development. Genes Dev. 2008 Jul 1;22(13):1838-50
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:213512 Werber M, Wittler L, Timmermann B, Grote P, Herrmann BG, The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development. 2014 Jun;141(11):2325-30
1	J:235644 Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K, Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. PLoS Genet. 2016 Sep;12(9):e1006355
1	J:301391 Yu Y, Jiang L, Wang H, Shen Z, Cheng Q, Zhang P, Wang J, Wu Q, Fang X, Duan L, Wang S, Wang K, An P, Shao T, Chung RT, Zheng S, Min J, Wang F, Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis. Blood. 2020 Aug 6;136(6):726-739