Gene Expression Literature Summary

• Symbol: Gast
• Name: gastrin
• ID: MGI:104768

35 matching records from 35 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E10.5	E11.5	E12.5	E13.5	E14	E14.5	E15.5	E16.5	E17	E17.5	E18	E18.5	P
Immunohistochemistry (section)				2	1	1	3	4	3	1	1		6	17
In situ RNA (section)		1					2							1
Northern blot														1
RT-PCR	1	1	1	1	1		2	2			4	1	4	5

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gast  gastrin   (Synonyms: GAS)
Results	Reference
2	J:338878 Abarinov V, Levine JA, Churchill AJ, Hopwood B, Deiter CS, Guney MA, Wells KL, Schrunk JM, Guo Y, Hammelman J, Gifford DK, Magnuson MA, Wichterle H, Sussel L, Major beta cell-specific functions of NKX2.2 are mediated via the NK2-specific domain. Genes Dev. 2023 Jun 1;37(11-12):490-504
1*	J:104158 Alanentalo T, Chatonnet F, Karlen M, Sulniute R, Ericson J, Andersson E, Ahlgren U, Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development. Gene Expr Patterns. 2006 Jan;6(2):162-70
1	J:177655 Arnold K, Sarkar A, Yram MA, Polo JM, Bronson R, Sengupta S, Seandel M, Geijsen N, Hochedlinger K, Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell. 2011 Oct 4;9(4):317-29
4	J:228228 Bonnavion R, Teinturier R, Jaafar R, Ripoche D, Leteurtre E, Chen YJ, Rehfeld JF, Lepinasse F, Hervieu V, Pattou F, Vantyghem MC, Scoazec JY, Bertolino P, Zhang CX, Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors. Mol Cell Biol. 2015 Oct;35(19):3274-83
2	J:119565 Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV, Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol. 2006 Oct 15;298(2):616-31
3	J:240413 Churchill AJ, Gutierrez GD, Singer RA, Lorberbaum DS, Fischer KA, Sussel L, Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development. Elife. 2017 Jan 10;6:e20010
1*	J:170654 Das P, May CL, Expression analysis of the Islet-1 gene in the developing and adult gastrointestinal tract. Gene Expr Patterns. 2011 Mar-Apr;11(3-4):244-54
5	J:73722 de Miguel MJ, Burrell MA, Immunocytochemical detection of orexin A in endocrine cells of the developing mouse gut. J Histochem Cytochem. 2002 Jan;50(1):63-9
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:314694 Douchi D, Yamamura A, Matsuo J, Melissa Lim YH, Nuttonmanit N, Shimura M, Suda K, Chen S, Pang S, Kohu K, Abe T, Shioi G, Kim G, Shabbir A, Srivastava S, Unno M, Bok-Yan So J, Teh M, Yeoh KG, Huey Chuang LS, Ito Y, Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus. Gastroenterology. 2021 Dec;161(6):1907-1923.e26
2	J:184887 Du A, McCracken KW, Walp ER, Terry NA, Klein TJ, Han A, Wells JM, May CL, Arx is required for normal enteroendocrine cell development in mice and humans. Dev Biol. 2012 May 1;365(1):175-88
1	J:141800 Edfalk S, Steneberg P, Edlund H, Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. Diabetes. 2008 Sep;57(9):2280-7
1	J:104617 Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV, Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev. 2006 Jan 15;20(2):253-66
1	J:138249 Goering W, Adham IM, Pasche B, Manner J, Ochs M, Engel W, Zoll B, Impairment of gastric acid secretion and increase of embryonic lethality in Foxq1-deficient mice. Cytogenet Genome Res. 2008;121(2):88-95
6*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
1*	J:225747 Jayewickreme CD, Shivdasani RA, Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Dev Biol. 2015 Sep 1;405(1):21-32
1	J:80672 Jenny M, Uhl C, Roche C, Duluc I, Guillermin V, Guillemot F, Jensen J, Kedinger M, Gradwohl G, Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J. 2002 Dec 2;21(23):6338-47
2	J:59312 Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD, Control of endodermal endocrine development by Hes-1. Nat Genet. 2000 Jan;24(1):36-44
1	J:20779 Jonsson J, Carlsson L, Edlund T, Edlund H, Insulin-promoter-factor 1 is required for pancreas development in mice. Nature. 1994 Oct 13;371(6498):606-9
1*	J:98305 Kim BM, Buchner G, Miletich I, Sharpe PT, Shivdasani RA, The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev Cell. 2005 Apr;8(4):611-22
1	J:170489 Kim BM, Woo J, Kanellopoulou C, Shivdasani RA, Regulation of mouse stomach development and Barx1 expression by specific microRNAs. Development. 2011 Mar;138(6):1081-6
1	J:138261 Kokubu H, Ohtsuka T, Kageyama R, Mash1 is required for neuroendocrine cell development in the glandular stomach. Genes Cells. 2008 Jan;13(1):41-51
6	J:57954 Lay JM, Gillespie PJ, Samuelson LC, Murine prenatal expression of cholecystokinin in neural crest, enteric neurons, and enteroendocrine cells. Dev Dyn. 1999 Oct;216(2):190-200
1	J:272578 Liu J, Banerjee A, Herring CA, Attalla J, Hu R, Xu Y, Shao Q, Simmons AJ, Dadi PK, Wang S, Jacobson DA, Liu B, Hodges E, Lau KS, Gu G, Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity. Dev Cell. 2019 Jan 7;48(1):49-63.e7
1	J:161480 Mellitzer G, Beucher A, Lobstein V, Michel P, Robine S, Kedinger M, Gradwohl G, Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival. J Clin Invest. 2010 May 3;120(5):1708-21
1*	J:279976 Oz-Levi D, Olender T, Bar-Joseph I, Zhu Y, Marek-Yagel D, Barozzi I, Osterwalder M, Alkelai A, Ruzzo EK, Han Y, Vos ESM, Reznik-Wolf H, Hartman C, Shamir R, Weiss B, Shapiro R, Pode-Shakked B, Tatarskyy P, Milgrom R, Schvimer M, Barshack I, Imai DM, Coleman-Derr D, Dickel DE, Nord AS, Afzal V, van Bueren KL, Barnes RM, Black BL, Mayhew CN, Kuhar MF, Pitstick A, Tekman M, Stanescu HC, Wells JM, Kleta R, de Laat W, Goldstein DB, Pras E, Visel A, Lancet D, Anikster Y, Pennacchio LA, Noncoding deletions reveal a gene that is critical for intestinal function. Nature. 2019 Jul;571(7763):107-111
2	J:292845 Piccand J, Vagne C, Blot F, Meunier A, Beucher A, Strasser P, Lund ML, Ghimire S, Nivlet L, Lapp C, Petersen N, Engelstoft MS, Thibault-Carpentier C, Keime C, Correa SJ, Schreiber V, Molina N, Schwartz TW, De Arcangelis A, Gradwohl G, Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production. Mol Metab. 2019 Nov;29:24-39
2	J:291600 Rodriguez-Seguel E, Villamayor L, Arroyo N, De Andres MP, Real FX, Martin F, Cano DA, Rojas A, Loss of GATA4 causes ectopic pancreas in the stomach. J Pathol. 2020 Apr;250(4):362-373
2	J:174028 Salbaum JM, Kruger C, Zhang X, Delahaye NA, Pavlinkova G, Burk DH, Kappen C, Altered gene expression and spongiotrophoblast differentiation in placenta from a mouse model of diabetes in pregnancy. Diabetologia. 2011 Jul;54(7):1909-20
2	J:101154 Stanger BZ, Datar R, Murtaugh LC, Melton DA, Direct regulation of intestinal fate by Notch. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12443-8
5	J:205763 Suissa Y, Magenheim J, Stolovich-Rain M, Hija A, Collombat P, Mansouri A, Sussel L, Sosa-Pineda B, McCracken K, Wells JM, Heller RS, Dor Y, Glaser B, Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. PLoS One. 2013;8(8):e70397
1	J:121610 Vanhorenbeeck V, Jenny M, Cornut JF, Gradwohl G, Lemaigre FP, Rousseau GG, Jacquemin P, Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation. Dev Biol. 2007 May 15;305(2):685-94
1	J:141778 Verzi MP, Khan AH, Ito S, Shivdasani RA, Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells. Gastroenterology. 2008 Aug;135(2):591-600
2	J:145575 Wang YC, Gallego-Arteche E, Iezza G, Yuan X, Matli MR, Choo SP, Zuraek MB, Gogia R, Lynn FC, German MS, Bergsland EK, Donner DB, Warren RS, Nakakura EK, Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors. Endocr Relat Cancer. 2009 Mar;16(1):267-279
1	J:73284 Yang Q, Bermingham NA, Finegold MJ, Zoghbi HY, Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science. 2001 Dec 7;294(5549):2155-8