Gene Expression Literature Summary

• Symbol: Cdk2
• Name: cyclin dependent kinase 2
• ID: MGI:104772

79 matching records from 79 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E7.5	E8	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)					1							1		2			1				2	1	1		1	1	1	8
In situ RNA (section)												1			1		2	1	1									1
Immunohistochemistry (whole mount)																												1
In situ RNA (whole mount)	1	1	1	1				1		1		1	1
Northern blot														1														1
Western blot								1		4	1	3	1	5	4		6		3	1	4	1	2	1	5	1	1	26
RT-PCR		1				1	1	1	1	2		3	1	2	1	1	2		1	1	1			1	2		1	9

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cdk2  cyclin dependent kinase 2   (Synonyms: A630093N05Rik)
Results	Reference
1*	J:45218 Ahuja HS, Zhu Y, Zakeri Z, Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death. Dev Genet. 1997;21(4):258-67
3*	J:314268 Akagawa R, Nabeshima YI, Kawauchi T, Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons. Front Cell Dev Biol. 2021;9:753175
3*	J:108720 Berthet C, Klarmann KD, Hilton MB, Suh HC, Keller JR, Kiyokawa H, Kaldis P, Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell. 2006 May;10(5):563-73
3*	J:171293 Campbell GR, Baudhuin A, Vranizan K, Ngai J, Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Mol Cell Neurosci. 2011 Feb;46(2):548-61
2	J:228026 Capecchi MR, Pozner A, ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination. Nat Commun. 2015;6:8763
1	J:55748 Casaccia-Bonnefil P, Hardy RJ, Teng KK, Levine JM, Koff A, Chao MV, Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation. Development. 1999 Sep;126(18):4027-37
1	J:92551 Chaudhry HW, Dashoush NH, Tang H, Zhang L, Wang X, Wu EX, Wolgemuth DJ, Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J Biol Chem. 2004 Aug 20;279(34):35858-66
1	J:137996 Chen H, Zhuang F, Liu YH, Xu B, Del Moral P, Deng W, Chai Y, Kolb M, Gauldie J, Warburton D, Moses HL, Shi W, TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. Eur Respir J. 2008 Aug;32(2):285-95
2*	J:211539 Chen Y, Gridley T, Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis. J Bone Miner Res. 2013 Jun;28(6):1412-21
1	J:158060 Chesnokova V, Wong C, Zonis S, Gruszka A, Wawrowsky K, Ren SG, Benshlomo A, Yu R, Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence. Endocrinology. 2009 Jun;150(6):2603-10
2	J:336417 Chong D, Gu Y, Zhang T, Xu Y, Bu D, Chen Z, Xu N, Li L, Zhu X, Wang H, Li Y, Zheng F, Wang D, Li P, Xu L, Hu Z, Li C, Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming. Cell Discov. 2022 Oct 11;8(1):106
1	J:297431 Dewhurst MR, Ow JR, Zafer G, van Hul NKM, Wollmann H, Bisteau X, Brough D, Choi H, Kaldis P, Loss of hepatocyte cell division leads to liver inflammation and fibrosis. PLoS Genet. 2020 Nov;16(11):e1009084
1	J:305174 Dong X, Kwan KM, Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis. Mol Brain. 2020 Jul 23;13(1):104
2	J:110865 Donovan SL, Schweers B, Martins R, Johnson D, Dyer MA, Compensation by tumor suppressor genes during retinal development in mice and humans. BMC Biol. 2006;4:14
1	J:224084 Elliott EN, Sheaffer KL, Schug J, Stappenbeck TS, Kaestner KH, Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium. Development. 2015 Jun 15;142(12):2163-72
1	J:51430 ElShamy WM, Fridvall LK, Ernfors P, Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3. Neuron. 1998 Nov;21(5):1003-15
1	J:149800 Falk S, Wurdak H, Ittner LM, Ille F, Sumara G, Schmid MT, Draganova K, Lang KS, Paratore C, Leveen P, Suter U, Karlsson S, Born W, Ricci R, Gotz M, Sommer L, Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell. 2008 May 8;2(5):472-83
1	J:303558 Felipe-Medina N, Caburet S, Sanchez-Saez F, Condezo YB, de Rooij DG, Gomez-H L, Garcia-Valiente R, Todeschini AL, Duque P, Sanchez-Martin MA, Shalev SA, Llano E, Veitia RA, Pendas AM, A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1. Elife. 2020 Aug 26;9:e56996
1	J:31366 Fromm L, Overbeek PA, Regulation of cyclin and cyclin-dependent kinase gene expression during lens differentiation requires the retinoblastoma protein. Oncogene. 1996 Jan 4;12(1):69-75
1	J:149918 Fuchs S, Herzog D, Sumara G, Buchmann-Moller S, Civenni G, Wu X, Chrostek-Grashoff A, Suter U, Ricci R, Relvas JB, Brakebusch C, Sommer L, Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Cell Stem Cell. 2009 Mar 6;4(3):236-47
1	J:236448 Fujimura K, Mitsuhashi T, Shibata S, Shimozato S, Takahashi T, In Utero Exposure to Valproic Acid Induces Neocortical Dysgenesis via Dysregulation of Neural Progenitor Cell Proliferation/Differentiation. J Neurosci. 2016 Oct 19;36(42):10908-10919
1	J:183925 Ganuza M, Saiz-Ladera C, Canamero M, Gomez G, Schneider R, Blasco MA, Pisano D, Paramio JM, Santamaria D, Barbacid M, Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J. 2012 May 30;31(11):2498-510
1	J:66707 Geng Y, Yu Q, Sicinska E, Das M, Bronson RT, Sicinski P, Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):194-9
1	J:215459 Hellbach N, Weise SC, Vezzali R, Wahane SD, Heidrich S, Roidl D, Pruszak J, Esser JS, Vogel T, Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet. 2014 Dec 1;23(23):6177-90
1*	J:257896 Huang W, Feng Y, Liang J, Yu H, Wang C, Wang B, Wang M, Jiang L, Meng W, Cai W, Medvedovic M, Chen J, Paul C, Davidson WS, Sadayappan S, Stambrook PJ, Yu XY, Wang Y, Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nat Commun. 2018 Feb 16;9(1):700
8*	J:168656 Ikeda Y, Matsunaga Y, Takiguchi M, Ikeda MA, Expression of cyclin E in postmitotic neurons during development and in the adult mouse brain. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):64-71
6	J:190540 Ikenishi A, Okayama H, Iwamoto N, Yoshitome S, Tane S, Nakamura K, Obayashi T, Hayashi T, Takeuchi T, Cell cycle regulation in mouse heart during embryonic and postnatal stages. Dev Growth Differ. 2012 Oct;54(8):731-8
2	J:299860 Jin L, Chen Y, Crossman DK, Datta A, Vu T, Mobley JA, Basu MK, Scarduzio M, Wang H, Chang C, Datta PK, STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells. Nat Commun. 2020 Nov 23;11(1):5941
1*	J:75787 Kalinichenko VV, Zhou Y, Bhattacharyya D, Kim W, Shin B, Bambal K, Costa RH, Haploinsufficiency of the Mouse Forkhead Box f1 Gene Causes Defects in Gall Bladder Development. J Biol Chem. 2002 Apr 5;277(14):12369-74
1	J:241385 Kim SY, Lee JH, Merrins MJ, Gavrilova O, Bisteau X, Kaldis P, Satin LS, Rane SG, Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary beta-Cell Dysfunction to Progressive Depletion of beta-Cell Mass and Diabetes. J Biol Chem. 2017 Mar 03;292(9):3841-3853
1	J:192860 Kosaka Y, Cieslik KA, Li L, Lezin G, Maguire CT, Saijoh Y, Toyo-oka K, Gambello MJ, Vatta M, Wynshaw-Boris A, Baldini A, Yost HJ, Brunelli L, 14-3-3epsilon plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle. Mol Cell Biol. 2012 Dec;32(24):5089-102
1	J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
1*	J:92563 Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K, Sicinski P, Mouse development and cell proliferation in the absence of D-cyclins. Cell. 2004 Aug 20;118(4):477-91
1	J:94883 Krupczak-Hollis K, Wang X, Kalinichenko VV, Gusarova GA, Wang IC, Dennewitz MB, Yoder HM, Kiyokawa H, Kaestner KH, Costa RH, The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev Biol. 2004 Dec 1;276(1):74-88
1	J:213268 Kumar P P, Emechebe U, Smith R, Franklin S, Moore B, Yandell M, Lessnick SL, Moon AM, Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife. 2014 May 29;:e02805
1*	J:171624 Machold R, Klein C, Fishell G, Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Gene Expr Patterns. 2011 Jun-Jul;11(5-6):349-59
1	J:231817 Matsumoto S, Kiryu-Seo S, Kiyama H, Motor Nerve Arborization Requires Proteolytic Domain of Damage-Induced Neuronal Endopeptidase (DINE) during Development. J Neurosci. 2016 Apr 27;36(17):4744-57
1	J:219252 Misra C, Chang SW, Basu M, Huang N, Garg V, Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation. Hum Mol Genet. 2014 Oct 1;23(19):5025-35
1	J:174493 Muzio L, Soria JM, Pannese M, Piccolo S, Mallamaci A, A mutually stimulating loop involving emx2 and canonical wnt signalling specifically promotes expansion of occipital cortex and hippocampus. Cereb Cortex. 2005 Dec;15(12):2021-8
5	J:178882 Odajima J, Wills ZP, Ndassa YM, Terunuma M, Kretschmannova K, Deeb TZ, Geng Y, Gawrzak S, Quadros IM, Newman J, Das M, Jecrois ME, Yu Q, Li N, Bienvenu F, Moss SJ, Greenberg ME, Marto JA, Sicinski P, Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell. 2011 Oct 18;21(4):655-68
2	J:205333 Otero JJ, Kalaszczynska I, Michowski W, Wong M, Gygli PE, Gokozan HN, Griveau A, Odajima J, Czeisler C, Catacutan FP, Murnen A, Schuller U, Sicinski P, Rowitch D, Cerebellar cortical lamination and foliation require cyclin A2. Dev Biol. 2014 Jan 15;385(2):328-39
1	J:117590 Panic L, Tamarut S, Sticker-Jantscheff M, Barkic M, Solter D, Uzelac M, Grabusic K, Volarevic S, Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol. 2006 Dec;26(23):8880-91
4	J:176173 Passemard S, El Ghouzzi V, Nasser H, Verney C, Vodjdani G, Lacaud A, Lebon S, Laburthe M, Robberecht P, Nardelli J, Mani S, Verloes A, Gressens P, Lelievre V, VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling. J Clin Invest. 2011 Aug 1;121(8):3071-87
1	J:101325 Persson JL, Zhang Q, Wang XY, Ravnik SE, Muhlrad S, Wolgemuth DJ, Distinct roles for the mammalian A-type cyclins during oogenesis. Reproduction. 2005 Oct;130(4):411-22
1	J:105554 Porse BT, Pedersen TA, Hasemann MS, Schuster MB, Kirstetter P, Luedde T, Damgaard I, Kurz E, Schjerling CK, Nerlov C, The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo. Mol Cell Biol. 2006 Feb;26(3):1028-37
1	J:101361 Pratap J, Javed A, Languino LR, van Wijnen AJ, Stein JL, Stein GS, Lian JB, The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol. 2005 Oct;25(19):8581-91
1	J:196206 Reynolds A, Qiao H, Yang Y, Chen JK, Jackson N, Biswas K, Holloway JK, Baudat F, de Massy B, Wang J, Hoog C, Cohen PE, Hunter N, RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. Nat Genet. 2013 Mar;45(3):269-78
3	J:29944 Rhee K, Wolgemuth DJ, Cdk family genes are expressed not only in dividing but also in terminally differentiated mouse germ cells, suggesting their possible function during both cell division and differentiation. Dev Dyn. 1995 Dec;204(4):406-20
1	J:161417 Risley MD, Clowes C, Yu M, Mitchell K, Hentges KE, The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development. Dev Biol. 2010 Jun 15;342(2):146-56
3	J:129766 Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Makela TP, Schneider MD, Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab. 2007 Feb;5(2):129-42
6	J:99492 Schmetsdorf S, Gartner U, Arendt T, Expression of cell cycle-related proteins in developing and adult mouse hippocampus. Int J Dev Neurosci. 2005 Feb;23(1):101-12
1	J:174303 Sekiya S, Suzuki A, Glycogen synthase kinase 3{beta}-dependent Snail degradation directs hepatocyte proliferation in normal liver regeneration. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11175-80
1	J:317430 Sharma D, Mirando AJ, Leinroth A, Long JT, Karner CM, Hilton MJ, HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly. PLoS Genet. 2021 Dec;17(12):e1009982
1	J:196596 Singh N, Gupta M, Trivedi CM, Singh MK, Li L, Epstein JA, Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Dev Biol. 2013 May 15;377(2):333-44
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1	J:211957 Tane S, Ikenishi A, Okayama H, Iwamoto N, Nakayama KI, Takeuchi T, CDK inhibitors, p21(Cip1) and p27(Kip1), participate in cell cycle exit of mammalian cardiomyocytes. Biochem Biophys Res Commun. 2014 Jan 17;443(3):1105-9
2	J:315979 Tane S, Kubota M, Okayama H, Ikenishi A, Yoshitome S, Iwamoto N, Satoh Y, Kusakabe A, Ogawa S, Kanai A, Molkentin JD, Nakamura K, Ohbayashi T, Takeuchi T, Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes. J Biol Chem. 2014 Jun 27;289(26):18033-44
3*	J:53930 Timchenko NA, Wilde M, Darlington GJ, C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol Cell Biol. 1999 Apr;19(4):2936-45
1*	J:90397 Toyo-oka K, Hirotsune S, Gambello MJ, Zhou ZQ, Olson L, Rosenfeld MG, Eisenman R, Hurlin P, Wynshaw-Boris A, Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome. Hum Mol Genet. 2004 May 15;13(10):1057-67
1	J:88517 Tsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, Hatakeyama S, Bessho Y, Kageyama R, Suda T, Nakayama KI, Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem. 2004 Mar 5;279(10):9417-23
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1	J:285937 Volland C, Schott P, Didie M, Manner J, Unsold B, Toischer K, Schmidt C, Urlaub H, Nickels K, Knoll R, Schmidt A, Guan K, Hasenfuss G, Seidler T, Control of p21Cip by BRCA1-associated protein is critical for cardiomyocyte cell cycle progression and survival. Cardiovasc Res. 2020 Mar 1;116(3):592-604
4	J:91314 Waclaw RR, Chatot CL, Patterns of expression of cyclins A, B1, D, E and cdk 2 in preimplantation mouse embryos. Zygote. 2004 Feb;12(1):19-30
1	J:233746 Wang X, Wang Y, Snitow ME, Stewart KM, Li S, Lu M, Morrisey EE, Expression of histone deacetylase 3 instructs alveolar type I cell differentiation by regulating a Wnt signaling niche in the lung. Dev Biol. 2016 Jun 15;414(2):161-9
5*	J:213574 Wang XQ, Chan KK, Ming X, Lui VC, Poon RY, Lo CM, Norbury C, Poon RT, G1 checkpoint establishment in vivo during embryonic liver development. BMC Dev Biol. 2014;14:23
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1	J:151770 Wu X, Wang L, Schroer S, Choi D, Chen P, Okada H, Woo M, Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice. Diabetologia. 2009 Oct;52(10):2130-41
2	J:305400 Wu Y, Dong J, Feng S, Zhao Q, Duan P, Xiong M, Wen Y, Lv C, Wang X, Yuan S, Maternal UHRF1 Is Essential for Transcription Landscapes and Repression of Repetitive Elements During the Maternal-to-Zygotic Transition. Front Cell Dev Biol. 2020;8:610773
1	J:187715 Xie L, Hoffmann AD, Burnicka-Turek O, Friedland-Little JM, Zhang K, Moskowitz IP, Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation. Dev Cell. 2012 Aug 14;23(2):280-91
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3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
4	J:255076 Zhang D, Wang Y, Lu P, Wang P, Yuan X, Yan J, Cai C, Chang CP, Zheng D, Wu B, Zhou B, REST regulates the cell cycle for cardiac development and regeneration. Nat Commun. 2017 Dec 7;8(1):1979
1	J:52552 Zhang PM, Wong C, Liu D, Finegold M, Harper JW, Elledge SJ, p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step. Genes Dev. 1999 JAN 15;13(2):213-224
1	J:40391 Zhang Q, Ahuja HS, Zakeri ZF, Wolgemuth DJ, Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling. Dev Biol. 1997 Mar 15;183(2):222-33
1	J:195854 Zhu Y, Pires KM, Whitehead KJ, Olsen CD, Wayment B, Zhang YC, Bugger H, Ilkun O, Litwin SE, Thomas G, Kozma SC, Abel ED, Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS One. 2013;8(1):e54221
3	J:44526 Zindy F, Soares H, Herzog KH, Morgan J, Sherr CJ, Roussel MF, Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development. Cell Growth Differ. 1997 Nov;8(11):1139-50
2	J:196602 Zou Y, Mi J, Wang W, Lu J, Zhao W, Liu Z, Hu H, Yang Y, Gao X, Jiang B, Shao C, Gong Y, CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade. J Cell Biol. 2013 Mar 18;200(6):743-56