Symbol Name ID |
Smyd1
SET and MYND domain containing 1 MGI:104790 |
Age | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11.5 | E12.5 | E13.5 | E14 | E14.5 | E15.5 | E16.5 | E18.5 | P |
Immunohistochemistry (section) | 1 | 1 | 1 | 1 | ||||||||||||
In situ RNA (section) | 1 | 3 | 1 | 1 | 1 | 1 | 1 | |||||||||
In situ RNA (whole mount) | 1 | 1 | 2 | 1 | 6 | 3 | 2 | |||||||||
In situ reporter (knock in) | 1 | |||||||||||||||
Northern blot | 1 | 1 | ||||||||||||||
Western blot | 1 | 1 | 1 | |||||||||||||
RT-PCR | 2 | 3 | 1 | 3 | 1 | 1 | 1 | 1 | 2 | |||||||
cDNA clones | 2 |
Smyd1 SET and MYND domain containing 1 (Synonyms: 4632404M21Rik, Bop) | |
Results | Reference |
2* | J:169899 Brown MA, Sims RJ 3rd, Gottlieb PD, Tucker PW, Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Mol Cancer. 2006;5:26 |
2 | J:332132 Cattaneo P, Hayes MGB, Baumgarten N, Hecker D, Peruzzo S, Aslan GS, Kunderfranco P, Larcher V, Zhang L, Contu R, Fonseca G, Spinozzi S, Chen J, Condorelli G, Dimmeler S, Schulz MH, Heinz S, Guimaraes-Camboa N, Evans SM, DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal. Nat Commun. 2022 Dec 2;13(1):7444 |
1 | J:108510 Diehl AG, Zareparsi S, Qian M, Khanna R, Angeles R, Gage PJ, Extraocular muscle morphogenesis and gene expression are regulated by Pitx2 gene dose. Invest Ophthalmol Vis Sci. 2006 May;47(5):1785-93 |
5* | J:158898 Diehl F, Brown MA, van Amerongen MJ, Novoyatleva T, Wietelmann A, Harriss J, Ferrazzi F, Bottger T, Harvey RP, Tucker PW, Engel FB, Cardiac deletion of Smyd2 is dispensable for mouse heart development. PLoS One. 2010;5(3):e9748 |
7 | J:76212 Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D, Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet. 2002 May;31(1):25-32 |
2 | J:158135 Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D, A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol. 2009 Aug;11(8):951-7 |
6 | J:229482 Nagandla H, Lopez S, Yu W, Rasmussen TL, Tucker HO, Schwartz RJ, Stewart MD, Defective myogenesis in the absence of the muscle-specific lysine methyltransferase SMYD1. Dev Biol. 2016 Feb 1;410(1):86-97 |
2 | J:172819 Nakazawa M, Uchida K, Aramaki M, Kodo K, Yamagishi C, Takahashi T, Mikoshiba K, Yamagishi H, Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field. J Mol Cell Cardiol. 2011 Jul;51(1):58-66 |
1 | J:321574 Niu Z, Iyer D, Conway SJ, Martin JF, Ivey K, Srivastava D, Nordheim A, Schwartz RJ, Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17824-9 |
1* | J:167169 Park CY, Pierce SA, von Drehle M, Ivey KN, Morgan JA, Blau HM, Srivastava D, skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration. Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20750-5 |
2* | J:98506 Phan D, Rasmussen TL, Nakagawa O, McAnally J, Gottlieb PD, Tucker PW, Richardson JA, Bassel-Duby R, Olson EN, BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart. Development. 2005 Jun;132(11):2669-78 |
1 | J:129041 Potthoff MJ, Arnold MA, McAnally J, Richardson JA, Bassel-Duby R, Olson EN, Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Mol Cell Biol. 2007 Dec;27(23):8143-51 |
1 | J:316108 Saita S, Shirane M, Ishitani T, Shimizu N, Nakayama KI, Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway. J Biol Chem. 2014 Sep 12;289(37):25639-54 |
2 | J:347802 Shi W, Wasson LK, Dorr KM, Robbe ZL, Wilczewski CM, Hepperla AJ, Davis IJ, Seidman CE, Seidman JG, Conlon FL, CHD4 and SMYD1 repress common transcriptional programs in the developing heart. Development. 2024 Apr 15;151(8):dev202505 |
4* | J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754 |
1 | J:305418 Smith SJ, Towers N, Saldanha JW, Shang CA, Mahmood SR, Taylor WR, Mohun TJ, The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is essential for heart chamber outgrowth and acts on muscle actin filament assembly. Dev Biol. 2016 Aug 15;416(2):373-88 |
2 | J:222450 Uribe V, Badia-Careaga C, Casanova JC, Dominguez JN, de la Pompa JL, Sanz-Ezquerro JJ, Arid3b is essential for second heart field cell deployment and heart patterning. Development. 2014 Nov;141(21):4168-81 |
5* | J:313931 Wang Z, Schwartz RJ, Liu J, Sun F, Li Q, Ma Y, Smyd1 Orchestrates Early Heart Development Through Positive and Negative Gene Regulation. Front Cell Dev Biol. 2021;9:654682 |
1 | J:134299 Weng J, Luo J, Cheng X, Jin C, Zhou X, Qu J, Tu L, Ai D, Li D, Wang J, Martin JF, Amendt BA, Liu M, Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6081-6 |
3* | J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48 |
1 | J:263025 Zoupa M, Xavier GM, Bryan S, Theologidis I, Arno M, Cobourne MT, Gene expression profiling in the developing secondary palate in the absence of Tbx1 function. BMC Genomics. 2018 Jun 4;19(1):429 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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