Gene Expression Literature Summary

• Symbol: Nkx1-2
• Name: NK1 homeobox 2
• ID: MGI:104806

27 matching records from 27 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1.5	E2	E2.5	E3	E3.5	E6	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15.5	E16	E16.5	E18	E18.5	P
Immunohistochemistry (section)	1	1	1	1	1	1																				1			2
In situ RNA (section)									1	2	2	5	3	3		4	1	1		2	3	1		1					3
Immunohistochemistry (whole mount)	1	1	1	1	1	1																							1
In situ RNA (whole mount)							2	2	2	5	4	8	4	6	1	5	1	3		1	1			2
In situ reporter (knock in)										1		1
Northern blot																													1
RT-PCR								1		1				1	1				1										1
cDNA clones												1											1					1
RNase protection															1				1			1			1		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nkx1-2  NK1 homeobox 2   (Synonyms: Nkx-1.1, Nkx-1.2, Sax1)
Results	Reference
6*	J:236309 Aires R, Jurberg AD, Leal F, Novoa A, Cohn MJ, Mallo M, Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity. Dev Cell. 2016 Aug 8;38(3):262-74
2	J:197180 Buniello A, Hardisty-Hughes RE, Pass JC, Bober E, Smith RJ, Steel KP, Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness. PLoS One. 2013;8(2):e56274
2*	J:119269 Caqueret A, Boucher F, Michaud JL, Laminar organization of the early developing anterior hypothalamus. Dev Biol. 2006 Oct 1;298(1):95-106
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
4	J:237421 Cunningham TJ, Colas A, Duester G, Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors. Biol Open. 2016 Dec 15;5(12):1821-1833
4	J:269325 De Castro SCP, Gustavsson P, Marshall AR, Gordon WM, Galea G, Nikolopoulou E, Savery D, Rolo A, Stanier P, Andersen B, Copp AJ, Greene NDE, Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice. Hum Mol Genet. 2018 Dec 15;27(24):4218-4230
2*	J:258769 De Castro SCP, Hirst CS, Savery D, Rolo A, Lickert H, Andersen B, Copp AJ, Greene NDE, Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues. Dev Biol. 2018 Mar 15;435(2):130-137
4	J:294824 Dias A, Lozovska A, Wymeersch FJ, Novoa A, Binagui-Casas A, Sobral D, Martins GG, Wilson V, Mallo M, A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation. Elife. 2020 Jun 29;9:e56615
1	J:73345 Gaikwad JS, Cavender A, D'Souza RN, Identification of tooth-specific downstream targets of Runx2. Gene. 2001 Nov 14;279(1):91-7
1*	J:43763 Gavalas A, Davenne M, Lumsden A, Chambon P, Rijli FM, Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning. Development. 1997 Oct;124(19):3693-702
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2*	J:186535 Herriges JC, Yi L, Hines EA, Harvey JF, Xu G, Gray PA, Ma Q, Sun X, Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
2	J:189004 Iwafuchi-Doi M, Matsuda K, Murakami K, Niwa H, Tesar PJ, Aruga J, Matsuo I, Kondoh H, Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development. 2012 Nov;139(21):3926-37
14	J:348701 Nakagawa S, Carnevali D, Tan X, Alvarez MJ, Parfitt DE, Di Vicino U, Arumugam K, Shin W, Aranda S, Normanno D, Sebastian-Perez R, Cannata C, Cortes P, Neguembor MV, Shen MM, Califano A, Cosma MP, The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development. Stem Cell Reports. 2024 May 14;19(5):689-709
15*	J:266577 Rodrigo Albors A, Halley PA, Storey KG, Lineage tracing of axial progenitors using Nkx1-2CreER(T2) mice defines their trunk and tail contributions. Development. 2018 Oct 2;145(19):dev164319
2	J:232202 Rolo A, Savery D, Escuin S, de Castro SC, Armer HE, Munro PM, Mole MA, Greene N, Copp AJ, Regulation of cell protrusions by small GTPases during fusion of the neural folds. Elife. 2016;5:e13273
11*	J:60862 Rovescalli AC, Cinquanta M, Ferrante J, Kozak CA, Nirenberg M, The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at canonical and noncanonical splice sites. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):1982-7
16*	J:26182 Schubert FR, Fainsod A, Gruenbaum Y, Gruss P, Expression of the novel murine homeobox gene Sax-1 in the developing nervous system. Mech Dev. 1995 May;51(1):99-114
1	J:86868 Simon R, Lufkin T, Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation. Mol Cell Biol. 2003 Dec;23(24):9046-60
1	J:278240 Tahara N, Kawakami H, Chen KQ, Anderson A, Yamashita Peterson M, Gong W, Shah P, Hayashi S, Nishinakamura R, Nakagawa Y, Garry DJ, Kawakami Y, Sall4 regulates neuromesodermal progenitors and their descendants during body elongation in mouse embryos. Development. 2019 Jul 15;146(14):dev177659
7*	J:317900 Tamashiro DA, Alarcon VB, Marikawa Y, Nkx1-2 is a transcriptional repressor and is essential for the activation of Brachyury in P19 mouse embryonal carcinoma cell. Differentiation. 2012 Jun;83(5):282-92
3*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
1*	J:48372 Tang SJ, Hoodless PA, Lu Z, Breitman ML, McInnes RR, Wrana JL , Buchwald M, The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development. 1998 May;125(10):1877-87
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
1*	J:132031 Wong RL, Wlodarczyk BJ, Min KS, Scott ML, Kartiko S, Yu W, Merriweather MY, Vogel P, Zambrowicz BP, Finnell RH, Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube. Hum Mol Genet. 2008 Feb 15;17(4):587-601
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48