Gene Expression Literature Summary

• Symbol: Jarid2
• Name: jumonji and AT-rich interaction domain containing 2
• ID: MGI:104813

39 matching records from 39 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E2.5	E3	E3.5	E4.5	E6.5	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16.5	E17	E17.5	E18.5	E19.5	E	P
Immunohistochemistry (section)				1	1							1		1			1		1						1				1
In situ RNA (section)							1			1		3	1	1			1	1	1		8	1		1				1	2
In situ RNA (whole mount)												3		3	2							1
In situ reporter (knock in)									2	2	1	2	1	2	2		2		2		3		3			2	1	1	4
Northern blot																	1			1			1						1
Western blot															2		1		1		1		1		1				2
RT-PCR	2	2	1	1	2	1		1		1		2		2					1		1		1			1			3
cDNA clones										1						1									1				1
RNase protection																	1				1		1		1				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Jarid2  jumonji and AT-rich interaction domain containing 2   (Synonyms: Jmj, jumonji)
Results	Reference
4*	J:85152 Anzai H, Kamiya A, Shirato H, Takeuchi T, Miyajima A, Impaired differentiation of fetal hepatocytes in homozygous jumonji mice. Mech Dev. 2003 Jul;120(7):791-800
5	J:40477 Baker RK, Haendel MA, Swanson BJ, Shambaugh JC, Micales BK, Lyons GE, In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
3*	J:161212 Barth JL, Clark CD, Fresco VM, Knoll EP, Lee B, Argraves WS, Lee KH, Jarid2 is among a set of genes differentially regulated by Nkx2.5 during outflow tract morphogenesis. Dev Dyn. 2010 Jul;239(7):2024-33
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
7	J:280323 Cho E, Kang H, Kang DK, Lee Y, Myocardial-specific ablation of Jumonji and AT-rich interaction domain-containing 2 (Jarid2) leads to dilated cardiomyopathy in mice. J Biol Chem. 2019 Mar 29;294(13):4981-4996
5	J:267108 Cho E, Mysliwiec MR, Carlson CD, Ansari A, Schwartz RJ, Lee Y, Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development. J Biol Chem. 2018 Jul 27;293(30):11659-11673
1*	J:262237 Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Pratt-Kelly I, Koseki Y, Nakayama M, Ishikura T, Streubel G, Wynne K, Hokamp K, McLysaght A, Ciferri C, Di Croce L, Cagney G, Margueron R, Koseki H, Bracken AP, A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. Mol Cell. 2018 May 3;70(3):408-421.e8
2	J:240642 Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova TB, Anil-Kirmizitas B, Bassett A, Kooistra SM, Agger K, Helin K, Heard E, Brockdorff N, Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nat Commun. 2016 Nov 28;7:13661
1*	J:296013 Dehghan Z, Mohammadi-Yeganeh S, Salehi M, MiRNA-155 regulates cumulus cells function, oocyte maturation, and blastocyst formation. Biol Reprod. 2020 Aug 21;103(3):548-559
1*	J:266522 Elsen GE, Bedogni F, Hodge RD, Bammler TK, MacDonald JW, Lindtner S, Rubenstein JLR, Hevner RF, The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1. Front Neurosci. 2018;12:571
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1	J:112633 Jukkola T, Lahti L, Naserke T, Wurst W, Partanen J, FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region. Dev Biol. 2006 Sep 1;297(1):141-57
5	J:63359 Lee Y, Song AJ, Baker R, Micales B, Conway SJ, Lyons GE, Jumonji, a nuclear protein that is necessary for normal heart development [see comments]. Circ Res. 2000 May 12;86(9):932-8
1	J:350444 Martinez-Mayer J, Brinkmeier ML, O'Connell SP, Ukagwu A, Marti MA, Miras M, Forclaz MV, Benzrihen MG, Cheung LYM, Camper SA, Ellsworth BS, Raetzman LT, Perez-Millan MI, Davis SW, Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
1*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
2*	J:42772 Motoyama J, Kitajima K, Kojima M, Kondo S, Takeuchi T, Organogenesis of the liver, thymus and spleen is affected in jumonji mutant mice. Mech Dev. 1997 Aug;66(1-2):27-37
1*	J:172692 Mysliwiec MR, Bresnick EH, Lee Y, Endothelial jarid2/jumonji is required for normal cardiac development and proper notch1 expression. J Biol Chem. 2011 May 13;286(19):17193-204
2*	J:179668 Mysliwiec MR, Carlson CD, Tietjen J, Hung H, Ansari AZ, Lee Y, Jarid2 (Jumonji, AT Rich Interactive Domain 2) Regulates NOTCH1 Expression via Histone Modification in the Developing Heart. J Biol Chem. 2012 Jan 6;287(2):1235-41
1*	J:114450 Mysliwiec MR, Chen J, Powers PA, Bartley CR, Schneider MD, Lee Y, Generation of a conditional null allele of jumonji. Genesis. 2006 Sep;44(9):407-11
1	J:161350 Nath AK, Krauthammer M, Li P, Davidov E, Butler LC, Copel J, Katajamaa M, Oresic M, Buhimschi I, Buhimschi C, Snyder M, Madri JA, Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects. PLoS One. 2009;4(1):e4221
1*	J:149737 Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ, The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511
3*	J:165463 Scapoli L, Martinelli M, Pezzetti F, Palmieri A, Girardi A, Savoia A, Bianco AM, Carinci F, Expression and association data strongly support JARID2 involvement in nonsyndromic cleft lip with or without cleft palate. Hum Mutat. 2010 Jul;31(7):794-800
6	J:109567 Shen WB, Plachez C, Mongi AS, Richards LJ, Identification of candidate genes at the corticoseptal boundary during development. Gene Expr Patterns. 2006 Jun;6(5):471-81
4*	J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
1	J:159133 Shirato H, Ogawa S, Nakajima K, Inagawa M, Kojima M, Tachibana M, Shinkai Y, Takeuchi T, A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9. J Biol Chem. 2009 Jan 9;284(2):733-9
1	J:119194 Takahashi M, Kojima M, Nakajima K, Suzuki-Migishima R, Takeuchi T, Functions of a jumonji-cyclin D1 pathway in the coordination of cell cycle exit and migration during neurogenesis in the mouse hindbrain. Dev Biol. 2007 Mar 15;303(2):549-60
6*	J:57069 Takeuchi T, Kojima M, Nakajima K, Kondo S, jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background. Mech Dev. 1999 Aug;86(1-2):29-38
11	J:25641 Takeuchi T, Yamazaki Y, Katoh-Fukui Y, Tsuchiya R, Kondo S, Motoyama J, Higashinakagawa T, Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev. 1995 May 15;9(10):1211-22
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
3	J:107647 Thuret S, Bhatt L, O'Leary DD, Simon HH, Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Mol Cell Neurosci. 2004 Mar;25(3):394-405
2*	J:114180 Toyoda M, Kojima M, Takeuchi T, Jumonji is a nuclear protein that participates in the negative regulation of cell growth. Biochem Biophys Res Commun. 2000 Aug 2;274(2):332-6
7	J:267650 Toyoda M, Shirato H, Nakajima K, Kojima M, Takahashi M, Kubota M, Suzuki-Migishima R, Motegi Y, Yokoyama M, Takeuchi T, jumonji downregulates cardiac cell proliferation by repressing cyclin D1 expression. Dev Cell. 2003 Jul;5(1):85-97
2	J:104600 Trokovic R, Jukkola T, Saarimaki J, Peltopuro P, Naserke T, Weisenhorn DM, Trokovic N, Wurst W, Partanen J, Fgfr1-dependent boundary cells between developing mid- and hindbrain. Dev Biol. 2005 Feb 15;278(2):428-39
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:108444 Watanabe Y, Kokubo H, Miyagawa-Tomita S, Endo M, Igarashi K, Aisaki KI, Kanno J, Saga Y, Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse. Development. 2006 May;133(9):1625-34
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
3	J:313616 Zhang F, Zhao X, Jiang R, Wang Y, Wang X, Gu Y, Xu L, Ye J, Chen CD, Guo S, Zhang D, Zhao D, Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice. Front Cell Dev Biol. 2021;9:642931
4	J:334713 Zhang J, Roberts JM, Chang F, Schwakopf J, Vetter ML, Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1. Cell Rep. 2023 Mar 28;42(3):112237