Symbol Name ID |
Gpc4
glypican 4 MGI:104902 |
Age | E6.5 | E7 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E18 | E | P |
Immunohistochemistry (section) | 1 | 2 | 1 | 1 | 1 | 1 | ||||||||||||||||||
In situ RNA (section) | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 4 | ||||||
In situ RNA (whole mount) | 1 | 1 | 3 | 1 | 3 | 1 | 5 | 1 | 2 | |||||||||||||||
In situ reporter (knock in) | 1 | |||||||||||||||||||||||
Northern blot | 1 | |||||||||||||||||||||||
Western blot | 1 | 1 | 1 | |||||||||||||||||||||
RT-PCR | 1 | 1 | 1 | 2 | 1 | 2 | ||||||||||||||||||
cDNA clones | 1 | 1 | 1 |
Gpc4 glypican 4 (Synonyms: 9530073D23Rik, K-glypican) | |
Results | Reference |
1 | J:153618 Ahrens MJ, Li Y, Jiang H, Dudley AT, Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins. Development. 2009 Oct;136(20):3463-74 |
1 | J:297362 Bachvarova V, Dierker T, Esko J, Hoffmann D, Kjellen L, Vortkamp A, Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate. Matrix Biol. 2020 Nov;93:43-59 |
1* | J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034 |
1 | J:230611 Dierker T, Bachvarova V, Krause Y, Li JP, Kjellen L, Seidler DG, Vortkamp A, Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones. Matrix Biol. 2016 Jan;49:82-92 |
1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
1 | J:296619 Fan Y, Richelme S, Avazeri E, Audebert S, Helmbacher F, Dono R, Maina F, Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis. PLoS Genet. 2015;11(9):e1005533 |
4* | J:317820 Fico A, De Chevigny A, Egea J, Bosl MR, Cremer H, Maina F, Dono R, Modulating Glypican4 suppresses tumorigenicity of embryonic stem cells while preserving self-renewal and pluripotency. Stem Cells. 2012 Sep;30(9):1863-74 |
3* | J:83696 Ford-Perriss M, Turner K, Guimond S, Apedaile A, Haubeck HD, Turnbull J, Murphy M, Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. Dev Dyn. 2003 Jun;227(2):170-84 |
1 | J:152858 Garcia-Ortiz JE, Pelosi E, Omari S, Nedorezov T, Piao Y, Karmazin J, Uda M, Cao A, Cole SW, Forabosco A, Schlessinger D, Ottolenghi C, Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. BMC Dev Biol. 2009;9:36 |
7 | J:65676 Hagihara K, Watanabe K, Chun J, Yamaguchi Y, Glypican-4 is an FGF2-binding heparan sulfate proteoglycan expressed in neural precursor cells. Dev Dyn. 2000 Nov;219(3):353-67 |
1 | J:83512 Hikake T, Mori T, Iseki K, Hagino S, Zhang Y, Takagi H, Yokoya S, Wanaka A, Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development. Anat Embryol (Berl). 2003 Apr;206(5):373-80 |
2 | J:219796 Ko JS, Pramanik G, Um JW, Shim JS, Lee D, Kim KH, Chung GY, Condomitti G, Kim HM, Kim H, de Wit J, Park KS, Tabuchi K, Ko J, PTPsigma functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1874-9 |
1* | J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9 |
1 | J:218235 Lopez-Escobar B, Cano DA, Rojas A, de Felipe B, Palma F, Sanchez-Alcazar JA, Henderson D, Ybot-Gonzalez P, The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye. Dis Model Mech. 2015 Feb;8(2):157-68 |
3 | J:264113 Lopez-Escobar B, Caro-Vega JM, Vijayraghavan DS, Plageman TF, Sanchez-Alcazar JA, Moreno RC, Savery D, Marquez-Rivas J, Davidson LA, Ybot-Gonzalez P, The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate. Development. 2018 May 8;145(9):dev157487 |
11* | J:116479 Luxardi G, Galli A, Forlani S, Lawson K, Maina F, Dono R, Glypicans are differentially expressed during patterning and neurogenesis of early mouse brain. Biochem Biophys Res Commun. 2007 Jan 5;352(1):55-60 |
1 | J:197761 McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck D, Higashi Y, Rubenstein JL, Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. Neuron. 2013 Jan 9;77(1):83-98 |
2 | J:331869 Shi W, Filmus J, Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling. Dev Dyn. 2022 Dec;251(12):2015-2028 |
5* | J:28429 Watanabe K, Yamada H, Yamaguchi Y, K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. J Cell Biol. 1995 Sep;130(5):1207-18 |
5 | J:337768 Wishart TFL, Lovicu FJ, Spatiotemporal Localisation of Heparan Sulphate Proteoglycans throughout Mouse Lens Morphogenesis. Cells. 2023 May 11;12(10) |
1* | J:286311 Wu J, Li H, Han L, Sun T, Tian Y, Wang X, The spatiotemporal expression pattern of Syndecans in murine embryonic teeth. Gene Expr Patterns. 2020 Mar 24;36:119109 |
1 | J:326953 Wu X, Sosunov AA, Lado W, Teoh JJ, Ham A, Li H, Al-Dalahmah O, Gill BJA, Arancio O, Schevon CA, Frankel WN, McKhann GM 2nd, Sulzer D, Goldman JE, Tang G, Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex. Cell Rep. 2022 Jul 19;40(3):111085 |
14* | J:98790 Ybot-Gonzalez P, Copp AJ, Greene ND, Expression pattern of glypican-4 suggests multiple roles during mouse development. Dev Dyn. 2005 Apr 13;233(3):1013-1017 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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