Gene Expression Literature Summary

• Symbol: Crybb1
• Name: crystallin, beta B1
• ID: MGI:104992

19 matching records from 19 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E11.5	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E17.5	E18	E	P
Immunohistochemistry (section)	1		2		1	2	1			1	5
In situ RNA (section)		1				1	1			1
Northern blot							1				1
Western blot							1				1
RT-PCR	1	1		1	1	2	1	2	1		5

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Crybb1  crystallin, beta B1   (Synonyms: 3110006K12Rik)
Results	Reference
1	J:334326 Brioschi S, Belk JA, Peng V, Molgora M, Rodrigues PF, Nguyen KM, Wang S, Du S, Wang WL, Grajales-Reyes GE, Ponce JM, Yuede CM, Li Q, Baer JM, DeNardo DG, Gilfillan S, Cella M, Satpathy AT, Colonna M, A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages. Immunity. 2023 Feb 8;
2	J:158529 Burgess D, Zhang Y, Siefker E, Vaca R, Kuracha MR, Reneker L, Overbeek PA, Govindarajan V, Activated Ras alters lens and corneal development through induction of distinct downstream targets. BMC Dev Biol. 2010;10:13
2	J:74730 Chen Q, Ash JD, Branton P, Fromm L, Overbeek PA, Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice. Oncogene. 2002 Feb 7;21(7):1028-37
3*	J:34072 Duncan MK, Li X, Ogino H, Yasuda K, Piatigorsky J, Developmental regulation of the chicken beta B1-crystallin promoter in transgenic mice. Mech Dev. 1996 Jun;57(1):79-89
1	J:93431 Duncan MK, Xie L, David LL, Robinson ML, Taube JR, Cui W, Reneker LW, Ectopic Pax6 expression disturbs lens fiber cell differentiation. Invest Ophthalmol Vis Sci. 2004 Nov;45(10):3589-98
3*	J:332312 Jiao X, Kabir F, Irum B, Khan AO, Wang Q, Li D, Khan AA, Husnain T, Akram J, Riazuddin S, Hejtmancik JF, Riazuddin SA, A Common Ancestral Mutation in CRYBB3 Identified in Multiple Consanguineous Families with Congenital Cataracts. PLoS One. 2016;11(6):e0157005
2	J:214344 Kerr CL, Zaveri MA, Robinson ML, Williams T, West-Mays JA, AP-2alpha is required after lens vesicle formation to maintain lens integrity. Dev Dyn. 2014 Oct;243(10):1298-309
1	J:270067 Limi S, Zhao Y, Guo P, Lopez-Jones M, Zheng D, Singer RH, Skoultchi AI, Cvekl A, Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers. Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):234-244
2	J:246153 Logan CM, Rajakaruna S, Bowen C, Radice GL, Robinson ML, Menko AS, N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. Dev Biol. 2017 Aug 01;428(1):118-134
1	J:151537 Maeda A, Moriguchi T, Hamada M, Kusakabe M, Fujioka Y, Nakano T, Yoh K, Lim KC, Engel JD, Takahashi S, Transcription factor GATA-3 is essential for lens development. Dev Dyn. 2009 Jul 21;238(9):2280-2291
6	J:95535 Min JN, Zhang Y, Moskophidis D, Mivechi NF, Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Genesis. 2004 Dec;40(4):205-17
2	J:37334 Reneker LW, Overbeek PA, Lens-specific expression of PDGF-A alters lens growth and development. Dev Biol. 1996 Dec 15;180(2):554-65
2*	J:56583 Ring BZ, Cordes SP, Overbeek PA, Barsh GS, Regulation of mouse lens fiber cell development and differentiation by the Maf gene. Development. 2000 Jan;127(2):307-17
2	J:254701 Suzuki-Kerr H, Baba Y, Tsuhako A, Koso H, Dekker JD, Tucker HO, Kuribayashi H, Watanabe S, Forkhead Box Protein P1 Is Dispensable for Retina but Essential for Lens Development. Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):1916-1929
1	J:53431 Wigle JT, Chowdhury K, Gruss P, Oliver G, Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet. 1999 Mar;21(3):318-22
1	J:178731 Xie Q, Cvekl A, The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71
1*	J:314897 Xie Q, McGreal R, Harris R, Gao CY, Liu W, Reneker LW, Musil LS, Cvekl A, Regulation of c-Maf and alphaA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling. J Biol Chem. 2016 Feb 19;291(8):3947-58
2	J:293760 Yu W, Yu Z, Wu D, Zhang J, Zhu Y, Zhang Y, Ning H, Wang M, Zhang J, Zhao J, Lens-specific conditional knockout of Msx2 in mice leads to ocular anterior segment dysgenesis via activation of a calcium signaling pathway. Lab Invest. 2019 Nov;99(11):1714-1727
1	J:197830 Zhang R, Huang H, Cao P, Wang Z, Chen Y, Pan Y, Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse. J Biol Chem. 2013 Apr 12;288(15):10275-85