Gene Expression Literature Summary

• Symbol: Pgf
• Name: placental growth factor
• ID: MGI:105095

27 matching records from 27 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18.5	P
Immunohistochemistry (section)											1				1			1		1	1
In situ RNA (section)		1		1		1		1		1	1	1		1	1	2	1				3
In situ RNA (whole mount)																1
Northern blot								1			1										2
Western blot																					2
RT-PCR	1		2		6		1		1		2		3		2	2	1	4	2	4	11
cDNA clones						1															1
RNase protection																					1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pgf  placental growth factor   (Synonyms: PIGF, placenta growth factor, PLGF)
Results	Reference
12*	J:44540 Achen MG, Gad JM, Stacker SA, Wilks AF, Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development. Growth Factors. 1997;15(1):69-80
2*	J:271257 Apicella I, Cicatiello V, Acampora D, Tarallo V, De Falco S, Full Functional Knockout of Placental Growth Factor by Knockin with an Inactive Variant Able to Heterodimerize with VEGF-A. Cell Rep. 2018 Jun 19;23(12):3635-3646
1	J:186528 Bainbridge SA, Minhas A, Whiteley KJ, Qu D, Sled JG, Kingdom JC, Adamson SL, Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice. Hypertension. 2012 Mar;59(3):732-9
2	J:231798 Chen CY, Chan CH, Chen CM, Tsai YS, Tsai TY, Wu Lee YH, You LR, Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 July 15;25(14):2905-2922
1	J:169692 Copeland JN, Feng Y, Neradugomma NK, Fields PE, Vivian JL, Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac. BMC Dev Biol. 2011;11:12
2	J:311143 Courtney JA, Wilson RL, Cnota J, Jones HN, Conditional Mutation of Hand1 in the Mouse Placenta Disrupts Placental Vascular Development Resulting in Fetal Loss in Both Early and Late Pregnancy. Int J Mol Sci. 2021 Sep 2;22(17)
1	J:171226 Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B, GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64
5*	J:30836 DiPalma T, Tucci M, Russo G, Maglione D, Lago CT, Romano A, Saccone S, Della Valle G, De Gregorio L, Dragani TA, Viglietto G, Persico MG, The placenta growth factor gene of the mouse. Mamm Genome. 1996 Jan;7(1):6-12
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
4	J:200722 Hick AC, Delmarcelle AS, Bouquet M, Klotz S, Copetti T, Forez C, Van Der Smissen P, Sonveaux P, Collet JF, Feron O, Courtoy PJ, Pierreux CE, Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation. Dev Biol. 2013 Sep 1;381(1):227-40
1	J:244834 Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B, ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017 Aug 18;357(6352):707-713
3	J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
1	J:311572 Kang MC, Park SJ, Kim HJ, Lee J, Yu DH, Bae KB, Ji YR, Park SJ, Jeong J, Jang WY, Kim JH, Choi MS, Lee DS, Lee HS, Lee S, Kim SH, Kim MO, Park G, Choo YS, Cho JY, Ryoo ZY, Gestational loss and growth restriction by angiogenic defects in placental growth factor transgenic mice. Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2276-82
2	J:211963 Kawakami T, Yoshimi M, Kadota Y, Inoue M, Sato M, Suzuki S, Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):134-44
3*	J:147318 Lopez-Garcia C, Lopez-Contreras AJ, Cremades A, Castells MT, Marin F, Schreiber F, Penafiel R, Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice. Endocrinology. 2008 Oct;149(10):5012-23
8*	J:231234 Luna RL, Kay VR, Ratsep MT, Khalaj K, Bidarimath M, Peterson N, Carmeliet P, Jin A, Croy BA, Placental growth factor deficiency is associated with impaired cerebral vascular development in mice. Mol Hum Reprod. 2016 Feb;22(2):130-42
1*	J:74493 Maes C, Carmeliet P, Moermans K, Stockmans I, Smets N, Collen D, Bouillon R, Carmeliet G, Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF(164) and VEGF(188). Mech Dev. 2002 Feb;111(1-2):61-73
3	J:77722 Odorisio T, Schietroma C, Zaccaria ML, Cianfarani F, Tiveron C, Tatangelo L, Failla CM, Zambruno G, Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability. J Cell Sci. 2002 Jun 15;115(Pt 12):2559-67
2	J:97408 Ohlmann A, Scholz M, Goldwich A, Chauhan BK, Hudl K, Ohlmann AV, Zrenner E, Berger W, Cvekl A, Seeliger MW, Tamm ER, Ectopic norrin induces growth of ocular capillaries and restores normal retinal angiogenesis in Norrie disease mutant mice. J Neurosci. 2005 Feb 16;25(7):1701-10
1	J:216405 Oladipupo SS, Smith C, Santeford A, Park C, Sene A, Wiley LA, Osei-Owusu P, Hsu J, Zapata N, Liu F, Nakamura R, Lavine KJ, Blumer KJ, Choi K, Apte RS, Ornitz DM, Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13379-84
2	J:214095 Osipovich AB, Long Q, Manduchi E, Gangula R, Hipkens SB, Schneider J, Okubo T, Stoeckert CJ Jr, Takada S, Magnuson MA, Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug;141(15):2939-49
2	J:330449 Rusidze M, Faure MC, Sicard P, Raymond-Letron I, Giton F, Vessieres E, Prevot V, Henrion D, Arnal JF, Cornil CA, Lenfant F, Loss of function of the maternal membrane oestrogen receptor ERalpha alters expansion of trophoblast cells and impacts mouse fertility. Development. 2022 Oct 1;149(19):dev200683
1	J:358424 Sekimoto A, Takaso Y, Saruyama H, Ookawa M, Yamamoto M, Toyohara T, Saigusa D, Fukuuchi T, Otsuka M, Fushiki Y, Yamakoshi S, Tanaka K, Ikeda T, Tanaka T, Takahashi N, Mishima E, Sato E, Impacts of low birthweight on kidney development and intergenerational growth of the offspring. iScience. 2024 Nov 15;27(11):111159
1	J:171050 Thiagarajan RD, Georgas KM, Rumballe BA, Lesieur E, Chiu HS, Taylor D, Tang DT, Grimmond SM, Little MH, Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286
2	J:318908 Wilson RL, Troja W, Courtney J, Williams A, Jones HN, Placental and fetal characteristics of the Ohia mouse line recapitulate outcomes in human hypoplastic left heart syndrome. Placenta. 2022 Jan;117:131-138
2	J:85564 Zhang H, Palmer R, Gao X, Kreidberg J, Gerald W, Hsiao L, Jensen RV, Gullans SR, Haber DA, Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1. Curr Biol. 2003 Sep 16;13(18):1625-9
4	J:342401 Zhao H, Wong RJ, Stevenson DK, The placental vasculature is affected by changes in gene expression and glycogen-rich cells in a diet-induced obesity mouse model. PLoS One. 2023;18(11):e0294185