Gene Expression Literature Summary

• Symbol: Ube3a
• Name: ubiquitin protein ligase E3A
• ID: MGI:105098

24 matching records from 24 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E6.5	E7.5	E8.5	E9	E9.5	E10	E10.5	E11.5	E13.5	E14	E14.5	E15	E15.5	E16	E17	E18	E18.5	E	P
Immunohistochemistry (section)														1						4
In situ RNA (section)		1	1	1				1	2	1		1		3				1		4
Northern blot																				1
Western blot					1						1		1	1	1	1	1		1	8
RT-PCR	1		1			2	1		1	1		1	1	2	1		1	1	1	11

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ube3a  ubiquitin protein ligase E3A   (Synonyms: 5830462N02Rik, A130086L21Rik, E6-AP ubiquitin protein ligase, Hpve6a)
Results	Reference
6	J:42721 Albrecht U, Sutcliffe JS, Cattanach BM, Beechey CV, Armstrong D , Eichele G , Beaudet AL, Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons. Nat Genet. 1997 Sep;17(1):75-8
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2	J:206605 Faisal M, Kim H, Kim J, Sexual differences of imprinted genes' expression levels. Gene. 2014 Jan 1;533(1):434-8
2*	J:207208 Hattori T, Kishino T, Stephen S, Eberspaecher H, Maki S, Takigawa M, de Crombrugghe B, Yasuda H, E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein. J Biol Chem. 2013 Dec 6;288(49):35138-48
2	J:164010 Jiang YH, Pan Y, Zhu L, Landa L, Yoo J, Spencer C, Lorenzo I, Brilliant M, Noebels J, Beaudet AL, Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3. PLoS One. 2010;5(8)
3	J:169234 Kim JD, Kim H, Ekram MB, Yu S, Faulk C, Kim J, Rex1/Zfp42 as an epigenetic regulator for genomic imprinting. Hum Mol Genet. 2011 Apr 1;20(7):1353-62
1*	J:321365 Knoedler JR, Inoue S, Bayless DW, Yang T, Tantry A, Davis CH, Leung NY, Parthasarathy S, Wang G, Alvarado M, Rizvi AH, Fenno LE, Ramakrishnan C, Deisseroth K, Shah NM, A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior. Cell. 2022 Feb 17;185(4):654-671.e22
3	J:181118 Kohama C, Kato H, Numata K, Hirose M, Takemasa T, Ogura A, Kiyosawa H, ES cell differentiation system recapitulates the establishment of imprinted gene expression in a cell-type-specific manner. Hum Mol Genet. 2012 Mar 15;21(6):1391-401
1	J:132025 Labialle S, Yang L, Ruan X, Villemain A, Schmidt JV, Hernandez A, Wiltshire T, Cermakian N, Naumova AK, Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes. Hum Mol Genet. 2008 Jan 1;17(1):15-26
1	J:294716 Liang ZS, Cimino I, Yalcin B, Raghupathy N, Vancollie VE, Ibarra-Soria X, Firth HV, Rimmington D, Farooqi IS, Lelliott CJ, Munger SC, O'Rahilly S, Ferguson-Smith AC, Coll AP, Logan DW, Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity. PLoS Genet. 2020 Sep;16(9):e1008916
4	J:352712 Lin CW, Cheng YC, Yang CH, Huang HS, Light activates Ube3a, an Angelman syndrome-associated gene, by mediating the chromatin structures during postnatal development of mouse retina. J Neurochem. 2023 Dec;167(6):766-777
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:82790 Mager J, Montgomery ND, de Villena FP, Magnuson T, Genome imprinting regulated by the mouse Polycomb group protein Eed. Nat Genet. 2003 Apr;33(4):502-7
1	J:167914 Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP, Mardinly AR, Hu L, Greer PL, Bikoff JB, Ho HY, Soskis MJ, Sahin M, Greenberg ME, EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Cell. 2010 Oct 29;143(3):442-55
7*	J:193917 Miao S, Chen R, Ye J, Tan GH, Li S, Zhang J, Jiang YH, Xiong ZQ, The Angelman syndrome protein Ube3a is required for polarized dendrite morphogenesis in pyramidal neurons. J Neurosci. 2013 Jan 2;33(1):327-33
2	J:355918 Mould AW, Pang Z, Pakusch M, Tonks ID, Stark M, Carrie D, Mukhopadhyay P, Seidel A, Ellis JJ, Deakin J, Wakefield MJ, Krause L, Blewitt ME, Kay GF, Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation. Epigenetics Chromatin. 2013 Jul 2;6(1):19
4	J:217174 Nakagaki A, Osanai H, Kishino T, Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos. Gene. 2014 Dec 10;553(1):63-8
1	J:195360 Seibt J, Armant O, Le Digarcher A, Castro D, Ramesh V, Journot L, Guillemot F, Vanderhaeghen P, Bouschet T, Expression at the imprinted dlk1-gtl2 locus is regulated by proneural genes in the developing telencephalon. PLoS One. 2012;7(11):e48675
2*	J:152022 Skryabin BV, Gubar LV, Seeger B, Pfeiffer J, Handel S, Robeck T, Karpova E, Rozhdestvensky TS, Brosius J, Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation. PLoS Genet. 2007 Dec 28;3(12):e235
5	J:321233 Sonzogni M, Zhai P, Mientjes EJ, van Woerden GM, Elgersma Y, Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome. Mol Autism. 2020 Sep 18;11(1):70
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2*	J:276611 Vatsa N, Kumar V, Singh BK, Kumar SS, Sharma A, Jana NR, Down-Regulation of miRNA-708 Promotes Aberrant Calcium Signaling by Targeting Neuronatin in a Mouse Model of Angelman Syndrome. Front Mol Neurosci. 2019;12:35
2	J:338299 Xing L, Simon JM, Ptacek TS, Yi JJ, Loo L, Mao H, Wolter JM, McCoy ES, Paranjape SR, Taylor-Blake B, Zylka MJ, Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice. Cell Rep. 2023 Jun 28;42(7):112706
3*	J:82936 Yamasaki K, Joh K, Ohta T, Masuzaki H, Ishimaru T, Mukai T, Niikawa N, Ogawa M, Wagstaff J, Kishino T, Neurons but not glial cells show reciprocal imprinting of sense and antisense transcripts of Ube3a. Hum Mol Genet. 2003 Apr 15;12(8):837-47