Gene Expression Literature Summary

• Symbol: Gcna
• Name: germ cell nuclear acidic protein
• ID: MGI:105113

162 matching records from 162 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E8.5	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18	E18.5	E19	E19.5	E20	E	P
Immunohistochemistry (section)		1	1	1	1	15	23	1	35	1	33	36	1	26	14	3	33	1	6	1	1	93
In situ RNA (section)																						1
Immunohistochemistry (whole mount)	1						3		2		5	2					1		1			3
Western blot											1				1							2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Gcna  germ cell nuclear acidic protein   (Synonyms: Gcna1, Gm52429)
Results	Reference
5*	J:89199 Adams IR, McLaren A, Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells. Dev Dyn. 2004 Apr;229(4):733-44
3	J:339445 Ahmed AA, Salas E, Lanza DG, Heaney JD, Pangas SA, Generation of a novel Stra8-driven Cre recombinase strain for use in pre-meiotic germ cells in mice. Biol Reprod. 2023 Aug 10;109(2):184-191
1	J:308132 Alankarage D, Lavery R, Svingen T, Kelly S, Ludbrook L, Bagheri-Fam S, Koopman P, Harley V, SOX9 regulates expression of the male fertility gene Ets variant factor 5 (ETV5) during mammalian sex development. Int J Biochem Cell Biol. 2016 Oct;79:41-51
10*	J:133516 Alton M, Lau MP, Villemure M, Taketo T, The behavior of the X- and Y-chromosomes in the oocyte during meiotic prophase in the B6.Y(TIR)sex-reversed mouse ovary. Reproduction. 2008 Feb;135(2):241-52
4	J:120767 Alton M, Taketo T, Switch from BAX-dependent to BAX-independent germ cell loss during the development of fetal mouse ovaries. J Cell Sci. 2007 Feb 1;120(Pt 3):417-24
1*	J:194507 Arango NA, Li L, Dabir D, Nicolau F, Pieretti-Vanmarcke R, Koehler C, McCarrey JR, Lu N, Donahoe PK, Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (m1ap)-deficient mice. Biol Reprod. 2013;88(3):76
1	J:247201 Arora R, Abby E, Ross AD, Cantu AV, Kissner MD, Castro V, Ho HY, Livera G, Laird DJ, Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary. J Cell Sci. 2016 Jul 01;129(13):2493-9
1*	J:83663 Atchison FW, Capel B, Means AR, Pin1 regulates the timing of mammalian primordial germ cell proliferation. Development. 2003 Aug;130(15):3579-86
1*	J:171630 Bagheri-Fam S, Argentaro A, Svingen T, Combes AN, Sinclair AH, Koopman P, Harley VR, Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome. Hum Mol Genet. 2011 Jun 1;20(11):2213-24
1*	J:109310 Ballow D, Meistrich ML, Matzuk M, Rajkovic A, Sohlh1 is essential for spermatogonial differentiation. Dev Biol. 2006 Jun 1;294(1):161-7
1*	J:232556 Bao J, Vitting-Seerup K, Waage J, Tang C, Ge Y, Porse BT, Yan W, UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts. PLoS Genet. 2016 May;12(5):e1005863
1*	J:146199 Barrionuevo F, Georg I, Scherthan H, Lecureuil C, Guillou F, Wegner M, Scherer G, Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8. Dev Biol. 2009 Mar 15;327(2):301-12
1	J:173724 Barsoum I, Yao HH, Redundant and differential roles of transcription factors gli1 and gli2 in the development of mouse fetal Leydig cells. Biol Reprod. 2011 May;84(5):894-9
1*	J:46239 Beck ARP, Miller IJ, Anderson P, Streuli M, RNA-binding protein TIAR is essential for primordial germ cell development. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2331-6
3*	J:133652 Best D, Sahlender DA, Walther N, Peden AA, Adams IR, Sdmg1 is a conserved transmembrane protein associated with germ cell sex determination and germline-soma interactions in mice. Development. 2008 Apr;135(8):1415-25
2	J:335514 Bird AD, Frost ER, Bagheri-Fam S, Croft BM, Ryan JM, Zhao L, Koopman P, Harley VR, Somatic FGFR2 is Required for Germ Cell Maintenance in the Mouse Ovary. Endocrinology. 2023 Mar 13;164(5)
1	J:186901 Brown JP, Bullwinkel J, Baron-Luhr B, Billur M, Schneider P, Winking H, Singh PB, HP1gamma function is required for male germ cell survival and spermatogenesis. Epigenetics Chromatin. 2010;3(1):9
1	J:334017 Bunce C, Barske L, Zhang G, Capel B, Biased precursor ingression underlies the center-to-pole pattern of male sex determination in mouse. Development. 2023 Mar 1;150(5):dev201060
1*	J:334521 Burnet G, Feng CA, Cheung KMF, Bowles J, Spiller CM, Generation and characterization of a Ddx4-iCre transgenic line for deletion in the germline beginning at genital ridge colonization. Genesis. 2023 Mar;61(1-2):e23511
1*	J:157348 Burnicka-Turek O, Shirneshan K, Paprotta I, Grzmil P, Meinhardt A, Engel W, Adham IM, Inactivation of insulin-like factor 6 disrupts the progression of spermatogenesis at late meiotic prophase. Endocrinology. 2009 Sep;150(9):4348-57
3*	J:137617 Campagnolo L, Moscatelli I, Pellegrini M, Siracusa G, Stuhlmann H, Expression of EGFL7 in primordial germ cells and in adult ovaries and testes. Gene Expr Patterns. 2008 Jul;8(6):389-96
1	J:334514 Chakraborty P, Anderson RL, Roy SK, Bone morphogenetic protein 2- and estradiol-17beta-induced changes in ovarian transcriptome during primordial follicle formation. Biol Reprod. 2022 Sep 12;107(3):800-812
3	J:134687 Chang H, Gao F, Guillou F, Taketo MM, Huff V, Behringer RR, Wt1 negatively regulates {beta}-catenin signaling during testis development. Development. 2008 May;135(10):1875-85
1*	J:299356 Chassot AA, Le Rolle M, Jolivet G, Stevant I, Guigonis JM, Da Silva F, Nef S, Pailhoux E, Schedl A, Ghyselinck NB, Chaboissier MC, Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary. Sci Adv. 2020 May;6(21):eaaz1261
1*	J:166517 Chen G, Yang L, Begum S, Xu L, GPR56 is essential for testis development and male fertility in mice. Dev Dyn. 2010 Dec;239(12):3358-67
1	J:191131 Chen L, Faire M, Kissner MD, Laird DJ, Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet. 2013 Jan 15;22(2):313-27
1	J:149469 Cook MS, Coveney D, Batchvarov I, Nadeau JH, Capel B, BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. Dev Biol. 2009 Apr 15;328(2):377-83
3	J:112036 Costa Y, Speed RM, Gautier P, Semple CA, Maratou K, Turner JM, Cooke HJ, Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?. Hum Mol Genet. 2006 Aug 1;15(15):2324-34
3	J:76665 Cupp AS, Tessarollo L, Skinner MK, Testis Developmental Phenotypes in Neurotropin Receptor trkA and trkC Null Mutations: Role in Formation of Seminiferous Cords and Germ Cell Survival. Biol Reprod. 2002 Jun;66(6):1838-45
1	J:284723 DiTroia SP, Percharde M, Guerquin MJ, Wall E, Collignon E, Ebata KT, Mesh K, Mahesula S, Agathocleous M, Laird DJ, Livera G, Ramalho-Santos M, Maternal vitamin C regulates reprogramming of DNA methylation and germline development. Nature. 2019 Sep;573(7773):271-275
7*	J:305426 Du G, Oatley MJ, Law NC, Robbins C, Wu X, Oatley JM, Proper timing of a quiescence period in precursor prospermatogonia is required for stem cell pool establishment in the male germline. Development. 2021 May 1;148(9):dev194571
2	J:330530 Dura M, Teissandier A, Armand M, Barau J, Lapoujade C, Fouchet P, Bonneville L, Schulz M, Weber M, Baudrin LG, Lameiras S, Bourc'his D, DNMT3A-dependent DNA methylation is required for spermatogonial stem cells to commit to spermatogenesis. Nat Genet. 2022 Apr;54(4):469-480
1	J:183017 Encinas G, Zogbi C, Stumpp T, Detection of Four Germ Cell Markers in Rats during Testis Morphogenesis: Differences and Similarities with Mice. Cells Tissues Organs. 2012;195(5):443-55
11*	J:18484 Enders GC, May JJ 2nd, Developmentally regulated expression of a mouse germ cell nuclear antigen examined from embryonic day 11 to adult in male and female mice. Dev Biol. 1994 Jun;163(2):331-40
6	J:196310 Ene AC, Park S, Edelmann W, Taketo T, Caspase 9 is constitutively activated in mouse oocytes and plays a key role in oocyte elimination during meiotic prophase progression. Dev Biol. 2013 May 1;377(1):213-23
1	J:290670 Eozenou C, Gonen N, Touzon MS, Jorgensen A, Yatsenko SA, Fusee L, Kamel AK, Gellen B, Guercio G, Singh P, Witchel S, Berman AJ, Mainpal R, Totonchi M, Mohseni Meybodi A, Askari M, Merel-Chali T, Bignon-Topalovic J, Migale R, Costanzo M, Marino R, Ramirez P, Perez Garrido N, Berensztein E, Mekkawy MK, Schimenti JC, Bertalan R, Mazen I, McElreavey K, Belgorosky A, Lovell-Badge R, Rajkovic A, Bashamboo A, Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13680-13688
1	J:303699 Feng CW, Burnet G, Spiller CM, Cheung FKM, Chawengsaksophak K, Koopman P, Bowles J, Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse. Development. 2021 Mar 9;148(5):dev194977
1	J:333262 Feng S, Wen H, Liu K, Xiong M, Li J, Gui Y, Lv C, Zhang J, Ma X, Wang X, Yuan S, hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice. Development. 2023 Feb 15;150(3):dev201040
1	J:265538 Fu A, Oberholtzer SM, Bagheri-Fam S, Rastetter RH, Holdreith C, Caceres VL, John SV, Shaw SA, Krentz KJ, Zhang X, Hui CC, Wilhelm D, Jorgensen JS, Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries. PLoS Genet. 2018 Aug;14(8):e1007488
2*	J:111787 Gao F, Maiti S, Alam N, Zhang Z, Deng JM, Behringer RR, Lecureuil C, Guillou F, Huff V, The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11987-92
1	J:265597 Gao X, Ma W, Nie J, Zhang C, Zhang J, Yao G, Han J, Xu J, Hu B, Du Y, Shi Q, Yang Z, Huang X, Zhang Y, A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation. Cell Death Dis. 2015 Jan 22;6:e1610
2	J:217593 Garcia TX, Farmaha JK, Kow S, Hofmann MC, RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche. Development. 2014 Dec;141(23):4468-78
2	J:145878 Greenbaum MP, Iwamori N, Agno JE, Matzuk MM, Mouse TEX14 Is Required for Embryonic Germ Cell Intercellular Bridges but Not Female Fertility. Biol Reprod. 2009 Mar;80(3):449-57
2	J:215004 Grive KJ, Seymour KA, Mehta R, Freiman RN, TAF4b promotes mouse primordial follicle assembly and oocyte survival. Dev Biol. 2014 Aug 1;392(1):42-51
1	J:334094 Gu X, Heinrich A, Li SY, DeFalco T, Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions. Nat Commun. 2023 Mar 15;14(1):1439
4	J:342170 Gura MA, Bartholomew MA, Abt KM, Relovska S, Seymour KA, Freiman RN, Transcription and chromatin regulation by TAF4b during cellular quiescence of developing prospermatogonia. Front Cell Dev Biol. 2023;11:1270408
1	J:330390 Gura MA, Relovska S, Abt KM, Seymour KA, Wu T, Kaya H, Turner JMA, Fazzio TG, Freiman RN, TAF4b transcription networks regulating early oocyte differentiation. Development. 2022 Feb 1;149(3):dev200074
1	J:292511 Gustafson EA, Seymour KA, Sigrist K, Rooij DGDE, Freiman RN, ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis. Mol Cell Biol. 2020 Mar 16;40(7)
2	J:177071 Harris RM, Weiss J, Jameson JL, Male hypogonadism and germ cell loss caused by a mutation in polo-like kinase 4. Endocrinology. 2011 Oct;152(10):3975-85
2*	J:121524 Hasthorpe S, Tainton K, Peart M, Roeszler KN, Bell KM, Lusby PE, Hutson JM, Tymms MJ, G2/M checkpoint gene expression in developing germ cells. Mol Reprod Dev. 2007 May;74(5):531-8
3	J:293102 Heinrich A, Potter SJ, Guo L, Ratner N, DeFalco T, Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis. Cell Rep. 2020 Apr 14;31(2):107513
1	J:180915 Held T, Barakat AZ, Mohamed BA, Paprotta I, Meinhardt A, Engel W, Adham IM, Heat-shock protein HSPA4 is required for progression of spermatogenesis. Reproduction. 2011 Jul;142(1):133-44
3	J:173448 Holloway JK, Mohan S, Balmus G, Sun X, Modzelewski A, Borst PL, Freire R, Weiss RS, Cohen PE, Mammalian BTBD12 (SLX4) Protects against Genomic Instability during Mammalian Spermatogenesis. PLoS Genet. 2011 Jun;7(6):e1002094
1*	J:163555 Huang CC, Yao HH, Inactivation of Dicer1 in Steroidogenic factor 1-positive cells reveals tissue-specific requirement for Dicer1 in adrenal, testis, and ovary. BMC Dev Biol. 2010;10:66
1	J:131838 Huang X, Andreu-Vieyra CV, York JP, Hatcher R, Lu T, Matzuk MM, Zhang P, Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells. PLoS Biol. 2008 Jan;6(1):e15
3*	J:290712 Ishiguro KI, Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, Sugimoto M, Fujimura S, Hosokawa M, Chuma S, Ko MSH, Araki K, Niwa H, MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. Dev Cell. 2020 Feb 24;52(4):429-445.e10
1*	J:274541 Ito K, Yamazaki S, Yamamoto R, Tajima Y, Yanagida A, Kobayashi T, Kato-Itoh M, Kakuta S, Iwakura Y, Nakauchi H, Kamiya A, Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice. J Biol Chem. 2014 Oct 24;289(43):29892-911
3	J:316818 Ito T, Osada A, Ohta M, Yokota K, Nishiyama A, Niikura Y, Tamura T, Sekita Y, Kimura T, SWI/SNF chromatin remodeling complex is required for initiation of sex-dependent differentiation in mouse germline. Sci Rep. 2021 Dec 15;11(1):24074
1*	J:97633 Ivanova M, Dobrzycka KM, Jiang S, Michaelis K, Meyer R, Kang K, Adkins B, Barski OA, Zubairy S, Divisova J, Lee AV, Oesterreich S, Scaffold attachment factor B1 functions in development, growth, and reproduction. Mol Cell Biol. 2005 Apr;25(8):2995-3006
2	J:289708 Jiang X, Yin S, Fan S, Bao J, Jiao Y, Ali A, Iqbal F, Xu J, Zhang Y, Shi Q, Npat-dependent programmed Sertoli cell proliferation is indispensable for testis cord development and germ cell mitotic arrest. FASEB J. 2019 Aug;33(8):9075-9086
2	J:54458 Juneja SC, Barr KJ, Enders GC, Kidder GM, Defects in the germ line and gonads of mice lacking connexin43. Biol Reprod. 1999 May;60(5):1263-70
1*	J:63342 Kanno Y, Tamura M, Chuma S, Sakura T, Machida T, Nakatsuji N, A cystatin-related gene, testatin/cresp, shows male-specific expression in germ and somatic cells from the initial stage of murine gonadal sex-differentiation. Int J Dev Biol. 1999 Nov;43(8):777-84
1	J:173702 Kim B, Kim Y, Cooke PS, Ruther U, Jorgensen JS, The fused toes locus is essential for somatic-germ cell interactions that foster germ cell maturation in developing gonads in mice. Biol Reprod. 2011 May;84(5):1024-32
2	J:93127 Kolas NK, Cohen PE, Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination. Cytogenet Genome Res. 2004;107(3-4):216-31
2	J:290695 Kothandapani A, Lewis SR, Noel JL, Zacharski A, Krellwitz K, Baines A, Winske S, Vezina CM, Kaftanovskaya EM, Agoulnik AI, Merton EM, Cohn MJ, Jorgensen JS, GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation. PLoS Genet. 2020 Jun;16(6):e1008810
2*	J:215225 Koubova J, Hu YC, Bhattacharyya T, Soh YQ, Gill ME, Goodheart ML, Hogarth CA, Griswold MD, Page DC, Retinoic acid activates two pathways required for meiosis in mice. PLoS Genet. 2014 Aug;10(8):e1004541
1	J:182264 Kouznetsova A, Benavente R, Pastink A, Hoog C, Meiosis in mice without a synaptonemal complex. PLoS One. 2011;6(12):e28255
4	J:175257 Krentz AD, Murphy MW, Sarver AL, Griswold MD, Bardwell VJ, Zarkower D, DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary. Dev Biol. 2011 Aug 1;356(1):63-70
1	J:251802 Kumar M, Camlin NJ, Holt JE, Teixeira JM, McLaughlin EA, Tanwar PS, Germ cell specific overactivation of WNT/betacatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development. Sci Rep. 2016 Jun 6;6:27273
2	J:313942 Kuroki S, Maeda R, Yano M, Kitano S, Miyachi H, Fukuda M, Shinkai Y, Tachibana M, H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline. Stem Cell Reports. 2020 Aug 11;15(2):424-438
2	J:179805 Laird DJ, Altshuler-Keylin S, Kissner MD, Zhou X, Anderson KV, Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet. 2011 Dec;7(12):e1002428
1*	J:308476 Le Rolle M, Massa F, Siggers P, Turchi L, Loubat A, Koo BK, Clevers H, Greenfield A, Schedl A, Chaboissier MC, Chassot AA, Arrest of WNT/beta-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2023376118
5	J:128313 Lei N, Hornbaker KI, Rice DA, Karpova T, Agbor VA, Heckert LL, Sex-specific differences in mouse DMRT1 expression are both cell type- and stage-dependent during gonad development. Biol Reprod. 2007 Sep;77(3):466-75
1	J:101702 Li B, Nair M, Mackay DR, Bilanchone V, Hu M, Fallahi M, Song H, Dai Q, Cohen PE, Dai X, Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development. 2005 Mar;132(6):1463-73
1*	J:104848 Lin Y, Page DC, Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL/6 mice. Dev Biol. 2005 Dec 15;288(2):309-16
1	J:78200 Lipkin SM, Moens PB, Wang V, Lenzi M, Shanmugarajah D, Gilgeous A, Thomas J, Cheng J, Touchman JW, Green ED, Schwartzberg P, Collins FS, Cohen PE, Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet. 2002 Aug;31(4):385-90
6	J:294981 Liu X, Castle V, Taketo T, Interplay between Caspase 9 and X-linked Inhibitor of Apoptosis Protein (XIAP) in the oocyte elimination during fetal mouse development. Cell Death Dis. 2019 Oct 17;10(11):790
3	J:224165 Lovasco LA, Gustafson EA, Seymour KA, de Rooij DG, Freiman RN, TAF4b is required for mouse spermatogonial stem cell development. Stem Cells. 2015 Apr;33(4):1267-76
3*	J:112224 Maatouk DM, Kellam LD, Mann MR, Lei H, Li E, Bartolomei MS, Resnick JL, DNA methylation is a primary mechanism for silencing postmigratory primordial germ cell genes in both germ cell and somatic cell lineages. Development. 2006 Sep;133(17):3411-8
2*	J:279870 Makino Y, Jensen NH, Yokota N, Rossner MJ, Akiyama H, Shirahige K, Okada Y, Single cell RNA-sequencing identified Dec2 as a suppressive factor for spermatogonial differentiation by inhibiting Sohlh1 expression. Sci Rep. 2019 Apr 15;9(1):6063
1*	J:116231 Maldonado-Saldivia J, van den Bergen J, Krouskos M, Gilchrist M, Lee C, Li R, Sinclair AH, Surani MA, Western PS, Dppa2 and Dppa4 Are Closely Linked SAP Motif Genes Restricted to Pluripotent Cells and the Germ Line. Stem Cells. 2007 Jan;25(1):19-28
4	J:194288 Manosalva I, Gonzalez A, Kageyama R, Hes1 in the somatic cells of the murine ovary is necessary for oocyte survival and maturation. Dev Biol. 2013 Mar 15;375(2):140-51
1	J:105944 Mattiske D, Kume T, Hogan BL, The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. Dev Biol. 2006 Feb 15;290(2):447-58
4	J:83934 McClellan KA, Gosden R, Taketo T, Continuous loss of oocytes throughout meiotic prophase in the normal mouse ovary. Dev Biol. 2003 Jun 15;258(2):334-48
1*	J:175228 Medeiros LA, Dennis LM, Gill ME, Houbaviy H, Markoulaki S, Fu D, White AC, Kirak O, Sharp PA, Page DC, Jaenisch R, Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14163-8
2	J:145458 Memon MA, Anway MD, Covert TR, Uzumcu M, Skinner MK, Transforming growth factor beta (TGFbeta1, TGFbeta2 and TGFbeta3) null-mutant phenotypes in embryonic gonadal development. Mol Cell Endocrinol. 2008 Nov 6;294(1-2):70-80
2	J:184928 Miles DC, van den Bergen JA, Wakeling SI, Anderson RB, Sinclair AH, Western PS, The proto-oncogene Ret is required for male foetal germ cell survival. Dev Biol. 2012 May 1;365(1):101-9
2	J:214809 Moniot B, Ujjan S, Champagne J, Hirai H, Aritake K, Nagata K, Dubois E, Nidelet S, Nakamura M, Urade Y, Poulat F, Boizet-Bonhoure B, Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Development. 2014 Sep;141(18):3561-71
1	J:141327 Muir T, Wilson-Rawls J, Stevens JD, Rawls A, Schweitzer R, Kang C, Skinner MK, Integration of CREB and bHLH transcriptional signaling pathways through direct heterodimerization of the proteins: role in muscle and testis development. Mol Reprod Dev. 2008 Nov;75(11):1637-52
1*	J:96322 Murphy K, Carvajal L, Medico L, Pepling M, Expression of Stat3 in germ cells of developing and adult mouse ovaries and testes. Gene Expr Patterns. 2005 Apr;5(4):475-82
4*	J:64334 Nadler JJ, Braun RE, Fanconi anemia complementation group C is required for proliferation of murine primordial germ cells [letter]. Genesis. 2000 Jul;27(3):117-23
6	J:306151 Nguyen DH, Soygur B, Peng SP, Malki S, Hu G, Laird DJ, Apoptosis in the fetal testis eliminates developmentally defective germ cell clones. Nat Cell Biol. 2020 Dec;22(12):1423-1435
1	J:301847 Ni L, Xie H, Tan L, Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models. Mol Reprod Dev. 2016 Dec;83(12):1060-1069
1	J:282807 Nicholls PK, Schorle H, Naqvi S, Hu YC, Fan Y, Carmell MA, Dobrinski I, Watson AL, Carlson DF, Fahrenkrug SC, Page DC, Mammalian germ cells are determined after PGC colonization of the nascent gonad. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25677-25687
3	J:281436 Nicol B, Grimm SA, Chalmel F, Lecluze E, Pannetier M, Pailhoux E, Dupin-De-Beyssat E, Guiguen Y, Capel B, Yao HH, RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2. Nat Commun. 2019 Nov 11;10(1):5116
1	J:269319 Nicol B, Grimm SA, Gruzdev A, Scott GJ, Ray MK, Yao HH, Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads. Hum Mol Genet. 2018 Dec 15;27(24):4273-4287
1	J:300503 Nicol B, Rodriguez K, Yao HH, Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice. Biol Reprod. 2020 Oct 29;103(5):966-977
1*	J:166841 Nordstrand LM, Svard J, Larsen E, Nilsen A, Ougland R, Furu K, Lien GF, Rognes T, Namekawa SH, Lee JT, Klungland A, Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects. PLoS One. 2010;5(11):e13827
1	J:154435 Novak I, Wang H, Revenkova E, Jessberger R, Scherthan H, Hoog C, Cohesin Smc1beta determines meiotic chromatin axis loop organization. J Cell Biol. 2008 Jan 14;180(1):83-90
1	J:110210 Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM, Rajkovic A, Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8090-5
3	J:232363 Park E, Lee B, Clurman BE, Lee K, NUP50 is necessary for the survival of primordial germ cells in mouse embryos. Reproduction. 2016 Jan;151(1):51-8
2	J:168860 Payne CJ, Gallagher SJ, Foreman O, Dannenberg JH, Depinho RA, Braun RE, Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells. 2010 Aug;28(8):1424-34
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