Gene Expression Literature Summary

• Symbol: Matn1
• Name: matrilin 1, cartilage matrix protein
• ID: MGI:106591

37 matching records from 37 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)	1		1			2	1		3	3	3	3	2	3	3	2	2	1	5
In situ RNA (section)						2		3		5	1	1		3	1		3	1	3
Immunohistochemistry (whole mount)					1		1
In situ RNA (whole mount)		1				2
Northern blot		1		1		1		1		1		1			1				2
Western blot																			2
RT-PCR	1	1		2		2		3		2		2			1		2		2
cDNA clones																			1
RNase protection		1		1		1		1				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Matn1  matrilin 1, cartilage matrix protein   (Synonyms: CMP, Crtm, Mat1, matrilin-1)
Results	Reference
2	J:110553 Allen JM, Bateman JF, Hansen U, Wilson R, Bruckner P, Owens RT, Sasaki T, Timpl R, Fitzgerald J, WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan. J Biol Chem. 2006 Mar 17;281(11):7341-9
1	J:51376 Aszodi A, Chan D, Hunziker E, Bateman JF, Fassler R, Collagen II is essential for the removal of the notochord and the formation of intervertebral discs. J Cell Biol. 1998 Nov 30;143(5):1399-412
28*	J:32849 Aszodi A, Hauser N, Studer D, Paulsson M, Hiripi L, Bosze Z, Cloning, sequencing and expression analysis of mouse cartilage matrix protein cDNA. Eur J Biochem. 1996 Mar 15;236(3):970-7
1	J:85994 Aszodi A, Hunziker EB, Brakebusch C, Fassler R, Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev. 2003 Oct 1;17(19):2465-79
1	J:117910 Aszodi A, Hunziker EB, Olsen BR, Fassler R, The role of collagen II and cartilage fibril-associated molecules in skeletal development. Osteoarthritis Cartilage. 2001;9 Suppl A:S150-9
1	J:78596 Brandau O, Aszodi A, Hunziker EB, Neame PJ, Vestweber D, Fassler R, Chondromodulin I is dispensable during enchondral ossification and eye development. Mol Cell Biol. 2002 Sep;22(18):6627-35
1*	J:329220 Chen Y, Wu J, Zhang S, Gao W, Liao Z, Zhou T, Li Y, Su D, Liu H, Yang X, Su P, Xu C, Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1alpha-glycolysis axis. Cell Death Dis. 2022 Sep 20;13(9):803
1	J:58700 Costell M, Gustafsson E, Aszodi A, Morgelin M, Bloch W, Hunziker E, Addicks K, Timpl R, Fassler R, Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol. 1999 Nov 29;147(5):1109-22
1*	J:243210 Decker RS, Um HB, Dyment NA, Cottingham N, Usami Y, Enomoto-Iwamoto M, Kronenberg MS, Maye P, Rowe DW, Koyama E, Pacifici M, Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. Dev Biol. 2017 Jun 01;426(1):56-68
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
4	J:204883 Feenstra JM, Kanaya K, Pira CU, Hoffman SE, Eppey RJ, Oberg KC, Detection of genes regulated by Lmx1b during limb dorsalization. Dev Growth Differ. 2012 May;54(4):451-62
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:310008 Howard M, Tuan RS, Wallis GA, The function and interrelationship between GDF5 and ERG-010 during chondrogenesis in vitro. In Vitro Cell Dev Biol Anim. 2016 Feb;52(2):182-92
2*	J:58843 Huang X, Birk DE, Goetinck PF, Mice lacking matrilin-1 (cartilage matrix protein) have alterations in type II collagen fibrillogenesis and fibril organization. Dev Dyn. 1999 Dec;216(4-5):434-41
2	J:122506 Hyde G, Dover S, Aszodi A, Wallis GA, Boot-Handford RP, Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms. Dev Biol. 2007 Apr 15;304(2):825-33
1	J:224585 Jenner F, IJpma A, Cleary M, Heijsman D, Narcisi R, van der Spek PJ, Kremer A, van Weeren R, Brama P, van Osch GJ, Differential gene expression of the intermediate and outer interzone layers of developing articular cartilage in murine embryos. Stem Cells Dev. 2014 Aug 15;23(16):1883-98
6	J:148688 Kahn J, Shwartz Y, Blitz E, Krief S, Sharir A, Breitel DA, Rattenbach R, Relaix F, Maire P, Rountree RB, Kingsley DM, Zelzer E, Muscle contraction is necessary to maintain joint progenitor cell fate. Dev Cell. 2009 May;16(5):734-43
1	J:241397 Kamper M, Paulsson M, Zaucke F, Absence of collagen IX accelerates hypertrophic differentiation in the embryonic mouse spine through a disturbance of the Ihh-PTHrP feedback loop. Cell Tissue Res. 2017 Feb;367(2):359-367
1*	J:145763 Kawakami Y, Yoshida K, Yang JH, Suzuki T, Azuma N, Sakai K, Hashikawa T, Watanabe M, Yasuda K, Kuhara S, Hirabayashi Y, Furuya S, Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model. Neurosci Res. 2009 Mar;63(3):184-93
1*	J:69493 Klatt AR, Nitsche DP, Kobbe B, Macht M, Paulsson M, Wagener R, Molecular structure, processing, and tissue distribution of matrilin-4. J Biol Chem. 2001 May 18;276(20):17267-75
2	J:80149 Klatt AR, Paulsson M, Wagener R, Expression of matrilins during maturation of mouse skeletal tissues. Matrix Biol. 2002 Apr;21(3):289-96
3	J:87676 Ko Y, Kobbe B, Nicolae C, Miosge N, Paulsson M, Wagener R, Aszodi A, Matrilin-3 is dispensable for mouse skeletal growth and development. Mol Cell Biol. 2004 Feb;24(4):1691-9
1	J:204893 Lawson KA, Teteak CJ, Zou J, Hacquebord J, Ghatan A, Zielinska-Kwiatkowska A, Fernandes RJ, Chansky HA, Yang L, Mesenchyme-specific knockout of ESET histone methyltransferase causes ectopic hypertrophy and terminal differentiation of articular chondrocytes. J Biol Chem. 2013 Nov 8;288(45):32119-25
1	J:150519 Malin D, Sonnenberg-Riethmacher E, Guseva D, Wagener R, Aszodi A, Irintchev A, Riethmacher D, The extracellular-matrix protein matrilin 2 participates in peripheral nerve regeneration. J Cell Sci. 2009 Apr 1;122(Pt 7):995-1004
1	J:91587 Mates L, Nicolae C, Morgelin M, Deak F, Kiss I, Aszodi A, Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities. Matrix Biol. 2004 Jun;23(3):195-204
1	J:95408 McDonald KR, Fudge NJ, Woodrow JP, Friel JK, Hoff AO, Gagel RF, Kovacs CS, Ablation of calcitonin/calcitonin gene-related peptide-alpha impairs fetal magnesium but not calcium homeostasis. Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E218-26
1	J:257406 Metwalli KA, Do MA, Nguyen K, Mallick S, Kin K, Farokhnia N, Jun G, Fakhouri WD, Interferon Regulatory Factor 6 Is Necessary for Salivary Glands and Pancreas Development. J Dent Res. 2018 Feb;97(2):226-236
3	J:170582 Mundy C, Yasuda T, Kinumatsu T, Yamaguchi Y, Iwamoto M, Enomoto-Iwamoto M, Koyama E, Pacifici M, Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine. Dev Biol. 2011 Mar 1;351(1):70-81
7	J:60121 Murphy JM, Heinegard R, McIntosh A, Sterchi D, Barry FP, Distribution of cartilage molecules in the developing mouse joint. Matrix Biol. 1999 Oct;18(5):487-97
9*	J:74049 Segat D, Frie C, Nitsche PD, Klatt AR, Piecha D, Korpos E, Deak F, Wagener R, Paulsson M, Smyth N, Expression of matrilin-1, -2 and -3 in developing mouse limbs and heart. Matrix Biol. 2000 Dec;19(7):649-55
1	J:88817 Smits P, Dy P, Mitra S, Lefebvre V, Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol. 2004 Mar 1;164(5):747-58
1*	J:80666 Smits P, Li P, Mandel J, Zhang Z, Deng JM, Behringer RR, de Croumbrugghe B, Lefebvre V, The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell. 2001 Aug;1(2):277-90
1*	J:210059 Szenasi T, Kenesi E, Nagy A, Molnar A, Balint BL, Zvara A, Csabai Z, Deak F, Boros Olah B, Mates L, Nagy L, Puskas LG, Kiss I, Hmgb1 can facilitate activation of the matrilin-1 gene promoter by Sox9 and L-Sox5/Sox6 in early steps of chondrogenesis. Biochim Biophys Acta. 2013 Oct;1829(10):1075-91
4	J:112002 van der Weyden L, Wei L, Luo J, Yang X, Birk DE, Adams DJ, Bradley A, Chen Q, Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis. Am J Pathol. 2006 Aug;169(2):515-27
1	J:48562 Wai AW, Ng LJ, Watanabe H, Yamada Y, Tam PP, Cheah KS, Disrupted expression of matrix genes in the growth plate of the mouse cartilage matrix deficiency (cmd) mutant. Dev Genet. 1998;22(4):349-58
1	J:257670 Yang L, Gee AO, Zielinska-Kwiatkowska A, Chansky HA, Generation and characterization of mice with mesenchyme-specific deletion of the entire ESET histone methyltransferase protein. Genesis. 2018 Feb;56(2)
1	J:331689 Zhang CH, Gao Y, Hung HH, Zhuo Z, Grodzinsky AJ, Lassar AB, Creb5 coordinates synovial joint formation with the genesis of articular cartilage. Nat Commun. 2022 Nov 26;13(1):7295