Gene Expression Literature Summary

• Symbol: Mthfr
• Name: methylenetetrahydrofolate reductase
• ID: MGI:106639

10 matching records from 10 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E3	E3.5	E8.5	E9	E9.5	E10.5	E11	E11.5	E12.5	E13	E14.5	E15	E15.5	E17	E18	E18.5	P
Immunohistochemistry (section)					1		1	1			1	1		1	1		1	1	2
In situ RNA (section)										1			2		1				1
In situ reporter (knock in)								1											1
Western blot	1	1	1	1															1
RT-PCR		1		1		1			1		1	1		1		1			3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mthfr  methylenetetrahydrofolate reductase
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
7	J:184371 Cherukad J, Wainwright V, Watson ED, Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development. Placenta. 2012 May;33(5):440-8
1*	J:224837 Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP, Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Rep. 2015 Jul 21;12(3):371-9
4*	J:204010 Garner JL, Niles KM, McGraw S, Yeh JR, Cushnie DW, Hermo L, Nagano MC, Trasler JM, Stability of DNA methylation patterns in mouse spermatogonia under conditions of MTHFR deficiency and methionine supplementation. Biol Reprod. 2013 Nov;89(5):125
6*	J:312368 Imbard A, Schwendimann L, Lebon S, Gressens P, Blom HJ, Benoist JF, Liver and brain differential expression of one-carbon metabolism genes during ontogenesis. Sci Rep. 2021 Oct 26;11(1):21132
1*	J:147857 Liu SP, Li YS, Chen YJ, Chiang EP, Li AF, Lee YH, Tsai TF, Hsiao M, Huang SF, Chen YM, Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology. 2007 Nov;46(5):1413-25
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2	J:178814 Pickell L, Wu Q, Wang XL, Leclerc D, Friedman H, Peterson AC, Rozen R, Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation. Mamm Genome. 2011 Dec;22(11-12):635-47
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
8	J:332923 Young K, Tscherner AK, Zhang B, Meredith M, McClatchie T, Trasler JM, Baltz JM, 5,10-Methylenetetrahydrofolate reductase becomes phosphorylated during meiotic maturation in mouse oocytes. Zygote. 2022 Oct;30(5):674-688