Gene Expression Literature Summary

• Symbol: Efna3
• Name: ephrin A3
• ID: MGI:106644

43 matching records from 43 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E4	E4.5	E5.5	E6	E6.5	E7	E7.5	E8	E8.5	E9.5	E10	E10.5	E11.5	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)				1															1	1				1		3
In situ RNA (section)				1					1	1	1		1	2	3	4	2	5	1	7	1	3	1	1	3	7
Immunohistochemistry (whole mount)			1
In situ RNA (whole mount)				1	1	1	1	1	1	2	2	1	1	1						1					1
Northern blot																					1					1
Western blot																								1
RT-PCR	1	1	1	1		1								1	1	1		1	1	1	1	1	1	3		4
cDNA clones										1	1															1
RNase protection											1		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Efna3  ephrin A3   (Synonyms: EFL-2, Ehk1-L, Epl3, LERK-3)
Results	Reference
5	J:150093 Abdul-Aziz NM, Turmaine M, Greene ND, Copp AJ, EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion. Int J Dev Biol. 2009;53(4):559-68
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:179898 Coate TM, Raft S, Zhao X, Ryan AK, Crenshaw EB 3rd, Kelley MW, Otic Mesenchyme Cells Regulate Spiral Ganglion Axon Fasciculation through a Pou3f4/EphA4 Signaling Pathway. Neuron. 2012 Jan 12;73(1):49-63
1	J:99355 Depaepe V, Suarez-Gonzalez N, Dufour A, Passante L, Gorski JA, Jones KR, Ledent C, Vanderhaeghen P, Ephrin signalling controls brain size by regulating apoptosis of neural progenitors. Nature. 2005 Jun 30;435(7046):1244-50
12*	J:111163 Duffy SL, Steiner KA, Tam PP, Boyd AW, Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development. Gene Expr Patterns. 2006 Oct;6(7):719-23
1	J:61499 Feldheim DA, Kim YI, Bergemann AD, Frisen J, Barbacid M, Flanagan JG, Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron. 2000 Mar;25(3):563-74
1	J:51889 Feldheim DA, Vanderhaeghen P, Hansen MJ, Frisen J, Lu Q, Barbacid M, Flanagan JG, Topographic guidance labels in a sensory projection to the forebrain. Neuron. 1998 Dec;21(6):1303-13
6	J:60774 Feng G, Laskowski MB, Feldheim DA, Wang H, Lewis R, Frisen J, Flanagan JG, Sanes JR, Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers. Neuron. 2000 Feb;25(2):295-306
2	J:36483 Flenniken AM, Gale NW, Yancopoulos GD, Wilkinson DG, Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis. Dev Biol. 1996 Nov 1;179(2):382-401
7*	J:116642 Fujii H, Tatsumi K, Kosaka K, Yoshioka S, Fujiwara H, Fujii S, Eph-ephrin A system regulates murine blastocyst attachment and spreading. Dev Dyn. 2006 Dec;235(12):3250-8
1	J:309721 Garaffo G, Provero P, Molineris I, Pinciroli P, Peano C, Battaglia C, Tomaiuolo D, Etzion T, Gothilf Y, Santoro M, Merlo GR, Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome. Front Endocrinol (Lausanne). 2013;4:203
2	J:70266 Graef IA, Chen F, Chen L, Kuo A, Crabtree GR, Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001 Jun 29;105(7):863-75
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:294650 Hemker SL, Cerqueira DM, Bodnar AJ, Cargill KR, Clugston A, Anslow MJ, Sims-Lucas S, Kostka D, Ho J, Deletion of hypoxia-responsive microRNA-210 results in a sex-specific decrease in nephron number. FASEB J. 2020 Apr;34(4):5782-5799
2	J:314922 Hoshino N, Altarshan Y, Alzein A, Fernando AM, Nguyen HT, Majewski EF, Chen VC, Rochlin MW, Yu WM, Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem. J Comp Neurol. 2021 Nov;529(16):3633-3654
1	J:173651 Hsu YC, Osinski J, Campbell CE, Litwack ED, Wang D, Liu S, Bachurski CJ, Gronostajski RM, Mesenchymal nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation. Dev Biol. 2011 Jun 15;354(2):242-52
3	J:162837 Islam S, Loizides AM, Fialkovich JJ, Grand RJ, Montgomery RK, Developmental expression of Eph and ephrin family genes in mammalian small intestine. Dig Dis Sci. 2010 Sep;55(9):2478-88
3	J:67679 Knoll B, Zarbalis K, Wurst W, Drescher U, A role for the EphA family in the topographic targeting of vomeronasal axons. Development. 2001 Mar;128(6):895-906
2	J:95080 Luukko K, Loes S, Kvinnsland IH, Kettunen P, Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues. Cell Tissue Res. 2005 Jan;319(1):143-52
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1*	J:37329 Marcus RC, Gale NW, Morrison ME, Mason CA, Yancopoulos GD, Eph family receptors and their ligands distribute in opposing gradients in the developing mouse retina. Dev Biol. 1996 Dec 15;180(2):786-9
2*	J:119680 Millien G, Spira A, Hinds A, Wang J, Williams MC, Ramirez MI, Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development. BMC Dev Biol. 2006;6:35
1	J:240082 Noh H, Lee H, Park E, Park S, Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling. Development. 2016 Feb 01;143(3):461-72
1*	J:156952 North HA, Karim A, Jacquin MF, Donoghue MJ, EphA4 is necessary for spatially selective peripheral somatosensory topography. Dev Dyn. 2010 Feb;239(2):630-8
1	J:150346 North HA, Zhao X, Kolk SM, Clifford MA, Ziskind DM, Donoghue MJ, Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling. Development. 2009 Jul;136(14):2467-76
1*	J:282332 Okamura E, Tam OH, Posfai E, Li L, Cockburn K, Lee CQE, Garner J, Rossant J, Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos. Dev Biol. 2019 Nov 15;455(2):382-392
1	J:38350 Park S, Sanchez MP, The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. Oncogene. 1997 Feb 6;14(5):533-42
1*	J:83513 Pickles JO, Expression of Ephs and ephrins in developing mouse inner ear. Hear Res. 2003 Apr;178(1-2):44-51
2	J:173510 Rudolph J, Zimmer G, Steinecke A, Barchmann S, Bolz J, Ephrins guide migrating cortical interneurons in the basal telencephalon. Cell Adh Migr. 2010 Jul-Sep;4(3):400-8
5	J:230727 Stark DA, Coffey NJ, Pancoast HR, Arnold LL, Walker JP, Vallee J, Robitaille R, Garcia ML, Cornelison DD, Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation. J Cell Biol. 2015 Dec 7;211(5):1077-91
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:153504 Torii M, Hashimoto-Torii K, Levitt P, Rakic P, Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature. 2009 Sep 24;461(7263):524-8
3*	J:105961 van Eyll JM, Passante L, Pierreux CE, Lemaigre FP, Vanderhaeghen P, Rousseau GG, Eph receptors and their ephrin ligands are expressed in developing mouse pancreas. Gene Expr Patterns. 2006 Apr;6(4):353-9
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:214811 Weiss AC, Airik R, Bohnenpoll T, Greulich F, Foik A, Trowe MO, Rudat C, Costantini F, Adams RH, Kispert A, Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme. Development. 2014 Sep;141(17):3420-30
2	J:297072 Wurmser M, Chaverot N, Madani R, Sakai H, Negroni E, Demignon J, Saint-Pierre B, Mouly V, Amthor H, Tapscott S, Birchmeier C, Tajbakhsh S, Le Grand F, Sotiropoulos A, Maire P, SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell properties during fetal epaxial myogenesis. Development. 2020 Oct 9;147(19):dev185975
4*	J:231672 Xavier GM, Miletich I, Cobourne MT, Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue. Front Physiol. 2016;7:60
1	J:334513 Yan K, Bormuth I, Bormuth O, Tutukova S, Renner A, Bessa P, Schaub T, Rosario M, Tarabykin V, TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6. Cereb Cortex. 2023 Feb 20;33(5):1752-1767
1	J:144660 Yoshida Y, Han B, Mendelsohn M, Jessell TM, PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Neuron. 2006 Dec 7;52(5):775-88
1	J:78359 Yue Y, Chen ZY, Gale NW, Blair-Flynn J, Hu TJ, Yue X, Cooper M, Crockett DP, Yancopoulos GD, Tessarollo L, Zhou R, Mistargeting hippocampal axons by expression of a truncated Eph receptor. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10777-82
1	J:58437 Yue Y, Su J, Cerretti DP, Fox GM, Jing S, Zhou R, Selective inhibition of spinal cord neurite outgrowth and cell survival by the Eph family ligand ephrin-A5. J Neurosci. 1999 Nov 15;19(22):10026-35
2	J:81281 Yun ME, Johnson RR, Antic A, Donoghue MJ, EphA family gene expression in the developing mouse neocortex: Regional patterns reveal intrinsic programs and extrinsic influence. J Comp Neurol. 2003 Feb 10;456(3):203-16
2	J:154920 Zirzow S, Ludtke TH, Brons JF, Petry M, Christoffels VM, Kispert A, Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Dev Biol. 2009 Dec 15;336(2):145-55