Symbol Name ID |
Zic2
zinc finger protein of the cerebellum 2 MGI:106679 |
Age | E0.5 | E4.5 | E5.5 | E6.5 | E7 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E | P |
Immunohistochemistry (section) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 4 | 1 | 1 | 4 | 2 | 3 | 2 | 13 | 3 | 20 | 3 | 17 | 1 | 7 | 2 | 5 | 2 | 12 | |||||
In situ RNA (section) | 1 | 1 | 3 | 3 | 2 | 2 | 2 | 9 | 6 | 1 | 5 | 10 | 6 | 8 | 5 | 3 | 5 | 3 | 2 | 2 | 3 | 4 | ||||||||
Immunohistochemistry (whole mount) | 1 | 1 | 1 | 1 | 1 | 2 | 3 | 1 | 4 | 1 | ||||||||||||||||||||
In situ RNA (whole mount) | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 8 | 5 | 1 | 2 | 1 | 1 | |||||||||||||||||
Northern blot | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||||||||||
Western blot | 1 | 2 | 1 | 1 | 1 | |||||||||||||||||||||||||
RT-PCR | 2 | 3 | 1 | 3 | 2 | 3 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 3 | |||||||||
cDNA clones | 1 | 1 |
Zic2 zinc finger protein of the cerebellum 2 (Synonyms: GENA 29, Ku, odd-paired homolog) | |
Results | Reference |
2 | J:73494 Aruga J, Inoue T, Hoshino J, Mikoshiba K, Zic2 controls cerebellar development in cooperation with zic1. J Neurosci. 2002 Jan 1;22(1):218-25 |
6* | J:30607 Aruga J, Nagai T, Tokuyama T, Hayashizaki Y, Okazaki Y, Chapman VM, Mikoshiba K, The mouse zic gene family. Homologues of the Drosophila pair-rule gene odd-paired. J Biol Chem. 1996 Jan 12;271(2):1043-7 |
1* | J:184980 Assimacopoulos S, Kao T, Issa NP, Grove EA, Fibroblast growth factor 8 organizes the neocortical area map and regulates sensory map topography. J Neurosci. 2012 May 23;32(21):7191-201 |
1 | J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19 |
4 | J:266054 Barratt KS, Diamand KEM, Arkell RM, Identification of reference genes suitable for RT-qPCR studies of murine gastrulation and patterning. Mamm Genome. 2018 Oct;29(9-10):656-662 |
1* | J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034 |
3* | J:211641 Bhansali P, Rayport I, Rebsam A, Mason C, Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice. Neural Dev. 2014;9:11 |
3* | J:143129 Brown L, Brown S, Zic2 is expressed in pluripotent cells in the blastocyst and adult brain expression overlaps with makers of neurogenesis. Gene Expr Patterns. 2009 Jan;9(1):43-9 |
3* | J:84357 Brown LY, Kottmann AH, Brown S, Immunolocalization of Zic2 expression in the developing mouse forebrain. Gene Expr Patterns. 2003 Jun;3(3):361-7 |
2 | J:240943 Bruce FM, Brown S, Smith JN, Fuerst PG, Erskine L, DSCAM promotes axon fasciculation and growth in the developing optic pathway. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1702-1707 |
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1 | J:336226 Chen X, Chen T, Dong C, Chen H, Dong X, Yang L, Hu L, Wang H, Wu B, Yao Y, Xiong Y, Xiong M, Lin Y, Zhou W, Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia, ataxia, and psychiatric behavior in mice. J Genet Genomics. 2022 Sep;49(9):859-869 |
3 | J:110657 Cheng X, Hsu CM, Currle DS, Hu JS, Barkovich AJ, Monuki ES, Central roles of the roof plate in telencephalic development and holoprosencephaly. J Neurosci. 2006 Jul 19;26(29):7640-9 |
5* | J:198578 Chervenak AP, Hakim IS, Barald KF, Spatiotemporal expression of zic genes during vertebrate inner ear development. Dev Dyn. 2013 Jul;242(7):897-908 |
1 | J:105025 Cheung M, Chaboissier MC, Mynett A, Hirst E, Schedl A, Briscoe J, The transcriptional control of trunk neural crest induction, survival, and delamination. Dev Cell. 2005 Feb;8(2):179-92 |
2 | J:239874 Christ A, Christa A, Klippert J, Eule JC, Bachmann S, Wallace VA, Hammes A, Willnow TE, LRP2 Acts as SHH Clearance Receptor to Protect the Retinal Margin from Mitogenic Stimuli. Dev Cell. 2015 Oct 12;35(1):36-48 |
2 | J:266267 Clements R, Wright KM, Retinal ganglion cell axon sorting at the optic chiasm requires dystroglycan. Dev Biol. 2018 Oct 15;442(2):210-219 |
1 | J:92064 Ding YQ, Yin J, Kania A, Zhao ZQ, Johnson RL, Chen ZF, Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord. Development. 2004 Aug;131(15):3693-703 |
3* | J:268103 Dykes IM, Szumska D, Kuncheria L, Puliyadi R, Chen CM, Papanayotou C, Lockstone H, Dubourg C, David V, Schneider JE, Keane TM, Adams DJ, Brown SDM, Mercier S, Odent S, Collignon J, Bhattacharya S, A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity. Sci Rep. 2018 Jul 11;8(1):10439 |
9* | J:91213 Elms P, Scurry A, Davies J, Willoughby C, Hacker T, Bogani D, Arkell R, Overlapping and distinct expression domains of Zic2 and Zic3 during mouse gastrulation. Gene Expr Patterns. 2004 Sep;4(5):505-11 |
1* | J:86841 Elms P, Siggers P, Napper D, Greenfield A, Arkell R, Zic2 is required for neural crest formation and hindbrain patterning during mouse development. Dev Biol. 2003 Dec 15;264(2):391-406 |
1 | J:54722 Engelkamp D, Rashbass P, Seawright A, van Heyningen V, Role of Pax6 in development of the cerebellar system. Development. 1999 Aug;126(16):3585-96 |
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7 | J:207512 Escalante A, Murillo B, Morenilla-Palao C, Klar A, Herrera E, Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS. Neuron. 2013 Dec 18;80(6):1392-406 |
2 | J:335088 Escuin S, Rose Raza-Knight S, Savery D, Gaston-Massuet C, Galea GL, Greene NDE, Copp AJ, Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse. Dis Model Mech. 2023 Mar 1;16(3) |
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2* | J:98796 Gaston-Massuet C, Henderson DJ, Greene ND, Copp AJ, Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system. Dev Dyn. 2005 May 13;233(3):1110-1115 |
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1* | J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004; |
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5 | J:94392 Herrera E, Marcus R, Li S, Williams SE, Erskine L, Lai E, Mason C, Foxd1 is required for proper formation of the optic chiasm. Development. 2004 Nov;131(22):5727-39 |
8 | J:92220 Inoue T, Hatayama M, Tohmonda T, Itohara S, Aruga J, Mikoshiba K, Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives. Dev Biol. 2004 Jun 1;270(1):146-62 |
8 | J:134970 Inoue T, Ogawa M, Mikoshiba K, Aruga J, Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly. J Neurosci. 2008 Apr 30;28(18):4712-25 |
14* | J:122556 Inoue T, Ota M, Mikoshiba K, Aruga J, Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo. Dev Biol. 2007 Jun 15;306(2):669-84 |
5 | J:121744 Inoue T, Ota M, Ogawa M, Mikoshiba K, Aruga J, Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors. J Neurosci. 2007 May 16;27(20):5461-73 |
4* | J:273132 Ishiguro A, Hatayama M, Otsuka MI, Aruga J, Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression. Sci Rep. 2018 Feb 1;8(1):2140 |
2 | J:189004 Iwafuchi-Doi M, Matsuda K, Murakami K, Niwa H, Tesar PJ, Aruga J, Matsuo I, Kondoh H, Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development. 2012 Nov;139(21):3926-37 |
1 | J:272616 Iwai-Takekoshi L, Balasubramanian R, Sitko A, Khan R, Weinreb S, Robinson K, Mason C, Activation of Wnt signaling reduces ipsilaterally projecting retinal ganglion cells in pigmented retina. Development. 2018 Nov 2;145(21):dev163212 |
1 | J:237402 Iwai-Takekoshi L, Ramos A, Schaler A, Weinreb S, Blazeski R, Mason C, Retinal pigment epithelial integrity is compromised in the developing albino mouse retina. J Comp Neurol. 2016 Dec 15;524(18):3696-3716 |
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1 | J:188362 Kuwajima T, Yoshida Y, Takegahara N, Petros TJ, Kumanogoh A, Jessell TM, Sakurai T, Mason C, Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing. Neuron. 2012 May 24;74(4):676-90 |
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1 | J:344967 Le VH, Orniacki C, Murcia-Belmonte V, Denti L, Schutz D, Stumm R, Ruhrberg C, Erskine L, CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm. Development. 2024 Jan 15;151(2) |
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1 | J:82686 Liu J, Wilson S, Reh T, BMP receptor 1b is required for axon guidance and cell survival in the developing retina. Dev Biol. 2003 Apr 1;256(1):34-48 |
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1 | J:203346 Milla LA, Arros A, Espinoza N, Remke M, Kool M, Taylor MD, Pfister SM, Wainwright BJ, Palma V, Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression. Int J Cancer. 2014 Jan 1;134(1):21-31 |
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1 | J:171526 Murali D, Kawaguchi-Niida M, Deng CX, Furuta Y, Smad4 Is Required Predominantly in the Developmental Processes Dependent on the BMP Branch of the TGF-{beta} Signaling System in the Embryonic Mouse Retina. Invest Ophthalmol Vis Sci. 2011;52(6):2930-7 |
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2 | J:226023 Murillo B, Ruiz-Reig N, Herrera M, Fairen A, Herrera E, Zic2 Controls the Migration of Specific Neuronal Populations in the Developing Forebrain. J Neurosci. 2015 Aug 12;35(32):11266-80 |
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1* | J:272594 Nakamoto C, Durward E, Horie M, Nakamoto M, Nell2 regulates the contralateral-versus-ipsilateral visual projection as a domain-specific positional cue. Development. 2019 Feb 18;146(4):dev170704 |
1 | J:310742 Odaka YS, Tohmonda T, Toyoda A, Aruga J, An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3. Sci Rep. 2018 Oct 8;8(1):14954 |
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1 | J:256025 Peng J, Fabre PJ, Dolique T, Swikert SM, Kermasson L, Shimogori T, Charron F, Sonic Hedgehog Is a Remotely Produced Cue that Controls Axon Guidance Trans-axonally at a Midline Choice Point. Neuron. 2018 Jan 17;97(2):326-340.e4 |
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1 | J:270726 Shimada IS, Hwang SH, Somatilaka BN, Wang X, Skowron P, Kim J, Kim M, Shelton JM, Rajaram V, Xuan Z, Taylor MD, Mukhopadhyay S, Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis. Cell Rep. 2018 Jan 30;22(5):1169-1184 |
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1* | J:142507 Tian NM, Pratt T, Price DJ, Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth-promoting activity. Development. 2008 Dec;135(24):4081-9 |
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3 | J:256746 Wang X, Shan X, Gregory-Evans CY, A mouse model of aniridia reveals the in vivo downstream targets of Pax6 driving iris and ciliary body development in the eye. Biochim Biophys Acta. 2017 Jan;1863(1):60-67 |
1 | J:138862 Warr N, Powles-Glover N, Chappell A, Robson J, Norris D, Arkell RM, Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation. Hum Mol Genet. 2008 Oct 1;17(19):2986-96 |
4* | J:178701 Watabe Y, Baba Y, Nakauchi H, Mizota A, Watanabe S, The role of Zic family zinc finger transcription factors in the proliferation and differentiation of retinal progenitor cells. Biochem Biophys Res Commun. 2011 Nov 11;415(1):42-7 |
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1 | J:210443 Yamada M, Seto Y, Taya S, Owa T, Inoue YU, Inoue T, Kawaguchi Y, Nabeshima Y, Hoshino M, Specification of spatial identities of cerebellar neuron progenitors by ptf1a and atoh1 for proper production of GABAergic and glutamatergic neurons. J Neurosci. 2014 Apr 2;34(14):4786-800 |
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3* | J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48 |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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