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Gene Expression Literature Summary
Symbol
Name
ID 		Hif1a
hypoxia inducible factor 1, alpha subunit
MGI:106918

179 matching records from 179 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1.5 E2 E2.5 E3 E3.5 E4 E4.5 E5.5 E6.5 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E20 E P
Immunohistochemistry (section) 1 6 1 5 3 9 4 13 13 2 12 8 5 2 6 1 12 1 2 27
In situ RNA (section) 2 3 1 6 1 5 2 1 2 2 10
Immunohistochemistry (whole mount) 1 1 1 1 1 1 1 1 2 2 1 1 2
In situ RNA (whole mount) 1 3 4 3 1 1 2
In situ reporter (knock in) 1 1
Northern blot 1 1 1 1 1 1 1 4
Western blot 4 2 8 1 8 1 5 2 6 1 5 2 5 2 4 2 3 2 3 2 1 1 21
RT-PCR 1 1 1 1 2 1 1 1 5 3 11 10 1 8 1 6 1 4 8 1 4 2 1 1 4 2 7 2 31
cDNA clones 1 1
RNase protection 1 1 1 1 2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Hif1a  hypoxia inducible factor 1, alpha subunit   (Synonyms: bHLHe78, HIF-1alpha, HIF1alpha, MOP1)
Results  Reference
1J:126336 Amarilio R, Viukov SV, Sharir A, Eshkar-Oren I, Johnson RS, Zelzer E, HIF1{alpha} regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development. 2007 Nov;134(21):3917-28
1*J:229890 Ang SY, Uebersohn A, Spencer CI, Huang Y, Lee JE, Ge K, Bruneau BG, KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation. Development. 2016 Mar 1;143(5):810-21
2J:327290 Appel S, Turnwald EM, Ankerne J, Wohlfarth M, Appel J, Rother E, Janoschek R, Alejandre Alcazar MA, Schnare M, Meissner U, Dotsch J, Hypoxia-Mediated Soluble Fms-Like Tyrosine Kinase 1 Increase Is Not Attenuated in Interleukin 6-Deficient Mice. Reprod Sci. 2015 Jun;22(6):735-42
4J:346910 Ayyangar U, Karkhanis A, Tay H, Afandi AFB, Bhattacharjee O, Ks L, Lee SH, Chan J, Raghavan S, Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. EMBO J. 2024 Apr;43(7):1113-1134
1J:111623 Barbosky L, Lawrence DK, Karunamuni G, Wikenheiser JC, Doughman YQ, Visconti RP, Burch JB, Watanabe M, Apoptosis in the developing mouse heart. Dev Dyn. 2006 Jul 31;235(9):2592-2602
1J:224431 Besschetnova TY, Ichimura T, Katebi N, St Croix B, Bonventre JV, Olsen BR, Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix Biol. 2015 Mar;42:56-73
3*J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
2J:277168 Bohuslavova R, Cerychova R, Papousek F, Olejnickova V, Bartos M, Gorlach A, Kolar F, Sedmera D, Semenza GL, Pavlinkova G, HIF-1alpha is required for development of the sympathetic nervous system. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13414-13423
1*J:316441 Bohuslavova R, Skvorova L, Sedmera D, Semenza GL, Pavlinkova G, Increased susceptibility of HIF-1alpha heterozygous-null mice to cardiovascular malformations associated with maternal diabetes. J Mol Cell Cardiol. 2013 Jul;60:129-41
1J:279716 Braitsch CM, Azizoglu DB, Htike Y, Barlow HR, Schnell U, Chaney CP, Carroll TJ, Stanger BZ, Cleaver O, LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382
2J:201804 Breckenridge RA, Piotrowska I, Ng KE, Ragan TJ, West JA, Kotecha S, Towers N, Bennett M, Kienesberger PC, Smolenski RT, Siddall HK, Offer JL, Mocanu MM, Yelon DM, Dyck JR, Griffin JL, Abramov AY, Gould AP, Mohun TJ, Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism. PLoS Biol. 2013 Sep;11(9):e1001666
13*J:180152 Bridges JP, Lin S, Ikegami M, Shannon JM, Conditional hypoxia inducible factor-1alpha induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol. 2012 Feb 1;362(1):24-41
1J:320189 Buchholz B, Schley G, Faria D, Kroening S, Willam C, Schreiber R, Klanke B, Burzlaff N, Jantsch J, Kunzelmann K, Eckardt KU, Hypoxia-inducible factor-1alpha causes renal cyst expansion through calcium-activated chloride secretion. J Am Soc Nephrol. 2014 Mar;25(3):465-74
3J:347732 Buth JE, Dyevich CE, Rubin A, Wang C, Gao L, Marks T, Harrison MR, Kong JH, Ross ME, Novitch BG, Pearson CA, Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha signaling to promote neural progenitor cell maintenance. EMBO Rep. 2024 Apr 10;
1J:345820 Cardarelli S, Biglietto M, Orsini T, Fustaino V, Monaco L, de Oliveira do Rego AG, Liccardo F, Masciarelli S, Fazi F, Naro F, De Angelis L, Pellegrini M, Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress. Cell Death Dis. 2024 Feb 23;15(2):169
1J:276713 Cargill K, Hemker SL, Clugston A, Murali A, Mukherjee E, Liu J, Bushnell D, Bodnar AJ, Saifudeen Z, Ho J, Bates CM, Kostka D, Goetzman ES, Sims-Lucas S, Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation. J Am Soc Nephrol. 2019 Jul;30(7):1192-1205
1J:92203 Chae SS, Paik JH, Allende ML, Proia RL, Hla T, Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. Dev Biol. 2004 Apr 15;268(2):441-7
5J:210983 Chang AC, Garside VC, Fournier M, Smrz J, Vrljicak P, Umlandt P, Fuller M, Robertson G, Zhao Y, Tam A, Jones SJ, Marra MA, Hoodless PA, Karsan A, A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion. Dev Dyn. 2014 Jul;243(7):894-905
1*J:185962 Chen D, Tian W, Li Y, Tang W, Zhang C, Osteoblast-specific transcription factor Osterix (Osx) and HIF-1alpha cooperatively regulate gene expression of vascular endothelial growth factor (VEGF). Biochem Biophys Res Commun. 2012 Jul 20;424(1):176-81
2J:151951 Chen H, Ko G, Zatti A, Di Giacomo G, Liu L, Raiteri E, Perucco E, Collesi C, Min W, Zeiss C, De Camilli P, Cremona O, Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13838-43
1*J:329220 Chen Y, Wu J, Zhang S, Gao W, Liao Z, Zhou T, Li Y, Su D, Liu H, Yang X, Su P, Xu C, Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1alpha-glycolysis axis. Cell Death Dis. 2022 Sep 20;13(9):803
2J:141453 Cheng J, Kang X, Zhang S, Yeh ET, SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007 Nov 2;131(3):584-95
1J:77480 Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, Nemery B, Dewerchin M, Van Veldhoven P, Plate K, Moons L, Collen D, Carmeliet P, Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med. 2002 Jul;8(7):702-10
2J:105812 Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B, HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006 Mar 1;20(5):557-70
2J:301004 Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J, Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon. Cell Rep. 2020 Oct 13;33(2):108256
1J:256264 Diman NY, Brooks G, Kruithof BP, Elemento O, Seidman JG, Seidman CE, Basson CT, Hatcher CJ, Tbx5 is required for avian and Mammalian epicardial formation and coronary vasculogenesis. Circ Res. 2014 Oct 24;115(10):834-44
7*J:41526 Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y, A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4273-8
1J:202337 Estrada KD, Wang W, Retting KN, Chien CT, Elkhoury FF, Heuchel R, Lyons KM, Smad7 regulates terminal maturation of chondrocytes in the growth plate. Dev Biol. 2013 Oct 15;382(2):375-84
2J:284149 Fame RM, Shannon ML, Chau KF, Head JP, Lehtinen MK, A concerted metabolic shift in early forebrain alters the CSF proteome and depends on MYC downregulation for mitochondrial maturation. Development. 2019 Oct 24;146(20):dev182857
1J:164028 Firulli BA, McConville DP, Byers JS 3rd, Vincentz JW, Barnes RM, Firulli AB, Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability. Dev Dyn. 2010 Oct;239(10):2748-60
1J:159118 Fotopoulou S, Oikonomou N, Grigorieva E, Nikitopoulou I, Paparountas T, Thanassopoulou A, Zhao Z, Xu Y, Kontoyiannis DL, Remboutsika E, Aidinis V, ATX expression and LPA signalling are vital for the development of the nervous system. Dev Biol. 2010 Mar 15;339(2):451-64
1J:259576 Funato N, Kokubo H, Nakamura M, Yanagisawa H, Saga Y, Specification of jaw identity by the Hand2 transcription factor. Sci Rep. 2016 Jun 22;6:28405
2J:105998 Galabova-Kovacs G, Matzen D, Piazzolla D, Meissl K, Plyushch T, Chen AP, Silva A, Baccarini M, Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1325-30
2J:199499 Gerhardt C, Lier JM, Kuschel S, Ruther U, The ciliary protein Ftm is required for ventricular wall and septal development. PLoS One. 2013;8(2):e57545
2J:243840 Gerl K, Steppan D, Fuchs M, Wagner C, Willam C, Kurtz A, Kurt B, Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development. Am J Pathol. 2017 Jul;187(7):1496-1511
2J:70266 Graef IA, Chen F, Chen L, Kuo A, Crabtree GR, Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001 Jun 29;105(7):863-75
3*J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1J:325366 Greco ER, Engineer A, Saiyin T, Lu X, Zhang M, Jones DL, Feng Q, Maternal nicotine exposure induces congenital heart defects in the offspring of mice. J Cell Mol Med. 2022 Jun;26(11):3223-3234
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
5J:239361 Guimaraes-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, Kilberg MS, Johnson RS, Chen J, McCulloch AD, Nobrega MA, Evans SM, Zambon AC, HIF1alpha Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes. Dev Cell. 2015 Jun 08;33(5):507-21
2J:314936 Gumusoglu SB, Chilukuri ASS, Hing BWQ, Scroggins SM, Kundu S, Sandgren JA, Santillan MK, Santillan DA, Grobe JL, Stevens HE, Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model. Transl Psychiatry. 2021 Jan 28;11(1):79
1J:330572 Guo FH, Guan YN, Guo JJ, Zhang LJ, Qiu JJ, Ji Y, Chen AF, Jing Q, Single-Cell Transcriptome Analysis Reveals Embryonic Endothelial Heterogeneity at Spatiotemporal Level and Multifunctions of MicroRNA-126 in Mice. Arterioscler Thromb Vasc Biol. 2022 Mar;42(3):326-342
7*J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
2J:122656 Habuchi H, Nagai N, Sugaya N, Atsumi F, Stevens RL, Kimata K, Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. J Biol Chem. 2007 May 25;282(21):15578-88
3J:316639 He MY, Wang G, Han SS, Jin Y, Li H, Wu X, Ma ZL, Cheng X, Tang X, Yang X, Liu GS, Nrf2 signalling and autophagy are involved in diabetes mellitus-induced defects in the development of mouse placenta. Open Biol. 2016 Jul;6(7)
1J:168483 He S, Pirity MK, Wang WL, Wolf L, Chauhan BK, Cveklova K, Tamm ER, Ashery-Padan R, Metzger D, Nakai A, Chambon P, Zavadil J, Cvekl A, Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics Chromatin. 2010;3(1):21
2*J:186535 Herriges JC, Yi L, Hines EA, Harvey JF, Xu G, Gray PA, Ma Q, Sun X, Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
3J:245009 Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almodovar C, Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun. 2017 Mar 06;8:14583
1J:99584 Hitz C, Vogt-Weisenhorn D, Ruiz P, Wurst W, Floss T, Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality. Genesis. 2005 Jun;42(2):91-103
1J:264903 Hoang TV, Horowitz ER, Chaffee BR, Qi P, Flake RE, Bruney DG, Rasor BJ, Rosalez SE, Wagner BD, Robinson ML, Lens development requires DNMT1 but takes place normally in the absence of both DNMT3A and DNMT3B activity. Epigenetics. 2017 Jan 2;12(1):27-40
2J:47665 Hogenesch JB, Gu YZ, Jain S, Bradfield CA, The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5474-9
2J:170943 Holscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A, Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury. J Biol Chem. 2011 Apr 1;286(13):11185-94
1J:238096 Houlihan SL, Lanctot AA, Guo Y, Feng Y, Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis. Elife. 2016 Sep 24;5:e17823
1J:321245 Hu S, Mahadevan A, Elysee IF, Choi J, Souchet NR, Bae GH, Taboada AK, Sanketi B, Duhamel GE, Sevier CS, Tao G, Kurpios NA, The asymmetric Pitx2 gene regulates gut muscular-lacteal development and protects against fatty liver disease. Cell Rep. 2021 Nov 23;37(8):110030
1J:253786 Hu X, Li J, Zhang Q, Zheng L, Wang G, Zhang X, Zhang J, Gu Q, Ye Y, Guo SW, Yang X, Wang L, Phosphoinositide 3-Kinase (PI3K) Subunit p110delta Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse. Sci Rep. 2016 Jun 16;6:28201
1J:198291 Huang Y, Kapere Ochieng J, Kempen MB, Munck AB, Swagemakers S, van Ijcken W, Grosveld F, Tibboel D, Rottier RJ, Hypoxia inducible factor 3alpha plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development. PLoS One. 2013;8(2):e57695
1J:68468 Huss WJ, Hanrahan CF, Barrios RJ, Simons JW, Greenberg NM, Angiogenesis and prostate cancer: identification of a molecular progression switch. Cancer Res. 2001 Mar 15;61(6):2736-43
2J:162597 Hyvarinen J, Hassinen IE, Sormunen R, Maki JM, Kivirikko KI, Koivunen P, Myllyharju J, Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem. 2010 Apr 30;285(18):13646-57
1*J:152650 Ivey KN, Sutcliffe D, Richardson J, Clyman RI, Garcia JA, Srivastava D, Transcriptional regulation during development of the ductus arteriosus. Circ Res. 2008 Aug 15;103(4):388-95
6J:45554 Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, Semenza GL, Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 1998 Jan 15;12(2):149-62
5*J:47697 Jain S, Maltepe E, Lu MM, Simon C, Bradfield CA, Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse. Mech Dev. 1998 Apr;73(1):117-23
1J:294932 Janardhan HP, Meng X, Dresser K, Hutchinson L, Trivedi CM, KRAS or BRAF mutations cause hepatic vascular cavernomas treatable with MAP2K-MAPK1 inhibition. J Exp Med. 2020 Jul 6;217(7)
3J:333870 Jazwiec PA, Patterson VS, Ribeiro TA, Yeo E, Kennedy KM, Mathias PCF, Petrik JJ, Sloboda DM, Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism. Biol Reprod. 2022 Aug 9;107(2):574-589
1J:339746 Jin R, Zhang H, Lin C, Guo J, Zou W, Chen Z, Liu H, Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis. Exp Mol Med. 2023 Jan;55(1):69-80
1J:294228 Kalailingam P, Wang KQ, Toh XR, Nguyen TQ, Chandrakanthan M, Hasan Z, Habib C, Schif A, Radio FC, Dallapiccola B, Weiss K, Nguyen LN, Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome. J Clin Invest. 2020 Aug 3;130(8):4081-4093
4J:137276 Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF, Kalluri R, Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature. 2008 Jun 19;453(7198):1117-21
2J:311572 Kang MC, Park SJ, Kim HJ, Lee J, Yu DH, Bae KB, Ji YR, Park SJ, Jeong J, Jang WY, Kim JH, Choi MS, Lee DS, Lee HS, Lee S, Kim SH, Kim MO, Park G, Choo YS, Cho JY, Ryoo ZY, Gestational loss and growth restriction by angiogenic defects in placental growth factor transgenic mice. Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2276-82
1J:336227 Karatsai O, Lehka L, Wojton D, Grabowska AI, Duda MK, Lenartowski R, Redowicz MJ, Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166748
1J:211789 Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, Aiba A, Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell Rep. 2014 Jun 12;7(5):1626-39
4J:211963 Kawakami T, Yoshimi M, Kadota Y, Inoue M, Sato M, Suzuki S, Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):134-44
2J:313928 Kim EJ, Lee JE, Yoon S, Lee DJ, Mai HN, Ida-Yonemochi H, Choi J, Jung HS, Hypoxia-Responsive Oxygen Nanobubbles for Tissues-Targeted Delivery in Developing Tooth Germs. Front Cell Dev Biol. 2021;9:626224
4*J:331512 Kimura S, Takeshita N, Oyanagi T, Seki D, Jiang W, Hidaka K, Fukumoto S, Takahashi I, Takano-Yamamoto T, HIF-2alpha Inhibits Ameloblast Differentiation via Hey2 in Tooth Development. J Dent Res. 2022 Dec;101(13):1637-1644
17J:321522 Kirschner KM, Kelterborn S, Stehr H, Penzlin JLT, Jacobi CLJ, Endesfelder S, Sieg M, Kruppa J, Dame C, Sciesielski LK, Adaptation of the Oxygen Sensing System during Lung Development. Oxid Med Cell Longev. 2022;2022:9714669
2J:88407 Knabe W, Knerlich F, Washausen S, Kietzmann T, Siren AL, Brunnett G, Kuhn HJ, Ehrenreich H, Expression patterns of erythropoietin and its receptor in the developing midbrain. Anat Embryol (Berl). 2004 Mar;207(6):503-12
1J:320427 Kobayashi H, Liu J, Urrutia AA, Burmakin M, Ishii K, Rajan M, Davidoff O, Saifudeen Z, Haase VH, Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development. Kidney Int. 2017 Dec;92(6):1370-1383
2J:287160 Komabayashi-Suzuki M, Yamanishi E, Watanabe C, Okamura M, Tabata H, Iwai R, Ajioka I, Matsushita J, Kidoya H, Takakura N, Okamoto T, Kinoshita K, Ichihashi M, Nagata KI, Ema M, Mizutani KI, Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development. Cell Rep. 2019 Oct 29;29(5):1113-1129.e5
2J:272613 Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYR, USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 Feb 22;146(4):dev174037
15J:155281 Krishnan J, Ahuja P, Bodenmann S, Knapik D, Perriard E, Krek W, Perriard JC, Essential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function. Circ Res. 2008 Nov 7;103(10):1139-46
1J:169855 Kroger C, Vijayaraj P, Reuter U, Windoffer R, Simmons D, Heukamp L, Leube R, Magin TM, Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues. Am J Pathol. 2011 Apr;178(4):1578-90
2J:137720 Kubota Y, Hirashima M, Kishi K, Stewart CL, Suda T, Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice. J Clin Invest. 2008 Jul;118(7):2393-403
3J:160163 Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H, von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development. 2010 May;137(9):1563-71
5J:231532 Lange C, Turrero Garcia M, Decimo I, Bifari F, Eelen G, Quaegebeur A, Boon R, Zhao H, Boeckx B, Chang J, Wu C, Le Noble F, Lambrechts D, Dewerchin M, Kuo CJ, Huttner WB, Carmeliet P, Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis. EMBO J. 2016 May 2;35(9):924-41
2J:185536 Lange CA, Luhmann UF, Mowat FM, Georgiadis A, West EL, Abrahams S, Sayed H, Powner MB, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JW, Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development. Development. 2012 Jul;139(13):2340-50
1*J:184934 Lee SH, Che X, Jeong JH, Choi JY, Lee YJ, Lee YH, Bae SC, Lee YM, Runx2 protein stabilizes hypoxia-inducible factor-1alpha through competition with von Hippel-Lindau protein (pVHL) and stimulates angiogenesis in growth plate hypertrophic chondrocytes. J Biol Chem. 2012 Apr 27;287(18):14760-71
1J:268341 Lee SY, Abel ED, Long F, Glucose metabolism induced by Bmp signaling is essential for murine skeletal development. Nat Commun. 2018 Nov 16;9(1):4831
3J:354214 Li M, Jin H, Zhao Y, Zhu G, Liu Y, Long H, Shen X, PHD2 safeguards modest mesendoderm development. Commun Biol. 2024 Sep 7;7(1):1100
2J:232444 Li S, Moore AK, Zhu J, Li X, Zhou H, Lin J, He Y, Xing F, Pan Y, Bohler HC, Ding J, Cooney AJ, Lan Z, Lei Z, Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation. Biol Reprod. 2016 Feb;94(2):41
1J:207483 Li Y, Hao H, Tzatzalos E, Lin RK, Doh S, Liu LF, Lyu YL, Cai L, Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells. Biol Open. 2014;3(2):172-84
2J:314167 Lim S, Kim YJ, Park S, Choi JH, Sung YH, Nishimori K, Kozmik Z, Lee HW, Kim JW, mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Muller glia. Elife. 2021 Oct 22;10:e70079
4J:301718 Lowenstein ED, Rusanova A, Stelzer J, Hernaiz-Llorens M, Schroer AE, Epifanova E, Bladt F, Isik EG, Buchert S, Jia S, Tarabykin V, Hernandez-Miranda LR, Olig3 regulates early cerebellar development. Elife. 2021 Feb 16;10:e64684
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