Gene Expression Literature Summary

• Symbol: Sin3a
• Name: transcriptional regulator, SIN3A (yeast)
• ID: MGI:107157

24 matching records from 24 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E4	E4.5	E8.5	E9.5	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E18	E18.5	E	P
Immunohistochemistry (section)		1									1	1		1	1		1	2		1	1	3		2		5
In situ RNA (section)													2			1		3	1	1						4
Immunohistochemistry (whole mount)	1	3	1	3	2	2																				1
In situ RNA (whole mount)									1		1	1		1				1		1
Western blot	1	1		1		1					1												1			2
RT-PCR	1	2		2	1	2	1	1			1		1	1		2	1	2		2	1	2	1	2		5
cDNA clones																									1
RNase protection										1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sin3a  transcriptional regulator, SIN3A (yeast)   (Synonyms: mSin3A, Sin3)
Results	Reference
1	J:32479 Ayer DE, Lawrence QA, Eisenman RN, Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell. 1995 Mar 10;80(5):767-76
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
3*	J:171293 Campbell GR, Baudhuin A, Vranizan K, Ngai J, Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Mol Cell Neurosci. 2011 Feb;46(2):548-61
5*	J:100438 Chen HW, Chen JJ, Yu SL, Li HN, Yang PC, Su CM, Au HK, Chang CW, Chien LW, Chen CS, Tzeng CR, Transcriptome analysis in blastocyst hatching by cDNA microarray. Hum Reprod. 2005 Sep;20(9):2492-501
1*	J:266522 Elsen GE, Bedogni F, Hodge RD, Bammler TK, MacDonald JW, Lindtner S, Rubenstein JLR, Hevner RF, The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1. Front Neurosci. 2018;12:571
2	J:316721 Fu AK, Hung KW, Wong HH, Fu WY, Ip NY, Cdk5 phosphorylates a component of the HDAC complex and regulates histone acetylation during neuronal cell death. Neurosignals. 2013;21(1-2):55-60
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
2*	J:61357 Grimes JA, Nielsen SJ, Battaglioli E, Miska EA, Speh JC, Berry DL, Atouf F, Holdener BC, Mandel G, Kouzarides T, The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. J Biol Chem. 2000 Mar 31;275(13):9461-7
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:93248 Hamatani T, Falco G, Carter MG, Akutsu H, Stagg CA, Sharov AA, Dudekula DB, VanBuren V, Ko MS, Age-associated alteration of gene expression patterns in mouse oocytes. Hum Mol Genet. 2004 Nov 1;13(19):2263-78
15*	J:227506 Jimenez R, Melo EO, Davydenko O, Ma J, Mainigi M, Franke V, Schultz RM, Maternal SIN3A regulates reprogramming of gene expression during mouse preimplantation development. Biol Reprod. 2015 Oct;93(4):89
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
5*	J:182713 McDonel P, Demmers J, Tan DW, Watt F, Hendrich BD, Sin3a is essential for the genome integrity and viability of pluripotent cells. Dev Biol. 2012 Mar 1;363(1):62-73
1*	J:313620 Nabeshima R, Nishimura O, Maeda T, Shimizu N, Ide T, Yashiro K, Sakai Y, Meno C, Kadota M, Shiratori H, Kuraku S, Hamada H, Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters. Elife. 2018 Aug 2;7:e36435
3	J:240892 Nitarska J, Smith JG, Sherlock WT, Hillege MM, Nott A, Barshop WD, Vashisht AA, Wohlschlegel JA, Mitter R, Riccio A, A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development. Cell Rep. 2016 Nov 01;17(6):1683-1698
4	J:224146 O'Shaughnessy-Kirwan A, Signolet J, Costello I, Gharbi S, Hendrich B, Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification. Development. 2015 Aug 1;142(15):2586-97
6	J:168860 Payne CJ, Gallagher SJ, Foreman O, Dannenberg JH, Depinho RA, Braun RE, Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells. 2010 Aug;28(8):1424-34
10	J:345642 Stokes G, Li Z, Talaba N, Genthe W, Brix MB, Pham B, Wienhold MD, Sandok G, Hernan R, Wynn J, Tang H, Tabima DM, Rodgers A, Hacker TA, Chesler NC, Zhang P, Murad R, Yuan JX, Shen Y, Chung WK, McCulley DJ, Rescuing lung development through embryonic inhibition of histone acetylation. Sci Transl Med. 2024 Jan 31;16(732):eadc8930
1*	J:73369 Trumpp A, Refaeli Y, Oskarsson T, Gasser S, Murphy M, Martin GR, Bishop JM, c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature. 2001 Dec 13;414(6865):768-73
12*	J:281257 Witteveen JS, Willemsen MH, Dombroski TC, van Bakel NH, Nillesen WM, van Hulten JA, Jansen EJ, Verkaik D, Veenstra-Knol HE, van Ravenswaaij-Arts CM, Wassink-Ruiter JS, Vincent M, David A, Le Caignec C, Schieving J, Gilissen C, Foulds N, Rump P, Strom T, Cremer K, Zink AM, Engels H, de Munnik SA, Visser JE, Brunner HG, Martens GJ, Pfundt R, Kleefstra T, Kolk SM, Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity. Nat Genet. 2016 Aug;48(8):877-87
3	J:293336 Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, Wright CVE, Lau KS, Gu G, Coregulator Sin3a Promotes Postnatal Murine beta-Cell Fitness by Regulating Genes in Ca(2+) Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response. Diabetes. 2020 Jun;69(6):1219-1231
5	J:242896 Yao C, Carraro G, Konda B, Guan X, Mizuno T, Chiba N, Kostelny M, Kurkciyan A, David G, McQualter JL, Stripp BR, Sin3a regulates epithelial progenitor cell fate during lung development. Development. 2017 Jul 15;144(14):2618-2628
1	J:333801 Zhang X, Zhang C, Zhou D, Zhang T, Chen X, Ren J, He C, Meng F, Zhou Q, Yang Q, Dai C, Lin G, Zeng S, Leng L, Telomeres cooperate in zygotic genome activation by affecting DUX4/Dux transcription. iScience. 2023 Mar 17;26(3):106158
2	J:123923 Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA, A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell. 2007 Jul;13(1):103-14