Gene Expression Literature Summary

• Symbol: Hmx1
• Name: H6 homeobox 1
• ID: MGI:107178

22 matching records from 22 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E8	E9.5	E10.5	E11	E11.5	E12.5	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18.5	E19.5	E	P
Immunohistochemistry (section)				1	1	3	2	1		1	2		1		1	1		1
In situ RNA (section)				4	1	5	4	5	1	3	2	1	2		2		2	4
In situ RNA (whole mount)	1	1	1	5			1				2
In situ reporter (knock in)								1		1	1					1		1
RT-PCR						1				1			1	1				1
cDNA clones					1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hmx1  H6 homeobox 1   (Synonyms: Nkx5-3)
Results	Reference
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
1	J:259576 Funato N, Kokubo H, Nakamura M, Yanagisawa H, Saga Y, Specification of jaw identity by the Hand2 transcription factor. Sci Rep. 2016 Jun 22;6:28405
7	J:198834 Furlan A, Lubke M, Adameyko I, Lallemend F, Ernfors P, The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification. EMBO J. 2013 May 29;32(11):1613-25
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
5	J:126770 Hodge LK, Klassen MP, Han BX, Yiu G, Hurrell J, Howell A, Rousseau G, Lemaigre F, Tessier-Lavigne M, Wang F, Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. Neuron. 2007 Aug 16;55(4):572-86
1	J:226696 Laumonnerie C, Bechara A, Vilain N, Kurihara Y, Kurihara H, Rijli FM, Facial whisker pattern is not sufficient to instruct a whisker-related topographic map in the mouse somatosensory brainstem. Development. 2015 Nov 1;142(21):3704-12
6*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
1*	J:147782 Monroe RJ, Prabhu V, Acland GM, Johnson KR, Harris BS, O'Brien TP, Welsh IC, Noden DM, Schimenti JC, Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass. BMC Dev Biol. 2009;9(1):27
2*	J:192680 Quina LA, Kuramoto T, Luquetti DV, Cox TC, Serikawa T, Turner EE, Deletion of a conserved regulatory element required for Hmx1 expression in craniofacial mesenchyme in the dumbo rat: a newly identified cause of congenital ear malformation. Dis Model Mech. 2012 Nov;5(6):812-22
8	J:184845 Quina LA, Tempest L, Hsu YW, Cox TC, Turner EE, Hmx1 is required for the normal development of somatosensory neurons in the geniculate ganglion. Dev Biol. 2012 May 1;365(1):152-63
4*	J:235740 Rosin JM, Li W, Cox LL, Rolfe SM, Latorre V, Akiyama JA, Visel A, Kuramoto T, Bobola N, Turner EE, Cox TC, A distal 594 bp ECR specifies Hmx1 expression in pinna and lateral facial morphogenesis and is regulated by the Hox-Pbx-Meis complex. Development. 2016 Jul 15;143(14):2582-92
5*	J:139285 Schorderet DF, Nichini O, Boisset G, Polok B, Tiab L, Mayeur H, Raji B, de la Houssaye G, Abitbol MM, Munier FL, Mutation in the human homeobox gene NKX5-3 causes an oculo-auricular syndrome. Am J Hum Genet. 2008 May;82(5):1178-84
1	J:86868 Simon R, Lufkin T, Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation. Mol Cell Biol. 2003 Dec;23(24):9046-60
1	J:357469 Sivori M, Dempsey B, Chettouh Z, Boismoreau F, Ayerdi M, et al., The pelvic organs receive no parasympathetic innervation. Elife. 2024;15
2	J:221159 Stubbusch J, Narasimhan P, Hennchen M, Huber K, Unsicker K, Ernsberger U, Rohrer H, Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015 Apr 15;400(2):210-23
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
3*	J:66281 Wang W, Lo P, Frasch M, Lufkin T, Hmx: an evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and drosophila. Mech Dev. 2000 Dec;99(1-2):123-37
1*	J:46379 Wang W, Van De Water T, Lufkin T, Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development. 1998 Feb;125(4):621-34
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
11*	J:48156 Yoshiura Ki, Leysens NJ, Reiter RS, Murray JC, Cloning, characterization, and mapping of the mouse homeobox gene hmx1. Genomics. 1998 May 15;50(1):61-8
3	J:314661 Zhang Q, Huang R, Ye Y, Guo X, Lu J, Zhu F, Gong X, Zhang Q, Yan J, Luo L, Zhuang S, Chen Y, Zhao X, Evans SM, Jiang C, Liang X, Sun Y, Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. Cell Death Dis. 2018 Feb 14;9(2):247