Gene Expression Literature Summary

• Symbol: Pitx1
• Name: paired-like homeodomain transcription factor 1
• ID: MGI:107374

125 matching records from 125 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E19	E	P
Immunohistochemistry (section)		1				1		6		11		10		3		6				3		1	4		1	3
In situ RNA (section)	1	1	1	1	1	3	2	14		12	2	4		10	1	13		6	1	1	1	5	1	1	2	6
Immunohistochemistry (whole mount)				1	1
In situ RNA (whole mount)		1	2	3	5	18	6	41	1	12		3	1	3				1							1
In situ reporter (knock in)							1			1	1			1								1
Northern blot		1								1				1				1				1				1
Western blot										1		1		1		1
RT-PCR					1	1	1	6		2	1	3		3		3	2	2		1			2			1
cDNA clones									1					1												2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pitx1  paired-like homeodomain transcription factor 1   (Synonyms: Bft, Potx, P-OTX, Ptx1)
Results	Reference
2	J:310312 Abe M, Cox TC, Firulli AB, Kanai SM, Dahlka J, Lim KC, Engel JD, Clouthier DE, GATA3 is essential for separating patterning domains during facial morphogenesis. Development. 2021 Sep 1;148(17):dev199534
2	J:81154 Agarwal P, Wylie JN, Galceran J, Arkhitko O, Li C, Deng C, Grosschedl R, Bruneau BG, Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo. Development. 2003 Feb;130(3):623-33
2	J:163487 Aggarwal VS, Carpenter C, Freyer L, Liao J, Petti M, Morrow BE, Mesodermal Tbx1 is required for patterning the proximal mandible in mice. Dev Biol. 2010 Aug 15;344(2):669-81
1*	J:236309 Aires R, Jurberg AD, Leal F, Novoa A, Cohn MJ, Mallo M, Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity. Dev Cell. 2016 Aug 8;38(3):262-74
1	J:207610 Akiyama R, Kawakami H, Taketo MM, Evans SM, Wada N, Petryk A, Kawakami Y, Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the beta-catenin pathway. Dev Biol. 2014 Mar 1;387(1):37-48
1	J:310136 Armfield BA, Cohn MJ, Single cell transcriptomic analysis of external genitalia reveals complex and sexually dimorphic cell populations in the early genital tubercle. Dev Biol. 2021 Sep;477:145-154
1	J:152830 Balic A, Adams D, Mina M, Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process. Dev Dyn. 2009 Sep 23;238(10):2599-2613
4	J:334460 Bando H, Brinkmeier ML, Castinetti F, Fang Q, Lee MS, Saveanu A, Albarel F, Dupuis C, Brue T, Camper SA, Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man. Hum Mol Genet. 2023 Jan 13;32(3):367-385
1	J:173619 Barron F, Woods C, Kuhn K, Bishop J, Howard MJ, Clouthier DE, Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis. Development. 2011 Jun;138(11):2249-59
2*	J:80696 Beverdam A, Merlo GR, Paleari L, Mantero S, Genova F, Barbieri O, Janvier P, Levi G, Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: Mirror of the past?. Genesis. 2002 Dec;34(4):221-7
6	J:83660 Bobola N, Carapuco M, Ohnemus S, Kanzler B, Leibbrandt A, Neubuser A, Drouin J, Mallo M, Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1. Development. 2003 Aug;130(15):3403-14
2	J:248734 Bolt CC, Negi S, Guimaraes-Camboa N, Zhang H, Troy JM, Lu X, Kispert A, Evans SM, Stubbs L, Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate. PLoS One. 2016;11(4):e0154413
2	J:127546 Brinkmeier ML, Potok MA, Davis SW, Camper SA, TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. Dev Biol. 2007 Nov 15;311(2):396-407
1*	J:116770 Britanova O, Depew MJ, Schwark M, Thomas BL, Miletich I, Sharpe P, Tarabykin V, Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development. Am J Hum Genet. 2006 Oct;79(4):668-78
1*	J:214666 Brunskill EW, Potter AS, Distasio A, Dexheimer P, Plassard A, Aronow BJ, Potter SS, A gene expression atlas of early craniofacial development. Dev Biol. 2014 Jul 15;391(2):133-46
2*	J:98076 Cai J, Ash D, Kotch LE, Jabs EW, Attie-Bitach T, Auge J, Mattei G, Etchevers H, Vekemans M, Korshunova Y, Tidwell R, Messina DN, Winston JB, Lovett M, Gene expression in pharyngeal arch 1 during human embryonic development. Hum Mol Genet. 2005 Apr 1;14(7):903-12
2	J:171194 Capellini TD, Handschuh K, Quintana L, Ferretti E, Di Giacomo G, Fantini S, Vaccari G, Clarke SL, Wenger AM, Bejerano G, Sharpe J, Zappavigna V, Selleri L, Control of pelvic girdle development by genes of the Pbx family and Emx2. Dev Dyn. 2011 May;240(5):1173-89
3	J:245758 Carreno G, Apps JR, Lodge EJ, Panousopoulos L, Haston S, Gonzalez-Meljem JM, Hahn H, Andoniadou CL, Martinez-Barbera JP, Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors. Development. 2017 Sep 15;144(18):3289-3302
6	J:99227 Charles MA, Suh H, Hjalt TA, Drouin J, Camper SA, Gage PJ, PITX genes are required for cell survival and Lhx3 activation. Mol Endocrinol. 2005 Jul;19(7):1893-903
4	J:347865 Chen KQ, Kawakami H, Anderson A, Corcoran D, Soni A, Nishinakamura R, Kawakami Y, Sall genes regulate hindlimb initiation in mouse embryos. Genetics. 2024 Feb 22;
1	J:185743 Cotney J, Leng J, Oh S, DeMare LE, Reilly SK, Gerstein MB, Noonan JP, Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. Genome Res. 2012 Jun;22(6):1069-80
1	J:65294 Dassule HR, Lewis P, Bei M, Maas R, McMahon AP, Sonic hedgehog regulates growth and morphogenesis of the tooth. Development. 2000 Nov;127(22):4775-85
5*	J:121318 Davis SW, Camper SA, Noggin regulates Bmp4 activity during pituitary induction. Dev Biol. 2007 May 1;305(1):145-60
1	J:131535 De Langhe SP, Carraro G, Tefft D, Li C, Xu X, Chai Y, Minoo P, Hajihosseini MK, Drouin J, Kaartinen V, Bellusci S, Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS One. 2008;3(1):e1516
1	J:79553 Depew MJ, Lufkin T, Rubenstein JL, Specification of jaw subdivisions by Dlx genes. Science. 2002 Oct 11;298(5592):381-5
1	J:294824 Dias A, Lozovska A, Wymeersch FJ, Novoa A, Binagui-Casas A, Sobral D, Martins GG, Wilson V, Mallo M, A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation. Elife. 2020 Jun 29;9:e56615
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:115876 Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Farinas I, Karsenty G, Grosschedl R, SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell. 2006 Jun 2;125(5):971-86
5*	J:178677 Duboc V, Logan MP, Pitx1 is necessary for normal initiation of hindlimb outgrowth through regulation of Tbx4 expression and shapes hindlimb morphologies via targeted growth control. Development. 2011 Dec;138(24):5301-9
1	J:311931 Duboc V, Sulaiman FA, Feneck E, Kucharska A, Bell D, Holder-Espinasse M, Logan MPO, Tbx4 function during hindlimb development reveals a mechanism that explains the origins of proximal limb defects. Development. 2021 Oct 1;148(19):dev199580
2*	J:207523 Edlund RK, Ohyama T, Kantarci H, Riley BB, Groves AK, Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol. 2014 Jun 1;390(1):1-13
4*	J:130185 Ellsworth BS, Butts DL, Camper SA, Mechanisms underlying pituitary hypoplasia and failed cell specification in Lhx3-deficient mice. Dev Biol. 2008 Jan 1;313(1):118-29
1	J:104125 Evans AL, Gage PJ, Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development. Hum Mol Genet. 2005 Nov 15;14(22):3347-59
1	J:259576 Funato N, Kokubo H, Nakamura M, Yanagisawa H, Saga Y, Specification of jaw identity by the Hand2 transcription factor. Sci Rep. 2016 Jun 22;6:28405
1	J:191791 Garrido-Allepuz C, Gonzalez-Lamuno D, Ros MA, Sirenomelia phenotype in bmp7;shh compound mutants: a novel experimental model for studies of caudal body malformations. PLoS One. 2012;7(9):e44962
1	J:193110 Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ, Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 1;374(1):185-97
2	J:305202 Gualtieri A, Kyprianou N, Gregory LC, Vignola ML, Nicholson JG, Tan R, Inoue SI, Scagliotti V, Casado P, Blackburn J, Abollo-Jimenez F, Marinelli E, Besser REJ, Hogler W, Karen Temple I, Davies JH, Gagunashvili A, Robinson ICAF, Camper SA, Davis SW, Cutillas PR, Gevers EF, Aoki Y, Dattani MT, Gaston-Massuet C, Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans. Nat Commun. 2021 Apr 1;12(1):2028
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:166749 Hammock EA, Eagleson KL, Barlow S, Earls LR, Miller DM 3rd, Levitt P, Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain. Neural Dev. 2010;5(1):32
1	J:214763 He F, Hu X, Xiong W, Li L, Lin L, Shen B, Yang L, Gu S, Zhang Y, Chen Y, Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect. Dev Biol. 2014 Jul 15;391(2):170-81
4	J:184018 Itou J, Kawakami H, Quach T, Osterwalder M, Evans SM, Zeller R, Kawakami Y, Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos. Development. 2012 May;139(9):1620-9
2	J:191667 Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT, Martinez-Barbera JP, SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest. 2012 Oct 1;122(10):3635-46
1	J:139700 Jeong J, Li X, McEvilly RJ, Rosenfeld MG, Lufkin T, Rubenstein JL, Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development. 2008 Sep;135(17):2905-16
1	J:89445 Jeong J, Mao J, Tenzen T, Kottmann AH, McMahon AP, Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 2004 Apr 15;18(8):937-51
2	J:178771 Kawakami Y, Marti M, Kawakami H, Itou J, Quach T, Johnson A, Sahara S, O'Leary DD, Nakagawa Y, Lewandoski M, Pfaff S, Evans SM, Izpisua Belmonte JC, Islet1-mediated activation of the beta-catenin pathway is necessary for hindlimb initiation in mice. Development. 2011 Oct;138(20):4465-73
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2*	J:166760 Keyte AL, Smith KK, Developmental origins of precocial forelimbs in marsupial neonates. Development. 2010 Dec;137(24):4283-94
1*	J:98305 Kim BM, Buchner G, Miletich I, Sharpe PT, Shivdasani RA, The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev Cell. 2005 Apr;8(4):611-22
1	J:292005 Kim E, Jiang M, Huang H, Zhang Y, Tjota N, Gao X, Robert J, Gilmore N, Gan L, Que J, Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation. Dev Cell. 2019 Dec 16;51(6):675-683.e4
2	J:58952 Kioussi C, O'Connell S, St-Onge L, Treier M, Gleiberman AS, Gruss P, Rosenfeld MG, Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14378-82
1*	J:222399 Kitazawa T, Fujisawa K, Narboux-Neme N, Arima Y, Kawamura Y, Inoue T, Wada Y, Kohro T, Aburatani H, Kodama T, Kim KS, Sato T, Uchijima Y, Maeda K, Miyagawa-Tomita S, Minoux M, Rijli FM, Levi G, Kurihara Y, Kurihara H, Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process. Dev Biol. 2015 Jun 15;402(2):162-74
1	J:105332 Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG, Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet. 2006 Feb;38(2):175-183
2	J:268374 Kragesteen BK, Spielmann M, Paliou C, Heinrich V, Schopflin R, Esposito A, Annunziatella C, Bianco S, Chiariello AM, Jerkovic I, Harabula I, Guckelberger P, Pechstein M, Wittler L, Chan WL, Franke M, Lupianez DG, Kraft K, Timmermann B, Vingron M, Visel A, Nicodemi M, Mundlos S, Andrey G, Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis. Nat Genet. 2018 Oct;50(10):1463-1473
1	J:290226 Kuwahara A, Lewis AE, Coombes C, Leung FS, Percharde M, Bush JO, Delineating the early transcriptional specification of the mammalian trachea and esophagus. Elife. 2020 Jun 9;9:e55526
3	J:89087 Lamolet B, Poulin G, Chu K, Guillemot F, Tsai MJ, Drouin J, Tpit-independent function of NeuroD1(BETA2) in pituitary corticotroph differentiation. Mol Endocrinol. 2004 Apr;18(4):995-1003
3*	J:33258 Lamonerie T, Tremblay JJ, Lanctot C, Therrien M, Gauthier Y, Drouin J, Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene. Genes Dev. 1996 May 15;10(10):1284-95
8*	J:228711 Lanctot C, Gauthier Y, Drouin J, Pituitary homeobox 1 (Ptx1) is differentially expressed during pituitary development. Endocrinology. 1999 Mar;140(3):1416-22
12*	J:41811 Lanctot C, Lamolet B, Drouin J, The bicoid-related homeoprotein Ptx1 defines the most anterior domain of the embryo and differentiates posterior from anterior lateral mesoderm. Development. 1997 Jul;124(14):2807-17
1*	J:52671 Lanctot C, Moreau A, Chamberland M, Tremblay ML, Drouin J, Hindlimb patterning and mandible development require the Ptx1 gene. Development. 1999 May;126(9):1805-10
2	J:243780 Li F, Fu G, Liu Y, Miao X, Li Y, Yang X, Zhang X, Yu D, Gan L, Qiu M, Chen Y, Zhang Z, Zhang Z, ISLET1-Dependent beta-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw. Mol Cell Biol. 2017 Apr 15;37(8)
3	J:136396 Liao X, Collins MD, All-trans retinoic acid-induced ectopic limb and caudal structures: murine strain sensitivities and pathogenesis. Dev Dyn. 2008 Jun;237(6):1553-64
1*	J:70462 Liu J, Lin C, Gleiberman A, Ohgi KA, Herman T, Huang HP, Tsai MJ, Rosenfeld MG, Tbx19, a tissue-selective regulator of POMC gene expression. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8674-9
1	J:87220 Liu W, Selever J, Lu MF, Martin JF, Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration. Development. 2003 Dec;130(25):6375-85
1*	J:99697 Liu W, Selever J, Murali D, Sun X, Brugger SM, Ma L, Schwartz RJ, Maxson R, Furuta Y, Martin JF, Threshold-specific requirements for Bmp4 in mandibular development. Dev Biol. 2005 Jul 15;283(2):282-93
1	J:97214 Liu W, Sun X, Braut A, Mishina Y, Behringer RR, Mina M, Martin JF, Distinct functions for Bmp signaling in lip and palate fusion in mice. Development. 2005 Mar;132(6):1453-61
2	J:346456 Lozovska A, Korovesi AG, Dias A, Lopes A, Fowler DA, Martins GG, Novoa A, Mallo M, Tgfbr1 controls developmental plasticity between the hindlimb and external genitalia by remodeling their regulatory landscape. Nat Commun. 2024 Mar 20;15(1):2509
4*	J:80020 Marcil A, Dumontier E, Chamberland M, Camper SA, Drouin J, Pitx1 and Pitx2 are required for development of hindlimb buds. Development. 2003 Jan;130(1):45-55
2	J:234759 Matsumaru D, Haraguchi R, Moon AM, Satoh Y, Nakagata N, Yamamura K, Takahashi N, Kitazawa S, Yamada G, Genetic analysis of the role of Alx4 in the coordination of lower body and external genitalia formation. Eur J Hum Genet. 2014 Mar;22(3):350-7
1	J:147041 Matsuyama M, Aizawa S, Shimono A, Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet. 2009 Mar;5(3):e1000427
1	J:243618 McCracken KW, Aihara E, Martin B, Crawford CM, Broda T, Treguier J, Zhang X, Shannon JM, Montrose MH, Wells JM, Wnt/beta-catenin promotes gastric fundus specification in mice and humans. Nature. 2017 Jan 12;541(7636):182-187
1	J:144153 Melnick M, Petryk A, Abichaker G, Witcher D, Person AD, Jaskoll T, Embryonic salivary gland dysmorphogenesis in Twisted gastrulation deficient mice. Arch Oral Biol. 2006 May;51(5):433-8
1	J:144017 Minoux M, Antonarakis GS, Kmita M, Duboule D, Rijli FM, Rostral and caudal pharyngeal arches share a common neural crest ground pattern. Development. 2009 Feb;136(4):637-45
7*	J:130823 Mitsiadis TA, Drouin J, Deletion of the Pitx1 genomic locus affects mandibular tooth morphogenesis and expression of the Barx1 and Tbx1 genes. Dev Biol. 2008 Jan 15;313(2):887-96
1	J:164590 Mitsiadis TA, Graf D, Luder H, Gridley T, Bluteau G, BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation. Development. 2010 Sep;137(18):3025-35
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1	J:218295 Mortensen AH, Schade V, Lamonerie T, Camper SA, Deletion of OTX2 in neural ectoderm delays anterior pituitary development. Hum Mol Genet. 2015 Feb 15;24(4):939-53
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1	J:254493 Munoz-Bravo JL, Flores-Martinez A, Herrero-Martin G, Puri S, Taketo MM, Rojas A, Hebrok M, Cano DA, Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity. PLoS One. 2016;11(10):e0164714
1	J:356554 Nahaboo W, Eski SE, Despin-Guitard E, Vermeersch M, Versaevel M, Saykali B, Monteyne D, Gabriele S, Magin TM, Schwarz N, Leube RE, Zwijsen A, Perez-Morga D, Singh SP, Migeotte I, Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo. EMBO J. 2022 Apr 4;41(7):e108747
1*	J:83256 Naiche LA, Papaioannou VE, Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois. Development. 2003 Jun;130(12):2681-93
1	J:178324 Nakamura T, Nakagawa M, Ichisaka T, Shiota A, Yamanaka S, Essential roles of ECAT15-2/Dppa2 in functional lung development. Mol Cell Biol. 2011 Nov;31(21):4366-78
1*	J:126341 Nam JS, Park E, Turcotte TJ, Palencia S, Zhan X, Lee J, Yun K, Funk WD, Yoon JK, Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb. Dev Biol. 2007 Nov 1;311(1):124-35
1	J:78407 O'Rourke MP, Soo K, Behringer RR, Hui CC, Tam PP, Twist plays an essential role in FGF and SHH signal transduction during mouse limb development. Dev Biol. 2002 Aug 1;248(1):143-56
1*	J:90465 Ozeki H, Kurihara Y, Tonami K, Watatani S, Kurihara H, Endothelin-1 regulates the dorsoventral branchial arch patterning in mice. Mech Dev. 2004 Apr;121(4):387-95
1*	J:187969 Pazin DE, Gamer LW, Cox KA, Rosen V, Molecular profiling of synovial joints: Use of microarray analysis to identify factors that direct the development of the knee and elbow. Dev Dyn. 2012 Nov;241(11):1816-26
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2*	J:336866 Puelles L, Hidalgo-Sanchez M, The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer. Int J Mol Sci. 2023 Jun 5;24(11)
1	J:79850 Raetzman LT, Ward R, Camper SA, Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia. Development. 2002 Sep;129(18):4229-39
1*	J:83258 Rallis C, Bruneau BG, Del Buono J, Seidman CE, Seidman JG, Nissim S, Tabin CJ, Logan MP, Tbx5 is required for forelimb bud formation and continued outgrowth. Development. 2003 Jun;130(12):2741-51
1	J:188151 Repetto E, Briata P, Kuziner N, Harfe BD, McManus MT, Gherzi R, Rosenfeld MG, Trabucchi M, Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet. 2012 Jul;8(7):e1002823
1	J:150130 Sambasivan R, Gayraud-Morel B, Dumas G, Cimper C, Paisant S, Kelly R, Tajbakhsh S, Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Dev Cell. 2009 Jun;16(6):810-21
5*	J:264122 Sarro R, Kocher AA, Emera D, Uebbing S, Dutrow EV, Weatherbee SD, Nottoli T, Noonan JP, Disrupting the three-dimensional regulatory topology of the Pitx1 locus results in overtly normal development. Development. 2018 Apr 9;145(7):dev158550
1	J:224515 Sato T, Kurihara Y, Asai R, Kawamura Y, Tonami K, Uchijima Y, Heude E, Ekker M, Levi G, Kurihara H, An endothelin-1 switch specifies maxillomandibular identity. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18806-11
6*	J:63167 Semina EV, Murray JC, Reiter R, Hrstka RF, Graw J, Deletion in the promoter region and altered expression of pitx3 homeobox gene in aphakia mice. Hum Mol Genet. 2000 Jul 1;9(11):1575-85
12*	J:41274 Shang J, Luo Y, Clayton DA, Backfoot is a novel homeobox gene expressed in the mesenchyme of developing hind limb. Dev Dyn. 1997 Jun;209(2):242-53
1	J:353075 Shao F, Phan AV, Yu W, Guo Y, Thompson J, Coppinger C, Venugopalan SR, Amendt BA, Van Otterloo E, Cao H, Transcriptional programs of Pitx2 and Tfap2a/Tfap2b controlling lineage specification of mandibular epithelium during tooth initiation. PLoS Genet. 2024 Jul;20(7):e1011364
4*	J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
7*	J:151467 Smith TM, Wang X, Zhang W, Kulyk W, Nazarali AJ, Hoxa2 plays a direct role in murine palate development. Dev Dyn. 2009 Aug 3;238(9):2364-2373
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