Gene Expression Literature Summary

• Symbol: Aqp4
• Name: aquaporin 4
• ID: MGI:107387

54 matching records from 54 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E1.5	E2	E2.5	E3	E4	E5.5	E9	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	E20	E	P
Immunohistochemistry (section)							1	1			1		1	1	2	2	3		2	1	4	5	2	1	1	1	20
In situ RNA (section)									1			1		1		1	1	1		2		3					7
Northern blot													1														1
Western blot												1		2		2	2	1		1		3	1				9
RT-PCR	1	1	2	1	1	1			1	1	1	3	1	3	1	4	1	3	1	3	1	9		1			15

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Aqp4  aquaporin 4   (Synonyms: aquaporin-4)
Results	Reference
4	J:183431 Aboudehen K, Hilliard S, Saifudeen Z, El-Dahr SS, Mechanisms of p53 activation and physiological relevance in the developing kidney. Am J Physiol Renal Physiol. 2012 Apr;302(8):F928-40
1	J:317822 Chern T, Achilleos A, Tong X, Hill MC, Saltzman AB, Reineke LC, Chaudhury A, Dasgupta SK, Redhead Y, Watkins D, Neilson JR, Thiagarajan P, Green JBA, Malovannaya A, Martin JF, Rosenblatt DS, Poche RA, Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Nat Commun. 2022 Jan 10;13(1):134
2	J:166533 Daneman R, Zhou L, Kebede AA, Barres BA, Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature. 2010 Nov 25;468(7323):562-6
1	J:160729 Das G, Choi Y, Sicinski P, Levine EM, Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells. Neural Dev. 2009;4:15
1	J:342336 Davaapil H, Hopkins J, Bonnin N, Papadaki V, Leung A, Kosuge H, Tashima T, Nakakido M, Sekido R, Tsumoto K, Sagoo MS, Ohnuma SI, PRELP secreted from mural cells protects the function of blood brain barrier through regulation of endothelial cell-cell integrity. Front Cell Dev Biol. 2023;11:1147625
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:250520 Dubey M, Bugiani M, Ridder MC, Postma NL, Brouwers E, Polder E, Jacobs JG, Baayen JC, Klooster J, Kamermans M, Aardse R, de Kock CP, Dekker MP, van Weering JR, Heine VM, Abbink TE, Scheper GC, Boor I, Lodder JC, Mansvelder HD, van der Knaap MS, Mice with megalencephalic leukoencephalopathy with cysts: a developmental angle. Ann Neurol. 2015 Jan;77(1):114-31
4*	J:63371 Edashige K, Sakamoto M, Kasai M, Expression of mRNAs of the aquaporin family in mouse oocytes and embryos. Cryobiology. 2000 Mar;40(2):171-5
3	J:315134 Ezan P, Andre P, Cisternino S, Saubamea B, Boulay AC, Doutremer S, Thomas MA, Quenech'du N, Giaume C, Cohen-Salmon M, Deletion of astroglial connexins weakens the blood-brain barrier. J Cereb Blood Flow Metab. 2012 Aug;32(8):1457-67
5*	J:214989 Fallier-Becker P, Vollmer JP, Bauer HC, Noell S, Wolburg H, Mack AF, Onset of aquaporin-4 expression in the developing mouse brain. Int J Dev Neurosci. 2014 Aug;36:81-9
3	J:88614 Felszeghy S, Modis L, Nemeth P, Nagy G, Zelles T, Agre P, Laurikkala J, Fejerskov O, Thesleff I, Nielsen S, Expression of aquaporin isoforms during human and mouse tooth development. Arch Oral Biol. 2004 Apr;49(4):247-57
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
2	J:355111 Gao C, Zhang L, Chen E, Zhang W, Aqp2(+) Progenitor Cells Maintain and Repair Distal Renal Segments. J Am Soc Nephrol. 2022 Jul;33(7):1357-1376
1*	J:124920 Garrison WD, Battle MA, Yang C, Kaestner KH, Sladek FM, Duncan SA, Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology. 2006 Apr;130(4):1207-20
1	J:355142 Gomez-Del Arco P, Isern J, Jimenez-Carretero D, Lopez-Maderuelo D, Pineiro-Sabaris R, El Abdellaoui-Soussi F, Torroja C, Vera-Pedrosa ML, Grima-Terren M, Benguria A, Simon-Chica A, Queiro-Palou A, Dopazo A, Sanchez-Cabo F, Jalife J, de la Pompa JL, Filgueiras-Rama D, Munoz-Canoves P, Redondo JM, The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602
2	J:241013 Grassmeyer J, Mukherjee M, deRiso J, Hettinger C, Bailey M, Sinha S, Visvader JE, Zhao H, Fogarty E, Surendran K, Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression. Dev Biol. 2017 Apr 01;424(1):77-89
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:314936 Gumusoglu SB, Chilukuri ASS, Hing BWQ, Scroggins SM, Kundu S, Sandgren JA, Santillan MK, Santillan DA, Grobe JL, Stevens HE, Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model. Transl Psychiatry. 2021 Jan 28;11(1):79
1	J:316110 Guo Q, Wang Y, Tripathi P, Manda KR, Mukherjee M, Chaklader M, Austin PF, Surendran K, Chen F, Adam10 mediates the choice between principal cells and intercalated cells in the kidney. J Am Soc Nephrol. 2015 Jan;26(1):149-59
1*	J:78912 Hellstrom M, Gerhardt H, Kalen M, Li X, Eriksson U, Wolburg H, Betsholtz C, Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol. 2001 Apr 30;153(3):543-53
3	J:292950 Hinze C, Ruffert J, Walentin K, Himmerkus N, Nikpey E, Tenstad O, Wiig H, Mutig K, Yurtdas ZY, Klein JD, Sands JM, Branchi F, Schumann M, Bachmann S, Bleich M, Schmidt-Ott KM, GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation. J Am Soc Nephrol. 2018 Mar;29(3):857-868
5*	J:80146 Huang D, Chen P, Chen S, Nagura M, Lim DJ, Lin X, Expression patterns of aquaporins in the inner ear: evidence for concerted actions of multiple types of aquaporins to facilitate water transport in the cochlea. Hear Res. 2002 Mar;165(1-2):85-95
1	J:154589 Jeong HW, Jeon US, Koo BK, Kim WY, Im SK, Shin J, Cho Y, Kim J, Kong YY, Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. J Clin Invest. 2009 Nov;119(11):3290-300
4	J:279157 Jing B, Zhang C, Liu X, Zhou L, Liu J, Yao Y, Yu J, Weng Y, Pan M, Liu J, Wang Z, Sun Y, Sun YE, Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity. Protein Cell. 2018 Mar;9(3):298-309
1	J:306396 Kim YS, Fan R, Kremer L, Kuempel-Rink N, Mildner K, Zeuschner D, Hekking L, Stehling M, Bedzhov I, Deciphering epiblast lumenogenesis reveals proamniotic cavity control of embryo growth and patterning. Sci Adv. 2021 Mar;7(11)
13*	J:160026 Larsen HS, Ruus AK, Galtung HK, Aquaporin expression patterns in the developing mouse salivary gland. Eur J Oral Sci. 2009 Dec;117(6):655-62
1	J:187341 Lloyd-Burton S, Roskams AJ, SPARC-like 1 (SC1) is a diversely expressed and developmentally regulated matricellular protein that does not compensate for the absence of SPARC in the CNS. J Comp Neurol. 2012 Aug 15;520(12):2575-90
1*	J:270210 Loo L, Simon JM, Xing L, McCoy ES, Niehaus JK, Guo J, Anton ES, Zylka MJ, Single-cell transcriptomic analysis of mouse neocortical development. Nat Commun. 2019 Jan 11;10(1):134
1	J:353383 MacArthur IC, Ma L, Huang CY, Bhavsar H, Suzuki M, Dawlaty MM, Developmental DNA demethylation is a determinant of neural stem cell identity and gliogenic competence. Sci Adv. 2024 Aug 30;10(35):eado5424
15	J:326571 Mader S, Brimberg L, Vo A, Strohl JJ, Crawford JM, Bonnin A, Carrion J, Campbell D, Huerta TS, La Bella A, Berlin R, Dewey SL, Hellman M, Eidelberg D, Dujmovic I, Drulovic J, Bennett JL, Volpe BT, Huerta PT, Diamond B, In utero exposure to maternal anti-aquaporin-4 antibodies alters brain vasculature and neural dynamics in male mouse offspring. Sci Transl Med. 2022 Apr 20;14(641):eabe9726
1	J:252094 Matuzelski E, Bunt J, Harkins D, Lim JWC, Gronostajski RM, Richards LJ, Harris L, Piper M, Transcriptional regulation of Nfix by NFIB drives astrocytic maturation within the developing spinal cord. Dev Biol. 2017 Dec 15;432(2):286-297
5*	J:333334 Mayo F, Gonzalez-Vinceiro L, Hiraldo-Gonzalez L, Calle-Castillejo C, Morales-Alvarez S, Ramirez-Lorca R, Echevarria M, Aquaporin-4 Expression Switches from White to Gray Matter Regions during Postnatal Development of the Central Nervous System. Int J Mol Sci. 2023 Feb 3;24(3)
2	J:161480 Mellitzer G, Beucher A, Lobstein V, Michel P, Robine S, Kedinger M, Gradwohl G, Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival. J Clin Invest. 2010 May 3;120(5):1708-21
9	J:175556 Merigo F, Mucignat-Caretta C, Cristofoletti M, Zancanaro C, Epithelial membrane transporters expression in the developing to adult mouse vomeronasal organ and olfactory mucosa. Dev Neurobiol. 2011 Oct;71(10):854-69
1*	J:205051 Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Sestan N, Gage FH, Lein ES, Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
1	J:162601 Mutai H, Nagashima R, Sugitani Y, Noda T, Fujii M, Matsunaga T, Expression of Pou3f3/Brn-1 and its genomic methylation in developing auditory epithelium. Dev Neurobiol. 2009 Dec;69(14):913-30
7	J:89984 Nico B, Paola Nicchia G, Frigeri A, Corsi P, Mangieri D, Ribatti D, Svelto M, Roncali L, Altered blood-brain barrier development in dystrophic MDX mice. Neuroscience. 2004;125(4):921-35
4*	J:65472 Offenberg H, Barcroft LC, Caveney A, Viuff D, Thomsen PD, Watson AJ, mRNAs encoding aquaporins are present during murine preimplantation development. Mol Reprod Dev. 2000 Dec;57(4):323-30
1	J:310854 Okada N, Kawakita T, Ito M, Tsubota K, Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells. Biomed Res Int. 2021;2021:6888494
1	J:331057 Parichha A, Datta D, Suresh V, Chatterjee M, Holtzman MJ, Tole S, Dentate gyrus morphogenesis is regulated by beta-catenin function in hem-derived fimbrial glia. Development. 2022 Nov 1;149(21):dev200953
9*	J:151683 Parreira KS, Debaix H, Cnops Y, Geffers L, Devuyst O, Expression patterns of the aquaporin gene family during renal development: influence of genetic variability. Pflugers Arch. 2009 Aug;458(4):745-59
1	J:154739 Quina LA, Wang S, Ng L, Turner EE, Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. J Neurosci. 2009 Nov 11;29(45):14309-22
2	J:239656 Reyahi A, Nik AM, Ghiami M, Gritli-Linde A, Ponten F, Johansson BR, Carlsson P, Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier. Dev Cell. 2015 Jul 06;34(1):19-32
1	J:156199 Robel S, Mori T, Zoubaa S, Schlegel J, Sirko S, Faissner A, Goebbels S, Dimou L, Gotz M, Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis. Glia. 2009 Nov 15;57(15):1630-47
1	J:331695 Siret C, van Lessen M, Bavais J, Jeong HW, Reddy Samawar SK, Kapupara K, Wang S, Simic M, de Fabritus L, Tchoghandjian A, Fallet M, Huang H, Sarrazin S, Sieweke MH, Stumm R, Sorokin L, Adams RH, Schulte-Merker S, Kiefer F, van de Pavert SA, Deciphering the heterogeneity of the Lyve1(+) perivascular macrophages in the mouse brain. Nat Commun. 2022 Nov 30;13(1):7366
2	J:275375 Sun S, Zhu XJ, Huang H, Guo W, Tang T, Xie B, Xu X, Zhang Z, Shen Y, Dai ZM, Qiu M, WNT signaling represses astrogliogenesis via Ngn2-dependent direct suppression of astrocyte gene expression. Glia. 2019 Jul;67(7):1333-1343
2	J:350439 Tan RL, Sciandra F, Hubner W, Bozzi M, Reimann J, Schoch S, Brancaccio A, Blaess S, The missense mutation C667F in murine beta-dystroglycan causes embryonic lethality, myopathy and blood-brain barrier destabilization. Dis Model Mech. 2024 Jun 1;17(6)
1	J:188109 Tan SL, Nishi M, Ohtsuka T, Matsui T, Takemoto K, Kamio-Miura A, Aburatani H, Shinkai Y, Kageyama R, Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development. Development. 2012 Oct;139(20):3806-16
2*	J:250201 Tanahashi H, Tian QB, Hara Y, Sakagami H, Endo S, Suzuki T, Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. Sci Rep. 2016 Feb 5;6:20241
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:252682 Toutounchian JJ, McCarty JH, Selective expression of eGFP in mouse perivascular astrocytes by modification of the Mlc1 gene using T2A-based ribosome skipping. Genesis. 2017 Oct;55(10)
1	J:120884 Varadaraj K, Kumari SS, Mathias RT, Functional expression of aquaporins in embryonic, postnatal, and adult mouse lenses. Dev Dyn. 2007 May;236(5):1319-28
1	J:326953 Wu X, Sosunov AA, Lado W, Teoh JJ, Ham A, Li H, Al-Dalahmah O, Gill BJA, Arancio O, Schevon CA, Frankel WN, McKhann GM 2nd, Sulzer D, Goldman JE, Tang G, Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex. Cell Rep. 2022 Jul 19;40(3):111085
1	J:347284 Zhang Y, Song Z, Wu R, Kong X, Zhang H, Li S, Gong X, Gong S, Cheng J, Yuan F, Wu H, Wang S, Yuan Z, PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA. Cell Rep. 2024 Mar 26;43(3):113930