Symbol Name ID |
Cdh6
cadherin 6 MGI:107435 |
Age | E1.5 | E2 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E19.5 | E | P |
Immunohistochemistry (section) | 1 | 1 | 1 | 4 | 1 | 4 | 1 | 6 | 2 | 2 | 2 | 3 | 6 | |||||||||||||||
In situ RNA (section) | 1 | 3 | 2 | 5 | 7 | 6 | 1 | 8 | 1 | 4 | 3 | 8 | 9 | 1 | 6 | 1 | 3 | 2 | 16 | 1 | 1 | 4 | 23 | |||||
Immunohistochemistry (whole mount) | 1 | 1 | 1 | |||||||||||||||||||||||||
In situ RNA (whole mount) | 1 | 3 | 4 | 3 | 8 | 1 | 6 | 1 | 3 | 1 | 1 | 2 | 2 | 1 | ||||||||||||||
Northern blot | 1 | 1 | 1 | 1 | 1 | 2 | ||||||||||||||||||||||
Western blot | 1 | 1 | 2 | 1 | 3 | |||||||||||||||||||||||
RT-PCR | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 3 | ||||||||||||||||||
cDNA clones | 1 | 1 | 1 | 1 | 2 |
Cdh6 cadherin 6 (Synonyms: cad6, K-cadherin) | |
Results | Reference |
3* | J:137001 Akins MR, Benson DL, Greer CA, Cadherin expression in the developing mouse olfactory system. J Comp Neurol. 2007 Apr 1;501(4):483-97 |
2 | J:128980 Awatramani R, Soriano P, Rodriguez C, Mai JJ, Dymecki SM, Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet. 2003 Sep;35(1):70-5 |
1 | J:125289 Backer S, Hidalgo-Sanchez M, Offner N, Portales-Casamar E, Debant A, Fort P, Gauthier-Rouviere C, Bloch-Gallego E, Trio controls the mature organization of neuronal clusters in the hindbrain. J Neurosci. 2007 Sep 26;27(39):10323-32 |
1 | J:208419 Basta JM, Robbins L, Kiefer SM, Dorsett D, Rauchman M, Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58 |
1* | J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034 |
1 | J:353444 Bessa P, Newman AG, Yan K, Schaub T, Dannenberg R, Lajko D, Eilenberger J, Brunet T, Textoris-Taube K, Kemmler E, Deng P, Banerjee P, Ravindran E, Preissner R, Rosario M, Tarabykin V, Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring. Nat Commun. 2024 Aug 16;15(1):7059 |
1* | J:245526 Bibollet-Bahena O, Okafuji T, Hokamp K, Tear G, Mitchell KJ, A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. PLoS One. 2017;12(5):e0177977 |
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1 | J:61535 Bishop KM, Goudreau G, O'Leary DD, Regulation of area identity in the mammalian neocortex by Emx2 and Pax6. Science. 2000 Apr 14;288(5464):344-9 |
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1 | J:206586 Boyle SC, Liu Z, Kopan R, Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development. 2014 Jan;141(2):346-54 |
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1 | J:213869 Caronia-Brown G, Yoshida M, Gulden F, Assimacopoulos S, Grove EA, The cortical hem regulates the size and patterning of neocortex. Development. 2014 Jul;141(14):2855-65 |
1 | J:73073 Chapouton P, Schuurmans C, Guillemot F, Gotz M, The transcription factor neurogenin 2 restricts cell migration from the cortex to the striatum. Development. 2001 Dec;128(24):5149-59 |
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1 | J:147282 Chen L, Guo Q, Li JY, Transcription factor Gbx2 acts cell-nonautonomously to regulate the formation of lineage-restriction boundaries of the thalamus. Development. 2009 Apr;136(8):1317-26 |
1 | J:119907 Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R, Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development. 2007 Feb;134(4):801-11 |
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1 | J:121300 Cholfin JA, Rubenstein JL, Patterning of frontal cortex subdivisions by Fgf17. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7652-7 |
1 | J:265843 Chowdhury R, Laboissonniere LA, Wester AK, Muller M, Trimarchi JM, The Trim family of genes and the retina: Expression and functional characterization. PLoS One. 2018;13(9):e0202867 |
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2 | J:74658 Dahl U, Sjodin A, Larue L, Radice GL, Cajander S, Takeichi M, Kemler R, Semb H, Genetic dissection of cadherin function during nephrogenesis. Mol Cell Biol. 2002 Mar;22(5):1474-87 |
1 | J:254118 De Clercq S, Keruzore M, Desmaris E, Pollart C, Assimacopoulos S, Preillon J, Ascenzo S, Matson CK, Lee M, Nan X, Li M, Nakagawa Y, Hochepied T, Zarkower D, Grove EA, Bellefroid EJ, DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation. Cereb Cortex. 2018 Feb 1;28(2):493-509 |
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1 | J:287010 Deacon P, Concodora CW, Chung E, Park JS, beta-catenin regulates the formation of multiple nephron segments in the mouse kidney. Sci Rep. 2019 Nov 4;9(1):15915 |
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1* | J:214586 Duan X, Krishnaswamy A, De la Huerta I, Sanes JR, Type II cadherins guide assembly of a direction-selective retinal circuit. Cell. 2014 Aug 14;158(4):793-807 |
1 | J:263194 Ebisu H, Iwai-Takekoshi L, Fujita-Jimbo E, Momoi T, Kawasaki H, Foxp2 Regulates Identities and Projection Patterns of Thalamic Nuclei During Development. Cereb Cortex. 2017 Jul 1;27(7):3648-3659 |
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2 | J:306457 Fiorentino A, Christophorou A, Massa F, Garbay S, Chiral M, Ramsing M, Rasmussen M, Gubler MC, Bessieres B, Heidet L, Fischer E, Pontoglio M, Developmental Renal Glomerular Defects at the Origin of Glomerulocystic Disease. Cell Rep. 2020 Oct 27;33(4):108304 |
1 | J:84663 Fukuchi-Shimogori T, Grove EA, Emx2 patterns the neocortex by regulating FGF positional signaling. Nat Neurosci. 2003 Aug;6(8):825-31 |
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1 | J:82309 Garel S, Huffman KJ, Rubenstein JL, Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants. Development. 2003 May;130(9):1903-14 |
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4 | J:152865 Georgas K, Rumballe B, Valerius MT, Chiu HS, Thiagarajan RD, Lesieur E, Aronow BJ, Brunskill EW, Combes AN, Tang D, Taylor D, Grimmond SM, Potter SS, McMahon AP, Little MH, Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol. 2009 Aug 15;332(2):273-86 |
1 | J:253278 Greig LC, Woodworth MB, Greppi C, Macklis JD, Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex. Neuron. 2016 Apr 20;90(2):261-77 |
5* | J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004; |
1* | J:312419 Haddad-Tovolli R, Heide M, Zhou X, Blaess S, Alvarez-Bolado G, Mouse thalamic differentiation: gli-dependent pattern and gli-independent prepattern. Front Neurosci. 2012;6:27 |
1 | J:253351 Hanley O, Zewdu R, Cohen LJ, Jung H, Lacombe J, Philippidou P, Lee DH, Selleri L, Dasen JS, Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns. Neuron. 2016 Sep 7;91(5):1005-1020 |
1* | J:278751 Hatakeyama J, Sakamoto S, Kageyama R, Hes1 and Hes5 regulate the development of the cranial and spinal nerve systems. Dev Neurosci. 2006;28(1-2):92-101 |
1 | J:194051 Heliot C, Desgrange A, Buisson I, Prunskaite-Hyyrylainen R, Shan J, Vainio S, Umbhauer M, Cereghini S, HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2. Development. 2013 Feb;140(4):873-85 |
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2 | J:183823 Hertel N, Redies C, Absence of layer-specific cadherin expression profiles in the neocortex of the reeler mutant mouse. Cereb Cortex. 2011 May;21(5):1105-17 |
5 | J:301496 Hiraga K, Inoue YU, Asami J, Hotta M, Morimoto Y, Tatsumoto S, Hoshino M, Go Y, Inoue T, Redundant type II cadherins define neuroepithelial cell states for cytoarchitectonic robustness. Commun Biol. 2020 Oct 15;3(1):574 |
1 | J:333402 Ihermann-Hella A, Hirashima T, Kupari J, Kurtzeborn K, Li H, Kwon HN, Cebrian C, Soofi A, Dapkunas A, Miinalainen I, Dressler GR, Matsuda M, Kuure S, Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation. Stem Cell Reports. 2018 Oct 9;11(4):912-928 |
1 | J:44094 Ikeya M, Lee SM, Johnson JE, McMahon AP, Takada S, Wnt signalling required for expansion of neural crest and CNS progenitors. Nature. 1997 Oct 30;389(6654):966-70 |
13* | J:39345 Inoue T, Chisaka O, Matsunami H, Takeichi M, Cadherin-6 expression transiently delineates specific rhombomeres, other neural tube subdivisions, and neural crest subpopulations in mouse embryos. Dev Biol. 1997 Mar 15;183(2):183-94 |
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1* | J:61153 Inoue T, Nakamura S, Osumi N, Fate mapping of the mouse prosencephalic neural plate. Dev Biol. 2000 Mar 15;219(2):373-83 |
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3* | J:67150 Inoue T, Tanaka T, Takeichi M, Chisaka O, Nakamura S, Noriko O, Role of cadherins in maintaining the compartment boundary between the cortex and striatum during development. Development. 2001 Feb;128(4):561-9 |
1 | J:102844 Ishii M, Han J, Yen HY, Sucov HM, Chai Y, Maxson RE Jr, Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development. 2005 Nov;132(22):4937-50 |
1 | J:139007 Kataoka A, Shimogori T, Fgf8 controls regional identity in the developing thalamus. Development. 2008 Sep;135(17):2873-81 |
1 | J:117793 Kudo LC, Karsten SL, Chen J, Levitt P, Geschwind DH, Genetic analysis of anterior-posterior expression gradients in the developing mammalian forebrain. Cereb Cortex. 2007 Sep;17(9):2108-22 |
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1 | J:293412 Lipiec MA, Bem J, Kozinski K, Chakraborty C, Urban-Ciecko J, Zajkowski T, Dabrowski M, Szewczyk LM, Toval A, Ferran JL, Nagalski A, Wisniewska MB, TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus. Development. 2020 Aug 25;147(16):dev190181 |
1 | J:150482 Little GE, Lopez-Bendito G, Runker AE, Garcia N, Pinon MC, Chedotal A, Molnar Z, Mitchell KJ, Specificity and plasticity of thalamocortical connections in Sema6A mutant mice. PLoS Biol. 2009 Apr 28;7(4):e98 |
1 | J:199727 Lokmane L, Proville R, Narboux-Neme N, Gyory I, Keita M, Mailhes C, Lena C, Gaspar P, Grosschedl R, Garel S, Sensory map transfer to the neocortex relies on pretarget ordering of thalamic axons. Curr Biol. 2013 May 6;23(9):810-6 |
1* | J:91057 Louvi A, Sisodia SS, Grove EA, Presenilin 1 in migration and morphogenesis in the central nervous system. Development. 2004 Jul;131(13):3093-105 |
3* | J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86 |
1 | J:165487 Magnani D, Hasenpusch-Theil K, Jacobs EC, Campagnoni AT, Price DJ, Theil T, The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence. J Neurosci. 2010 Oct 13;30(41):13883-94 |
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1 | J:63064 Mallamaci A, Muzio L, Chan CH, Parnavelas J, Boncinelli E, Area identity shifts in the early cerebral cortex of Emx2-/- mutant mice [see comments]. Nat Neurosci. 2000 Jul;3(7):679-86 |
4 | J:171425 Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM 3rd, Hofmann I, Mostov KE, Reichardt LF, p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011 May;138(10):2099-109 |
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2 | J:235675 Martinez-Garay I, Gil-Sanz C, Franco SJ, Espinosa A, Molnar Z, Mueller U, Cadherin 2/4 signaling via PTP1B and catenins is crucial for nucleokinesis during radial neuronal migration in the neocortex. Development. 2016 Jun 15;143(12):2121-34 |
2 | J:194050 Massa F, Garbay S, Bouvier R, Sugitani Y, Noda T, Gubler MC, Heidet L, Pontoglio M, Fischer E, Hepatocyte nuclear factor 1beta controls nephron tubular development. Development. 2013 Feb;140(4):886-96 |
1 | J:56699 Miyashita-Lin EM, Hevner R, Wassarman KM, Martinez S, Rubenstein JL, Early neocortical regionalization in the absence of thalamic innervation. Science. 1999 Aug 6;285(5429):906-9 |
4* | J:35398 Munro SB, Blaschuk OW, A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction. Biol Reprod. 1996 Oct;55(4):822-7 |
1 | J:98698 Muzio L, Mallamaci A, Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial pallium. J Neurosci. 2005 Apr 27;25(17):4435-41 |
1* | J:102092 Muzio L, Mallamaci A, Emx1, emx2 and pax6 in specification, regionalization and arealization of the cerebral cortex. Cereb Cortex. 2003 Jun;13(6):641-7 |
1 | J:186888 Nagalakshmi VK, Ren Q, Pugh MM, Valerius MT, McMahon AP, Yu J, Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int. 2011 Feb;79(3):317-30 |
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1 | J:330740 Narayanan R, Pham L, Kerimoglu C, Watanabe T, Castro Hernandez R, Sokpor G, Ulmke PA, Kiszka KA, Tonchev AB, Rosenbusch J, Seong RH, Teichmann U, Frahm J, Fischer A, Bonn S, Stoykova A, Staiger JF, Tuoc T, Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex. iScience. 2018 Jun 29;4:109-126 |
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1 | J:309553 Pal S, Dwivedi D, Pramanik T, Godbole G, Iwasato T, Jabaudon D, Bhalla US, Tole S, An Early Cortical Progenitor-Specific Mechanism Regulates Thalamocortical Innervation. J Neurosci. 2021 Aug 11;41(32):6822-6835 |
1 | J:166792 Palmesino E, Rousso DL, Kao TJ, Klar A, Laufer E, Uemura O, Okamoto H, Novitch BG, Kania A, Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 2010;8(8):e1000446 |
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5 | J:319470 Polanco J, Reyes-Vigil F, Weisberg SD, Dhimitruka I, Bruses JL, Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse. Front Mol Neurosci. 2021;14:633719 |
1 | J:124278 Rinon A, Lazar S, Marshall H, Buchmann-Moller S, Neufeld A, Elhanany-Tamir H, Taketo MM, Sommer L, Krumlauf R, Tzahor E, Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis. Development. 2007 Sep;134(17):3065-75 |
3 | J:174195 Saarimaki-Vire J, Alitalo A, Partanen J, Analysis of Cdh22 expression and function in the developing mouse brain. Dev Dyn. 2011 Aug;240(8):1989-2001 |
1 | J:69138 Saxton TM, Cheng AM, Ong SH, Lu Y, Sakai R, Cross JC, Pawson T, Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis. Curr Biol. 2001 May 1;11(9):662-70 |
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1 | J:339312 Sinclair-Wilson A, Lawrence A, Ferezou I, Cartonnet H, Mailhes C, Garel S, Lokmane L, Plasticity of thalamocortical axons is regulated by serotonin levels modulated by preterm birth. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2301644120 |
1 | J:351383 Song L, Li Q, Xia L, Sahay AE, Qiu Q, Li Y, Li H, Sasaki K, Susztak K, Wu H, Wan L, Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape. Nat Commun. 2024 Jul 15;15(1):5937 |
2* | J:73288 Sonnenberg-Riethmacher E, Miehe M, Stolt CC, Goerich DE, Wegner M, Riethmacher D, Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10. Mech Dev. 2001 Dec;109(2):253-65 |
1 | J:159839 Stevens HE, Smith KM, Maragnoli ME, Fagel D, Borok E, Shanabrough M, Horvath TL, Vaccarino FM, Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits. J Neurosci. 2010 Apr 21;30(16):5590-602 |
1 | J:145945 Szabo NE, Zhao T, Zhou X, Alvarez-Bolado G, The role of Sonic hedgehog of neural origin in thalamic differentiation in the mouse. J Neurosci. 2009 Feb 25;29(8):2453-66 |
2* | J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208 |
1 | J:190432 Taniguchi Y, Tanaka O, Sekiguchi M, Takekoshi S, Tsukamoto H, Kimura M, Imai K, Inoko H, Enforced expression of the transcription factor HOXD3 under the control of the Wnt1 regulatory element modulates cell adhesion properties in the developing mouse neural tube. J Anat. 2011 Nov;219(5):589-600 |
5* | J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23 |
3 | J:107647 Thuret S, Bhatt L, O'Leary DD, Simon HH, Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Mol Cell Neurosci. 2004 Mar;25(3):394-405 |
1 | J:279607 Tonchev AB, Tuoc TC, Rosenthal EH, Studer M, Stoykova A, Zbtb20 modulates the sequential generation of neuronal layers in developing cortex. Mol Brain. 2016 Jun 9;9(1):65 |
1 | J:58999 Trumpp A, Depew MJ, Rubenstein JL, Bishop JM, Martin GR, Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 1999 Dec 1;13(23):3136-48 |
3 | J:175465 Urness LD, Bleyl SB, Wright TJ, Moon AM, Mansour SL, Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development. Dev Biol. 2011 Aug 15;356(2):383-97 |
1 | J:290264 Vagnozzi AN, Garg K, Dewitz C, Moore MT, Cregg JM, Jeannotte L, Zampieri N, Landmesser LT, Philippidou P, Phrenic-specific transcriptional programs shape respiratory motor output. Elife. 2020 Jan 16;9:e52859 |
1* | J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6 |
1* | J:73066 Voiculescu O, Taillebourg E, Pujades C, Kress C, Buart S, Charnay P, Schneider-Maunoury S, Hindbrain patterning: Krox20 couples segmentation and specification of regional identity. Development. 2001 Dec;128(24):4967-78 |
1* | J:73282 Watari N, Kameda Y, Takeichi M, Chisaka O, Hoxa3 regulates integration of glossopharyngeal nerve precursor cells. Dev Biol. 2001 Dec 1;240(1):15-31 |
1 | J:176365 Yallowitz AR, Hrycaj SM, Short KM, Smyth IM, Wellik DM, Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma. PLoS One. 2011;6(8):e23410 |
2 | J:124256 Ybot-Gonzalez P, Gaston-Massuet C, Girdler G, Klingensmith J, Arkell R, Greene ND, Copp AJ, Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling. Development. 2007 Sep;134(17):3203-11 |
1 | J:142685 Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, McMahon AP, A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development. 2009 Jan;136(1):161-71 |
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